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| 1 | MiR-375 frequently downregulated in gastric cancer inhibits cell proliferation by targeting JAK2显示文摘新兴的证据与肿瘤开发和前进显示出异常地表示的 microRNAs (miRNAs ) 的协会。然而,很少在胃的 carcinogenesis 对 miRNAs 的潜在的角色被知道。这里,我们执行了 miRNA microarray 屏蔽在配对的胃的癌症和他们的邻近的 nontumor 纸巾表示并且发现 miR-375 是的 miRNAs 差别极大地在胃的癌症纸巾的 downregulated。量的即时 PCR 分析证实那 miR-375 表情显著地从经历胃的切除术的病人与他们的 nontumor 对应物相比在超过 90% 主要胃的癌症被减少。miR-375 的 Overexpression 显著地在 vitro 并且在 vivo 禁止了胃的癌症房间增长。在胃的癌症房间的 miR-375 的强迫的表示显著地减少了 Janus kinase 的蛋白质水平 2 ( JAK2 )并且镇压带 JAK2 的 3 鈥? untranslated 区域的一个酶记者的活动,被预言的 miR-375-binding 地点的变化废除,显示那 JAK2 可以是 miR-375 目标基因。由由 RNAi 的 JAK2 的 AG490 或 silencing 的 JAK2 活动的任何一个抑制压制了类似于 miR-375 overexpression 的胃的癌症房间增长。而且, JAK2 的宫外的表示能部分颠倒 miR-375 引起的房间增长的抑制。最后,我们在胃的癌症发现了在 miR-375 表示和 JAK2 蛋白质水平之间的重要反的关联。因此,这些数据建议 miR-375 可以作为肿瘤 suppressor 工作由指向 JAK2 oncogene 潜在地调整胃的癌症房间增长,含有在胃的癌症的致病的 miR-375 的一个角色。 | Ling Ding Yanjun Xu Wei Zhang Yujie Deng Misi Si Ying Du Haomi Yao Xuyan Liu Yuehai Ke Jianmin Si Tianhua Zhou | 2010 | Cell Research2010，20，7： | 59 |
| 2 | Air pollution characteristics and their relationship with emissions and meteorology in the Yangtze River Delta region during 2014–2016显示文摘With rapid economic growth and urbanization, the Yangtze River Delta(YRD) region in China has experienced serious air pollution challenges. In this study, we analyzed the air pollution characteristics and their relationship with emissions and meteorology in the YRD region during 2014–2016. In recent years, the concentrations of all air pollutants, except O3,decreased. Spatially, the PM2.5, PM10, SO2, and CO concentrations were higher in the northern YRD region, and NO2 and O3 were higher in the central YRD region. Based on the number of non-attainment days(i.e., days with air quality index greater than 100), PM2.5 was the largest contributor to air pollution in the YRD region, followed by O3, PM10, and NO2.However, particulate matter pollution has declined gradually, while O3 pollution worsened.Meteorological conditions mainly influenced day-to-day variations in pollutant concentrations. PM2.5 concentration was inversely related to wind speed, while O3 concentration was positively correlated with temperature and negatively correlated with relative humidity.The air quality improvement in recent years was mainly attributed to emission reductions.During 2014–2016, PM2.5, PM10, SO2, NOx, CO, NH3, and volatile organic compound(VOC)emissions in the YRD region were reduced by 26.3%, 29.2%, 32.4%, 8.1%, 15.9%, 4.5%, and0.3%, respectively. Regional transport also contributed to the air pollution. During regional haze periods, pollutants from North China and East China aggravated the pollution in the YRD region. Our findings suggest that emission reduction and regional joint prevention and control helped to improve the air quality in the YRD region. | Tao Ma Fengkui Duan Kebin He Yu Qin Dan Tong Guannan Geng Xuyan Liu Hui Li Shuo Yang Siqi Ye Beiyao Xu Qiang Zhang Yongliang Ma | 2019 | Journal of Environmental Sciences2019，31，9： | 26 |
| 3 | Molecular Characterisation of the Faecal Microbiota in Patients with Type II Diabetes显示文摘 | Xiaokang Wu Chaofeng Ma Lei Han Muhammad Nawaz Fei Gao Xuyan Zhang Pengbo Yu Chang’an Zhao Lianchuan Li Aiping Zhou Juan Wang John E. Moore B. Cherie Millar Jiru Xu | 2010 | Current Microbiology2010，，1： | 2 |
| 4 | Tracing PRX1+cells during molar formation and periodontal ligament reconstruction显示文摘Neural crest-derived mesenchymal stem cells(MSCs)are known to play an essential function during tooth and skeletal development.PRX1+cells constitute an important MSC subtype that is implicated in osteogenesis.However,their potential function in tooth development and regeneration remains elusive.In the present study,we first assessed the cell fate of PRX1+cells during molar development and periodontal ligament(PDL)formation in mice.Furthermore,single-cell RNA sequencing analysis was performed to study the distribution of PRX1+cells in PDL cells.The behavior of PRX1+cells during PDL reconstruction was investigated using an allogeneic transplanted tooth model.Although PRX1+cells are spatial specific and can differentiate into almost all types of mesenchymal cells in first molars,their distribution in third molars is highly limited.The PDL formation is associated with a high number of PRX1+cells;during transplanted teeth PDL reconstruction,PRX1+cells from the recipient alveolar bone participate in angiogenesis as pericytes.Overall,PRX1+cells are a key subtype of dental MSCs involved in the formation of mouse molar and PDL and participate in angiogenesis as pericytes during PDL reconstruction after tooth transplantation. | Xuyan Gong Han Zhang Xiaoqiao Xu Yunpeng Ding Xingbo Yang Zhiyang Cheng Dike Tao Congjiao Hu Yaozu Xiang Yao Sun | 2022 | International Journal of Oral Science2022，14，1： | 2 |
| 5 | An optimization model for fragmentation-based routing in delay tolerant networks显示文摘The explosive growth of mobile data traffic has raised big penetration to cellular network. Fortunately, offloading part of traffic through Delay Tolerant Network(DTN) would be a promising option to relieve load pressure. However, the existing routing strategies designed for DTNs are inappropriate in offloading scenario, where i) large data item would take on the dominance of mobile traffic, ii) centralized control can be exploited with merge between DTN and cellular network. To improve the routing performance of large data transmission, we propose a novel optimization model by creating two-tier solution space based on fragmentation,maximizing the probability that the requested data item is successfully delivered before expiration, taking limited buffer space as constraint metric. Moreover, a specific routing scheme is instantiated from our model, which is supported by uniform fragmentation and fine-grained path selection. Extensive trace-driven simulations show that our scheme is more appropriate for offloading case with outstanding performance in terms of replication overhead and acceptable routing capability. | Xuyan BAO Yong ZHANG Da GUO Mei SONG | 2016 | Science China(Information Sciences)2016，59，2： | 1 |
| 6 | Origins of black carbon from anthropogenic emissions and open biomass burning transported to Xishuangbanna, Southwest China显示文摘Black carbon(BC) has importance regarding aerosol composition, radiative balance, and human exposure. This study adopted a backward-trajectory approach to quantify the origins of BC from anthropogenic emissions(BCAn) and open biomass burning(BCBB) transported to Xishuangbanna in 2017. Haze months, between haze and clean months, and clean months in Xishuangbanna were defined according to daily PM_(2.5)concentrations of >75, 35–75, and<35 μg/m^(3), respectively. Results showed that the transport efficiency density(TED) of BC transported to Xishuangbanna was controlled by the prevailing winds in different seasons.The yearly contributions to the effective emission intensity of BCAnand BCBBtransported to Xishuangbanna were 52% and 48%, respectively. However, when haze occurred in Xishuangbanna, the average BCAnand BCBBcontributions were 23% and 77%, respectively. This suggests that open biomass burning(BB) becomes the dominant source in haze months. Myanmar, India, and Laos were the dominant source regions of BC transported to Xishuangbanna during haze months, accounting for 59%, 18%, and 13% of the total, respectively. Furthermore, India was identified as the most important source regions of BCAntransported to Xishuangbanna in haze months, accounting for 14%. The two countries making the greatest contributions to BCBBtransported to Xishuangbanna were Myanmar and Laos in haze months, accounting for 55% and 13%, respectively. BC emissions from Xishuangbanna had minimal effects on the results of the present study. It is suggested that open BB in Myanmar and Laos, and anthropogenic emissions in India were responsible for poor air quality in Xishuangbanna. | Xuyan Liu SiwenWang Qianqian Zhang Chunlai Jiang Linlin Liang Shihao Tang Xingying Zhang Xiuzhen Han Lin Zhu | 2023 | Journal of Environmental Sciences2023，，3： | 1 |
| 7 | Biosafety materials:Ushering in a new era of infectious disease diagnosis and treatment with the CRISPR/Cas system显示文摘Despite multiple virus outbreaks over the past decade,including the devastating coronavirus disease 2019(COVID-19)pandemic,the lack of accurate and timely diagnosis and treatment technologies has wreaked havoc on global biosecurity.The clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated proteins(Cas)system has the potential to address these critical needs for tackling infectious diseases to detect viral nucleic acids and inhibit viral replication.This review summarizes how the CRISPR/Cas system is being utilized for the treatment and diagnosis of infectious diseases with the help of biosafety materials and highlights the design principle and in vivo and in vitro efficacy of advanced biosafety materials used to deal with virus attacks. | Yuquan Zhang Ziyue Li Julien Milon Essola Kun Ge Xuyan Dai Huining He Haihua Xiao Yuhua Weng Yuanyu Huang | 2022 | Biosafety and Health2022，4，2： | 1 |
| 8 | Peutz-Jeghers综合征相关性小肠腺癌:5例个案报道及文献综述(英文)显示文摘Peutz-Jeghers syndrome(PJS) is a rare autosomal dominant inherited disorder, manifested as multiple hamartomatous polyps of gastrointestinal tract, mucocutaneous pigmentations and increased risk of cancers. In this manuscript, we reported five cases of small intestinal carcinoma associated with the PJS. All the five patients have a history of PJS and postoperative pathological examination confirmed the diagnosis of small intestinal carcinoma. Histopathological features and recommended surveillance were additionally discussed. | Yafei Zhang Xuyan Mao Jichun Zheng Zhanfei Zu Gaoping Mao Shoubin Ning | 2014 | The Chinese-German Journal of Clinical Oncology2014，13，7： | 1 |
| 9 | Tooth number abnormality:from bench to bedside显示文摘Tooth number abnormality is one of the most common dental developmental diseases,which includes both tooth agenesis and supernumerary teeth.Tooth development is regulated by numerous developmental signals,such as the well-known Wnt,BMP,FGF,Shh and Eda pathways,which mediate the ongoing complex interactions between epithelium and mesenchyme.Abnormal expression of these crutial signalling during this process may eventually lead to the development of anomalies in tooth number;however,the underlying mechanisms remain elusive.In this review,we summarized the major process of tooth development,the latest progress of mechanism studies and newly reported clinical investigations of tooth number abnormality.In addition,potential treatment approaches for tooth number abnormality based on developmental biology are also discussed.This review not only provides a reference for the diagnosis and treatment of tooth number abnormality in clinical practice but also facilitates the translation of basic research to the clinical application. | Han Zhang Xuyan Gong Xiaoqiao Xu Xiaogang Wang Yao Sun | 2023 | International Journal of Oral Science2023，15，1： | 1 |
| 10 | 1α,25(OH)2D3对斑马鱼脂肪组织中脂肪酸氧化的促进显示文摘文章简介1α,25(OH)2D3被认为是哺乳类动物的矿物质代谢的重要调控激素,但其在动物脂肪组织代谢中的精确机制却不够清晰。肝细胞微小体中的细胞色素P450酶2R1(CYP2R1)是活化维生素D3的第一步,即25位的羟基化的羟基化酶,此功能在脊椎动物中是保守。 | Xuyan Peng Guohui Shang Wenqing Wang Xiaowen Chen Qiyong Lou Gang Zhai Dongliang Li Zhenyu Du Yali Ye Xia Jin Jiangyan He Yi Zhang 殷战 | 2018 | 科学新闻2018，0，4： | 0 |
| 11 | A Weighted Combination Forecasting Model for Power Load Based on Forecasting Model Selection and Fuzzy Scale Joint Evaluation显示文摘To solve the medium and long term power load forecasting problem,the combination forecasting method is further expanded and a weighted combination forecasting model for power load is put forward.This model is divided into two stages which are forecasting model selection and weighted combination forecasting.Based on Markov chain conversion and cloud model,the forecasting model selection is implanted and several outstanding models are selected for the combination forecasting.For the weighted combination forecasting,a fuzzy scale joint evaluation method is proposed to determine the weight of selected forecasting model.The percentage error and mean absolute percentage error of weighted combination forecasting result of the power consumption in a certain area of China are 0.7439%and 0.3198%,respectively,while the maximum values of these two indexes of single forecasting models are 5.2278%and 1.9497%.It shows that the forecasting indexes of proposed model are improved significantly compared with the single forecasting models. | Bingbing Chen Zhengyi Zhu Xuyan Wang Can Zhang | 2021 | Energy Engineering2021，118，5： | 0 |
| 12 | Power Quality Assessment Based on Rough AHP and Extension Analysis显示文摘Due to the increasing power consumption of whole society and widely using of new non-linear and asymmetric electrical equipment,power quality assessment problem in the new period has attracted more and more attention.The mathematical essence of comprehensive assessment of power quality is a multiattribute optimal decision-making problem.In order to solve the key problem of determining the indicator weight in the process of power quality assessment,a rough analytic hierarchy process(AHP)is proposed to aggregate the judgment opinions of multiple experts and eliminate the subjective effects of single expert judgment.Based on the advantage of extension analysis for solving the incompatibility problem,extension analysis method is adopted to assess the power quality.The assessment grades of both total power quality and each assessment indicator are obtained by correlation function.Through a case of 110 kV bus of a converting station in a wind farm of China,the feasibility and effectiveness of the propose method are demonstrated.The result shows that the proposed method can determine the overall power quality of power grid,as well as compare the differences among the performance of assessment indicators and provide the basis for further improving of power quality. | Guofeng Liu Can Zhang Zhengyi Zhu Xuyan Wang | 2022 | Energy Engineering2022，119，3： | 0 |
| 13 | Satellite-observed significant improvement in nearshore transparency of the Bohai Sea during pollution control显示文摘The Bohai Sea(BS)is the unique semi-closed inland sea of China,characterized by degraded water quality due to significant terrestrial pollution input.In order to improve its water quality,a dedicated action named“Uphill Battles for Integrated Bohai Sea Management”(UBIBSM,2018–2020)was implemented by the Chinese government.To evaluate the action effectiveness toward water quality improvement,variability of the satelliteobserved water transparency(Secchi disk depth,Z_(SD))was explored,with special emphasis on the nearshore waters(within 20 km from the coastline)prone to terrestrial influence.(1)Compared to the status before the action began(2011–2017),majority(87.3%)of the nearshore waters turned clear during the action implementation period(2018–2020),characterized by the elevated Z_(SD)by 11.6%±12.1%.(2)Nevertheless,the improvement was not spatially uniform,with higher Z_(SD)improvement in provinces of Hebei,Liaoning,and Shandong(13.2%±16.5%,13.2%±11.6%,10.8%±10.2%,respectively)followed by Tianjin(6.2%±4.7%).(3)Bayesian trend analysis found the abrupt Z_(SD)improvement in April 2018,which coincided with the initiation of UBIBSM,implying the water quality response to pollution control.More importantly,the independent statistics of land-based pollutant discharge also indicated that the significant reduction of terrestrial pollutant input during the UBIBSM action was the main driver of observed Z_(SD)improvement.(4)Compared with previous pollution control actions in the BS,UBIBSM was found to be the most successful one during the past 20 years,in terms of transparency improvement over nearshore waters.The presented results proved the UBIBSM-achieved remarkable water quality improvement,taking the advantage of long-term consistent and objective data record from satellite ocean color observation. | Xuyan Li Jinzhao Xiang Liudi Zhu Zhibin Yang Ting Wei Bing Mu Xiaobo Zhang Tingwei Cui | 2023 | Acta Oceanologica Sinica2023，42，12： | 0 |
| 14 | Influence of High Relative Humidity on Secondary Organic Carbon: Observations at a Background Site in East China显示文摘To investigate the impacts of relative humidity(RH) on secondary organic aerosol(SOA) concentrations and chemical reactions, the carbonaceous aerosol components [i.e., organic carbon(OC) and element carbon(EC)] were quantified in daily PM2.5 samples collected at a background site in East China during summer 2015. Based on the method of EC-tracer, the concentration of secondary organic carbon(SOC) demonstrated an obvious negative relationship with RH higher than 60%. Moreover, the ratio of SOC/EC also exhibited obvious decreasing trends with increasing RH, indicating negative effects for chemical production of SOA under high RH conditions. Due to high RH,photochemistry was weakened, gaseous oxidant concentrations was lowered(e.g., significantly decreased O3 levels),and the production rates of SOA were relatively low. On the other hand, because of more water uptake under higher RH conditions, the aerosol droplet acidity was reduced and enhancement of SOA formation by acidity was accordingly absent. In addition, high RH also plays an important role in changing viscosity of pre-existing aerosol coatings,which can affect reactive uptake yield of SOA. Overall, the results from this study imply that SOA production may be more associated with photochemical processes, while aqueous-phase chemistry is not very important for some SOA formation in a moist ambient environment. In the ambient atmosphere, oxidant concentrations, reaction rates,airborne species, etc., are highly variable. How do these factors affect SOA yields under given ambient environment warrants further detailed investigations. | Linlin LIANG Guenter ENGLING Yuan CHENG Xiaoye ZHANG Junying SUN Wanyun XU Chang LIU Gen ZHANG Hui XU Xuyan LIU Qianli MA | 2019 | Journal of Meteorological Research2019，33，5： | 0 |
| 15 | cDNA Microarray Analysis of Insulin Resistance-associated Genes in Fructose-fed Rats显示文摘This study was conducted to investigate the gene expression in fructose-fed rat skeletal muscle by cDNA chip which could provide support to elucidate the molecular mechanisms underlying insulin resistance. The rats were divided into two groups,one of which was normal control and the other was fed with fructose-rich diet. The mRNA was isolated and purified from the skeletal muscle of two groups. The mRNA from two kinds of tissue was reverse transcribed to cDNA with Cy3-dU TP and Cy5-dUTP separately to prepare hybridization probes. The mixed probes were hybridized to cDNA microarray. The microarray was scanned,analyzed and repeated for two times. Among the total 4 096 tested genes,140 genes were differently expressed,62 up-regulated,78 down-regulated,the expression of Ptprd and Gilz and multiple genes of oxidative metabolism is associated in insulin resistance. The differential expression of gene may be related to the pathogenesis of insulin resistance. | Bo WANG Yuming LI Xuyan ZHAO Shaoxi CAO Yanwei ZHANG | 2018 | Agricultural Biotechnology2018，7，4： | 0 |
| 16 | High-frequency characterization of high-speed modulators and photodetectors in a link with low-speed photonic sampling显示文摘We propose a low-speed photonic sampling for independent high-frequency characterization of a Mach–Zehnder modulator(MZM)and a photodetector(PD)in an optical link.A low-speed mode-locked laser diode(MLLD)provides an ultrawideband optical stimulus with scalable frequency range,working as the photonic sampling source of the link.The uneven spectrum lines of the MLLD are firstly characterized with symmetric modulation within the interesting frequency range.Then,the electro-optic modulated signals are down-converted to the first Nyquist frequency range,yielding the self-referenced extraction of modulation depth and half-wave voltage of the MZM without correcting the responsivity fluctuation of the PD in the link.Finally,the frequency responsivity of the PD is self-referenced measured under null modulation of the MZM.As frequency responses of the MZM and the PD can be independently obtained,our method allows self-referenced high-frequency measurement for a high-speed optical link.In the proof-of-concept experiment,a 96.9 MS/s MLLD is used for measuring a MZM and a PD within the frequency range up to 50 GHz.The consistency between our method and the conventional method verifies that the ultra-wideband and self-referenced high-frequency characterization of high-speed MZMs and PDs. | Mengke Wang Shangjian Zhang Zhao Liu Xuyan Zhang Yutong He Yangxue Ma Yali Zhang Zhiyao Zhang Yong Liu | 2021 | Journal of Semiconductors2021，42，4： | 0 |
| 17 | Cellular traffic offloading utilizing set-cover based caching in mobile social networks显示文摘To cope with the explosive data demands, offloading cellular traffic through mobile social networks(MSNs) has become a promising approach to alleviate traffic load. Indeed, the repeated data transmission results in a great deal of unnecessary traffic. Existing solutions generally adopt proactive caching and achieve traffic shifting by exploiting opportunistic contacts. The key challenge to maximize the offloading utility needs leveraging the trade-off between the offloaded traffic and the users' delay requirement. Since current caching scheme rarely address this challenge, in this paper, we first quantitatively interpret the offloading revenues on the cellular operator side associated with the scale of caching users, then develop a centralized caching protocol to maximize the offloading revenues, which includes the selective algorithm of caching location based on set-cover, the cached-data dissemination strategy based on multi-path routing and the cache replacement policy based on data popularity. The experimental results on real-world mobility traces show that the proposed caching protocol outperforms existing schemes in offloading scenario. | Bao Xuyan Zhou Xiaojin Zhang Yong Song Mei | 2016 | The Journal of China Universities of Posts and Telecommunications2016，23，2： | 0 |
| 18 | Unprecedent green macroalgae bloom:mechanism and implication to disaster prediction and prevention显示文摘Green macroalgae bloom(GMB),with the dominant species of Ulva prolifera,has regularly occurred since 2007 along the China coast.Although disaster prevention and control achieved favorable results in 2020,the satellite-observed GMB annual maximum coverage(AMC)rebounded sharply in 2021 to an unprecedented level.The reasons for this rebound and the significant interannual variability over past 15 years are still open questions.Here,by using long-term time-series(2007-2022)optical and Synthetic Aperture Radar satellite observations(1000+scenes),meteorological data and water quality statistics,the mechanism analysis was performed by exploring effects from natural factors and human activities.Two key determinants for AMC are successfully identified from numerous potential factors which are the macroalgae distribution in a key area(the Subei Shoal)during a critical period(from April to May 20)and the nutrient availability.Furthermore,by using these two parameters,a novel model for AMC prediction(R^(2)=0.87,p<0.01)is proposed and independently validated,which can reasonably explain the significant interannual variability(2014-2021)and agree well with the latest observation in 2022(percentage difference 12%).Finally,suggestions are proposed for future disaster prevention and alleviation.This work may aid future bloom prediction and management measure optimization. | Mengmeng Cao Xuyan Li Tingwei Cui Xinliang Pan Yan Li Yanlong Chen Ning Wang Yanfang Xiao Xingai Song Yuzhu Xu Runa A Bing Mu Song Qing Rongjie Liu Wenjing Zhao Yuhai Bao Jie Zhang Lan Wei | 2023 | International Journal of Digital Earth2023，16，1： | 0 |
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