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| 1 | METTL3-mediated N^6-methyladenosine mRNA modification enhances long-term memory consolidation显示文摘 | Zeyu Zhang Meng Wang Dongfang Xie Zenghui Huang Lisha Zhang Ying Yang Dongxue Ma Wenguang Li Qi Zhou Yun-Gui Yang Xiu-Jie Wang | 2018 | Cell Research2018，28，11： | 29 |
| 2 | A Road Extraction Method for Remote Sensing Image Based on Encoder-Decoder Network显示文摘According to the characteristics of the road features,an Encoder-Decoder deep semantic segmentation network is designed for the road extraction of remote sensing images.Firstly,as the features of the road target are rich in local details and simple in semantic features,an Encoder-Decoder network with shallow layers and high resolution is designed to improve the ability to represent detail information.Secondly,as the road area is a small proportion in remote sensing images,the cross-entropy loss function is improved,which solves the imbalance between positive and negative samples in the training process.Experiments on large road extraction datasets show that the proposed method gets the recall rate 83.9%,precision 82.5%and F1-score 82.9%,which can extract the road targets in remote sensing images completely and accurately.The Encoder-Decoder network designed in this paper performs well in the road extraction task and needs less artificial participation,so it has a good application prospect. | Hao HE Shuyang WANG Shicheng WANG Dongfang YANG Xing LIU | 2020 | Journal of Geodesy and Geoinformation Science2020，3，2： | 20 |
| 3 | Lightning Activity and Its Relation to the Intensity of Typhoons over the Northwest Pacific Ocean显示文摘Data from the World Wide Lightning Location Network(WWLLN) were used to analyze the lightning activity and the relationship between maximum sustained wind and lightning rate in 69 tropical cyclones over the Northwest Pacific Ocean from 2005 to 2009. The minimum lightning density was observed in the category 2 typhoon Kong-Rey(2007), with a value of only 1.15 d-1(100 km)-2. The maximum lightning density occurred in the category 2 typhoon Mitag(2007), with a value of 510.42 d-1(100 km)-2. The average lightning density decreased with radius from the typhoon center in both weak(categories 1–3) and super(categories 4–5) typhoons. The average lightning density in the inner core of super typhoons was more than twice as large as that for weak typhoons. Both groups of typhoons showed a near-monotonic decrease in lightning density with radius. Results also showed that lightning activity was more active in typhoons that made landfall than in those that did not. The mean correlation coefficient between the accumulated flashes within a 600-km radius and the maximum wind speed in the weak typhoons and super typhoons was 0.81 and 0.74, respectively. For more than 78%(56%) of the super(weak) typhoons, the lightning activity peaked before the maximum sustained wind speed, with the most common leading time being 30(60) h. The results suggest that, for the Northwest Pacific Ocean, lightning activity might be used as a measurement of the intensification of typhoons. | PAN Lunxiang QIE Xiushu WANG Dongfang | 2014 | Advances in Atmospheric Sciences2014，31，3： | 12 |
| 4 | The lightning activities in super typhoons over the Northwest Pacific显示文摘The spatial and temporal characteristics of lightning activities have been studied in seven super typhoons from 2005 to 2008 over the Northwest Pacific, using data from the World Wide Lightning Location Network (WWLLN). The results indicated that there were three distinct lightning flash regions in mature typhoon, a significant maximum in the eyewall regions (20-80 km from the center), a minimum from 80-200 km, and a strong maximum in the outer rainbands (out of 200 km from the center). The lightning flashes in the outer rainbands were much more than those in the inner rainbands, and less than 1% of flashes occurred within 100 km of the center. Each typhoon produced eyewall lightning outbreak during the periods of its intensification, usually several hours prior to its maximum intensity, indicating that lightning activity might be used as a proxy of intensification of super typhoon. Little lightning occurred near the center after landing of the typhoon. | PAN LunXiang QIE XiuShu LIU DongXia WANG DongFang YANG Jing | 2010 | Science China Earth Sciences2010，53，8： | 7 |
| 5 | Reversible hydrogels with tunable mechanical properties for optically controlling cell migration显示文摘 | Xin Wu Wenmao Huang Wen-Hao Wu Bin Xue Dongfang Xiang Ying Li Meng Qin Fei Sun Wei Wang Wen-Bin Zhang Yi Cao | 2018 | Nano Research2018，11，10： | 6 |
| 6 | A novel none once per revolution blade tip timing based blade vibration parameters identification method显示文摘The vibration caused blade High Cycle Fatigue(HCF)is seriously affects the safety operation of turbomachinery especially for aero-engine.Thus,it is crucial important to identify the blade vibration parameters and then evaluate the dynamic stress amplitude.Blade Tip Timing(BTT)method is one of the promising method to solve these problems.While,it need a high resolution Once Per Revolution(OPR)signal which is difficult to get for the aero-engine.Here,a Coupled Vibration Analysis(CVA)method for identifying blade vibration parameters by a none OPR BTT is proposed.The method assumes that every real blade has its own vibration performance at a given speed.Whereby,it can take any blade as the reference blade,and the other blades using the reference blade as the OPR for vibration displacement calculating and further parameter identifying.The proposed method is validated by numerical model.Also,experimental studies are carried out on a straight blade and a twisted three dimensional blade test rig as well as a large industrial axial compressor respectively.The results show that the proposed method can accurately identify the blade synchronous vibration parameters and quantitatively evaluate the mistuning in bladed disks,which lays a foundation for the reliability improvement of aero-engine. | Weimin WANG Xulong ZHANG Dongfang HU Dengpeng ZHANG Paul ALLAIRE | 2020 | Chinese Journal of Aeronautics2020，33，7： | 6 |
| 7 | Pathological changes in the lungs and lymphatic organs of 12 COVID-19 autopsy cases显示文摘Systematic autopsy and comprehensive pathological analyses of COVID-19 decedents should provide insights into the disease characteristics and facilitate the development of novel therapeutics.In this study,we report the autopsy findings from the lungs and lymphatic organs of 12 COVID-19 decedents—findings that evaluated histopathological changes;immune cell signature and inflammatory factor expression in the lungs,spleen and lymph nodes.Here we show that the major pulmonary alterations included diffuse alveolar damage,interstitial fibrosis and exudative inflammation featured with extensive serous and fibrin exudates,macrophage infiltration and abundant production of inflammatory factors(IL-6,IP-10,TNFo?and IL-I f).The spleen and hilar lymph nodes contained lesions with tissue structure disruption and immune cell dysregulation,including lymphopenia and macrophage accumulation.These findings provide pathological evidence that links injuries of the lungs and lymphatic organs with the fatal systematic respiratory and immune malfunction in critically ill COVID-19 patients. | Qian Liu Yu Shi Jun Cai Yaqi Duan Rongshuai Wang Hongyan Zhang Qiurong Ruan Jiansha Li Lei Zhao Yifang Ping Rong Chen Liang Ren Xiaochun Fei Heng Zhang Rui Tang Xi Wang Tao Luo Xindong Liu Xuequan Huang Zhenhua Liu Qilin Ao Yong Ren Jing Xiong Zhicheng He Haibo Wu Wenjuan Fu Pengnan Zhao Xinwei Chen Guoqiang Qu Yunyun Wang Xi Wang Jia Liu Dongfang Xiang Sanpeng Xu Xiaowei Zhou Qingrui Li Jinghong Ma Heng Li Jie Zhang Sizhe Huang Xiaohong Yao Yiwu Zhou Chaofu Wang Dingyu Zhang Guoping Wang Liang Liu Xiu-Wu Bian | 2020 | National Science Review2020，7，12： | 6 |
| 8 | Global sources, emissions, transport and deposition of dust and sand and their effects on the climate and environment: a review显示文摘 | Feng Wang Xueqiu Zhao Cynthia Gerlein-Safdi Yue Mu Dongfang Wang Qi Lu | 2017 | Frontiers of Environmental Science & Engineering2017，11，1： | 5 |
| 9 | Monitoring strata behavior due to multi-slicing top coal caving longwall mining in steeply dipping extra thick coal seam显示文摘For studying the strata behavior due to multi-slicing top coal caving longwall mining along-the-strike direction in steeply dipping extra thick coal seams,the shield support pressures of the upper and lower slices of panel 37220 in Dongxia Coal Mine were monitored using the KJ513 dynamic monitoring system.The set up rooms adopted the 'horizontal line-arc segment-inclined line' form and used different types of shield supports.The results show that the strata pressure of upper slice panel 37220-1 changed slightly along the strike direction,while along the dip direction it exhibited strong to weak pressure from bottom to top.The first weighting interval of lower slice panel 37220-2 was about 60.8 m,and the average periodic weighting interval were about 22.6 m.The strata behavior of panel 37220-2 exhibited a spatiotemporal characteristic in that periodic weighting occurred first in the middle-upper part,followed by the middle and upper parts,arc segment,and finally the lower part.During the periodic weighting,the weighting interval and intensity also exhibited strong space characteristics.The average dynamic load coefficient was 1.48 and the maximum lateral load of the side shield was 20-25 MPa. | Yun Dongfeng Liu Zhu Cheng Wendong Fan Zhendong Wang Dongfang Zhang Yuanhao | 2017 | International Journal of Mining Science and Technology2017，27，1： | 5 |
| 10 | Plasma Characteristic of Lightning Discharge Channel显示文摘The plasma characteristics of a lightning discharge channel are reviewed.The spectrum of the natural lightning is investigated by employing the slit-less spectrograph.It is found that the spectrum characteristics are closely related to the intensity of the lightning discharge.The lines in the lightning spectrum are classified into essential lines and characteristic lines,according to the characteristics of lightning spectra with different intensities.The characteristics of the lightning channel and the radiation of the lighting plasma are analyzed in the visible and infrared regions.It is shown that,the visible spectrum of lightning is determined by the radiation generated from the early stage to the development of lightning,while the near-infrared spectrum is determined by the radiation generated after current of lightning reaches the peak.The channel temperature and the electron density are calculated using the information obtained from the lightning spectrum.Both the temperature and the density decrease with the increasing length of lightning channel.Moreover,X-rays and neutrons are produced in the process of lighting mainly due to the pinch effects. | ZHANG Huaming YUAN Ping ZHANG Yijun WAN Jianjie OUYANG Yuhua WANG Dongfang | 2013 | 高电压技术2013，39，10： | 5 |
| 11 | VASC: Dimension Reduction and Visualization of Single-cell RNA-seq Data by Deep Variational Autoencoder显示文摘Single-cell RNA sequencing(scRNA-seq) is a powerful technique to analyze the transcriptomic heterogeneities at the single cell level. It is an important step for studying cell subpopulations and lineages, with an effective low-dimensional representation and visualization of the original scRNA-Seq data. At the single cell level, the transcriptional fluctuations are much larger than the average of a cell population, and the low amount of RNA transcripts will increase the rate of technical dropout events. Therefore, scRNA-seq data are much noisier than traditional bulk RNA-seq data. In this study, we proposed the deep variational autoencoder for scRNA-seq data(VASC), a deep multi-layer generative model, for the unsupervised dimension reduction and visualization of scRNA-seq data. VASC can explicitly model the dropout events and find the nonlinear hierarchical feature representations of the original data. Tested on over 20 datasets, VASC shows superior performances in most cases and exhibits broader dataset compatibility compared to four state-of-the-art dimension reduction and visualization methods. In addition, VASC provides better representations for very rare cell populations in the 2D visualization. As a case study, VASC successfully re-establishes the cell dynamics in pre-implantation embryos and identifies several candidate marker genes associated with early embryo development. Moreover, VASC also performs well on a 10× Genomics dataset with more cells and higher dropout rate. | Dongfang Wang Jin Gu | 2018 | Genomics, Proteomics & Bioinformatics2018，16，5： | 5 |
| 12 | HCCDB: A Database of Hepatocellular Carcinoma Expression Atlas显示文摘Hepatocellular carcinoma(HCC) is highly heterogeneous in nature and has been one of the most common cancer types worldwide. To ensure repeatability of identified gene expression patterns and comprehensively annotate the transcriptomes of HCC, we carefully curated 15 public HCC expression datasets that cover around 4000 clinical samples and developed the database HCCDB to serve as a one-stop online resource for exploring HCC gene expression with userfriendly interfaces. The global differential gene expression landscape of HCC was established by analyzing the consistently differentially expressed genes across multiple datasets. Moreover, a 4 D metric was proposed to fully characterize the expression pattern of each gene by integrating data from The Cancer Genome Atlas(TCGA) and Genotype-Tissue Expression(GTEx). To facilitate a comprehensive understanding of gene expression patterns in HCC, HCCDB also provides links to third-party databases on drug, proteomics, and literatures, and graphically displays the resultsfrom computational analyses, including differential expression analysis, tissue-specific and tumorspecific expression analysis, survival analysis, and co-expression analysis. HCCDB is freely accessible at http://gffzzbcb113a830484641hpf0xu0cwuk5566cv.ffgz.tsg.suse.edu.cn/database/hccdb. | Qiuyu Lian Shicheng Wang Guchao Zhang Dongfang Wang Guijuan Luo Jing Tang Lei Chen Jin Gu | 2018 | Genomics, Proteomics & Bioinformatics2018，16，4： | 5 |
| 13 | Bimetallic nano-mushrooms with DNA-mediated interior nanogaps for high-efficiency SERS signal amplification显示文摘有为散布的提高表面的拉曼(重量的单位) 分析的 ultrasensitive 的明确的 nanogaps 抓住伟人诺言的一致包含银的金属 nanostructures。不过,有强壮、稳定的重量的单位的如此的 nanostructures 的直接合成表明极其质问的遗体。这里,我们与内部 nanogaps 为金银的 nano 蘑菇的直接合成报导一条调停 DNA 的途径。这些 nano 蘑菇的重量的单位紧张极其依赖于在金头和银帽子之间的 nanogap 的区域。我们发现 nanogaps 的形成由控制在金 nanoparticles 上标记搁浅单人赛的 DNA (ssDNA ) 的 6-carboxy-X-rhodamine (ROX ) 的表面密度是细微地悦耳的。我们与 1.0 的一个高重量的单位信号改进因素在高产量获得了 nano 蘑菇我们作为一项 retrofit 措施在 CHS 在用阶段变化材料(脉冲编码调制) 的热存储的采纳以后。结果显示那与融化 23 的温度使用脉冲编码调制 ? 訄吗?? | Jianlei Shen Jing Su Juan Yan Bin Zhao Dongfang Wang Siyi Wang Kun Li Mengmeng Liu Yao He Sanjay Mathur Chunhai Fan Shiping Song | 2015 | Nano Research2015，8，3： | 4 |
| 14 | A multi-axis robot-based bioprinting system supporting natural cell function preservation and cardiac tissue fabrication显示文摘Despite the recent advances in artificial tissue and organ engineering,how to generate large size viable and functional complex organs still remains as a grand challenge for regenerative medicine.Three-dimensional bioprinting has demonstrated its advantages as one of the major methods in fabricating simple tissues,yet it still faces difficulties to generate vasculatures and preserve cell functions in complex organ production.Here,we overcome the limitations of conventional bioprinting systems by converting a six degree-of-freedom robotic arm into a bioprinter,therefore enables cell printing on 3D complex-shaped vascular scaffolds from all directions.We also developed an oil bath-based cell printing method to better preserve cell natural functions after printing.Together with a self-designed bioreactor and a repeated print-and-culture strategy,our bioprinting system is capable to generate vascularized,contractible,and long-term survived cardiac tissues.Such bioprinting strategy mimics the in vivo organ development process and presents a promising solution for in vitro fabrication of complex organs. | Zeyu Zhang Chenming Wu Chengkai Dai Qingqing Shi Guoxin Fang Dongfang Xie Xiangjie Zhao Yong-Jin Liu Charlie CLWang Xiu-Jie Wang | 2022 | Bioactive Materials2022，7，12： | 4 |
| 15 | Spatial Pattern Evolution and Influencing Factors of Cold Storage in China显示文摘Cold storage is the vital infrastructure of cold chain logistics. In this study, we analyzed the spatial pattern evolution characteristics, spatial autocorrelation and influencing factors of cold storage in China by using kernel density estimation(KDE), spatial autocorrelation analysis(SAA), and spatial error model(SEM). Results showed that: 1) the spatial distribution of cold storage in China is unbalanced, and has evolved from ‘one core’ to ‘one core and many spots’, that is, ‘one core’ refers to the Bohai Rim region mainly including Beijing, Tianjin, Hebei, Shandong and Liaoning regions, and ‘many spots’ mainly include the high-density areas such as Shanghai, Fuzhou, Guangzhou, Zhengzhou, Hefei, Wuhan, ürümqi. 2) The distribution of cold storage has significant global spatial autocorrelation and local spatial autocorrelation, and the ‘High-High’ cluster area is the most stable, mainly concentrated in the Bohai Rim;the ‘Low-Low’ cluster area is grouped in the southern China. 3) Economic development level, population density, traffic accessibility, temperature and land price, all affect the location choice of cold storage in varying degrees, while the impact of market demand on it is not explicit. | LI Jinfeng XU Haicheng LIU Wanwan WANG Dongfang ZHOU Shuang | 2020 | Chinese Geographical Science2020，30，3： | 4 |
| 16 | Poly IC pretreatment suppresses B cell-mediated lupus-like autoimmunity through induction of Peli1显示文摘 | Yan Wang Jia Yuan Dongfang Dai Junli Liu Jing Xu Xiang Miao Huan Wang Chaoming Mao Yichuan Xiao | 2018 | Acta Biochimica et Biophysica Sinica2018，50，9： | 3 |
| 17 | Simultaneous estimation of ego-motion and vehicle distance by using a monocular camera显示文摘Auto navigation and vehicle distance estimation are of the critical importance in intelligent vehicles.This paper proposes a novel approach to solve these two problems simultaneously by using a monocular camera.First,we introduce an incremental depth parameterized model to overcome the scale ambiguity problem in monocular vision,which differs from other parameterized models with reduced state-dimension and consistent observability.In addition,the view-field of camera is divided into static and dynamic parts so that the egomotion and vehicle-space can be calculated simultaneously.Outdoor experiments are implemented to validate the effectiveness of the proposed approach. | YANG DongFang SUN FuChun WANG ShiCheng ZHANG JinSheng | 2014 | Science China(Information Sciences)2014，57，5： | 3 |
| 18 | Fabrication of bilayer Pd-Pt nanocages with sub-nanometer thin shells for enhanced hydrogen evolution reaction显示文摘The hydrogen evolution reaction (HER),which generates molecular hydrogen through the electrochemical reduction of water,is an important clean-energy technology.Platinum (Pt) is an ideal material for HER electrocatalysts in terms of low overpotential and fast kinetics.An effective method to improve the atom utilization efficiency of Pt is to fabricate Pt-based core-shell or nanocage structures with ultra-thin walls.This paper describes the construction of bilayer palladium (Pd)-Pt alloy nanocages catalyst with enhanced HER catalytic activity.The nanocages were fabricated by etching away the Pd templates of multishelled nanocubes composed of alternate shells of Pd and Pt with well-defined (100) facets.The bilayer Pd-Pt nanocages with sub-nanometer shells have a high dispersion of the active atoms on the outside and inside surfaces of outer layer and inner layer,respectively.Moreover,the Pd-Pt alloy lowers the overpotential for HER and speeds up the reaction rate of HER due to the synergies between Pd and Pt.The rational design of bilayer nanocages provided a novel route for boosting the atom utilization efficiency of Pt catalysts. | Yihe Wang Lei Zhang Congling Hu Shengnan Yu Piaoping Yang Dongfang Cheng Zhi-Jian Zhao Jinlong Gong | 2019 | Nano Research2019，12，9： | 3 |
| 19 | Bioaccumulation and transformation of cadmium by Phaeodactylum tricornutum显示文摘In this paper,we report the bioaccumulation and transformation of cadmium (Cd) by Phaeodactylum tricornutum in the presence of ethylenediamine tetra acetic acid (EDTA) and cysteine (Cys). Both EDTA and Cys can alleviate the toxicity of Cd to P. tricornutum. Short term intracellular uptake and extracellular adsorption experiments using ICP-MS indicated that the amounts of Cd accumulated on the cell surface of P. tricornutum and inside the cell decreased along with the increase of EDTA concentration,which conformed to the prediction of the Free Ion Activity Model (FIAM). However,extracellular adsorption of Cd increased at first and then decreased along with the increase in the concentration of Cys,while intracellular uptake increased under Cys concentrations from the blank value to 4.45 μmol/L,and then tended to remain at the same level when the Cys concentration was greater than 4.45 μmol/L,and this deviated remarkably from the FIAM. The interactions of Cd with _Si_OH,_C_OH and NH2(CO) _OH on the cell wall were confirmed using FT-IR and XPS studies. The results obtained using HPLC of the phytochelatins (PCs) produced by P. tricornutum under CdCl2,Cd_EDTA and Cd_Cys stress suggested that the main reason for the different effects of EDTA and Cys on the bioaccumulation and transformation of Cd by P. tricornutum was that Cys is not only a complexing ligand to Cd,as is EDTA,but also it is a precursor of the intracellular synthesizing PCs participating in the cellular defense mechanism against Cd. Furthermore,the discovery of in vivo PCs and oxidized_PCs as well as Cd-PC2 in P. tricornutum using ESI-IT-MS provided the evidence for deactivation of Cd by the PCs,reducing Cd-toxicity to P. tricornutum. | SI DongFang YANG LiMin YAN Hua WANG QiuQuan | 2009 | Science China Chemistry2009，52，12： | 3 |
| 20 | Control synthesis for a class of nonlinear systems based on partition of unity显示文摘一条 partition-of-unity-based 途径被建议为非线性的系统的一个班导出一个近似模型。近似模型的精确被使用连续功能的连续性的模量分析。近似模型的系统稳定性被使用 Lyapunov 稳定性理论分析。为构造与追踪与追踪错误有关的性能追踪控制器的一个设计算法基于近似模型和统一方法的分区被给。 | Dongfang HAN Yinhe WANG Siying ZHANG | 2007 | 控制理论与应用(英文版)2007，5，2： | 2 |
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