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| 1 | Discovery of biclonal origin and a novel oncogene SLC12A5 in colon cancer by single-cell sequencing显示文摘单个房间的定序是为描出的一个强大的工具为个性化的癌症管理的同种细胞的关系和识别关键司机基因。这里,我们执行了结肠癌的一个盒子的单个房间的定序的分析。人口遗传分析在肿瘤房间人口识别了二独立克隆。主要肿瘤克隆作为早 oncogenic 事件怀有 APC 和 TP53 变化,而次要的克隆包含了优势的 CDC27 和 PABPC1 变化。在这二克隆的次要的克隆支持的 APC 和 TP53 变化的缺席从二细胞的起源被导出。体的变化等位基因频率系列的检查另外 21 个整个织物的定序 exome 的盒子在结肠癌揭示了同种细胞的起源的异质。下次,我们识别了在单个房间的水平显示出变化的高频率,但是在人口水平展出了低流行的变异的基因 SLC12A5。变异的 SLC12A5 的功能的描述在结肠癌揭示了它的潜在的 oncogenic 效果。我们的学习在单个房间的水平支持提供第一条 exome 宽的证据那结肠癌能具有 biclonal 起源,并且建议在一个队的低流行的变化可以也在单个水平起重要 protumorigenic 作用。 | Chang Yu Jun Yu Xlaotlan Yao Wllham KK Wu Youyong Lu Senwel Tang Xiangchun Li Li Bao Xiaoxing Li Yong Hou Renhua Wu Min Jian Ruoyan Chen Fan Zhang Lixia Xu Fan Fan Jun He Qiaoyi Liang Hongyi Wang Xueda Hu Minghui He Xiang Zhang Hancheng Zheng Qibin Li Hanjie Wu Yan Chen Xu Yang Shida Zhu Xun Xu Huanming Yang Jian Wang Xiuqing Zhang Joseph JY Sung Yingrui Li Jun Wang | 2014 | Cell Research2014，，6： | 16 |
| 2 | New innovations in pavement materials and engineering:A review on pavement engineering research 2021显示文摘Sustainable and resilient pavement infrastructure is critical for current economic and environmental challenges.In the past 10 years,the pavement infrastructure strongly supports the rapid development of the global social economy.New theories,new methods,new technologies and new materials related to pavement engineering are emerging.Deterioration of pavement infrastructure is a typical multi-physics problem.Because of actual coupled behaviors of traffic and environmental conditions,predictions of pavement service life become more and more complicated and require a deep knowledge of pavement material analysis.In order to summarize the current and determine the future research of pavement engineering,Journal of Traffic and Transportation Engineering(English Edition)has launched a review paper on the topic of'New innovations in pavement materials and engineering:A review on pavement engineering research 2021'.Based on the joint-effort of 43 scholars from 24 well-known universities in highway engineering,this review paper systematically analyzes the research status and future development direction of 5 major fields of pavement engineering in the world.The content includes asphalt binder performance and modeling,mixture performance and modeling of pavement materials,multi-scale mechanics,green and sustainable pavement,and intelligent pavement.Overall,this review paper is able to provide references and insights for researchers and engineers in the field of pavement engineering. | JTTE Editorial Office Jiaqi Chen Hancheng Dan Yongjie Ding Yangming Gao Meng Guo Shuaicheng Guo Bingye Han Bin Hong Yue Hou Chichun Hu Jing Hu Ju Huyan Jiwang Jiang Wei Jiang Cheng Li Pengfei Liu Yu Liu Zhuangzhuang Liu Guoyang Lu Jian Ouyang Xin Qu Dongya Ren Chao Wang Chaohui Wang Dawei Wang Di Wang Hainian Wang Haopeng Wang Yue Xiao Chao Xing Huining Xu Yu Yan Xu Yang Lingyun You Zhanping You Bin Yu Huayang Yu Huanan Yu Henglong Zhang Jizhe Zhang Changhong Zhou Changjun Zhou Xingyi Zhu | 2021 | Journal of Traffic and Transportation Engineering(English Edition)2021，8，6： | 7 |
| 3 | Endothelial PDGF-BB/PDGFR-βsignaling promotes osteoarthritis by enhancing angiogenesis-dependent abnormal subchondral bone formation显示文摘The mechanisms that coordinate the shift from joint homeostasis to osteoarthritis(OA)remain unknown.No pharmacological intervention can currently prevent the progression of osteoarthritis.Accumulating evidence has shown that subchondral bone deterioration is a primary trigger for overlying cartilage degeneration.We previously found that H-type vessels modulate aberrant subchondral bone formation during the pathogenesis of OA.However,the mechanism responsible for the elevation of H-type vessels in OA is still unclear.Here,we found that PDGFR-βexpression,predominantly in the CD31^(hi)Emcn^(hi) endothelium,was substantially elevated in subchondral bones from OA patients and rodent OA models.A mouse model of OA with deletion of PDGFR-βin endothelial cells(ECs)exhibited fewer H-type vessels,ameliorated subchondral bone deterioration and alleviated overlying cartilage degeneration.Endothelial PDGFR-βpromotes angiogenesis through the formation of the PDGFR-β/talin1/FAK complex.Notably,endothelium-specific inhibition of PDGFR-βby local injection of AAV9 in subchondral bone effectively attenuated the pathogenesis of OA compared with that of the vehicle-treated controls.Based on the results from this study,targeting PDGFR-βis a novel and promising approach for the prevention or early treatment of OA. | Zhuang Cui Hangtian Wu Ye Xiao Ting Xu Junjie Jia Hancheng Lin Rongmin Lin Kun Chen Yihuang Lin Kaiqun Li Xiaohu Wu Changjun Li Bin Yu | 2022 | Bone Research2022，10，4： | 4 |
| 4 | Optimizing Building Envelope Dimensions for Passive Solar Houses in the Qinghai-Tibetan Region: Window to Wall Ratio and Depth of Sunspace显示文摘It has been a focus to reduce the energy consumption and improve the space heating performance of high-altitude buildings in winter seasons. In view of the abundant solar energy resources of the high-altitude region, the establishment of passive solar houses should be an effective strategy to deal with the problem of thermal comfort. Both window to wall ratio(WWR) and sunspace depth are of vital importance to determine the thermal comfort level of passive solar houses, while there are limited studies on analyzing their impacts on passive solar houses in high-altitude regions. Therefore, this study is designed to examine how WWR and sunspace depth affect space heating of passive solar houses in the Qinghai-Tibetan region. To be specific, the hourly radiation temperature variations and percentages of dissatisfaction of the residential building with different sunspace depth/WWR(including 0.9 m/33%, 0.9 m/45%, 0.9 m/60%, 1.2 m/33% and 1.5 m/33%) were quantitatively examined. Results indicated that under the condition of 0.9 m/45%, the overall average radiation temperature of the building was approximately 16°C during the entire heating season, which could better satisfy the heating requirements. Meanwhile, the average temperature was higher, and the thermal comfort level was better under the ratio of 45% or the depth of 1.5 m, when only an individual factor in either ratio or depth was considered. These findings can provide references for the determination of dimensions of passive solar houses in high-altitude regions. | LIU Zhijian WU Di LI Junyang YU Hancheng HE Baojie | 2019 | Journal of Thermal Science2019，28，6： | 4 |
| 5 | An improved approach for the application of Trombe wall system to building construction with selective thermo-insulation faades显示文摘An improved Trombe wall is proposed to adapt to building construction with selective thermo-insula-tion faades (internal and cavity wall insulation, but not external wall insulation system). The case study is conducted in Xining, Capital city of Qinghai province in China, where the general building faades are mostly selective thermo-insulation faades to fight against the severe cold. A numerical analysis is undertaken to show the effects on the improvement of the building's thermal environment by comparing the improved Trombe wall system with the classical Trombe wall system. The operating efficiency of the improved Trombe wall can be up to 33.85%, an increase of 56%. The results show that the improved Trombe wall works more effectively than the classical Trombe wall system in utilizing solar energy for the sample building. | JI Jie LUO ChengLong SUN Wei YU HanCheng HE Wei PEI Gang | 2009 | Chinese Science Bulletin2009，54，11： | 3 |
| 6 | Optimisation of the double skin facade in hot and humid climates through altering the design parameter combinations显示文摘Architects welcome double skin facade(DSF)due to its aesthetic quality.The first DSF structure was intended to prevent cold weather and strong winds.Nowadays,the application of DSF under different climates has been investigated in many previous studies.Fiowever,little work had been done on the behaviour of DSF in hot and humid climates.Therefore,this paper aimed to extend the application into this specific climate and Guangzhou was selected as the sample city.Both the climate and the design influence the performance of DSF.In this paper,rather than explore how each design parameter influences the performance,the design was evaluated from an overall aspect.The Designbuilder software was used to build the single skin facade(SSF)and double skin facade base model.Annual HVAC energy consumption for both the two models was calculated and compared.An optimisation process was conducted to figure out what kinds of parameter combination could make the design more energy-saving and thermally comfortable.The results indicated that it was possible to design an energy-saving DSF system applied in hot and humid climates compared with the SSF model.The efficiency of the DSF could be further enhanced with a better parameter combination.The optimised options had some features in common,which could provide some inspirations for the application of DSF in hot and humid climates. | Meng Wang Jingxin Hou Zhongting Hu Wei He Hancheng Yu | 2021 | Building Simulation2021，14，3： | 3 |
| 7 | High-performance distributed feedback quantum dot lasers with laterally coupled dielectric gratings显示文摘The combination of grating-based frequency-selective optical feedback mechanisms,such as distributed feedback(DFB)or distributed Bragg reflector(DBR)structures,with quantum dot(QD)gain materials is a main approach towards ultrahigh-performance semiconductor lasers for many key novel applications,as either stand-alone sources or on-chip sources in photonic integrated circuits.However,the fabrication of conventional buried Bragg grating structures on GaAs,GaAs/Si,GaSb,and other material platforms has been met with major material regrowth difficulties.We report a novel and universal approach of introducing laterally coupled dielectric Bragg gratings to semiconductor lasers that allows highly controllable,reliable,and strong coupling between the grating and the optical mode.We implement such a grating structure in a low-loss amorphous silicon material alongside GaAs lasers with InAs/GaAs QD gain layers.The resulting DFB laser arrays emit at pre-designed 0.8 THz local area network wavelength division multiplexing frequency intervals in the 1300 nm band with record performance parameters,including sidemode suppression ratios as high as 52.7 dB,continuous-wave output power of 26.6 mW(room temperature)and 6 mW(at 55℃),and ultralow relative intensity noise(RIN)of<-165 dB/Hz(2.5-20 GHz).The devices are also capable of isolator-free operating under very high external reflection levels of up to-12.3 dB while maintaining high spectral purity and ultralow RIN qualities.These results validate the novel laterally coupled dielectric grating as a technologically superior and potentially cost-effective approach for fabricating DFB and DBR lasers free of their semiconductor material constraints,which are thus universally applicable across different material platforms and wavelength bands. | ZHUOHUI YANG ZHENGQING DING LIN LIU HANCHENG ZHONG SHENG CAO XINZHONG ZHANG SHIZHE LIN XIAOYING HUANG HUADI DENG YING YU SIYUAN YU | 2022 | Photonics Research2022，10，5： | 3 |
| 8 | Multiple resistance of Botrytis cinerea from vegetable crops to carbendazim, diethofencarb, procymidone, and pyrimethanil in China 显示文摘 | Sun Haiyan Wang Hancheng Chen Yu | 2010 | Plant Dis2010，94，5： | 1 |
| 9 | Smart luminescent solar concentrator as a BICPV window显示文摘Building integrated concentrating photovoltaic(BICPV)windows have attracted numerous studies in recent years.However,there is a tradeoff between the light transmittance and power generation efficiency in the design of BICPV window.In this paper,a smart luminescent solar concentrator(LSC)is introduced as the BICPV window.The proposed smart LSC system features on the combination of fluorescent dyes with thermochromic materials to enhance photoelectric conversion efficiency as well as form a dynamic response mechanism to ambient solar radiation and environmental temperature.In this study,a BICPV smart window system consists of the waveguide doped with organic dye Lumogen F Red-305(BASF)and the thermochromic hydrogel membrane has been developed.The research on analytic design parameters is executed through optical simulation by ray tracing technology along with outdoor comparative experiments.From simulations for a smart LSC of 100 mm×100 mm×3 mm with a bottom-mounted solar cell of 100 mm×10 mm,the optical effective concentration is found to be with the range of 1.23 to 1.31 when a highest gain of 1.26 in power over the bare solar cell is obtained from experiments. | Ying Nie Wei He Xianghua Liu Zhongting Hu Hancheng Yu Haixiang Liu | 2022 | Building Simulation2022，15，10： | 1 |
| 10 | Mn(Ⅲ) porphyrins immobilized on magnetic polymer nanospherese as biomimetic catalysts hydroxylating cyclohexane with molecular oxygen显示文摘 | FU Bo YU Hancheng HUANG Jinwang | 2009 | J Mole Catal2009，298，： | 1 |
| 11 | Effects of the US withdrawal from Paris Agreement on the carbon emission space and cost of China and India显示文摘 | Hancheng DAI Yang XIE Haibin ZHANG Zhongjue YU Wentao WANG | 2018 | Frontiers in Energy2018，12，3： | 1 |
| 12 | Multipleresistance of Botrytis cinerea from vegetable crops tocarbendazim,diethofencarb,procymidone,and pyrimethanil inChina 显示文摘 | SUN Haiyan WANG Hancheng CHEN Yu | 2010 | Plant Dw2010，94，5： | 1 |
| 13 | Image denoising u- sing tfivariate shrinkage filter in the wavelet domain and joint bilater- al fiher in the spatial domain显示文摘 | YU HANCHENG ZHAO LI WANG HAIXIA | 2009 | IEEE Transactions on Image Pro- cessing2009，18，10： | 1 |
| 14 | Mn(III)porphyrins immobilized on magnetic polymer nanospheres asbiomimetic catalysts hydroxylating cyclohexane with molecular oxygen显示文摘 | Fu Bo Yu Hancheng Huang Jinwang | 2009 | Journal of Molecular Catalysis A: Chemical2009，298，1： | 1 |
| 15 | Multiple resistance of Botrytis cinerea from vegetable crops to carbendazim, diethofencarb, procymidone, and pyrimethanil in China显示文摘 | Sun Haiyan Wang Hancheng Chen Yu | 2010 | Plant Disease2010，94，5： | 1 |
| 16 | A new derivatization approach for the rapid and sensitive analysis of brassinosteroids by using ultra high performance liquid chromatography-electrospray ionization triple quadrupole mass spectrometry显示文摘 | Feifeng Huo Xin Wang Yehua Han Yu Bai Wei Zhang Hancheng Yuan Huwei Liu | 2012 | Talanta2012，，： | 1 |
| 17 | Image denoising using trivariate shrinkage filter in the wavelet domain and joint bilateral filter in the spatial domain显示文摘 | Yu Hancheng Zhao Li Wang Hanxian | 2009 | IEEE Transaction on Image Processing2009，18，10： | 1 |
| 18 | Synergetic roadmap of carbon neutrality and clean air for China显示文摘It is well recognized that carbon dioxide and air pollutants share similar emission sources so that synergetic policies on climate change mitigation and air pollution control can lead to remarkable co-benefits on greenhouse gas reduction,air quality improvement,and improved health.In the context of carbon peak,carbon neutrality,and clean air policies,this perspective tracks and analyzes the process of the synergetic governance of air pollution and climate change in China by developing and monitoring 18 indicators.The 18 indicators cover the following five aspects:air pollution and associated weather-climate conditions,progress in structural transition,sources,inks,and mitigation pathway of atmospheric composition,health impacts and benefits of coordinated control,and synergetic governance system and practices.By tracking the progress in each indicator,this perspective presents the major accomplishment of coordinated control,identifies the emerging challenges toward the synergetic governance,and provides policy recommendations for designing a synergetic roadmap of Carbon Neutrality and Clean Air for China. | Qiang Zhang Zhicong Yin Xi Lu Jicheng Gong Yu Lei Bofeng Cai Cilan Cai Qimin Chai Huopo Chen Hancheng Dai Zhanfeng Dong Guannan Geng Dabo Guan Jianlin Hu Cunrui Huang Jianing Kang Tiantian Li Wei Li Yongsheng Lin Jun Liu Xin Liu Zhu Liu Jinghui Ma Guofeng Shen Dan Tong Xuhui Wang Xuying Wang Zhili Wang Yang Xie Honglei Xu Tao Xue Bing Zhang Da Zhang Shaohui Zhang Shaojun Zhang Xian Zhang Bo Zheng Yixuan Zheng Tong Zhu Jinnan Wang Kebin He | 2023 | Environmental Science and Ecotechnology2023，，4： | 0 |
| 19 | Skeleton Keypoints Extraction Method Combined with Object Detection显示文摘Big data is a comprehensive result of the development of the Internet of Things and information systems.Computer vision requires a lot of data as the basis for research.Because skeleton data can adapt well to dynamic environment and complex background,it is used in action recognition tasks.In recent years,skeleton-based action recognition has received more and more attention in the field of computer vision.Therefore,the keypoints of human skeletons are essential for describing the pose estimation of human and predicting the action recognition of the human.This paper proposes a skeleton point extraction method combined with object detection,which can focus on the extraction of skeleton keypoints.After a large number of experiments,our model can be combined with object detection for skeleton points extraction,and the detection efficiency is improved. | Jiabao Shi Zhao Qiu Tao Chen Jiale Lin Hancheng Huang Yunlong He d Yu Yang | 2022 | Journal of New Media2022，4，2： | 0 |
| 20 | Dose-Response Meta-Analysis on Risk of Diabetes in Relation to Red and Processed Meat Consumption—Asian Populations,2006−2021显示文摘Summary What is already known about this topic?Red and processed meat consumption has been positively related to an increased risk of diabetes in Western populations.However,the results remain inconclusive within Asian populations.What is added by this report?This dose-response meta-analysis of prospective cohort studies conducted in East Asian populations reveals a positive relation between the consumption of processed meat and increased risk of diabetes.Furthermore,a Ushaped association was identified between the consumption of unprocessed red meat and the risk of diabetes.What are the implications for public health practice?This research presents substantive evidence advocating for the reduction of processed and unprocessed red meat consumption as a viable strategy for mitigating the risk of diabetes in East Asian populations. | Hancheng Yu Jijuan Zhang Jinchi Xie Xianli Li Youjing Wang Yijia Yang Fengshuang Zhou Meichen Liu Zhe Zhang Zhilei Shan Gang Liu An Pan | 2023 | China CDC weekly2023，5，45： | 0 |
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