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| 1 | CapOX as neoadjuvant chemotherapy for locally advanced operable colon cancer patients: a prospective single-arm phase Ⅱ trial显示文摘Objective: The aim of this prospective, single-arm phase II trial was to confirm the safety and efficacy of neoadjuvant chemotherapy(NAC) using oxaliplatin plus capecitabine(Cap OX) for patients with operable locally advanced colon cancer(CC).Methods: Patients with computed tomography-defined T4 or lymph node-positive CCs were enrolled. After radiological staging, patients were treated with at least 2 cycles of NAC consisting of 130 mg/m2 oxaliplatin on d 1,plus 1,000 mg/m2 capecitabine twice daily for 14 d every 3 weeks, followed by surgery, and then with the rest cycles of adjuvant chemotherapy. Radiological response was evaluated after 2 cycles of NAC. Tumor response, treatment toxicity, and surgical complications were recorded. The pathological response to therapy was evaluated according to the tumor regression grade(TRG) score. The primary endpoint was pathologic tumor response. This trial is registered in Clinical Trials.gov(No: NCT02415829).Results: Forty-seven patients were enrolled in the study. Forty-two patients completed the planned treatments.The total radiological response rate was 68%(32/47), including complete and partial response rates of 2%(1/47)and 66%(31/47), respectively. Stable disease was observed in 32%(15/47) and progressive disease was observed in none. Complete pathologic response, major regression, and at least moderate regression were achieved in 1(2%), 2(4%), and 29(62%) patients, respectively. Four patients developed grade 3 treatment toxicities. One patient with wound infection occurred after operation(1/47, 2%). There was no treatment-related death.Conclusions: Our results suggest that NAC with Cap OX is an effective and safe treatment option for patients with locally advanced CCs. | Fangqi Liu Li Yang Yuchen Wu Cong Li Jiang Zhao Adili Keranmu Hongtu Zheng Dan Huang Lei Wang Tong Tong Junyan Xu Ji Zhu Sanjun Cai Ye Xu | 2016 | Chinese Journal of Cancer Research2016，28，6： | 14 |
| 2 | Myeloid-specific targeting of Notch ameliorates murine renal fibrosis via reduced infiltration and activation of bone marrowderived macrophage显示文摘Macrophages play critical roles in renal fibrosis.However,macrophages exhibit ontogenic and functional heterogeneities,and which population of macrophages contributes to renal fibrosis and the underlying mechanisms remain unclear.In this study,we genetically targeted Notch signaling by disrupting the transcription factor recombination signal binding protein-JK(RBP-J),to reveal its role in regulation of macrophages during the unilateral ureteral obstruction(UUO)-induced murine renal fibrosis.Myeloid-specific disruption of RBP-J attenuated renal fibrosis with reduced extracellular matrix deposition and myofibroblast activation,as well as attenuated epithelial-mesenchymal transition,likely owing to the reduced expression of TGF-β.Mean while,RBP-J deletion significantly hampered macrophage infiltration and activation in fibrotic kidney,although their proliferation appeared unaltered.By using macrophage clearance experiment,we found that kidney resident macrophages made negligible contribution,but bone marrow(BM)-derived macrophages played a major role in renal fibrogenesis.Further mechanistic analyses showed that Notch blockade reduced monocyte emigration from BM by down-regulating CCR2 expression.Finally,we found that myeloid-specific Notch activation aggravated renal fibrosis,which was mediated by CCR2^+macrophages infiltration.In summary,our data have unveiled that myeloid-specific targeting of Notch could ameliorate renal fibrosis by regulating BM-derived macrophages recruitment and activation,providing a novel strategy for intervention of this disease. | Yali Jiang Yuanyuan Wang Pengfei Ma Dongjie An Junlong Zhao Shiqian Liang Yuchen Ye Yingying Lu Peng Zhang Xiaowei Liu Hua Han Hongyan Qin | 2019 | Protein & Cell2019，10，3： | 10 |
| 3 | Direct observation of epitaxial alignment of Au on M0S2 at atomic resolution显示文摘The morphology and structural stability of metal/2D semic on ductor interfaces strongly affect the performa nee of 2D electronic devices and synergistic catalysis. However, the structural evolution at the interfaces has not been well explored particularly at atomic resolution. In this work, we study the structural evoluti on of Au nan oparticles (NPs) on few-layer MoS2 by high resol utio n transmissi on electro n microscopy (HRTEM) an d quan titative high-angle annular dark field seanning TEM. It is found that in the transition of Au from nan oparticles to den drites, a dynamically epitaxial align ment betwee n Au and MoS2 lattices is formed, and Moirc patter ns can be directly observed in HRTEM images due to the mismatch between Au and M0S2 lattices. This epitaxial alignment can occur in ambient conditions, and can also be accelerated by the irradiation of high-energy electron beam. In situ observation clearly reveals the rotation of Au NPs, the atom migration inside Au NPs, and the transfer of Au atoms between neighboring Au NPs, finally leading to the formation of epitaxially aligned Au dendrites on M0S2. The structural evoluti on of metal/2D semico nductor in terfaces at atomic scale can provide valuable information for the design and fabricatio n of the metal/2D semicon ductorn ano-devices with desired physical and chemical performa nces. | Yinghui Sun Haofei Zhao Dan Zhou Yuchen Zhu Huanyu Ye Yan Aung Moe | 2019 | Nano Research2019，12，4： | 4 |
| 4 | Reduction of COD in TNT red water through adsorption on macroporous polystyrene resin RS 50B显示文摘 | Quanlin Zhao Yuchen Gao Zhengfang Ye | 2013 | Vacuum2013，，： | 1 |
| 5 | Acute toxicity evaluation of explosive wastewater by bacterial bioluminescence assays using a freshwater luminescent bacterium, Vibrio qinghaiensis sp. Nov.显示文摘 | Zhengfang Ye Quanlin Zhao Mohe Zhang Yuchen Gao | 2010 | Journal of Hazardous Materials2010，，2： | 1 |
| 6 | Current status and future perspectives on neoadjuvant therapy in gastric cancer显示文摘Gastric cancer,with high morbidity and mortality rates,is one of the most heterogeneous tumors.Radical gastrectomy and postoperative chemotherapy are the standard treatments.However,the safety and efficacy of neoadjuvant therapy(NAT)need to be confirmed by many trials before implementation,creating a bottleneck in development.Although clinical benefits of NAT have been observed,a series of problems remain to be solved.Before therapy,more contributing factors should be offered for choice in the intended population and ideal regimens.Enhanced computed tomography(CT)scanning is usually applied to evaluate effectiveness according to Response Evaluation Criteria in Solid Tumors(RECIST),yet CT scanning results sometimes differ from pathological responses.After NAT,the appropriate time for surgery is still empirically defined.Our review aims to discuss the abovementioned issues regarding NAT for GC,including indications,selection of regimens,lesion assessment and NAT-surgery interval time. | Sheng Ao Yuchen Wang Qingzhi Song Yingjiang Ye Guoqing Lyu | 2021 | Chinese Journal of Cancer Research2021，33，2： | 1 |
| 7 | Taurocholic acid inhibits the response to interferon-αtherapy in patients with HBeAg-positive chronic hepatitis B by impairing CD8^(+)T and NK cell function显示文摘Pegylated interferon-alpha (PegIFNα) therapy has limited effectiveness in hepatitis B e-antigen (HBeAg)-positive chronic hepatitis B (CHB) patients. However, the mechanism underlying this failure is poorly understood. We aimed to investigate the influence of bile acids (BAs), especially taurocholic acid (TCA), on the response to PegIFNα therapy in CHB patients. Here, we used mass spectrometry to determine serum BA profiles in 110 patients with chronic HBV infection and 20 healthy controls (HCs). We found that serum BAs, especially TCA, were significantly elevated in HBeAg-positive CHB patients compared with those in HCs and patients in other phases of chronic HBV infection. Moreover, serum BAs, particularly TCA, inhibited the response to PegIFNα therapy in HBeAg-positive CHB patients. Mechanistically, the expression levels of IFN-γ, TNF-α, granzyme B, and perforin were measured using flow cytometry to assess the effector functions of immune cells in patients with low or high BA levels. We found that BAs reduced the number and proportion and impaired the effector functions of CD3^(+)CD8^(+) T cells and natural killer (NK) cells in HBeAg-positive CHB patients. TCA in particular reduced the frequency and impaired the effector functions of CD3^(+)CD8^(+) T and NK cells in vitro and in vivo and inhibited the immunoregulatory activity of IFN-α in vitro. Thus, our results show that BAs, especially TCA, inhibit the response to PegIFNα therapy by impairing the effector functions of CD3^(+)CD8^(+) T and NK cells in HBeAg-positive CHB patients. Our findings suggest that targeting TCA could be a promising approach for restoring IFN-α responsiveness during CHB treatment. | Zhen Xun Jinpiao Lin Qingqing Yu Can Liu Jinlan Huang Hongyan Shang Jianhui Guo Yuchen Ye Wennan Wu Yongbin Zeng Songhang Wu Siyi Xu Tianbin Chen Jing Chen Qishui Ou | 2021 | Cellular & Molecular Immunology2021，18，2： | 1 |
| 8 | Advanced glycation end products increase carbohydrate responsive element binding protein expression and promote cancer cell proliferation显示文摘 | Hanbei Chen Lifang Wu Yakui Li Jian Meng Ning Lin Dianqiang Yang Yemin Zhu Xiaoyong Li Minle Li Ye Xu Yuchen Wu Xuemei Tong Qing Su | 2014 | 2014 (1-2)2014，，1： | 1 |
| 9 | Reduction ofCOD in TNT red water through adsorption on macroporouspolystyrene resin RS 50B显示文摘 | Quanlin Zhao Yuchen Gao Zhengfagn Ye | 2013 | Vacuum2013，95，： | 1 |
| 10 | Ultrabroad-band,white light emission from carbon dot-based materials with hybrid fluorescence/phosphorescence for single component white light-emitting diodes显示文摘Benefiting from the large Stokes shift between fluorescence and phosphorescence,fluorescence/phosphorescence dual-emitting carbon dots(CDs)have gradually entered at the stage of single-phase white light-emitting diodes(WLEDs)as‘green material'.However,most of the developed dual-emitting CDs have weak phosphorescence,short emission wavelength and narrow emission band,resulting in relatively bluish white light emission and low color rendering index(CRI).Herein,an ultrabroad-band fluorescence/phosphorescence dual-emitting CD-based material(UB-CD@BA)is prepared by thermal treatment of boric acid(BA)and CDs with large conjugated structure.The stable covalent bonding between CDs and BA,as well as three-dimensional spatial restriction effect of selfpolymerization BA molecules around CDs during long-term heating efficiently rigidified the single/triplet excited states of CDs from non-radiative deactivation,thus producing strong dual emissive materials with the high phosphorescence quantum yield of 21%.Remarkable,the prepared UB-CD@BA powders exhibit bright pure white light emission with Commission Internationale de l'Eclairage(CIE)coordinates of(0.32,0.33)and the highest reported full width at half maximum of 250 nm.Based on the unique characteristics of UB-CD@BA,it was used as a color conversion layer to prepare a WLED with CIE coordinates of(0.35,0.33)and the CRI value of 87. | Yuchen Li Qijun Li Shuai Meng Yukun Qin Dengke Cheng Hailing Gu Zifei Wang Yunxia Ye Jing Tan | 2023 | Chinese Chemical Letters2023，34，5： | 0 |
| 11 | Anionic entanglement-induced giant thermopower in ionic thermoelectric material Gelatin-CF_(3)SO_(3)K–CH_(3)SO_(3)K显示文摘Ionic thermoelectric(i-TE)technologies can power Internet of Things(IoT)sensors by harvesting thermal energy from the environment because of their large thermopowers.Present research focuses mostly on using the interactions between ions and matrices to enhance i-TE performance,but i-TE materials can benefit from utilizing different methods to control ion transport.Here,we introduced a new strategy that employs an ion entanglement effect.A giant thermopower of 28 mV K^(-1)was obtained in a quasi-solid-state i-TE Gelatin-CF_(3)SO_(3)K–CH_(3)SO_(3)K gel via entanglement between CF_(3)SO_(3)^(-)and CH_(3)SO_(3)^(-)anions.The anionic entanglement effect involves complex interactions between these two anions,slowing anionic thermodiffusion and thus suppressing bipolar effects and boosting p-type thermopower.A Au@Cu|Gelatin-CF_(3)SO_(3)K–CH_(3)SO_(3)K|Au@Cu i-TE device with a generator mode delivers a specific output energy density of 67.2 mJ m^(-2)K^(-2)during 2 h of discharging.Long-term operation. | Qikai Li Cheng-Gong Han Shuaihua Wang Cai-Chao Ye Xinbo Zhang Xiao Ma Tao Feng Yuchen Li Weishu Liu | 2023 | eScience2023，3，5： | 0 |
| 12 | A HAase/NIR responsive surface on titanium implants for treating bacterial infection and improving osseointegration显示文摘Bacterial infection and insufficient osseointegration are critical factors affecting the long-term success of titanium-based implants.Unfortunately,the direct application of antibiotic on Ti implants easily leads to poor cytocompatibility,as well as the production of drug-resistant bacteria.So,in this work,we designed a prospective antibacterial strategy by combining photothermal and ciprofloxacin(CIP).The synergistic effect of photothermal and antibiotic may provide an effective bacteriostatic efficacy without sacrificing osteogenesis at a mild condition of moderate temperature and less antibiotic.Herein,CIP was loaded into mesoporous polydopamine(MPDA)nanoparticles(MPDA@CIP),which were anchored on the surface of titanium and finally covered with sodium hyaluronate-catechol(HAc)coating.The hydrophilic HAc layer could inhibit the early adhesion of bacteria,and some bacteria could secrete bacterial hyaluronidase to accelerate the degradation of HAc.This enabled smart enzyme-triggered release of antimicrobials at the site of infection on-demand and avoided unwanted side effects on normal tissues.In addition,NIR light irradiation had a positive influence on both CIP release and MPDA nanoparticle’s photothermal effect.Moreover,before anchoring MPDA@CIP,by the construction of hydroxyapatite microstructure on Ti sur-face with micro-arc oxidation and alkali heat treatment,the ability of bone formation of Ti could be promoted also.Both in vitro as well as in vivo assays demonstrated that functional Ti has an excellent antibacterial effect and osteogenic ability. | Dan Li Danyang Wang Ye He Bailong Tao Xiaoxia Liu Yulu Yang Lu Tan Yuchen Zhang Jingwei Hu Weihu Yang Yu Tang Kaiyong Cai | 2023 | Journal of Materials Science & Technology2023，，12： | 0 |
| 13 | Interaction of moiréexcitons with cavity photons in two-dimensional semiconductor hetero-bilayers显示文摘Moirématerials,composed of two single-layer two-dimensional semiconductors,are important because they are good platforms for studying strongly correlated physics.Among them,moirématerials based on transition metal dichalcogenides(TMDs)have been intensively studied.The hetero-bilayer can support moiréinterlayer excitons if there is a small twist angle or small lattice constant difference between the TMDs in the hetero-bilayer and form a type-Ⅱ band alignment.The coupling of moiréinterlayer excitons to cavity modes can induce exotic phenomena.Here,we review recent advances in the coupling of moiréinterlayer excitons to cavities,and comment on the current difficulties and possible future research directions in this field. | Yuchen Gao Yu Ye | 2023 | Journal of Semiconductors2023，44，1： | 0 |
| 14 | Dynamic Modeling and Sensitivity Analysis for an MEA-Based CO_(2) Capture Absorber显示文摘The absorber is the key unit in the post-combustion monoethanolamine(MEA)-based carbon dioxide(CO_(2))capture process.A rate-based dynamic model for the absorber is developed and validated using steady-state experimental data reported in open literature.Sensitivity analysis is performed with respect to important model parameters associated with the reaction,mass transport and phy-sical property relationships.Then,a singular value decomposition(SVD)-based subspace parameter estimation method is proposed to improve the model accu-racy.Finally,dynamic simulations are carried out to investigate the effects of the feed rate of lean MEA solution and the flue inlet conditions.Simulation results indicate that the established dynamic model can reasonably reflect the physical behavior of the absorber.Some new insights are gained from the simulation results. | Hongwei Guan Lingjian Ye Yurun Wang Feifan Shen Yuchen He | 2023 | Intelligent Automation & Soft Computing2023，，6： | 0 |
| 15 | Unveiling non-radiative center control in CsPbBr_(3) nanocrystals:A comprehensive comparative analysis of hot injection and ligandassisted reprecipitation approaches显示文摘Metal-halide perovskite nanocrystals(NCs)have gained significant attention in the field of optoelectronic and photonic devices due to their promising applications.Despite their exceptional optical properties,the impact of different synthetic strategies on the fundamental nature of NCs,such as nonradiative recombination centers,remains poorly understood.In this study,we investigated the photophysical properties of CsPbBr_(3) NCs synthesized using two distinct methods,hot injection and ligand-assisted reprecipitation,at the individual particle level.We observed different blinking behaviors under specific photoexcitation power densities and proposed,through intensity-lifetime analysis and Monte-Carlo simulations,that these different synthetic strategies can fabricate NCs with similar crystal structures but distinct surface quenchers with varying energy levels,which significantly affected the photo-induced blinking-down and blinking-up behaviors in individual NCs.Our findings indicate a practical and feasible approach for controlling defect engineering in perovskite NCs,with significant implications for their use in optoelectronic and other technological applications. | Daocheng Hong Yuchen Zhang Shuhan Pan Hanyu Liu Wei Mao Wanli Zhang Yuhui Ye Zhihong Wei Xuxing Lu Xiaoyong Wang Zhenda Lu Yuxi Tian | 2024 | Nano Research2024，17，5： | 0 |
| 16 | Polaron interfacial entropy as a route to high ther moelectric perfor mance in DAE-doped PEDOT:PSS films显示文摘Enhancing the thermoelectric transport properties of conductive polymer materials has been a long-term challenge,in spite of the success seen with molecular doping strategies.However,the strong coupling between the thermopower and the electrical conductivity limits thermoelectric performance.Here,we use polaron interfacial occupied entropy engineering to break through this intercoupling for a PEDOT:PSS(poly(3,4-ethylenedioxythiophene)-poly(4-styrenesulfonate))thin film by using photochromic diarylethene(DAE)dopants coupled with UV-light modulation.With a 10-fold enhancement of the thermopower from 13.5μV K^(-1) to 135.4μV K^(-1) and almost unchanged electrical conductivity,the DAE-doped PEDOT:PSS thin film achieved an extremely high power factor of 521.28μW m^(-1) K^(-2) from an original value of 6.78μW m^(-1) K^(-2).The thermopower was positively correlated with the UV-light intensity but decreased with increasing temperature,indicating resonant coupling between the planar closed DAE molecule and PEDOT.Both the experiments and theoretical calculations consistently confirmed the formation of an interface state due to this resonant coupling.Interfacial entropy engineering of polarons could play a critical role in enhancing the thermoelectric performance of the organic film. | Jiajia Zhang Caichao Ye Genwang Wei Liang Guo Yuhang Cai Zhi Li Xinzhi Wu Fangyi Sun Qikai Li Yupeng Wang Huan Li Yuchen Li Shuaihua Wang Wei Xu Xuefeng Guo Wenqing Zhang Weishu Liu | 2024 | National Science Review2024，11，3： | 0 |
| 17 | Deterministic and replaceable transfer of silver flakes for microcavities显示文摘How to fabricate high-quality microcavities simply and at low cost without causing damage to environmentally sensitive active layers such as perovskites are crucial for the studies of exciton–polaritons,however,it remains challenging in the field of microcavity fabrication.Usually,once the top mirror is deposited,the detuning of the microcavity is fixed and there is no easy way to tune it.Here,we have developed a method for deterministically transferring silver mirrors,which is relatively simple and guarantees the active layer from damaging of high temperature,particle bombardment,etc.,during the deposition of the top mirror.Furthermore,with the help of a glass probe,we demonstrate a replaceable silver transfer method to tune the detuning of the microcavity,thereby changing the coupling of photons and excitons therein.The developed deterministic and replaceable silver mirror transfer methods will provide the capability to fabricate high-quality and tunable microcavities and play an active role in the development of the exciton–polariton field. | Tingting Wang Zhihao Zang Yuchen Gao Kenji Watanabe Takashi Taniguchi Wei Bao Yu Ye | 2023 | Frontiers of physics2023，18，3： | 0 |
| 18 | In-situ optical pumping for polarizing 3He neutron spin filters at the China Spallation Neutron Source显示文摘In this paper,we present the performance of a recently developed in-situ spin-exchange optically pumped^(3)He-neutron spin filter system at the China Spallation Neutron Source(CSNS).The system achieved a^(3)He polarization of over 74%at the beamline BL-20.Analysis of neutron transmission experiment results reveals a neutron polarization of>90%and an average transmission of 27%for 2.2Åneutrons,which were maintained for a duration of 120 h of beam time.To the best of our knowledge,this is the first in-situ hyperpolarized^(3)He system incorporated on a neutron beamline in China.This technology is expected to provide stable,wide-angle,and highly polarized neutrons at the CSNS for materials research and fundamental neutron physics. | Junpei Zhang Chuyi Huang Zecong Qin Fan Ye Syed Mohd Amir Ahmed Salman Yuchen Dong Long Tian Zachary Norris Buck Wolfgang Kreuzpaintner Matthew Musgrave Xin Qi Tianhao Wang Xin Tong | 2022 | Science China(Physics,Mechanics & Astronomy)2022，65，4： | 0 |
| 19 | The concordance between the evolutionary trend and the clinical manifestation of the two SARS-CoV-2 variants显示文摘Coronavirus disease 2019(COVID-19),the disease caused by infection with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),has developed into a global pandemic that continues to pose an enormous threat to public health and the global economy.Since the first SARS-CoV-2 genome was released[1],thousands of genetic variants have been identified in SARS-CoV-2 strains isolated from worldwide patients. | Ben Hu Ran Liu Xiaolu Tang Yuchen Pan Ming Wang Yongqing Tong Guangming Ye Gaigai Shen Ruochen Ying Aisi Fu Di Li Wanxu Zhao Jing Peng Jie Guo Dong Men Xinmin Yao Yirong Wang Hong Zhang Zhihui Feng Junping Yu Liangjun Chen Zixin Deng Xuemei Lu Ya-Ping Zhang Yirong Li Bende Liu Lilei Yu Yan Li Jian Lu Tiangang Liu | 2021 | National Science Review2021，8，8： | 0 |
| 20 | Synergistic catalytic ozonation of toluene with manganese and cerium varies at low temperature显示文摘The temperature of waste gas in refuse transfer station,airport smoking area,and RTO terminal is low,which needs deep oxidation.Catalytic ozonation is one of the most effective treatment techniques in these scenarios.In this study,we reported that catalysts were modified under the condition of mag-netic field to simulate the low temperature dynamic conditions of low concentration toluene for catalytic ozonation.This paper aims to explore the relationship between oxygen vacancy and active oxygen species,and the specific pathways of toluene oxidation.The study found that citric acid can enhance the syner-gistic effect between Mn and Ce,and promote the generation of oxygen vacancies.The surface molecule adsorption oxygen is more conducive to catalytic oxidation than subsurface atom adsorption oxygen.Fi-nally,we proposed the main pathways of toluene in this reaction system,which runs through the whole process of the reaction. | Qi Gan Mingli Fu Peng Liu Yuchen Zhang Juxia Xiong Jinping Zhong Lei Liu Junliang Wu Xiaojun Niu Yun Hu Daiqi Ye | 2022 | Chinese Chemical Letters2022，33，5： | 0 |
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