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| 1 | Predicting the distribution of thin bed reservoirs by broad frequency band seismic显示文摘识别薄内部在在 Songliao 盆的中间浅的阶层的 bedded 水库是一个大困难。以便解决这个问题,我们在场为预言使用一个宽广频率乐队和极端高分辨率的薄水库的分发的一种技术地震。基于向前当模特儿,我们认出了那一张薄床地震思考被与改变频率改变振幅描绘(振幅对频率, AVF ) 。我们从他们的 AVF 特征计算薄水库的厚度并且用宽广频率乐队和极端高分辨率预言薄床水库的分发地震。这种技术在 3D 被使用了在 Songliao 盆的北部分的 Zhaoyuan 的地震区域。地震决定在的上到二或三次被增加常规地震并且许多薄水库被识别了。这种技术有广泛的申请到油和气体的探索和发展,例如优化探索井的地点,井(特别水平的井) 的设计,生产测试层的选择,等等在发展井分析水库连续性。 | Li Zishun Guo Xuebin | 2007 | Applied Geophysics2007，4，2： | 12 |
| 2 | The cytokine milieu in the interplay of pathogenic Th1/ Th17 cells and regulatory T cells in autoimmune disease显示文摘The propagation and regulation of an immune response is driven by a network of effector and regulatory T(Treg)cells.The interplay of effector T and Treg cells determines the direction of the immune response towards inflammation or its resolution in an autoimmune disease setting.In autoimmune diseases,this interplay shifts the balance in favor of the development of autoreactive effector T cells,resulting in inflammatory pathology.The objective of an effective therapeutic approach for autoimmune disease is to restore this balance.In this review,we describe the characteristics and development of pathogenic T helper 1(Th1)and Th17 cells and the beneficial Treg cells in autoimmune diseases and the crucial roles of the cytokine milieu in influencing the balance of these T-cell subsets.Given the importance of cytokines,we discuss current immunotherapeutic strategies using cytokine or cytokine receptor antibodies for the treatment of autoimmune diseases. | Stewart Leung Xuebin Liu Lei Fang Xi Chen Taylor Guo Jingwu Zhang | 2010 | Cellular & Molecular Immunology2010，7，3： | 8 |
| 3 | Blunted nitric oxide regulation in Tibetans under high-altitude hypoxia显示文摘Nitric oxide(NO) is an important molecule for vasomotor tone, and elevated NO signaling was previously hypothesized as a unique and adaptive physiological change in highland Tibetans. However, there has been lack of NO data from Tibetans living at low altitude and lowlander immigrants living at high altitude, which is crucial to test this hypothesis. Here, through cross-altitude(1990–5018 m) and cross-population(Tibetans and Han Chinese) analyses of serum NO metabolites(NOx) of 2086 individuals, we demonstrate that although Tibetans have a higher serum NOx level compared to lowlanders, Han Chinese immigrants living at high altitude show an even higher level than Tibetans. Consequently, our data contradict the previous proposal of increased NO signaling as the unique adaptive strategy in Tibetans.Instead, Tibetans have a relatively lower circulating NOx level at high altitude. This observation is further supported by data from the hypoxic experiments using human umbilical vein endothelial cells and gene knockout mice. No difference is detected between Tibetans and Han Chinese for endothelial nitric oxide synthase(e NOS), the key enzyme for circulating NO synthesis, suggesting that e NOS itself is unlikely to be the cause. We show that other NO synthesis-related genes(e.g. GCH1) carry Tibetan-enriched mutations significantly associated with the level of circulating NOx in Tibetans. Furthermore, gene network analysis revealed that the downregulation and upregulation of NOx is possibly achieved through distinct pathways.Collectively, our findings provide novel insights into the physiological and genetic mechanisms of the evolutionary adaptation of Tibetans to high-altitude hypoxia. | Yaoxi He Xuebin Qi Ouzhuluobu Shiming Liu Jun Li Hui Zhang Baimakangzhuo Caijuan Bai Wangshan Zheng Yongbo Guo Duojizhuoma Baimayangji Dejiquzong Bianba Gonggalanzi Yongyue Pan Qula Kangmin Cirenyangji Wei Guo Yangla Yi Peng Xiaoming Zhang Kun Xiang Zhaohui Yang Liangbang Wang Gengdeng Yanfeng Zhang Tianyi Wu Bing Su Chaoying Cui | 2018 | National Science Review2018，5，4： | 7 |
| 4 | De novo assembly of a Tibetan genome and identification of novel structural variants associated with high-altitude adaptation显示文摘Structural variants(SVs) may play important roles in human adaptation to extreme environments such as high altitude but have been under-investigated. Here, combining long-read sequencing with multiple scaffolding techniques, we assembled a high-quality Tibetan genome(ZF1), with a contig N50 length of 24.57 mega-base pairs(Mb) and a scaffold N50 length of 58.80 Mb. The ZF1 assembly filled 80 remaining N-gaps(0.25 Mb in total length) in the reference human genome(GRCh38). Markedly, we detected17 900 SVs, among which the ZF1-specific SVs are enriched in GTPase activity that is required for activation of the hypoxic pathway. Further population analysis uncovered a 163-bp intronic deletion in the MKL1 gene showing large divergence between highland Tibetans and lowland Han Chinese. This deletion is significantly associated with lower systolic pulmonary arterial pressure, one of the key adaptive physiological traits in Tibetans. Moreover, with the use of the high-quality de novo assembly, we observed a much higher rate of genome-wide archaic hominid(Altai Neanderthal and Denisovan) shared non-reference sequences in ZF1(1.32%–1.53%) compared to other East Asian genomes(0.70%–0.98%),reflecting a unique genomic composition of Tibetans. One such archaic hominid shared sequence-a662-bp intronic insertion in the SCUBE2 gene-is enriched and associated with better lung function(the FEV1/FVC ratio) in Tibetans. Collectively, we generated the first high-resolution Tibetan reference genome, and the identified SVs may serve as valuable resources for future evolutionary and medical studies. | Ouzhuluobu Yaoxi He Haiyi Lou Chaoying Cui Lian Deng Yang Gao Wangshan Zheng Yongbo Guo Xiaoji Wang Zhilin Ning Jun Li Bin Li Caijuan Bai Baimakangzhuo Gonggalanzi Dejiquzong Bianba Duojizhuoma Shiming Liu Tianyi Wu Shuhua Xu Xuebin Qi Bing Su | 2020 | National Science Review2020，7，2： | 4 |
| 5 | Potential applications of porous organic polymers as adsorbent for the adsorption of volatile organic compounds显示文摘Volatile organic compounds(VOCs)with high toxicity and carcinogenicity are emitted from kinds of industries,which endanger human health and the environment.Adsorption is a promising method for the treatment of VOCs due to its low cost and high efficiency.In recent years,activated carbons,zeolites,and mesoporous materials are widely used to remove VOCs because of their high specific surface area and abundant porosity.However,the hydrophilic nature and low desorption rate of those materials limit their commercial application.Furthermore,the adsorption capacities of VOCs still need to be improved.Porous organic polymers(POPs)with extremely high porosity,structural diversity,and hydrophobic have been considered as one of the most promising candidates for VOCs adsorption.This review generalized the superiority of POPs for VOCs adsorption compared to other porous materials and summarized the studies of VOCs adsorption on different types of POPs.Moreover,the mechanism of competitive adsorption between water and VOCs on the POPs was discussed.Finally,a concise outlook for utilizing POPs for VOCs adsorption was discussed,noting areas in which further work is needed to develop the next-generation POPs for practical applications. | Shuangchun Lu Qingling Liu Rui Han Miao Guo Jiaqi Shi Chunfeng Song Na Ji Xuebin Lu Degang Ma | 2021 | Journal of Environmental Sciences2021，33，7： | 4 |
| 6 | The Axin/TNKS complex interacts with KIF3A and is required for insulin-stimulated GLUT4 translocation显示文摘由葡萄糖 transporter GLUT4 的刺激胰岛素的葡萄糖举起在整个身体的葡萄糖动态平衡起一个中央作用,哪个导致类型 2 糖尿病的 dysregulation。然而,调整刺激胰岛素的葡萄糖举起的分子的部件和机制仍然保持大部分不清楚。这里,我们证明 Axin 与 ADP-ribosylase tankyrase 交往 2 (TNKS2 ) 并且 kinesin 马达蛋白质 KIF3A,响应胰岛素形成为 GLUT4 translocation 关键的第三的建筑群。特定到血浆膜的复杂稀释刺激胰岛素的 GLUT4 translocation 的单个部件击倒。重要地, TNKS2 −/− 老鼠展出减少的胰岛素敏感和更高的血葡萄糖层次什么时候在 fasting 以后的 re-fed。机械学地,我们证明当胰岛素不在时, Axin, TNKS 和 KIF3A 与 trans-Golgi 网络上的 GLUT4 是 co 局部性的。胰岛素处理压制 TNKS 的 ADP-ribosylase 活动,导致在自动数据处理 ribosylation 和 ubiquitination 的减小 Axin 和 TNKS,和建筑群的并发的稳定。Akt 的抑制,胰岛素发信号的主要受动器 kinase,废除调停胰岛素的复杂稳定。我们因此阐明了直接在刺激胰岛素的 GLUT4 translocation 与马达蛋白质 kinesin 被联系的新蛋白质建筑群。 | Hui-Ling Guo Cixiong Zhang Qi Liu Qinxi Li Guili Lian Di Wu Xuebin Li Wei Zhang Yuemao Shen Zhiyun Ye Slau-Yong Lin Sheng-Cai Lin | 2012 | Cell Research2012，22，8： | 4 |
| 7 | Thermodynamics of Fe-P-C in Mn-Based Solutions显示文摘ThermodynamicsofFe┐P┐CinMn┐BasedSolutionsChenErbao①,YuXuebin②,DongYuanchi①,GuoShangxing①ABSTRACTThesolubilitiesofcarboninMn-... | Chen Erbao Yu Xuebin Dong Yuanchi Guo Shangxing | 1997 | Journal of Iron and Steel Research(International)1997，4，2： | 2 |
| 8 | Influence of Allele Frequency on Predicting Animal Phenotype Using Back-Propagation Artificial Neural Networks显示文摘To overcome the obstacle of the fascinating relation in predicting animal phenotype value, we have developed a neural network model to detect the complex non-linear relationships between the genotypes and phenotypes and the possible interactions that cannot be expressed with equations. In this paper, back-propagation neural network is used to discuss the influences of different allele frequencies on estimating the polygenic phenotype value. To ensure the precision of prediction, normalization was needed to train the prediction model. The results show that back-propagation artificial neural networks can be used to predict the phenotype value and perform very well in allele frequency from 0.2 to 0.8, when the allele frequency is very small (less than 0.2) or big (more than 0.8); however, the prediction model was not reliable and the predicted value should be carefully tested. | LI Xuebin YU Xiaoling GUO Yunrui XIANG Zhifeng ZHAO Kun REN Fei | 2011 | Wuhan University Journal of Natural Sciences2011，16，2： | 2 |
| 9 | The hy- drogen-enriched A1-B-N system as an advanced solid hy- drogen-storage candidate 显示文摘 | Guo Yanhui Yu Xuebin Sun Weiwei | 2011 | Angewandte Chemie2011，123，5： | 1 |
| 10 | Retrospec-tive seroepidemiology indicated that human enterovirus71 and coxsackievirus A16 circulated wildly in centraland southern China before large-scale outbreaks from2008显示文摘 | Zhen Zhu Shuangli Zhu Xuebin Guo | 2011 | J Virol2011，4，7： | 1 |
| 11 | True complete left bundle branch block morphology strongly predicts good response to cardiac resynchronization therapy显示文摘 | Yun Tian Ping Zhang Xuebin Li Ying Gao Tiangang Zhu Long Wang Ding Li Jiayu Wang Cuizhen Yuan Jihong Guo | 2013 | Europace2013，，10： | 1 |
| 12 | Presence of notched QRS on paced electrocardiographs as a predictor of poor response to cardiac resynchronization therapy显示文摘 | Wang Jiayu Zhang Ping Li Xuebin Zhu Tiangang Li Hua Wang Long Li Ding Wu Cuncao Gao Ying Tian Yun Guo Jihong | 2014 | Chinese Medical Journal2014，，15： | 1 |
| 13 | Expert consensus on the prevention and treatment of substance use and addictive behaviour-related disorders during the COVID-19 pandemic显示文摘In early 2020,the COVID-19 outbreak complicated the diagnosis,treatm ent and rehabilitation of patients with substance use disorders and increased the risks of substance abuse and addictive behaviours,such as online gaming disorders,in the general public.Substance use disorder is a chronic recurrent brain disease characterised by strong cravings,high recurrence rates,and a high proportion of comorbidity of mental and physical disorders.1 Therefore,regular long-term therapeutic interventions are critical to preventing dm g relapses while maintaining withdrawal. | Jiang Du Ni Fan Min Zhao Wei Hao Tieqiao Liu Lin Lu Jie Shi Haifeng Jiang Na Zhong Xiaochang Lan Shichao Xu Hongxian Chen Xiaojun Xiang Xuyi Wang Hongqiang Sun Bing Li Yu-Ping Ning Jing Li Wanjun Guo Yajuan Niu Lixia Sheng Yi Li Xuebin Liu Xuhui Zhou Mincai Qian Wenhua Zhou Ruiling Zhang Hongxing Hu Yan Xia Zhonghua Su Ruimin Zhang Mei Yang Fen Liu Wei Yuan | 2020 | General Psychiatry2020，33，4： | 1 |
| 14 | Suppression of ZEAXANTHIN EPOXIDASE 1 restricts stripe rust growth in wheat显示文摘Reducing losses caused by pathogens is an effective strategy for stabilizing crop yields.Daunting challenges remain in cloning and characterizing genes that inhibit stripe rust,a devastating disease of wheat(Triticum aestivum)caused by Puccinia striiformis f.sp.tritici(Pst).We found that suppression of wheat zeaxanthin epoxidase 1(ZEP1)increased wheat defense against Pst.We isolated the yellow rust slower 1(yrs1)mutant of tetraploid wheat in which a premature stop mutation in ZEP1-B underpins the phenotype.Genetic analyses revealed increased H_(2)O_(2) accumulation in zep1 mutants and demonstrated a correlation between ZEP1 dysfunction and slower Pst growth in wheat.Moreover,wheat kinase START 1.1(WKS1.1,Yr36)bound,phosphorylated,and suppressed the biochemical activity of ZEP1.A rare natural allele in the hexaploid wheat ZEP1-B promoter reduced its transcription and Pst growth.Our study thus identified a novel suppressor of Pst,characterized its mechanism of action,and revealed beneficial variants for wheat disease control.This work opens the door to stacking wheat ZEP1 variants with other known Pst resistance genes in future breeding programs to enhance wheat tolerance to pathogens. | Chao-Yan Chang Shu-Xian Yang Mei-Qi Zhang Yue-Ting Guo Xiao-Ming Li Yan Yan Ci-Hang Ding Ke-Xin Niu Meng-Lu Wang Qin-Quan Li Junli Zhang Xuebin Zhang Shisheng Chen Chaojie Xie Zhongfu Ni Qixin Sun Jin-Ying Gou | 2023 | Plant Communications2023，4，5： | 0 |
| 15 | Characteristics of the Earth-Resistivity Change Before the Jingtai Earthquake with Ms=6.2显示文摘The earth-resistivity change recorded before the Jingtai earthquake(EQ).with Ms=6.2 at 11 geoelectric stations within 400 km of the EQ was discussed in this paper,and the following conclusions are made:1) imminent variations of earth-resistivity prior to the EQ were recorded at the Wuwei,Dingxi and Shandan stations immediately before the EQ;2) the recordability of the imminent variations at a station was related to the active deep faults and the strongly active faults inside and outside the focal zone,and to the causative stress field as well;3) the temporal and spatial characteristics of the earth-resistivity change immediately before the EQ showed that the EQ was probably induced by the NNW direction stress field(or by another one of similar direction)which was greatly increased during a short period immediately before the EQ and that the northern wall of the focal fault played a major role in the process of the EQ preparation and occurrence of the EQ. | Du Xuebin,Zhao Hevun,Chen Baozhi and Guo HuiminSeismolcgical Institute of Lanzhou,SSB,Lanzhou 730000,China | 1994 | Earthquake Research in China1994，8，3： | 0 |
| 16 | Seasonality and Sex-Biased Fluctuation of Birth Weight in Tibetan Populations显示文摘Birth weight(BW)is a key determinant of infant mortality.Previous studies have reported seasonal fluctuation of BW.However,the responsible environmental factors remain disputable.High-altitude environment provides a great opportunity to test the current hypotheses due to its distinctive climate conditions.We collected BW data of~9000 Tibetan singletons born at Lhasa(elevation:3660 m)from 2014 to 2018.Using regression models,we analyzed BW seasonality of highland Tibetans.Multivariate models with meteorological factors as independent variables were employed to examine responsible environmental factors accounting for seasonal variation.We compared BW,low-BW prevalence and sex ratio between high-land and lowland populations,and we observed a significant seasonal pattern of BW in Tibetans,with a peak in winter and a trough in summer.Notably,there is a marked sex-biased pattern of BW seasonality(more striking in males than in females).Sunlight exposure in the 3rd trimester and barometric pressure exposure in the 2nd trimester are significantly correlated with BW,and the latter can be explained by seasonal change of oxygen partial pressure.In particular,due to the male-biased BW seasonality,we found a more serious BW reduction and higher prevalence of low-BW in males,and a skewed sex ratio in highlanders.The infant BW of highland Tibetans has a clear pattern of seasonality.The winter BW is larger than the summer BW,due to the longer sunlight exposure during the late-trimester.Male infants are more sensitive to hypoxia than female infants during the 2nd trimester,leading to more BW reduction and higher mortality. | Yaoxi He Jun Li Tian Yue Wangshan Zheng Yongbo Guo Hui Zhang Li Chen Chunxia Li Hongyan Li Chaoying Cui Ouzhuluobu Xuebin Qi Bing Su | 2022 | Phenomics2022，2，1： | 0 |
| 17 | Phosphorylation of KAT-2B by WKS1/Yr36 redirects the lipid flux to jasmonates to enhance resistance against wheat stripe rust显示文摘Wheat(Triticum aestivum)is one of the most essential human energy and protein sources.However,wheat production is threatened by devastating fungal diseases such as stripe rust,caused by Puccinia striiformis Westend.f.sp.tritici(Pst).Here,we reveal that the alternations in chloroplast lipid profiles and the accumulation of jasmonate(JA)in the necrosis region activate JA signaling and trigger the host defense.The collapse of chloroplasts in the necrosis region results in accumulations of polyunsaturated membrane lipids and the lipid-derived phytohormone JA in transgenic lines of Yr36 that encodes Wheat Kinase START 1(WKS1),a high-temperature-dependent adult plant resistance protein.WKS1.1,a protein encoded by a full-length splicing variant of WKS1,phosphorylates and enhances the activity of keto-acyl thiolase(KAT-2B),a critical enzyme catalyzing theβ-oxidation reaction in JA biosynthesis.The premature stop mutant,kat-2b,accumulates less JA and shows defects in the host defense against Pst.Conversely,overexpression of KAT-2B results in a higher level of JA and limits the growth of Pst.Moreover,JA inhibits the growth and reduces pustule densities of Pst.This study illustrates the WKS1.1-KAT-2B-JA pathway for enhancing wheat defense against fungal pathogens to attenuate yield loss. | Yan Yan Xiao-Ming Li Yun Chen Tian-Tian Wu Ci-Hang Ding Mei-Qi Zhang Yue-Ting Guo Chu-Yang Wang Junli Zhang Xuebin Zhang Awais Rasheed Shengchun Xu Meng-Lu Wang Zhongfu Ni Qixin Sun 缑金营 | 2023 | Journal of Genetics and Genomics2023，50，11： | 0 |
| 18 | Synergistic effect of lithiophilic Zn nanoparticles and N-doping for stable Li metal anodes显示文摘Li metal is the most ideal anode material for next-generation high energy lithium-ion batteries.The uncontrollable growth of Li dendrites,however,hinders its practical application.Herein,we propose the adoption of Zn nanoparticles uniformly embedded in N-doped carbon polyhedra homogeneously built on carbon cloth(Zn@NC@CC)to prevent the formation of Li dendrites.Based on theoretical calculation and experimental observation,lithiophilic Zn nanoparticles and N-doping inside of the assynthesized Zn@NC play a synergistic role in enhancing the adsorption capacity with Li,thus resulting in uniform Li deposition and complete suppression of Li dendrites.Moreover,the porous N-doped carbon polyhedras uniformly distributed on carbon cloth effectively relieves the volume change of Li upon repeated Li stripping/plating process,which contributes to preserving the structural integrity of the whole electrode and hence enhancing its long-term cycling stability.Benefiting from these synergistic effects,the Li-Zn@NC@CC electrode delivers a prolonged lifespan of over 1200 h at 1 mA cm^(-2) with an areal capacity of 1 mA h cm^(-2) in symmetric cells and high Coulombic efficiencies of 95.4%under an ultrahigh capacity of 12 mA h cm^(-2).Remarkably,Li-Zn@NC@CC//LiFePO_(4) full cells deliver a high reversible capacity of 110.2 mA h g^(-1) at 1 C over 200 cycles. | Lei You Shunlong Ju Jianwen Liu Guanglin Xia Zaiping Guo Xuebin Yu | 2022 | Journal of Energy Chemistry2022，31，2： | 0 |
| 19 | A Poisoning Outbreak Caused by Anisodus tanguticus — Maqin County, Qinghai Province, China, July 2021显示文摘Summary What is already known about this topic?Anisodus tanguticus belongs to the Solanaceae family.The plant is toxic due to the tropane alkaloids it contains and can cause poisoning when it is ingested or used inappropriately.What is added by this report?A poisoning outbreak involved 10 patients,and one death was caused by Anisodus tanguticus.The etiological association of plant exposure and poisoning was confirmed with evidence from an epidemiological investigation,clinical manifestations,plant identification and a toxin analysis. | Xuebin Guo Qian He Bangguo Qi Chenye Sun DongJin Lyu Hongshun Zhang | 2022 | China CDC weekly2022，4，41： | 0 |
| 20 | High Arterial Oxygen Saturation in the Acclimatized Lowlanders Living at High Altitude显示文摘Blood oxygen saturation(SpO_(2))is a key indicator of oxygen availability in the body.It is known that a low SpO_(2)at high altitude is associated with morbidity and mortality risks due to physiological hypoxemia.Previously,it was proposed that the lowlander immigrants living at high altitude should have a lower SpO_(2)level compared to the highlander natives,but this proposal has not been rigorously tested due to the lack of data from the lowlander immigrants living at high altitude.In this study,we compared arterial oxygen saturation of 5929 Tibetan natives and 1034 Han Chinese immigrants living at altitudes ranging from 1120 m to 5020 m.Unexpectedly,the Han immigrants had a higher SpO_(2)than the Tibetan natives at the same high altitudes.At the same time,there is a higher prevalence of chronic mountain sickness in Han than in Tibetans at the same altitude.This result suggests that the relatively higher SpO_(2)level of the acclimatized Han is associated with a physiological cost,and the SpO_(2)level of Tibetans tends to be sub-optimal.Consequently,SpO_(2)alone is not a robust indicator of physiological performance at high altitude. | Yaoxi He Chaoying Cui Yongbo Guo Wangshan Zheng Tian Yue Hui Zhang Ouzhuluobu Tianyi Wu Xuebin Qi Bing Su | 2023 | Phenomics2023，3，4： | 0 |
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