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| 1 | Inhibition of the B7-H3 immune checkpoint limits tumor growth by enhancing cytotoxic lymphocyte function显示文摘在肿瘤和免疫系统之间的相互作用仍然糟糕被理解。重要临床的回答在对 CTLA4 和 PD-1/PD-L1 检查点与抗体对待的癌症病人被完成了;然而,仅仅病人的小部分对治疗作出回应,显示需要探索为癌症治疗的另外的 co 禁止的分子。B7-H3, B7 总科的一个成员,被我们以前显示出禁止 T 房间激活和 autoimmunity。在这研究,我们在肿瘤免疫分析了 B7-H3 的功能。B7-H3 的表示在多重肿瘤线,渗入肿瘤的树枝状的房间,和巨噬细胞被发现。与对抗抗体对待到 B7-H3 的 B7-H3-deficient 老鼠或老鼠显示出多重肿瘤的减少的生长,它取决于 NK 和 CD8 + T 房间。与细胞毒素的淋巴细胞表示的通常认为的受体, B7-H3 禁止了他们的激活,并且它的缺乏在忍受肿瘤的鼠标导致了增加的细胞毒素的淋巴细胞功能。B7-H3 和 PD-1 的联合封锁导致了迟了阶段的肿瘤的进一步提高的治疗学的控制。一起拿,我们的结果显示 B7-H3 检查点可以对癌症为免疫疗法用作一个新奇目标。 | Young-hee Lee Natalia Martin-Orozco Peilin Zheng Jing Li Peng Zhang Haidong Tan Hyun Jung Park Mira Jeong Seon Hee Chang Byung-Seok Kim Wei Xiong Wenjuan Zang Li Guo Yang Liu Zhong-jun Dong Willem W Overwijk Patrick Hwu Qing Yi Larry Kwak Zhiying Yang Tak W Mak Wei-Li Laszlo G Radvanyi Ling Ni Dongfang Liu Chen Dong | 2017 | Cell Research2017，27，8： | 29 |
| 2 | METTL3-mediated N^6-methyladenosine mRNA modification enhances long-term memory consolidation显示文摘 | Zeyu Zhang Meng Wang Dongfang Xie Zenghui Huang Lisha Zhang Ying Yang Dongxue Ma Wenguang Li Qi Zhou Yun-Gui Yang Xiu-Jie Wang | 2018 | Cell Research2018，28，11： | 29 |
| 3 | A Road Extraction Method for Remote Sensing Image Based on Encoder-Decoder Network显示文摘According to the characteristics of the road features,an Encoder-Decoder deep semantic segmentation network is designed for the road extraction of remote sensing images.Firstly,as the features of the road target are rich in local details and simple in semantic features,an Encoder-Decoder network with shallow layers and high resolution is designed to improve the ability to represent detail information.Secondly,as the road area is a small proportion in remote sensing images,the cross-entropy loss function is improved,which solves the imbalance between positive and negative samples in the training process.Experiments on large road extraction datasets show that the proposed method gets the recall rate 83.9%,precision 82.5%and F1-score 82.9%,which can extract the road targets in remote sensing images completely and accurately.The Encoder-Decoder network designed in this paper performs well in the road extraction task and needs less artificial participation,so it has a good application prospect. | Hao HE Shuyang WANG Shicheng WANG Dongfang YANG Xing LIU | 2020 | Journal of Geodesy and Geoinformation Science2020，3，2： | 20 |
| 4 | Studies on the evolution process of rockbursts in deep tunnels显示文摘This paper focuses on the evolution processes of different types of rockbursts occurring in deep tunnels. A series of laboratory tests and in-situ monitoring in deep tunnels excavated by tunnel boring machine (TBM) and drill-and-blast (D&B) method have been conducted to understand the mechanisms and processes of the evolution of different types of rockbursts, including strain rockburst, strain-structure slip rockburst, immediate rockburst and time-delayed rockburst. Three different risk assessment methods are proposed to evaluate the intensity and potential failure depth of rockbursts. These methods can be applied before excavation and the results can be updated according to the real-time information during excavation. Two micro-seismicity based real-time warning systems have been established for predicting various intensities of rockbursts, such as slight, moderate, intensive and extremely intensive rockbursts. Meanwhile, the probability and intensity of the rockburst are also given. The strategy for excavation and support design has been suggested for various intensities of rockbursts before excavation. The strategy for dynamic control of the rockburst evolution process is also proposed according to the monitoring results. The methodology has been successfully applied to rockburst risk reduction for deep tunnels at Jinping II hydropower project. The results have illustrated the applicability of the proposed methodology and techniques concerning rockbursts. | Xiating Feng Bingrui Chen Shaojun Li Chuanqing Zhang Yaxun Xiao Guangliang Feng Hui Zhou Shili Qiu Zhouneng Zhao Yang Yu Dongfang Chen Huajun Ming | 2012 | Journal of Rock Mechanics and Geotechnical Engineering2012，4，4： | 11 |
| 5 | The lightning activities in super typhoons over the Northwest Pacific显示文摘The spatial and temporal characteristics of lightning activities have been studied in seven super typhoons from 2005 to 2008 over the Northwest Pacific, using data from the World Wide Lightning Location Network (WWLLN). The results indicated that there were three distinct lightning flash regions in mature typhoon, a significant maximum in the eyewall regions (20-80 km from the center), a minimum from 80-200 km, and a strong maximum in the outer rainbands (out of 200 km from the center). The lightning flashes in the outer rainbands were much more than those in the inner rainbands, and less than 1% of flashes occurred within 100 km of the center. Each typhoon produced eyewall lightning outbreak during the periods of its intensification, usually several hours prior to its maximum intensity, indicating that lightning activity might be used as a proxy of intensification of super typhoon. Little lightning occurred near the center after landing of the typhoon. | PAN LunXiang QIE XiuShu LIU DongXia WANG DongFang YANG Jing | 2010 | Science China Earth Sciences2010，53，8： | 7 |
| 6 | Experimental and numerical study on fretting wear and fatigue of full-scale railway axles显示文摘This study investigated the fretting wear and fatigue of full-scale railway axles.Fatigue tests were conducted on full-scale railway axles,and the fretting wear and fretting fatigue in the fretted zone of the railway axles were analysed.Three-dimensional finite element models were established based on the experimental results.Then,multi-axial fatigue parameters and a linear elastic fracture mechanics-based approach were used to investigate the fretting fatigue crack initiation and propagation,respectively,in which the role of the fretting wear was taken into account.The experimental and simulated results showed that the fretted zone could be divided into zones I-III according to the surface damage morphologies.Fretting wear alleviated the stress concentration near the wheel seat edge and resulted in a new stress concentration near the worn/unworn boundary in zone II,which greatly promoted the fretting crack initiation at the inner side of the fretted zone.Meanwhile,the stress concentration also increased the equivalent stress intensity factor range DKeq below the mating surface,and thus promoted the propagation of fretting fatigue crack.Based on these findings,the effect of the stress redistribution resulting from fretting wear is suggested to be taken into account when evaluating the fretting fatigue in railway axles. | Lang Zou Dongfang Zeng Yabo Li Kai Yang Liantao Lu Caiqin Yuan | 2020 | Railway Engineering Science2020，28，4： | 7 |
| 7 | Shiga toxin-producing Escherichia coli O104:H4: An emerging 0important pathogen in food safety显示文摘In 2011, Shiga toxin-producing Escherichia coli O104 : H4 resulted in a large outbreak of bloody diarrhea and hemolytic uremic syndrome (HUS) in Germany and 15 other countries in Europe and North America. This event raised a serious public health crisis and caused more than two billion US dollars in economic losses. In this review, we describe the classification of E. coli, the Germany outbreak, and the characteristics and epidemical source-tracing of the causative agent. We also discuss the genomics analysis of the outbreak organism and propose an open-source genomics analysis as a new strategy in combating the emerging infectious diseases. | CUI YuJun LI DongFang YANG RuiFu | 2013 | Chinese Science Bulletin2013，58，14： | 5 |
| 8 | TGR5 expression in benign, preneoplastic and neoplastic lesions of Barrett's esophagus: Case series and findings显示文摘AIM To examined the bile acid receptor TGR5 expression in squamous mucosa, Barrett's mucosa, dysplasia and esophageal adenocarcinoma(EA). METHODS Slides were stained with TGR5 antibody. The staining intensity was scored as 1+, 2+ and 3+. The extent of staining(percentage of cells staining) was scored as follows: 1+, 1%-10%, 2+, 11%-50%, 3+, 51%-100%. A combined score of intensity and extent was calculated and categorized as negative, weak, moderate and strong staining. TGR5 m RNA was measured by real time PCR.RESULTS We found that levels of TGR5 mR NA were significantly increased in Barrett's dysplastic cell line CP-D and EA cell line SK-GT-4, when compared with Barrett's cell line CP-A. Moderate to strong TGR5 staining was significantly higher in high-grade dysplasia and EA cases than in Barrett's esophagus(BE) or in low-grade dysplasia. Moderate to strong staining was slightly higher in low-grade dysplasia than in BE mucosa, but there is no statistical significance. TGR5 staining had no significant difference between high-grade dysplasia and EA. In addition, TGR5 staining intensity was not associated with the clinical stage, the pathological stage and the status of lymph node metastasis.CONCLUSION We conclude that TGR5 immunostaining was much stronger in high-grade dysplasia and EA than in BE mucosa or low-grade dysplasia and that its staining intensity was not associated with the clinical stage, the pathological stage and the status of lymph node metastasis. TGR5 might be a potential marker for the progression from BE to high-grade dysplasia and EA. | Shivali Marketkar Dan Li Dongfang Yang Weibiao Cao | 2017 | World Journal of Gastroenterology2017，23，8： | 4 |
| 9 | Effects of trigonelline inhibition of the Nrf2 transcription factor M vitro on Echmococcus granulosus显示文摘 | Wenjuan Qin Dongfang Guan Rongji Ma Rentan Yang Guoqiang Xing Hongjuan Shi Guangyao Tang Jiajie Li Hailong Lv Yufeng Jiang | 2017 | Acta Biochimica et Biophysica Sinica2017，49，8： | 4 |
| 10 | Simultaneous estimation of ego-motion and vehicle distance by using a monocular camera显示文摘Auto navigation and vehicle distance estimation are of the critical importance in intelligent vehicles.This paper proposes a novel approach to solve these two problems simultaneously by using a monocular camera.First,we introduce an incremental depth parameterized model to overcome the scale ambiguity problem in monocular vision,which differs from other parameterized models with reduced state-dimension and consistent observability.In addition,the view-field of camera is divided into static and dynamic parts so that the egomotion and vehicle-space can be calculated simultaneously.Outdoor experiments are implemented to validate the effectiveness of the proposed approach. | YANG DongFang SUN FuChun WANG ShiCheng ZHANG JinSheng | 2014 | Science China(Information Sciences)2014，57，5： | 3 |
| 11 | Fabrication of bilayer Pd-Pt nanocages with sub-nanometer thin shells for enhanced hydrogen evolution reaction显示文摘The hydrogen evolution reaction (HER),which generates molecular hydrogen through the electrochemical reduction of water,is an important clean-energy technology.Platinum (Pt) is an ideal material for HER electrocatalysts in terms of low overpotential and fast kinetics.An effective method to improve the atom utilization efficiency of Pt is to fabricate Pt-based core-shell or nanocage structures with ultra-thin walls.This paper describes the construction of bilayer palladium (Pd)-Pt alloy nanocages catalyst with enhanced HER catalytic activity.The nanocages were fabricated by etching away the Pd templates of multishelled nanocubes composed of alternate shells of Pd and Pt with well-defined (100) facets.The bilayer Pd-Pt nanocages with sub-nanometer shells have a high dispersion of the active atoms on the outside and inside surfaces of outer layer and inner layer,respectively.Moreover,the Pd-Pt alloy lowers the overpotential for HER and speeds up the reaction rate of HER due to the synergies between Pd and Pt.The rational design of bilayer nanocages provided a novel route for boosting the atom utilization efficiency of Pt catalysts. | Yihe Wang Lei Zhang Congling Hu Shengnan Yu Piaoping Yang Dongfang Cheng Zhi-Jian Zhao Jinlong Gong | 2019 | Nano Research2019，12，9： | 3 |
| 12 | Bioaccumulation and transformation of cadmium by Phaeodactylum tricornutum显示文摘In this paper,we report the bioaccumulation and transformation of cadmium (Cd) by Phaeodactylum tricornutum in the presence of ethylenediamine tetra acetic acid (EDTA) and cysteine (Cys). Both EDTA and Cys can alleviate the toxicity of Cd to P. tricornutum. Short term intracellular uptake and extracellular adsorption experiments using ICP-MS indicated that the amounts of Cd accumulated on the cell surface of P. tricornutum and inside the cell decreased along with the increase of EDTA concentration,which conformed to the prediction of the Free Ion Activity Model (FIAM). However,extracellular adsorption of Cd increased at first and then decreased along with the increase in the concentration of Cys,while intracellular uptake increased under Cys concentrations from the blank value to 4.45 μmol/L,and then tended to remain at the same level when the Cys concentration was greater than 4.45 μmol/L,and this deviated remarkably from the FIAM. The interactions of Cd with _Si_OH,_C_OH and NH2(CO) _OH on the cell wall were confirmed using FT-IR and XPS studies. The results obtained using HPLC of the phytochelatins (PCs) produced by P. tricornutum under CdCl2,Cd_EDTA and Cd_Cys stress suggested that the main reason for the different effects of EDTA and Cys on the bioaccumulation and transformation of Cd by P. tricornutum was that Cys is not only a complexing ligand to Cd,as is EDTA,but also it is a precursor of the intracellular synthesizing PCs participating in the cellular defense mechanism against Cd. Furthermore,the discovery of in vivo PCs and oxidized_PCs as well as Cd-PC2 in P. tricornutum using ESI-IT-MS provided the evidence for deactivation of Cd by the PCs,reducing Cd-toxicity to P. tricornutum. | SI DongFang YANG LiMin YAN Hua WANG QiuQuan | 2009 | Science China Chemistry2009，52，12： | 3 |
| 13 | Recent advances in polymeric biomaterials-based gene delivery for cartilage repair显示文摘Untreated articular cartilage damage normally results in osteoarthritis and even disability that affects millions of people.However,both the existing surgical treatment and tissue engineering approaches are unable to regenerate the original structures of articular cartilage durably,and new strategies for integrative cartilage repair are needed.Gene therapy provides local production of therapeutic factors,especially guided by biomaterials can minimize the diffusion and loss of the genes or gene complexes,achieve accurate spatiotemporally release of gene products,thus provideing long-term treatment for cartilage repair.The widespread application of gene therapy requires the development of safe and effective gene delivery vectors and supportive gene-activated matrices.Among them,polymeric biomaterials are particularly attractive due to their tunable physiochemical properties,as well as excellent adaptive performance.This paper reviews the recent advances in polymeric biomaterial-guided gene delivery for cartilage repair,with an emphasis on the important role of polymeric biomaterials in delivery systems. | Ran Yang Fei Chen Jinshan Guo Dongfang Zhou Shifang Luan | 2020 | Bioactive Materials2020，5，4： | 3 |
| 14 | The Impact of Regional Rainfall on Runoff of Yachi River of Guizhou显示文摘Based on monthly runoff data of Yachi River of Guizhou from April 2014 to May 2015,and monthly rainfall data of Guiyang,Xichang,Wenjiang and Chongqing weather stations from January 2007 to November 2015,the influence of temporal-spatial component of regional rainfall on monthly runoff of Yachi River was analyzed by using REOF,multiple linear regression analysis and harmonic analysis.Temporal-spatial change of monthly rainfall around Yachi River mainly contained four kinds of modes.The first mode was northwest-southeast type,and the second mode was south-north type,and the third mode was east-west mode.Temporal components of the three modes were all quasi equilibrium seasonal and interannual changes.Among them,the first and second modes had stable seasonal change,while seasonal change of the third mode was the most unstable,and drought-flood situation of season variation was easy to happen.Seasonal change form of monthly runoff in Yachi River was obviously different from regional monthly rainfall,and it was mainly affected by underlying surface topography and human activity(reservoir and hydropower station),and could not make a natural response to seasonal change of rainfall in time.The third mode of regional monthly rainfall and cycle fitting amount of had insignificant impact on monthly runoff of Yachi River,while the first mode of regional monthly rainfall and cycle fitting amount showed significantly positive correlation with monthly runoff of Yachi River.The second mode of regional monthly rainfall and cycle fitting amount had significantly negative correlation with monthly runoff of Yachi River,and Yachi River had significant water-storage regulation effect on the mode component.Yachi River did not have water-storage regulation effect on flood component of seasonal variation of regional monthly rainfall. | Yang Dongfang Wang Fengyou Wang Lin Zhang Rong Zhu Sixi | 2017 | Meteorological and Environmental Research2017，8，1： | 2 |
| 15 | CILP-2 is a novel secreted protein and associated with insulin resistance显示文摘Genetic association studies have implicated that cartilage intermediate layer protein 2 (CILP-2) confers the risk susceptibility for type 2 diabetes (T2DM). However, it is still unknown whether CILP-2 is involved in the regulation of glucose homeostasis and insulin resistance (IR). In the current study, we initially observed that CILP-2 as a secreted protein was detected in both conditioned medium and lysates of cells transfected with an overexpressed vector. We then found that circulating CILP-2 levels had a progressive increase from normal to impaired glucose tolerance (a pre-diabetic status) and then to diabetes, which was correlated positively with waist-to-hip ratio, triglyceride, fasting blood glucose, 2-h blood glucose after glucose overload, HbA1c, fasting insulin, 2-h plasma insulin after glucose overload, and homeostasis model assessment of insulin resistance but negatively with HDL-C. CILP-2 expression was increased in the liver and muscle but decreased in adipose tissues of obese mice or T2DM patients. Furthermore, we demonstrated that CILP-2 circulating levels were affected by OGTT and Exenatide. CILP-2 overexpression resulted in impaired glucose tolerance and hepatic IR in vivo and increased PEPCK expression whereas suppressed phosphorylation of insulin receptor and Akt kinase in vitro. Based on these findings, we have identified a direct interaction between CILP-2 and PEPCK and suggested that CILP-2 plays an important role in the regulation of hepatic glucose production. | Tong Wu Qin Zhang Shaobo Wu Wenjing Hu Tingting Zhou Ke Li Dongfang Liu Harvest FGu Hongting Zheng Zhiming Zhu Ling Li and Gangyi Yang | 2019 | Journal of Molecular Cell Biology2019，11，12： | 2 |
| 16 | Review on Additive Manufacturing of Single-Crystal Nickel-based Superalloys显示文摘The conventional fabrication process for single-crystal nickel-based superalloy materials is directional solidifica-tion,which is classified as casting.With the rapid development of additive manufacturing(AM)technologies,a novel process for fabricating single-crystal superalloys has become possible.This article reviews recent research on the AM of single-crystal nickel-based superalloys.Laser AM technologies,particularly directed energy deposition,are mainly used to repair single-crystal materials.Electron beam powder bed fusion is an innovative method for the direct fabrication of single-crystal materials.Accordingly,the mechanisms of single-crystal formation during AM are analyzed to elucidate the potential of this process route.Furthermore,this article discusses the challenges faced by AM for single-crystal fabrication,and provides perspectives on the trends of future developments. | Yang Li Xiaoyu Liang Yefeng Yu Dongfang Wang Feng Lin | 2022 | Chinese Journal of Mechanical Engineering(Additive Manufacturing Frontiers)2022，1，1： | 2 |
| 17 | Simulation study on a novel high-dynamic GPS software receiver 显示文摘 | Wang Shicheng Yang Dongfang Liu Zhiguo | 2009 | The International Journal for Computation and Mathematics in Electrical and Electronic Engineering2009，28，6： | 1 |
| 18 | Biomechanical research on operations of hangmann fracture with finite element method 显示文摘 | Yang Guo Biao Ding Zhu Quan Wu Kui Wang Dongfang | 2006 | Key Engineering Materials2006，，： | 1 |
| 19 | Finite-Time Sideslip Differentiator-Based LOS Guidance for Robust Path Following of Snake Robots显示文摘This paper presents a finite-time sideslip differentiator-based line-of-sight(LOS)guidance method for robust path following of snake robots.Firstly,finite-time stable sideslip differentiator and adaptive LOS guidance method are proposed to counteract sideslip drift caused by cross-track velocity.The proposed differentiator can accurately observe the cross-track error and sideslip angle for snake robots to avoid errors caused by calculating sideslip angle approximately.In our method,the designed piecewise auxiliary function guarantees the finite-time stability of position errors.Secondly,for the case of external disturbances and state constraints,a Barrier Lyapunov functionbased backstepping adaptive path following controller is presented to improve the robot’s robustness.The uniform ultimate boundedness of the closed-loop system is proved by analyzing stability.Additionally,a gait frequency adjustment-based virtual velocity control input is derived to achieve the exponential convergence of the tangential velocity.At last,the availability and superiority of this work are shown through simulation and experiment results. | Yang Xiu Dongfang Li Miaomiao Zhang Hongbin Deng Rob Law Yun Huang Edmond Q.Wu Xin Xu | 2023 | IEEE/CAA Journal of Automatica Sinica2023，10，1： | 1 |
| 20 | The reduced triplet-triplet annihilation of electrophosphorescent device doped by an iridium complex with active hydrogen显示文摘 | HAN Liangliang YANG Dongfang LI Wenlian | 2008 | Applied Physics Letters2008，93，15： | 1 |
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