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| 1 | Neuroprotective effects of rutaecarpine on cerebral ischemia reperfusion injury显示文摘Rutaecarpine,an active component of the traditional Chinese medicine Tetradium ruticarpum,has been shown to improve myocardial ischemia reperfusion injury.Because both cardiovascular and cerebrovascular diseases are forms of ischemic vascular disease,they are closely related.We hypothesized that rutaecarpine also has neuroprotective effects on cerebral ischemia reperfusion injury.A cerebral ischemia reperfusion model was established after 84,252 and 504 μg/kg rutaecarpine were given to mice via intraperitoneal injection,daily for 7 days.Results of the step through test,2,3,5-triphenyl tetrazolium chloride dyeing and oxidative stress indicators showed that rutaecarpine could improve learning and memory ability,neurological symptoms and reduce infarction volume and cerebral water content in mice with cerebral ischemia reperfusion injury.Rutaecarpine could significantly decrease the malondialdehyde content and increase the activities of superoxide dismutase and glutathione peroxidase in mouse brain.Therefore,rutaecarpine could improve neurological function following injury induced by cerebral ischemia reperfusion,and the mechanism of this improvement may be associated with oxidative stress.These results verify that rutaecarpine has neuroprotective effects on cerebral ischemia reperfusion in mice. | Chunlin Yan Ji Zhang Shu Wang Guiping Xue Yong Hou | 2013 | Neural Regeneration Research2013，8，22： | 20 |
| 2 | Simultaneous Screening of 733 Pesticide Residues in Fruits and Vegetables by a GC/LC-Q-TOFMS Combination Technique显示文摘In this paper,we report the construction of two accurate mass databases and the development of a combination detection method that simultaneously screens for 733 pesticide and chemical contaminant multi-residues via high-throughput liquid chromatography(LC)-and gas chromatography(GC)-quadru pole-time-of-flight mass spectrometry(Q-TOFMS).This work demonstrates that electronic mass spectral standards may replace chemical-source standard materials as references through one sample preparation and the combination of GC/LC-Q-TOFMS screening.This cutting-edge technique has also replaced multiresidue determination using targeted detection with non-targeted screening.The pesticide residue types,sensitivity,recovery,and reproducibility of this combination technique are evaluated in eight fruit and vegetable matrices.This technique shows three advantages:①In comparison with the discovery capability of a single technique,the combination technique shows an improvement of 51.1%(GC-QTOFMS)and 39.6%(LC-Q-TOFMS),respectively;②the combination technique can satisfy a screening limit lower than 10μg·kg^-1 and meet the requirements of“uniform standards,”although some of the pesticide residues could be optimized to further improve screening sensitivity;③over 488 pesticides with recoveries between 60%-120%and relative standard deviation(RSD)<20%at a spiked level of 10μg·kg^-1 were detected with the combination technique in eight different matrices.From 2012 to 2017,this combination technique was applied in an investigation to screen pesticide residues from 1384 sampling locations for 38138 batched samples covering 18 categories and 134 types of fruits and vegetables obtained from across the mainland of China.After statistical analysis,533 pesticides in 115891 determinations were detected,and the regularity of pesticides in the fruits and vegetables sold on the Chinese market was shown. | Guofang Pang Qiaoying Chang Ruobin Bai Chunlin Fan Zijuan Zhang Hongyuan Yan Xingqiang Wu | 2020 | Engineering2020，6，4： | 11 |
| 3 | On Uplink Non-Orthogonal Multiple Access for 5G:Opportunities and Challenges显示文摘In this paper,the concept of grantfree non-orthogonal multiple access(NOMA) for uplink data transmission is elaborated.NOMA in combination with grant-free can be applied to ultra reliability low latency communication(URLLC),massive machine type communication(m MTC),enhanced mobile broadband(e MBB) small packet and two-step random-access channel(RACH) scenarios.The advantages of grant-free NOMA are low latency and signaling overhead,high access capability and efficient resource utilization.Candidate uplink NOMA schemes are summarized and preliminary comparison among a subset of schemes are presented.Furthermore,design aspects for grant-free NOMA are discussed,with special notes on particular issues such as blind UE identification and transmitter/receiver(Tx/Rx) impairments in realistic deployment. | Li Tian Chunlin Yan Weimin Li Zhifeng Yuan Wei Cao Yifei Yuan | 2017 | China Communications2017，14，12： | 9 |
| 4 | Toward automatic estimation of urban green volume using airborne LiDAR data and high resolution Remote Sensing images显示文摘城市的绿体积是为分析城市的植被结构,生态的评估,和绿经济的评价的重要指示物。这份报纸为城市的绿体积联合的自动化评价建议一个基于目标的方法三维(3D ) 从在空中的轻察觉的信息并且变化(激光雷达) 从高分辨率的数据和植被信息遥远地通过 Lujiazui 区域的案例研究察觉到图象,上海,中国。在空中的在红外线附近的相片被用于识别城市的植被分发的高分辨率。在空中的激光雷达数据提议提取单个树并且测量树的属性的可能性,例如树高度和王冠直径。在这研究,单个树和草地作为城市的植被的独立对象被识别,并且城市的绿卷作为二宽广部分的和被计算:单个树体积和草地体积。方法由后面的步骤组成:产生并且过滤规范的数字表面模型( nDSM ),定位本地最大值点,分割植被,提取基于规范的差别植被索引( NDVI )的城市的植被的 nDSM 单个树王冠和草地反对,并且计算每个植被目标的城市的绿体积。结果在 Lujiazui 区域显示出数量和城市的绿体积的分发特征,并且为城市的绿计划和管理提供珍贵参数。激光雷达数据和图象数据的综合申请介绍一个有效方法估计城市的绿体积,这也从这份报纸被结束[出版摘要] | Yan HUANG Bailang YU Jianhua ZHOU Chunlin HU Wenqi TAN Zhiming HU Jianping WU | 2013 | Frontiers of Earth Science2013，7，1： | 6 |
| 5 | Gut microbiota contributes to the development of endometrial glands in gilts during the ovary-dependent period显示文摘Background:The hyper-prolificacy Meishan gilts achieved a superior endometrial gland development(EGD)than white crossbred gilts during the ovary-independent period(before 60 d of age).Then,the EGD continues under the management of ovary-derived steroid hormones that regulated by gut microbiota(after 60 d of age).However,whether Meishan gilts’superiority in EGD lasting to the ovary-dependent period(after 60 d of age)and the role of gut microbiota in this period both remain unclear.Methods:Meishan gilts and Landrace x Yorkshire(LxY)gilts were raised under the same housing and feeding conditions until sexual maturity and then we compared their EGD and gut microbiota.Meanwhile,we transplanted fecal microbiota from Meishan gilts to L×Y gilts to explore the role of gut microbiota in EGD.We sampled plasma every 3 weeks and collected the uterus,ovary,liver,and rectal feces after the sacrifice.We then determined the hormone concentrations and expressions of the EGD-related genes.We also profiled the gut microbiota using 16S rDNA sequencing and metabolites of plasma and liver tissue using untargeted metabolomics.Finally,the correlation analysis and significant test was conducted between FMT-shifted gut microbes and EGD-related indices.Results:Meishan gilts have larger endometrial gland area(P<0.001),longer uterine horn length(P<0.01)but lighter uterine horn weight(P<0.05),a distinctive gut microbiota compared with L×Y gilts.Fecal microbiota transplantation(FMT)increased endometrial gland area(P<0.01).FMT markedly shifted the metabolite profiles of both liver and plasma,and these differential metabolites enriched in steroid hormone biosynthesis pathway.FMT increased estradiol and insulin-like growth factor 1 but decreased progesterone dynamically.FMT also increased the expression of the EGD-related genes estrogen receptor 1 gene,epithelial cadherin,and forkhead box protein A2.There is a significant correlation between FMT-shifted gut microbes and EGD-related indices.Conclusion:Sexually matured Meishan gilts achieved a superior EGD than LxY gilts.Meanwhile,gut microbiota contribute to the EGD potentially via regulating of steroid hormones during the ovary-dependent period. | Baoyang Xu Wenxia Qin Yiqin Yan Yimei Tang Shuyi Zhou Juncheng Huang Chunlin Xie Libao Ma Xianghua Yan | 2021 | Journal of Animal Science and Biotechnology2021，12，4： | 4 |
| 6 | Chrysophanol attenuates lead exposure-induced injury to hippocampal neurons in neonatal mice显示文摘Previous studies have shown that chrysophanol protects against learning and memory impairments in lead-exposed adult mice. In the present study, we investigated whether chrysophanol can alleviate learning and memory dysfunction and hippocampal neuronal injury in lead-exposed neonatal mice. At the end of lactation, chrysophanol(0.1, 1.0, 10.0 mg/kg) was administered to the neonatal mice by intraperitoneal injection for 15 days. Chrysophanol significantly alleviated injury to hippocampal neurons and improved learning and memory abilities in the lead-poisoned neonatal mice. Chrysophanol also significantly decreased lead content in blood, brain, heart, spleen, liver and kidney in the lead-exposed neonatal mice. The levels of malondialdehyde in the brain, liver and kidney were significantly reduced, and superoxide dismutase and glutathione peroxidase activities were significantly increased after chrysophanol treatment. Collectively, these findings indicate that chrysophanol can significantly reduce damage to hippocampal neurons in lead-exposed neonatal mice. | Ji Zhang Chunlin Yan Shu Wang Yong Hou Guiping Xue Li Zhang | 2014 | Neural Regeneration Research2014，9，9： | 4 |
| 7 | Multi-User Connection Performance Assessment of NOMA Schemes for Beyond 5G显示文摘Non-orthogonal multiple access(NOMA)is proved to be useful to satisfy the requirements of beyond 5th generation such as massive multi-user connection.Here we compare the performances of two NOMA schemes:low code rate spreading(LCRS)scheme and interleaver division multiple access(IDMA)scheme.It is found that LCRS is superior to IDMA when number of users is small due to coding gain achieved.While IDMA is preferred when number of users is high because repetition applied in IDMA can suppress multi-user interference effectively.And interleaver is important in IDMA for randomizing the interference.Also,this paper evaluates the impact of channel decoder.It is observed that Log-MAP decoder has much better performance than that of Max-Log-MAP when number of users is large.Thus,it is recommended to use Log-MAP decoder in NOMA in high user overloading case.We also compared the performance of NOMA by using different type of channel codes.We find that NOMA using specific convolutional code has a better performance than that of using specific LDPC code when number of users is high. | Baoxi Wang Chunlin Yan Wei Liu Hailin Zhang | 2020 | China Communications2020，17，12： | 3 |
| 8 | Integrated analysis of multi-tissues lipidome and gut microbiome reveals microbiota-induced shifts on lipid metabolism in pigs显示文摘Lipid metabolism is very important for meat quality in pigs.Accumulating evidence shows that gut microbiota can contribute to this physiological process.However,the gut microbiota that function in lipid metabolism and adipogenesis remains unclear.Here,we compared the characteristics of fat deposition and gut microbial community between Laiwu pigs and Duroc(LandraceYorkshire)(DLY)pigs.Fecal microbiota transplantation(FMT)was performed to determine the possible impact of gut microbiota on lipid metabolism in pigs.An integrated analysis of the gut microbiome and lipidome of the small intestine,plasma,and liver was conducted to investigate the effects of FMT on host lipid metabolism.The comparative analysis of the gut microbiome showed higher abundance of Bacteroidetes(P=0.0018)while lower abundance of Firmicutes(P=0.012)in Laiwu pigs,and the microbial composition can be transferred from Laiwu pigs into DLY pigs.Transmission electron microscope and Oil red-O staining were performed to analyze the effects of FMT on lipid deposition in liver,the main target organ for lipid metabolism.The results showed that FMT significantly increased the number of lipid droplets(P=0.0035)and lipid accumulation(P=0.0026)in liver.Furthermore,integrated multi-tissues lipidome analysis demonstrated that the fatty acyls and glycerophospholipids were significantly increased(P<0.01)in intestine and liver,while glycerolipids and fatty acyls were reduced(P<0.01)in plasma.In the small intestine,FMT increased(P<0.01)the relative abundance of polyketides and prenol lipids but reduced(P<0.01)the saccharolipids.Correlation analysis revealed the potential interactions between microbiota and lipid metabolites.Together,our results indicated that the gut microbiota may regulate the lipid metabolism and enhance the accumulation of lipid droplets in the liver of pigs. | Chunlin Xie Xiaoyan Zhu Baoyang Xu Yaorong Niu Xuelei Zhang Libao Ma Xianghua Yan | 2022 | Animal Nutrition2022，，3： | 2 |
| 9 | Environmental efficiency analysis of power industry in China based on an entropy SBM model显示文摘 | Yan Zhou Xinpeng Xing Kuangnan Fang Dapeng Liang Chunlin Xu | 2012 | Energy Policy2012，，： | 2 |
| 10 | An environmental database and temporal and spatial distribution of Chinese paleoanthropological sites显示文摘A comprehensive database of paleoenvironmental settings for paleoanthropological sites provides a useful tool to explore the link between human evolution and paleoenvironmental changes. A preliminary GIS-based environmental database for paleoanthropological sites in China (EDPC) was constructed based on data collected from published literature. The database currently contains 1114 paleoanthropological sites. It will be available for online access following the establishment of relevant rules, and after improvement and further development through regular and sustained updates by internal and external users. Preliminary analyses using the GIS system yielded new evidence regarding human-environmental relationships. | WU ChunLin ZHANG Yan LI Qin GUO ZhengTang GAO Xing | 2011 | Chinese Science Bulletin2011，56，31： | 2 |
| 11 | Synthesis and Characterization of Fluorodinitrobenzenes with Tunable Melting Point:Potential Low Sensitive Energetic Plasticizer and Melt-Cast Carrier显示文摘of main observation and conclusion In order to explore the effects of fluoro substituents on the energy and safety of energetic compounds,a series of fluorodinitrobenzenes including l,3-difluoro-2,4-dinitrobenzene(1),1,5-difluoro-2,4-dinitrobenzene(2),1,2,3-trifluoro-4,6-dinitrobenzne(3)and 1,3,5-trifluoro-2,4-dinitrobenzene(4)were prepared.All the compounds were fully characterized.The structures of 2 and 3 were further confirmed by single crystal X-ray diffraction analysis.The results show that these compounds exhibit comparable detonation properties(D=6703-6978 m s^-1,and p=21.3-23.76Pa)to those of 2,4,6-trinitrotoluene(TNT)due to the significantly increased density of fluorine introduced.Low sensitivity(IS>40 J,and FS>360 N)of these compounds along with different melting points make them potential candidates for different allocation.Among them,1 and 4 with the melting point of 42.5℃and 55.2℃,respectively,show promise for application in the field of energetic plasticizer.Compounds 2 and 3 are potential low sensitive melt-cast carrier due to their similar melting point and superior detonation performance to that of TNT. | Yunlu Li Peng Chen Yan Liu Ping Yin Chunlin He Siping Pang | 2020 | Chinese Journal of Chemistry2020，38，12： | 2 |
| 12 | Multi-omics analysis reveals gut microbiota-induced intramuscular fatdeposition via regulating expression of lipogenesis-associated genes显示文摘The gut microbiome has great effects on the digestion, absorption, and metabolism of lipids. However,the microbiota composition that can alter the fat deposition and the meat quality of pigs remains unclear.Here, we used Laiwu (LW) pigs (a native Chinese breed with higher intramuscular fat) compared withcommercial crossbreed Duroc×(Landrace×Yorkshire) (DLY) pigs to investigate the effects of microbiotaon meat quality, especially in intramuscular fat content. A total of 32 DLY piglets were randomly allottedto 4 groups and transplanted with fecal microbiota from healthy LW pigs. The results indicated that thehigh dose of fecal microbiota transplantation (HFMT) selectively enhanced fat deposition in longissimusdorsi (P < 0.05) but decreased backfat thickness (P < 0.05) compared with control group. HFMT significantlyaltered meat color and increased feed conversation ratio (P < 0.05). Furthermore, the multi-omicsanalysis revealed that Bacteroides uniformis, Sphaerochaeta globosa, Hydrogenoanaerobacterium saccharovorans,and Pyramidobacter piscolens are the core species which can regulate lipid deposition. A total of140 male SPF C57BL/6j mice were randomly allotted into 7 groups and administrated with these 4 microbesalone or consortium to validate the relationships between microbiota and lipid deposition.Inoculating the bacterial consortium into mice increased intramuscular fat content (P < 0.05) comparedwith control mice. Increased expressions of lipogenesis-associated genes including cluster of differentiation36 (Cd36), diacylglycerol O-acyltransferase 2 (Dgat2), and fatty acid synthase (FASN) wereobserved in skeletal muscle in the mice with mixed bacteria compared with control mice. Together, ourresults suggest that the gut microbiota may play an important role in regulating the lipid deposition in the muscle of pigs and mice. | Chunlin Xie Junyong Teng Xinkai Wang Baoyang Xu Yaorong Niu Libao Ma Xianghua Yan | 2022 | Animal Nutrition2022，，2： | 2 |
| 13 | Simulated microgravity increases heavy ion radiation-induced apoptosis in human B lymphoblasts显示文摘 | Bingrong Dang Yuping Yang Erdong Zhang Wenjian Li Xiangquan Mi Yue Meng Siqi Yan Zhuanzi Wang Wei Wei Chunlin Shao Rui Xing Changjun Lin | 2013 | Life Sciences2013，，： | 1 |
| 14 | Non-Orthogonal Multiple Access Schemes for 5G显示文摘Multiple access scheme is one of the key techniques in wireless communication systems. Each generation of wireless communica-tion is featured by a new multiple access scheme from 1G to 4G. In this article we review several non-orthogonal multiple access schemes for 5G. Their principles, advantages and disadvantages are discussed, and followed by a comprehensive comparison of these solutions from the perspective of user overload, receiver type, receiver complexity and so on. We also discuss the application challenges of non-orthogonal multiple access schemes in 5G. | YAN Chunlin YUAN Zhifeng LI Weimin YUAN Yifei | 2016 | ZTE Communications2016，14，4： | 1 |
| 15 | A novel design method for continuous-phase plate显示文摘 | Yang Chunlin Yan Hao Wang Jian | 2013 | Optics Express2013，21，11： | 1 |
| 16 | A Novel Frequency Offset Estimation Method for OFDM Systems With Large Estimation Range 显示文摘 | Yan Chunlin Li Shaoqian Tang Youxi | 2006 | IEEE Transactions on2006，52，1： | 1 |
| 17 | Pharmacokinetics,distribution,and excretion of sodium oligomannate,a recently approved anti-Alzheimer's disease drug in China显示文摘The National Medical Products Administration has authorized sodium oligomannate for treating mild-to-moderate Alzheimer’s disease.In this study,an LC-MS/MS method was developed and validated to quantitate sodium oligomannate in different biomatrices.The plasma pharmacokinetics,tissue distribution,and excretion of sodium oligomannate in Sprague-Dawley rats and beagle dogs were systematically investigated.Despite its complicated structural composition,the absorption,distribution,metabolism,and excretion profiles of the oligosaccharides in sodium oligomannate of different sizes and terminal derivatives were indiscriminate.Sodium oligomannate mainly crossed the gastrointestinal epithelium through paracellular transport following oral administration,with very low oral bioavailability in rats(0.6%-1.6%)and dogs(4.5%-9.3%).Absorbed sodium oligomannate mainly resided in circulating body fluids in free form with minimal distribution into erythrocytes and major tissues.Sodium oligomannate could penetrate the blood-cerebrospinal fluid(CSF)barrier of rats,showing a constant area under the concentration-time curve ratio(CSF/plasma)of approximately 5%.The cumulative urinary excretion of sodium oligomannate was commensurate with its oral bioavailability,supporting that excretion was predominantly renal,whereas no obvious biliary secretion was observed following a single oral dose to bile duct-cannulated rats.Moreover,only 33.7%(male)and 26.3%(female)of the oral dose were recovered in the rat excreta within 96 h following a single oral administration,suggesting that the intestinal flora may have ingested a portion of unabsorbed sodium oligomannate as a nutrient. | Jiaojiao Lu Qiongqun Pan Jieqiang Zhou Yan Weng Kaili Chen Lv Shi Guanxiu Zhu Chunlin Chen Liang Li Meiyu Geng Zhenqing Zhang | 2022 | Journal of Pharmaceutical Analysis2022，12，1： | 1 |
| 18 | Two newiridoid glucosides from Hedyotis diffusa显示文摘 | Yongyong Zhang Yan Chen Chunlin Fan | 2010 | Fitoterapia2010，81，： | 1 |
| 19 | A novel frequency offset estimation method for OFDM systems with large estimation range显示文摘 | Yan Chunlin Li Shaoqian Tang Youxi | 2006 | IEEE Transactions on Broadcasting2006，52，1： | 1 |
| 20 | Guidelines for the diagnosis and treatment of acute pancreatitis in China (2021)显示文摘Acute pancreatitis(AP)is a common acute abdominal condition of the digestive system.In recent years,treatment concepts,methods,and strategies for the diagnosis of AP have advanced,and this has played an important role in promoting the standardization of AP diagnosis and treatment and improving the treatment quality of AP patients.On the basis of previous guidelines and expert consensus,this guideline adopts an evidence-based,problem-based expression;synthesizes important clinical research data at home and abroad in the most recent 5 years;and forms 29 recommendations through multidisciplinary expert discussion,including diagnosis,treatment,and follow-up.It is expected to provide evidence support for the treatment of AP in the clinical setting in China. | Fei Li Shouwang Cai Feng Cao Rufu Chen Deliang Fu Chunlin Ge Chunyi Hao Jihui Hao Heguang Huang Zhixiang Jian Gang Jin Ang Li Haimin Li Shengping Li Weiqin Li Yixiong Li Tingbo Liang Xubao Liu Wenhui Lou Yi Miao Yiping Mou Chenghong Peng Renyi Qin Chenghao Shao Bei Sun Guang Tan Xiaodong Tian Huaizhi Wang Lei Wang Wei Wang Weilin Wang Junmin Wei Heshui Wu Wenming Wu Zheng Wu Changqing Yan Yinmo Yang Xiaoyu Yin Xianjun Yu Chunhui Yuan Taiping Zhang Yupei Zhao on behalf of the Chinese Pancreatic Surgery Association | 2021 | Journal of Pancreatology2021，4，2： | 1 |
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