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| 1 | Hydrogen sulfide protects against amyloid beta-peptide induced neuronal injury via attenuating inflammatory responses in a rat model显示文摘Neuroinflammation has been recognized to play a critical role in the pathogenesis of Alzheimer's disease (AD), which is pathologically characterized by the accumulation of senile plaques containing activated microglia and amyloid β-peptides (Aβ). In the present study, we examined the neuroprotective effects of hydrogen sulfide (H2S) on neuroinflammation in rats with Aβ1-40 hippocampal injection. We found that Aβ-induced rats exhibited a disorder of pyramidal cell layer arrangement, and a decrease of mean pyramidal cell number in the CA1 hippocampal region compared with those in sham operated rats. NaHS (a donor of H2S, 5.6 mg/kg/d, i.p.) treatment for 3 weeks rescued neuronal cell death significantly. Moreover, we found that H2S dramatically suppressed the release of TNF-α, IL-1β and IL-6 in the hippocampus. Consistently, both immunohistochemistry and Western blotting assays showed that H2S inhibited the upregulation of COX-2 and the activation of NF-κB in the hippocampus. In conclusion, our data indicate that H2S suppresses neuroinflammation via inhibition of the NF-κB activation pathway in the Aβ-induced rat model and has potential value for AD therapy. | Hao Fan YuGuo Xiaoyan Liang Yibiao Yuan Xiaohong Qi Min Wang Jianhua Ma Hong Zhou | 2013 | The Journal of Biomedical Research2013，27，4： | 10 |
| 2 | MATRIEX imaging:multiarea two-photon real-time in vivo explorer显示文摘Two-photon laser scanning microscopy has been extensively applied to study in vivo neuronal activity at cellular and subcellular resolutions in mammalian brains.However,the extent of such studies is typically confined to a single functional region of the brain.Here,we demonstrate a novel technique,termed the multiarea two-photon real-time in vivo explorer(MATRIEX),that allows the user to target multiple functional brain regions distributed within a zone of up to 12mm in diameter,each with a field of view(FOV)of ~200μm in diameter,thus performing two-photon Ca2+imaging with single-cell resolution in all of the regions simultaneously.For example,we demonstrate real-time functional imaging of single-neuron activities in the primary visual cortex,primary motor cortex and hippocampal CA1 region of mice in both anesthetized and awake states.A unique advantage of the MATRIEX technique is the configuration of multiple microscopic FOVs that are distributed in three-dimensional space over macroscopic distances(>1 mm)both laterally and axially but that are imaged by a single conventional laser scanning device.In particular,the MATRIEX technique can be effectively implemented as an add-on optical module for an existing conventional single-beam-scanning two-photon microscope without requiring any modification to the microscope itself.Thus,the MATRIEX technique can be readily applied to substantially facilitate the exploration of multiarea neuronal activity in vivo for studies of brain-wide neural circuit function with single-cell resolution. | Mengke Yang Zhenqiao Zhou Jianxiong Zhang Shanshan Jia Tong Li Jiangheng Guan Xiang Liao Bing Leng Jing Lyu Kuan Zhang Min Li Yan Gong Zhiming Zhu Junan Yan Yi Zhou Jian K Liu Zsuzsanna Varga Arthur Konnerth Yuguo Tang Jinsong Gao Xiaowei Chen Hongbo Jia | 2019 | Light(Science & Applications)2019，8，1： | 4 |
| 3 | An efficient route towards R-2-phenoxypropionic acid synthesis for biotransformative production of R-2-(4-hydroxyphenoxy)propionic acid显示文摘R2(4hydroxyphenoxy)propionic acid(RHPPA)is a key intermediate for the synthesis of classic herbicides with high selectivity against grassy weed.The main route for RHPPA biosynthesis is to hydroxylate the substrate R2phenoxypropionic acid(RPPA)at C4 position with microbes.In order to provide sufficient RPPA for the industrial production of RHPPA,an effective RPPA synthesis method was established and optimized in this work.The synthesis process mainly consisted of two steps:(1)synthesis of S2chloropropionic acid from Lalanine via diazotization and chlorination reactions;and(2)synthesis of RPPA from S2chloropropionic acid and phenol via etherification reaction.The optimal reaction conditions were as follows:HCl:NaNO_(2):KI:LAla=2.0:1.2:0.7:1.0(in molar),125℃reflux for 1.5 h,with KI as catalyst,and KI:S2chloropropionic acid:phenol=0.075:1.2:1.0(in molar).Under these conditions,an improved molar conversion rate(74.9%,calculated in phenol)was achieved.After extraction using anionic exchange resin Amberlite IRA400(CI),RPPA product with a purity of 95.08%was obtained.The purified RPPA was identified and evaluated in the application of the biotransformative production of RHPPA.The results indicated that the synthesized RPPA supported the RHPPA biosynthesis with a comparable yield as that of the standard RPPA.The RPPA synthesis method provided herein exhibited the advantages of low price and easy availability of raw materials,less toxicity of reagents,simple manipulations,and low equipment/instrument requirements. | Haiyan Zhou Yizuo Li Rui Jiang Xianlin Wang Yuanshan Wang Yaping Xue Yuguo Zheng | 2021 | Chinese Journal of Chemical Engineering2021，34，4： | 2 |
| 4 | Relationships between land cover and the surface urban heat island: seasonal variability and effects of spatial and thematic resolution of land cover data on predicting land surface temperatures显示文摘 | ZHOU Weiqi QIAN Yuguo LI Xiaoma | 2014 | Landscape Ecology2014，29，： | 1 |
| 5 | Land surface hydrology parameterization over heteorogeneous surface for the study of regional mean runoff ratio with its simulation显示文摘 | Liu Jingmiao Ding Yuguo Zhou Xiuji | 2002 | Adv Atmos Sci2002，19，1： | 1 |
| 6 | Fracture Behavior and Processing Deformation of C71500 Cupronickel Alloy during Hot Tensile Deformation显示文摘The hot tensile deformation properties and microstructure evolution of high purity C71500 cupronickel alloy at 1023-1273 K and 0.0001-0.1 s^(-1)strain rates were studied by uniaxial hot tensile deformation method.Based on the experimental data,the flow behavior,microstructure and fracture characteristics of the alloy were analyzed after considering the influence of different deformation parameters.The relationship between microstructure and high temperature(T≥1023 K)plasticity is discussed,and the fracture mechanism is revealed.The relationship between strain rate sensitivity coefficient and stress index and plastic deformation is discussed.The constitutive equation of the alloy is established by Johnson-Cook model.Based on the dynamic material model,the energy dissipation model is established,and Prasad’s instability criterion based on Ziegler’s expected rheological theory is used to predict the unstable region in the processing map.Processing map in hot tensile is analyzed to provide theoretical basis for different processing technology. | 高鑫 武会宾 LIU Ming ZHANG Yuanxiang ZHOU Xiangdong ZHONG Yuguo | 2021 | Journal of Wuhan University of Technology(Materials Science)2021，36，3： | 1 |
| 7 | Solid-liquid equilibria of the 1,2-cyclohexanediol-ethyl acetate-water ternary system显示文摘 | GAO Yuguo ZHOU Cairong SHI Xiaohua at al | 2006 | Journal of Chemical & Engineering Data2006，51，2： | 1 |
| 8 | Land surface hydrology parameterization over heterogeneous surface for the study of regional mean runoff ratio with its simulations显示文摘 | Liu Jinmiao Ding Yuguo Zhou Xiuji | 2002 | A AS2002，19，1： | 1 |
| 9 | Stress field near the crack tip in nonlocal anisotropic elasticity显示文摘 | Sun Yuguo Zhou Zhengong | 2004 | European Journal of Mechanics A:Solids2004，23，2： | 1 |
| 10 | Beyond city expansion:multi-scale environmental impacts of urban megaregion formation in China显示文摘Environmental degradation caused by rapid urbanization is a pressing global issue.However,little is known about how urban changes operate and affect environments across multiple scales.Focusing on China,we found urbanization was indeed massive from 2000 to 2015,but it was also very uneven,exhibiting high internal city dynamics.Urban areas in China as a whole became less green,warmer,and had exacerbated PM2.5 pollution.However,environmental impacts differed in newly developed versus older areas of cities.Adverse impacts were prominent in newly urbanized areas,while old urban areas generally showed improved environmental quality.In addition,regional environmental issues are emerging as cities expand,connect and interact to form urban megaregions.To turn urbanization into an opportunity for,rather than an obstacle to,sustainable development,we must move beyond documenting urban expansion to understand the environmental consequences of both internal city dynamics and the formation of urban megaregions. | Weiqi Zhou Wenjuan Yu Yuguo Qian Lijian Han Steward T.A.Pickett Jing Wang Weifeng Li Zhiyun Ouyang | 2022 | National Science Review2022，9，1： | 1 |
| 11 | Land surface hydrology parameterization over heterogeneous surface for the study of regional mean runoff ratio with its simulation显示文摘 | Liu Jingmiao Ding Yuguo Zhou Xiuji | 2002 | Adv Atmos Sci2002，19，1： | 1 |
| 12 | Integrating structure and function:mapping the hierarchical spatial heterogeneity of urban landscapes显示文摘Background:Cities are social-ecological systems characterized by remarkably high spatial and temporal heterogeneity,which are closely related to myriad urban problems.However,the tools to map and quantify this heterogeneity are lacking.We here developed a new three-level classification scheme,by considering ecosystem types(level 1),urban function zones(level 2),and land cover elements(level 3),to map and quantify the hierarchical spatial heterogeneity of urban landscapes.Methods:We applied the scheme using an object-based approach for classification using very high spatial resolution imagery and a vector layer of building location and characteristics.We used a top-down classification procedure by conducting the classification in the order of ecosystem types,function zones,and land cover elements.The classification of the lower level was based on the results of the higher level.We used an objectbased methodology to carry out the three-level classification.Results:We found that the urban ecosystem type accounted for 45.3%of the land within the Shenzhen city administrative boundary.Within the urban ecosystem type,residential and industrial zones were the main zones,accounting for 38.4%and 33.8%,respectively.Tree canopy was the dominant element in Shenzhen city,accounting for 55.6%over all ecosystem types,which includes agricultural and forest.However,in the urban ecosystem type,the proportion of tree canopy was only 22.6%because most trees were distributed in the forest ecosystem type.The proportion of trees was 23.2% in industrial zones,2.2%higher than that in residential zones.That information“hidden”in the usual statistical summaries scaled to the entire administrative unit of Shenzhen has great potential for improving urban management.Conclusions:This paper has taken the theoretical understanding of urban spatial heterogeneity and used it to generate a classification scheme that exploits remotely sensed imagery,infrastructural data available at a municipal level,and object-based spatial analysis.For effective planning and management,the hierarchical levels of landscape classification(level 1),the analysis of use and cover by urban zones(level 2),and the fundamental elements of land cover(level 3),each exposes different respects relevant to city plans and management. | Yuguo Qian Weiqi Zhou Steward T.A.Pickett Wenjuan Yu Dingpeng Xiong Weimin Wang Chuanbao Jing | 2020 | Ecological Processes2020，9，1： | 1 |
| 13 | Nitrogen source and fate of typical orchard with gentle slope in semi-arid areas显示文摘Excessive nitrogen (N) exports caused by human activities are one of the main reasons for the numerous environmental problems in agricultural production. Orchards, as an essential part of agricultural production, play a crucial role in rural economic development and ecological environment construction. Understanding the migration pathways of N in orchards is significant for the scientific management of orchards and the reduction of environmental pollution. In this research, the source and fate of N in a typical orchard in Beijing were quantitatively analyzed. N management strategies were proposed in combination with agricultural production habits. The total N input into the orchard was 487.19 kg/hm^(2)·a, of which 85.44%, 10.99%, 3.30% and 0.27% of N input were from fertilizer application, atmospheric deposition, biological N fixation and pesticide, respectively. A large amount of N fertilizer application was the primary source of N input in the orchard. For the N fate, the N surplus in the soil could reach up to 68.40% of total N inputs, and only 20.16% were absorbed and utilized by plants. The amount of N losses through ammonia volatilization, runoff and sediment, nitrification and denitrification accounted for 10.68%, 0.39% and 0.37%, respectively. N input in the orchard mainly remained in soil, while N loss was mainly through ammonia volatilization. There were 176.72, 99.00, and 57.52 kg/hm^(2)·a N surplus in 0-40 cm, 40-80 cm, and over 80 cm soil layers, respectively. To deal with the N accumulation on the soil surface and the migration of N from the soil surface to the deep layer of orchards, reducing N fertilizer application, substituting circular furrow for the whole orchard fertilization, adjusting irrigation schedule by reducing the amount of single irrigation, increasing the frequency of irrigation to three times in the normal year, and adopting efficient water-saving irrigation technology are realizable methods. | Miaoying An Ying Xie Yuguo Han Jinxing Zhou Hulin Guo Zhixu Qu | 2023 | International Journal of Agricultural and Biological Engineering2023，16，6： | 0 |
| 14 | DROUGHT-INDUCED UNKNOWN PROTEIN 1 positively modulates drought tolerance in cultivated alfalfa(Medicago sativa L.)显示文摘Alfalfa is the most widely cultivated perennial legume forage crop worldwide.Drought is one of the major environmental factors influencing alfalfa productivity.However,the molecular mechanisms underlying alfalfa responses to drought stress are still largely unknown.This study identified a drought-inducible gene of unknown function,designated as Medicago sativa DROUGHT-INDUCED UNKNOWN PROTEIN 1(MsDIUP1).MsDIUP1 was localized to the nucleus,chloroplast,and plasma membranes.Overexpression of MsDIUP1 in Arabidopsis resulted in increased tolerance to drought,with higher seed germination,root length,fresh weight,and survival rate than in wild-type(WT)plants.Consistently,analysis of MsDIUP1 over-expression(OE)alfalfa plants revealed that MsDIUP1 also increased tolerance to drought stress,accompanied by physiological changes including reduced malondialdehyde(MDA)content and increased osmoprotectants accumulation(free proline and soluble sugar),relative to the WT.In contrast,disruption of MsDIUP1 expression by RNA interference(RNAi)in alfalfa resulted in a droughthypersensitive phenotype,with a lower chlorophyll content,higher MDA content,and less osmoprotectants accumulation than that of the WT.Transcript profiling of alfalfa WT,OE,and RNAi plants during drought stress showed differential responses for genes involved in stress signaling,antioxidant defense,and osmotic adjustment.Taken together,these results reveal a positive role for MsDIUP1 in regulating drought tolerance. | Dong Luo Xi Zhang Jie Liu Yuguo Wu Qiang Zhou Longfa Fang Zhipeng Liu | 2023 | The Crop Journal2023，11，1： | 0 |
| 15 | Leucine deprivation results in antidepressant effects via GCN2 in AgRP neurons显示文摘Essential amino acids(EAAs)are crucial nutrients,whose levels change in rodents and patients with depression.However,how the levels of a single EAA affects depressive behaviors remains elusive.Here,we demonstrate that although deprivation of the EAA leucine has no effect in unstressed mice,it remarkably reverses the depression-like behaviors induced by chronic restraint stress(CRS).This beneficial effect is independent of feeding and is applicable to the dietary deficiency of other EAAs.Furthermore,the effect of leucine deprivation is suppressed by central injection of leucine or mimicked by central injection of leucinol.Moreover,hypothalamic agouti-related peptide(AgRP)neural activity changes during CRS and leucine deprivation,and chemogenetically inhibiting AgRP neurons eliminates the antidepressant effects of leucine deprivation.Finally,the leucine deprivation-regulated behavioral effects are mediated by amino acid sensor general control non-derepressible 2(GCN2)in AgRP neurons.Taken together,our results suggest a new drug target and/or dietary intervention for the reduction of depressive symptoms. | Feixiang Yuan Shangming Wu Ziheng Zhou Fuxin Jiao Hanrui Yin Yuguo Niu Haizhou Jiang Shanghai Chen Feifan Guo | 2023 | Life Metabolism2023，2，1： | 0 |
| 16 | Research on the Dissemination and Influencing Factors of Big Data and Artificial Intelligence Related Courses in Colleges and Universities-Taking MOOC as an Example显示文摘The rapid development of information technologies such as artificial intelligence,Internet and big data has promoted the deep integration of technology and education,especially the rise of large-scale online courses,which provides a great opportunity for curriculum teaching reform in colleges and universities.At the same time,artificial intelligence,as a cutting-edge technology,has good development prospects and has become a popular professional course in colleges and universities,artificial intelligence technology has become the focus of subject education in many universities.The combination of online education and AI courses will also greatly enhance the enthusiasm of users and expand the dissemination scope of big data and AI related courses.Based on the grounded theory and technology acceptance model,this paper obtains the users’perception evaluation of learning MOOC big data and artificial intelligence courses through field interviews,summarizes the core categories,constructs MOOC user acceptance model,collects sample data by questionnaire and makes an empirical study.It is found that perceived usefulness,expectation confirmation and primary communication effect have a significant positive impact on the secondary communication effect,and the content quality and socialization interaction indirectly affect the secondary communication effect of MOOC curriculum by affecting the primary communication effect. | Zhu Junyan Min Yuguo Li Yudi Chen Xiaoyu Zhou Yu | 2022 | Journal on Artificial Intelligence2022，4，2： | 0 |
| 17 | Dynamic Analysis of Launch Vehicle Piping Systems显示文摘Due to complex assembly boundaries and working environment of the piping system in a launch vehicle,it is difficult to simulate realistic flight conditions on the ground.The lack of analysis on the complex environment and boundary conditions in the design process may lead to flight failures,even cause the fuel to combust and destroy the launch vehicle.This paper studies the technology and methods for dynamic simulation analysis of piping systems in launch vehicles,and established a dynamic simulation model of representative pipelines,which is expected to provide a basis for simulation analysis of piping system states in realistic flight. | WANG Shuai LI Chao ZHOU Yuguo ZHANG Xinyao YANG Dongsheng ZHONG Sheng | 2023 | Aerospace China2023，24，3： | 0 |
| 18 | Role of pyroptotic cell death in the pathogenesis of NASH显示文摘Nonalcoholic fatty liver disease(NAFLD)represents a huge threat to public health of the whole world.Around 25%of NAFLD patients will progress to nonalcoholic steatohepatitis(NASH),which has been predicted to be the main reason for liver transplantation in the United States in 2020.Extensive effort has been devoted to investigating the underlying molecular mechanisms of NASH pathogenesis and developing new promising treatments.Recent studies have demonstrated that pyroptosis,an inflammatory programmed cell death mediated by inflammasome and gasdermin-D(GSDMD),is involved in the development and progression of NASH.This review aims to summarize the recent findings regarding the role of pyroptosis and related molecules in the pathogenesis of NASH. | Yuguo YI Jiamin ZHENG Yang ZHOU Zhiqin LIU Dan WENG | 2020 | BIOCELL2020，44，1： | 0 |
| 19 | Acute ST-elevation myocardial infarction in a patient with polycythemia vera显示文摘To the editor:Little is known about the management of acute myocardial infarction (AMI) in patient with polycythemia vera (PV),especially in those with primary percutaneous coronary intervention (PCI). | Zhang Wei Zhang Yan Liu Yuguo Gokool Indivar Rai Zhang Duoduo Li Pai Kong Jingjing Wang Yanfu Zhou Xuchen | 2014 | Chinese Medical Journal2014，，2： | 0 |
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