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| 1 | Aerodynamic Design Methodology for Blended Wing Body Transport显示文摘This paper puts forward a design idea for blended wing body(BWB).The idea is described as that cruise point,maximum lift to drag point and pitch trim point are in the same flight attitude.According to this design idea,design objectives and constraints are defined.By applying low and high fidelity aerodynamic analysis tools,BWB aerodynamic design methodology is established by the combination of optimization design and inverse design methods.High lift to drag ratio,pitch trim and acceptable buffet margin can be achieved by this design methodology.For 300-passenger BWB configuration based on static stability design,as compared with initial configuration,the maximum lift to drag ratio and pitch trim are achieved at cruise condition,zero lift pitching moment is positive,and buffet characteristics is well.Fuel burn of 300-passenger BWB configuration is also significantly reduced as compared with conventional civil transports.Because aerodynamic design is carried out under the constraints of BWB design requirements,the design configuration fulfills the demands for interior layout and provides a solid foundation for continuous work. | LI Peifeng ZHANG Binqian CHEN Yingchun YUAN Changsheng LIN Yu | 2012 | Chinese Journal of Aeronautics2012，25，4： | 29 |
| 2 | Whole-genome sequencing of 508 patients identifies key molecular features associated with poor prognosis in esophageal squamous cell carcinoma显示文摘Esophageal squamous cell carcinoma(ESCC)is a poor-prognosis cancer type with limited understanding of its molecular etiology.Using 508 ESCC genomes,we identified five novel significantly mutated genes and uncovered mutational signature clusters associated with metastasis and patients’outcomes.Several functional assays implicated that NFE2L2 may act as a tumor suppressor in ESCC and that mutations in NFE2L2 probably impaired its tumor-suppressive function,or even conferred oncogenic activities.Additionally,we found that the NFE2L2 mutations were significantly associated with worse prognosis of ESCC.We also identified potential noncoding driver mutations including hotspot mutations in the promoter region of SLC35E2 that were correlated with worse survival.Approximately 5.9%and 15.2%of patients had high tumor mutation burden or actionable mutations,respectively,and may benefit from immunotherapy or targeted therapies.We found clinically relevant coding and noncoding genomic alterations and revealed three major subtypes that robustly predicted patients’outcomes.Collectively,we report the largest dataset of genomic profiling of ESCC useful for developing ESCC-specific biomarkers for diagnosis and treatment. | Yongping Cui Hongyan Chen Ruibin Xi Heyang Cui Yahui Zhao Enwei Xu Ting Yan Xiaomei Lu Furong Huang Pengzhou Kong Yang Li Xiaolin Zhu Jiawei Wang Wenjie Zhu Jie Wang Yanchun Ma Yong Zhou Shiping Guo Ling Zhang Yiqian Liu Bin Wang Yanfeng Xi Ruifang Sun Xiao Yu Yuanfang Zhai Fang Wang Jian Yang Bin Yang Caixia Cheng Jing Liu Bin Song Hongyi Li Yi Wang Yingchun Zhang Xiaolong Cheng Qimin Zhan Yanhong Li Zhihua Liu-Show | 2020 | Cell Research2020，30，10： | 19 |
| 3 | A Model Output Machine Learning Method for Grid Temperature Forecasts in the Beijing Area显示文摘In this paper, the model output machine learning (MOML) method is proposed for simulating weather consultation, which can improve the forecast results of numerical weather prediction (NWP). During weather consultation, the forecasters obtain the final results by combining the observations with the NWP results and giving opinions based on their experience. It is obvious that using a suitable post-processing algorithm for simulating weather consultation is an interesting and important topic. MOML is a post-processing method based on machine learning, which matches NWP forecasts against observations through a regression function. By adopting different feature engineering of datasets and training periods, the observational and model data can be processed into the corresponding training set and test set. The MOML regression function uses an existing machine learning algorithm with the processed dataset to revise the output of NWP models combined with the observations, so as to improve the results of weather forecasts. To test the new approach for grid temperature forecasts, the 2-m surface air temperature in the Beijing area from the ECMWF model is used. MOML with different feature engineering is compared against the ECMWF model and modified model output statistics (MOS) method. MOML shows a better numerical performance than the ECMWF model and MOS, especially for winter. The results of MOML with a linear algorithm, running training period, and dataset using spatial interpolation ideas, are better than others when the forecast time is within a few days. The results of MOML with the Random Forest algorithm, year-round training period, and dataset containing surrounding gridpoint information, are better when the forecast time is longer. | Haochen LI Chen YU Jiangjiang XIA Yingchun WANG Jiang ZHU Pingwen ZHANG | 2019 | Advances in Atmospheric Sciences2019，36，10： | 9 |
| 4 | Visible light photodegradation of methylene blue by AgBr-TiO_2/SiO_2@Fe_3O_4 magnetic photocatalysts显示文摘Visible photoactive AgBr/TiO_2 was immobilized on a SiO_2@Fe_3O_4 magnetic support by solvothermal and sol-gel methods to form a AgBr-TiO_2/SiO_2@Fe_3O_4 magnetic photocatalyst.Samples were characterized by X-ray diffraction,high-resolution transmission electron microscopy and magnetometry.Hetero-structured AgBr/TiO_2 was well seeded on the shell-core SiO_2@Fe_3O_4 structure.The AgBr-TiO_2/SiO_2@Fe_3O_4 magnetic photocatalyst exhibited high photocatalytic activity in the degradation of methylene blue under visible light.The photocatalyst was superparamagnetic,which is beneficial for facile magnetic separation. | Jianjun Liu Shengli Zuo Liming Yu Yingchun Yu Baoshan Li Pengwan Chen | 2013 | Particuology2013，11，6： | 7 |
| 5 | Modulation of nitrate-induced phosphate response by the MYB transcription factor RLI1/HINGE1 in the nucleus显示文摘The coordinated utilization of nitrogen(N)and phosphorus(P)is vital for plants to maintain nutrient balance and achieve optimal growth.Previously,we revealed a mechanism by which nitrate induces genes for phosphate utilization;this mechanism depends on NRT1.1B-facilitated degradation of cytoplasmic SPX4,which in turn promotes cytoplasmic-nuclear shuttling of PHR2,the central transcription factor of phosphate signaling,and triggers the nitrate-induced phosphate response(NIPR)and N-P coordinated utilization in rice.In this study,we unveiled a fine-tuning mechanism of NIPR in the nucleus regulated by Highly Induced by Nitrate Gene 1(HINGE1,also known as RLI1),a MYB-transcription factor closely related to PHR2.RLI1/HINGE1,which is transcriptionally activated by PHR2 under nitrate induction,can directly activate the expression of phosphate starvation-induced genes.More importantly,RLI1/HINGE1 competes with PHR2 for binding to its repressor proteins in the nucleus(SPX proteins),and consequently releases PHR2 to further enhance phosphate response.Therefore,RLI1/HINGE1 amplifies the phosphate response in the nucleus downstream of the cytoplasmic SPX4-PHR2 cascade,thereby enabling fine-tuning of N-P balance when nitrate supply is sufficient. | Zhihua Zhang Zhao Li Wei Wang Zhimin Jiang Liping Guo Xiaohan Wang Yangwen Qian Xiahe Huang Yongqiang Liu Xiujie Liu Yahong Liu Aifu Li Yu Yan Junpeng Xie Shouyun Cao Stanislav Kopriva Legong Li Fanjiang Kong Baohui Liu Yingchun Wang Bin Hu Chengcai Chu | 2021 | Molecular Plant2021，14，3： | 4 |
| 6 | Mea6 controls VLDL transport through the coordinated regulation of COPil assembly显示文摘 | Yaqing Wang Liang Liu Hongsheng Zhang Junwan Fan FengZhang Mei Yu Lei Shi Lin Yang Sin Man Lam Huimin Wang Xiaowei Chen Yingchun Wang Fei Gao Guanghou Shui Zhiheng Xu | 2016 | Cell Research2016，26，7： | 4 |
| 7 | Heteroatom-doped porous carbon from methyl orange dye wastewater for oxygen reduction显示文摘Banana peel-derived porous carbon(BPPC) was prepared from banana peel and used as an adsorbent for methyl orange(MO) wastewater removal. BPPC-MO50 is a N,S-doped BPPC obtained via secondary carbonization. The BPPC-MO50 exhibited a high specific surface area of1774.3 m^2/g. Heteroatom-doped porous carbon(PC) was successfully synthesized from the BPPC absorbed MO at high temperature and used for oxygen reduction. The BPPC-MO50 displayed the highest ORR onset potential among all carbon-based electrocatalysts, i.e., 0.93 V vs.reversible hydrogen electrode(RHE). This is the first report to describe porous carbon-activated materials from agriculture and forestry waste that is used for adsorption of dyes from wastewater via an enhanced heteroatom(N,S) content. These results may contribute to the sustainable development of dye wastewater treatment by transforming saturated PC into an effective material and has potential applications in fuel cells or as energy sources. | Yiqing Wang Mingyuan Zhu Yingchun Li Mengjuan Zhang Xueyan Xue Yulin Shi Bin Dai Xuhong Guo Feng Yu | 2018 | Green Energy & Environment2018，3，2： | 4 |
| 8 | OsMPK4 promotes phosphorylation and degradation of IPA1 in response to salt stress to confer salt tolerance in rice显示文摘Salt stress adversely affects plant growth,development,and crop yield.Rice(Oryza sativa L.)is one of the most salt-sensitive cereal crops,especially at the early seedling stage.Mitogen-activated protein kinase(MAPK/MPK)cascades have been shown to play critical roles in salt response in Arabidopsis.However,the roles of the MPK cascade signaling in rice salt response and substrates of Os MPK remain largely unknown.Here,we report that the salt-induced Os MPK4-Ideal Plant Architecture 1(IPA1)signaling pathway regulates the salt tolerance in rice.Under salt stress,Os MPK4 could interact with IPA1 and phosphorylate IPA1 at Thr180,leading to degradation of IPA1.Genetic evidence shows that IPA1 is a negative regulator of salt tolerance in rice,whereas Os MPK4 promotes salt response in an IPA1-dependent manner.Taken together,our results uncover an Os MPK4-IPA1 signal cascade that modulates the salt stress response in rice and sheds new light on the breeding of salt-tolerant rice varieties. | Meiru Jia Nan Luo Xiangbing Meng Xiaoguang Song Yanhui Jing Liquan Kou Guifu Liu Xiahe Huang Yingchun Wang Jiayang Li Bing Wang Hong Yu | 2022 | Journal of Genetics and Genomics2022，49，8： | 2 |
| 9 | Registration Based on ORB and FREAK Features for Augmented Reality Systems显示文摘This paper proposes a novel registration method for augmented reality(AR) systems based on Oriented FAST and RotatedBRIEF(ORB) and Fast Retina Keypoint(FREAK) natural features. In the proposed ORBFREAK method, feature extraction is implemented based on the combination of ORB and FREAK, and the feature points are matched using Hamming distance. To get good matching points, cross-checks and least median squares are used to perform outlier filtration, and camera pose is estimated using the matched points. Finally, AR is rendered.Experiments show that the proposed method improves the speed of registration to be in real time; the proposed method can accurately register the target object under the circumstances of partial occlusion of the object; and it also can overcome the effects of rotation, scale change, ambient light and distance. | Yang Yu Yingchun Guo Ruili Wang Susha Yin Ming Yu | 2017 | Transactions of Tianjin University2017，23，2： | 2 |
| 10 | Reactive oxygen species in paraventricular nucleus involved in cardiac sympathetic afferent reflex in rats显示文摘Objective: The present study was designed to determine if reactive oxygen species (ROS) in the paraventricular nucleus (PVN) were involved in modulating cardiac sympathetic afferent reflex (CSAR) in anesthetized rats. Methods: Malondialdehyde (MDA), the end product of lipid peroxidation, in the PVN, was determined by thiobarbituric acid (TBA) spectrometric method. Renal sympathetic nerve activity (RSNA) and arterial pressure were recorded in sinoaortic-denervated and cervical-vagotomized rats. The CSAR was evaluated by the response of the RSNA evoked by epicardial application of bradykinin (BK, 0.4 μg). Results: The MDA in the PVN was significantly increased after epicardial application of BK compared with control (2.0±0.3 vs 0.8±0.1 nmol/mg protein, P<0.01). Microinjection of a superoxide anion scavenger, tiron (20 nmol) into the PVN significantly inhibited the CSAR evoked by BK (12.3±1.9 vs 4.2±1.2%, P<0.01) and decreased MDA level (1.9±0.3 vs 0.6±0.1 nmol/mg protein, P<0.01) compared with control. Conclusion: The ROS in the PVN is involved in modulating the CSAR in rats. | Feng Zhang Yang Yu Ying Zhang Yingchun Li Luqing Zhang Lingling Fan Yingya Gao Guoqing Zhu | 2005 | Journal of Nanjing Medical University2005，19，6： | 2 |
| 11 | Selection of nitrite-degrading and biogenic amine-degrading strains and its involved genes显示文摘Objectives:Accumulation of nitrite and biogenic amines(BAs)in fermented meat products is a matter of public health concern.The study aimed to screen nitrite-degrading and BA-degrading strains from sour porridges and sausages and bacon products in China.Materials and Methods:After screening out 12 strains,the degradation of nitrite,the degradation of BAs,the activities of nitrite-reducing enzymes,and the detection of genes involved in the BAs were assessed by spectrophotometry method with hydrochloric acid naphthalene ethylenediamine,high-performance liquid chromatography,GENMED kit,and polymerase chain reaction,respectively.Results:Pediococcus pentosaceus labelled M SZ12 and M GC 2,Lactobacillus plantarum labelled M SZ22,and Staphylococcus xylosus labelled Y CC 3 were selected.The activity of nitrite-reducing enzyme in M SZ22 was 2.663 units/mg.The degradation rate of total BAs of M SZ22 was 93.24%.The degradation rates of nitrite and BAs of M SZ12 were 86.49%and 37.87%,respectively.The activity of nitrite-reducing enzyme in M SZ12 was up to 1.962 units/mg.M GC 2 showed higher degradation rates of nitrite(89.19%)and Y CC 3 showed higher degradation rates of BAs(36.16%).The genes encoding the multicopper oxidases(suf I/D2EK17)were detected in the four strains,which also did not contain BAs(histidine decarboxylase(hdc),tyrosine decarboxylase(tdc),ornithine decarboxylase(odc),lysine decarboxylase(ldc))formation encoding genes.Conclusion:These four strains(M SZ12,M GC 2,M SZ22,and Y CC 3)are promising candidates to use as starter cultures for nitrite and BAs in fermented sausages. | Yuxin Li Zhihui Yu Yingchun Zhu Zhixiang Cao | 2020 | Food Quality and Safety2020，4，4： | 2 |
| 12 | Photocatalytic activity of shock-treated TiO2 powder显示文摘 | Liu Jianjun Yu Yingchun He Hongliang | 2000 | Mater Res Bull2000，35，： | 1 |
| 13 | Carbon Nanotsbe Activated Pt Quartz - Crystal Microbalance for the Immunoassay of HumanlgG** 显示文摘 | Yu Yang Yingchun Zhu Qiang Chen | 2009 | small2009，5，3： | 1 |
| 14 | Water-soluble multicolored fluorescent CdTe quantum dots: Synthesis and application for fingerprint developing显示文摘 | Jianjun Liu Zhixia Shi Yingchun Yu Ruiqin Yang Shengli Zuo | 2009 | Journal of Colloid And Interface Science2009，，2： | 1 |
| 15 | An engineered platform for reconstituting functional multisubunit SCF E3 ligase in vitro显示文摘Multisubunit SKP1/Cullin1/F-box(SCF)E3 ligases play essential roles in regulating the stability of crucial regulatory factors and controlling growth and development in eukaryotes.Detecting E3 ligase activity in vitro is important forexploring the molecular mechanism of protein ubiquitination.However,in vitro ubiquitination assay systems for multisubunit E3 ligases remain difficult to achieve,especially in plants,mainly owing to difficulties in achieving active components of multisubunit E3 ligases with high purity and characterizing specific E2 and E3 pairs.In this study,we characterized components of the rice ScFDiwARF3(SCFDs)E3 ligase,screened the coordinated E2,and reconstituted active ScFD3 E3 ligase in vitro.We further engineered SCFD3 E3 ligase using a fused SKP1-Cullin1-RBX1(eSCR)protein and found that both the wild-type SCFD3 E3 ligase and the engineered SCFD3 E3 ligase catalyzed ubiquitination of the substrate D53,which is the key transcriptional repressor in strigolactone signaling.Finally,we replaced D3 with other F-box proteins from rice and humans and reconstituted active escF E3 ligases,including escFaID2,escFBxL1s,and escFcDC4 E3 ligases.Our work reconstitutes functional SCF E3 ligases in vitro and generates an engineered system with interchangeable F-box proteins,providing a powerful platform for studying the mechanisms of multisubunit SCF E3 ligases in eukaryotes. | Huihui Liu Simiao Liu Hong Yu Xiahe Huang Yingchun Wang Liang Jiang Xiangbing Meng Guifu Liu Mingjiang Chen Yanhui Jing Feifei Yui Bing Wang Jiayang Li | 2022 | Molecular Plant2022，15，8： | 1 |
| 16 | Dynamic landscape mapping of humoral immunity to SARS-CoY-2 identifies non-structural protein antibodies associated with the survival of critical COVID-19 patients显示文摘A comprehensive analysis of the humoral immune response to the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is essential in understanding COVID-19 pathogenesis and developing antibody-based diagnostics and therapy.In this work,we performed a longitudinal analysis of antibody responses to SARS-CoV-2 proteins in 104 serum samples from 49 critical COVID-19 patients using a peptide-based SARS-CoV-2 proteome microarray.Our data show that the binding epitopes of IgM and IgG antibodies differ across SARS-CoV-2 proteins and even within the same protein. | Linlin Cheng Xiaomei Zhang Yu Chen Dan Wang Dong Zhang Songxin Yan Hongye Wang Meng Xiao Te Liang Haolong Li Meng Xu Xin Hou jiayu Dai Xian Wu Mingyuan Li Minya Lu Dong Wu Ran Tian Jing Zhao Yan Zhang Wei Cao Jinglan Wang Xiaowei Yan Xiang Zhou Zhengyin Liu Yingchun Xu Fuchu He Yongzhe Li Xiaobo Yu Shuyang Zhang | 2021 | Signal Transduction and Targeted Therapy2021，6，9： | 1 |
| 17 | Calculation of the intracellular elastic modulus based on an atomic force microscope micro-cutting system显示文摘Better understanding of variations in the mechanical properties of cancer cells could help to provide novel solutions for the diagnosis,prevention,and treatment of cancers.We therefore developed a calculation model of the intracellular elastic modulus based on the contact pressure between the silicon tip of an atomic force microscope and the target cells,and cutting depth.Ovarian cells(UACC-1598) and colon cancer cells(NCI-H716) were cut into sequential layers using an atomic force microscope silicon tip.The cutting area on the cells was 8μm×8μm,and the loading force acting on the cells was increased from 17.523 to 32.126μN.The elastic modulus distribution was measured after each cutting process.There were significant differences in contact pressure and cutting depth between different cells under the same loading force,which could be attributed to differences in their intrinsic structures and mechanical properties.The differences between the average elastic modulus and surface elastic modulus for UACC-1598 and NCI-H716 cells were 0.288±0.08 kPa and 0.376±0.16 kPa,respectively.These results demonstrate that this micro-cutting method can be used to measure intracellular mechanical properties,which could in turn provide a more accurate experimental basis for the development of novel methods for the diagnosis and treatment of various diseases. | YU Miao WANG JingHe WANG HongXiang LIU Li YAN YongDa ZHANG JunJie LIANG YingChun DONG Shen | 2012 | Chinese Science Bulletin2012，57，15： | 1 |
| 18 | Differential inflammatory response to acrylonitrile in rat primary astrocytes and microglia显示文摘 | Samuel W. Caito Yingchun Yu Michael Aschner | 2014 | Neurotoxicology2014，，： | 1 |
| 19 | MicroRNA-146a negatively regulates PTGS2 expression induced by Helicobacter pylori in human gastric epithelial cells显示文摘 | Zhen Liu Di Wang Yongliang Hu Guoyong Zhou Chaohui Zhu Qi Yu Yingchun Chi Yingli Cao Chiyu Jia Quanming Zou | 2013 | Journal of Gastroenterology2013，，1： | 1 |
| 20 | Water-soluble multicolored fluorescent CdTe quantum dots: syn-thesis and application for fingerprint developing 显示文摘 | LIU Jianjun SHI Zhixia YU Yingchun | 2010 | J Colloid Interface Sci2010，342，2： | 1 |
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