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| 1 | Fusion mechanism of 2019-nCoV and fusion inhibitors targeting HR1 domain in spike protein显示文摘Very recently,a novel coronavirus,2019-nCoV,emerged in Wuhan,China and then quickly spread worldwide,resulting in>17,388 confirmed cases and 361 deaths as of 3 February 2020,thus calling for the development of safe and effective therapeutics and prophylatics.1,2 Similar to severe acute respiratory syndrome(SARS)-CoV,2019-nCoV belongs to lineage B betacoronavirus,and it has the ability to utilize human angiotensin-converting enzyme 2(ACE2)as a receptor to infect human cells. | Shuai Xia Yun Zhu Meiqin Liu Qiaoshuai Lan Wei Xu Yanling Wu Tianlei Ying Shuwen Liu Zhengli Shi Shibo Jiang Lu Lu | 2020 | Cellular & Molecular Immunology2020，17，7： | 27 |
| 2 | Comparison of sentinel lymph node detection performances using blue dye in conjunction with indocyanine green or radioisotope in breast cancer patients: a prospective singlecenter randomized study显示文摘Objective:This randomized study aimed to compare the clinical efficacy between the novel dual tracer composed of indocyanine green(ICG)and blue dye(BD)and the conventional dual tracer composed of radioisotope and BD for sentinel lymph node(SLN)mapping in patients with breast cancer.Methods:This study enrolled 471 clinically lymph node-negative patients with primary breast cancer.All patients underwent mastectomy,and those undergoing sentinel lymph node biopsy(SLNB)were randomized to receive blue dye plus radioisotope(RB group)or BD plus ICG(IB group).The detection performances on SLN identification rate,positive SLN counts,detection sensitivity,and false-negative rate were compared between the two groups.Results:In the IB group,97%(194/200)of the patients who underwent the ICG and BD dual tracer injection showed fluorescentpositive lymphatic vessels within 2–5 min.The identification rate of SLNs was comparable between the IB group(99.0%,198/200)and the RB group(99.6%,270/271)(P=0.79).No significant differences were observed in the identification rate of metastatic SLNs(22.5%vs.22.9%,P>0.05,RB group vs.IB group,the same below),positive SLN counts(3.72±2.28 vs.3.91±2.13,P>0.05),positive metastatic SLN counts(0.38±0.84 vs.0.34±0.78,P>0.05),SLNB detection sensitivity(94.4%vs.92.5%,P>0.05),or false-negative rate(5.6%vs.7.5%,P>0.05)between the two groups.Conclusions:ICG can be used as a promising alternative tracer for radioisotope in SLN mapping,and when it is combined with BD in lymphangiography,it offers comparable detection sensitivity compared to the conventional lymphatic mapping strategies that are widely used in clinical practice. | Long Yuan Xiaowei Qi Yi Zhang Xinhua Yang Fan Zhang Linjun Fan Li Chen Kongyong Zhang Ling Zhong Yanling Li Sijie Gan Wenying Fu Jun Jiang | 2018 | Cancer Biology & Medicine2018，15，4： | 9 |
| 3 | Construction of a genetic map and location of quantitative trait loci for dwarf trait in maize by RFLP markers显示文摘Using F2 population derived from the cross of tall inbred 7922 by dwarf inbred 5003, an RFLP linkage map of maize has been constructed, on which 85 markers are distributed among 10 linkage groups and span maize genome about 1827.8 cM with an average distance (24.4 cM) between markers. 106 F2:3 lines of the population were grown in a 10×11 simple rectangular lattice design of one-raw plots with two replications and evaluated for plant height (PH). With interval mapping procedure, 5 QTLs controlling plant height have been identified and their genetic effects and gene action determined. 2 major OTLs with opposite effect have been discovered. One for increasing plant height is ph 1 which is located at chromosome 2 and accounts for 51.8% of the total phenotypic variation; the other for decreasing plant height is ph3 which is located at chromosome 5 and accounts for 38.6% of the total phenotypic variation. The chromosomal location of ph3 might be the same as or close to the position of bv1, a dwarf mutant | CAO Yongguo WANG Guoying WANG Shoucai WEI Yanling LU Jiang XIE Youju DAI Jingrui | 2000 | Chinese Science Bulletin2000，45，3： | 9 |
| 4 | RBD-Fc-based COVID-19 vaccine candidate induces highly potent SARS-CoV-2 neutralizing antibody response显示文摘The pandemic of coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has posed serious threats to global health and economy,thus calling for the development of safe and effective vaccines.The receptorbinding domain(RBD)in the spike protein of SARS-CoV-2 is responsible for its binding to angiotensin-converting enzyme 2(ACE2)receptor.It contains multiple dominant neutralizing epitopes and serves as an important antigen for the development of COVID-19 vaccines.Here,we showed that immunization of mice with a candidate subunit vaccine consisting of SARS-CoV-2 RBD and Fc fragment of human IgG,as an immunopotentiator,elicited high titer of RBD-specific antibodies with robust neutralizing activity against both pseudotyped and live SARS-CoV-2 infections.The mouse antisera could also effectively neutralize infection by pseudotyped SARS-CoV-2 with several natural mutations in RBD and the IgG extracted from the mouse antisera could also show neutralization against pseudotyped SARS-CoV and SARS-related coronavirus(SARSr-CoV).Vaccination of human ACE2 transgenic mice with RBD-Fc could effectively protect mice from the SARS-CoV-2 challenge.These results suggest that SARS-CoV-2 RBD-Fc has good potential to be further developed as an effective and broad-spectrum vaccine to prevent infection of the current SARS-CoV-2 and its mutants,as well as future emerging SARSr-CoVs and re-emerging SARS-CoV. | Zezhong Liu Wei Xu Shuai Xia Chenjian Gu Xinling Wang Qian Wang Jie Zhou Yanling Wu Xia Cai Di Qu Tianlei Ying Youhua Xie Lu Lu Zhenghong Yuan Shibo Jiang | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 7 |
| 5 | Quantifying public health benefits of environmental strategy of PM2.5 air quality management in Beijing–Tianjin–Hebei region,China显示文摘In 2013,China issued 'Air Pollution Prevention and Control Action Plan(Action Plan)' to improve air quality.To assess the benefits of this program in Beijing-Tianjin-Hebei(BTH)region,where the density of population and emissions vary greatly,we simulated the air quality benefit based on Ben MAP to satisfy the Action Plan.In this study,we estimate PM_(2.5) concentration using Voronoi spatial interpolation method on a grid with a spatial resolution of 1 × 1 km^2.Combined with the exposure-response function between PM_(2.5) concentration and health endpoints,health effects of PM_(2.5) exposure are analyzed.The economic loss is assessed by using the willingness to pay(WTP) method and human capital(HC) method.When the PM_(2.5) concentration falls by 25% in BTH and reached 60 μg/m^3 in Beijing,the avoiding deaths will be in the range of 3175 to 14051 based on different functions each year.Of the estimated mortality attributable to all causes,3117 annual deaths were due to lung cancer,1924 – 6318 annual deaths were due to cardiovascular,and343 – 1697 annual deaths were due to respiratory.Based on WTP,the estimated monetary values for the avoided cases of all cause mortality,cardiovascular mortality,respiratory mortality and lung cancer ranged from 1110 to 29632,673 to 13325,120 to 3579,1091 to 6574 million yuan,respectively.Based on HC,the corresponding values for the avoided cases of these four mortalities were 267 to 1178,161 to 529,29 to 143 and 261 million yuan,respectively. | Li Chen Mengshuang Shi Suhuan Li Shuang Gao Hui Zhang Yanling Sun Jian Mao Zhipeng Bai Zhongliang Wang Jiang Zhou | 2017 | Journal of Environmental Sciences2017，29，7： | 6 |
| 6 | Facile preparation of N-doped corncob-derived carbon nanofiber efficiently encapsulating Fe2O3 nanocrystals towards high ORR electrocatalytic activity显示文摘Facile preparation of cost-effective and durable porous carbon-supported non-precious-metal/nitrogen electrocatalysts for oxygen reduction reaction(ORR)is extremely important for promoting the commercialized applications of such catalysts.In this work,the FeCl3-containing porphyrinato iron-based covalent porous polymer(FeCl3·FeP or-CPP)was fabricated in-situ onto porous corncob biomass supports via a simple one-pot method.Subsequent thermal-reduction pyrolysis at 700℃-900℃with CO2 gas as an activating agent resulted in Fe2O3-decorated and N-doped graphitic carbon composite Fe2O3@NC&bio-C with a high degree of graphitization of Fe-involved promotion during pyrolysis(Fe2O3=FeCl3·FePor-CPP derived Fe2O3;NC=N-doped graphene analog;bio-C=the corncob-derived hierarchically porous graphitic biomass carbon framework).The derivedα-Fe2O3 andγ-Fe2O3 nanocrystals(5-10 nm particle diameter)were all immobilized on the N-doped bio-C micro/nanofibers.Notably,the Fe2O3@NC&bio-C obtained at the pyrolysis temperature of 800℃(Fe2O3@NC&bio-C-800),exhibited unusual ORR catalytic efficiency via a 4-electron pathway with the onset and half-wave potentials of 0.96 V and 0.85 V vs.RHE,respectively.In addition,Fe2O3@NC&bio-C-800 also exhibited a high and stable limiting current density of-6.0 mA cm-2,remarkably stability(larger than 91%retention after 10000 s),and good methanol tolerance.The present work represents one of the best results for iron-based biomass material ORR catalysts reported to date.The high ORR activity is attributed to the uniformly distributedα-Fe2O3 andγ-Fe2O3 nanoparticles on the N-enriched carbon matrix with a large specific surface area of 772.6 m^2 g^-1.This facilitates favor faster electron movement and better adsorption of oxygen molecules on the surface of the catalyst.Nevertheless,comparative studies on the structure and ORR catalytic activity of Fe2O3@NC&bioC-800 with Fe2O3@bio-C-800 and NC&bio-C-800 clearly highlight the synergistic effect of the coexisting Fe2O3 nanocrystals,NC,and bio-C on the ORR performance. | Wei Yan Yanling Wu Yanli Chen Qi Liu Kang Wang Ning Cao Fangna Dai Xiyou Li Jianzhuang Jiang | 2020 | Journal of Energy Chemistry2020，29，5： | 3 |
| 7 | High Sensitive Ambipolar Response towards Oxidizing NO2 and Reducing NH3 Based on Bis(phthalocyaninato) Europium Semiconductors显示文摘 | Xia Kong Zhen Dong Yanling Wu Xiyou Li Yanli Chen Jianzhuang Jiang | 2016 | Chinese Journal of Chemistry2016，34，10： | 2 |
| 8 | Electroacupuncture enhances hippocampal NSCs proliferation in cerebral ischemia-reperfusion injured rats via activation of notch signaling pathway显示文摘 | Jing Tao Bin Chen Yanling Gao Shanli Yang Jia Huang Xin Jiang Yayin Wu Jun Peng Zhenfeng Hong Lidian Chen | 2014 | International Journal of Neuroscience2014，，3： | 2 |
| 9 | Prediction and Analysis of Post-Treatment of Sustainable Walnut Shell/Co-PES Parts by Laser Sintering显示文摘In order to enhance the strength of sustainable walnut shell/Co-PES(WSPC)sintered parts,wax-filtrated posttreatment was carried out.The effects of treating fluid temperature,preheating time and immersion time on the bending strength of WSPC wax-filtrated parts were analyzed by single factor analysis method.To obtain an accurate model for predicting the bending strength of the WSPC wax-filtrated part,the experiments were involved by using Box-Behnken design(BBD).Main parameters,such as treating fluid temperature,preheating time and immersion time,and their interactive effects were analyzed through analysis of variance(ANOVA)and graphical contours.The results demonstrated that all parameters’direct effects were significant to bending strength of the WSPC wax-filtrated part.Its optimum value was 5.0 MPa when the treating fluid temperature of 70°C,preheating time of 50 min,and immersion time of 20 s.The predicted models effectively validated had good predicting accuracy.The WSPC wax-filtrated part using optimal processing parameters was processed by investment casting,and then the metal casting of dimensional stability and smooth surface was obtained.Investment casting was done using WSPC wax-filtrated parts under optimal process parameters and then metal parts with stable structure size and smooth surface can be obtained,which indicates that WSPC material can be used for investment casting. | Yueqiang Yu Suling Wang Minzheng Jiang Yanling Guo Ting Jiang | 2021 | Journal of Renewable Materials2021，9，2： | 1 |
| 10 | Array-error estimation method for multi-channel SAR systems in azimuth显示文摘For multi-channel synthetic aperture radar(SAR) systems, since the minimum antenna area constraint is eliminated,wide swath and high resolution SAR image can be achieved.However, the unavoidable array errors, consisting of channel gainphase mismatch and position uncertainty, significantly degrade the performance of such systems. An iteration-free method is proposed to simultaneously estimate position and gain-phase errors.In our research, the steering vectors corresponding to a pair of Doppler bins within the same range bin are studied in terms of their rotational relationships. The method is based on the fact that the rotational matrix only depends on the position errors and the frequency spacing between the paired Doppler bins but is independent of gain-phase error. Upon combining the projection matrices corresponding to the paired Doppler bins, the position errors are directly obtained in terms of extracting the rotational matrix in a least squares framework. The proposed method, when used in conjunction with the self-calibration algorithm, performs stably as well as has less computational load, compared with the conventional methods. Simulations reveal that the proposed method behaves better than the conventional methods even when the signal-to-noise ratio(SNR) is low. | Lun Ma Guisheng Liao Aifei Liu Yanling Jiang Ling Chen | 2016 | Journal of Systems Engineering and Electronics2016，27，4： | 1 |
| 11 | Laser intensity effect on mechanical properties of wood-plastic composite parts fab- ricated by selective laser sintering 显示文摘 | Zeng Weiliang Guo Yanling Jiang Kaiyi | 2013 | Journal of Thermoplastic Composite Materials2013，26，1： | 1 |
| 12 | Simulation Analysis of Stress Field of Walnut Shell Composite Powder in Laser Additive Manufacturing Forming显示文摘A calculation model of stress field in laser additive manufacturing of walnut shell composite powder(walnut shell/Co-PES powder)was established.The DFLUX subroutine was used to implement the moveable application of a double ellipsoid heat source by considering the mechanical properties varying with temperature.The stress field was simulated by the sequential coupling method,and the experimental results were in good accordance with the simulation results.In addition,the distribution and variation of stress and strain field were obtained in the process of laser additive manufacturing of walnut shell composite powder.The displacement of laser additive manufacturing walnut shell composite parts gradually decreased with increasing preheating temperature,decreasing laser power and increasing scanning speed.During the cooling process,the displacement of laser additive manufacturing of walnut shell composite parts gradually increased with the increasing preheating temperature,decreasing scanning speed and increasing laser power. | Yueqiang Yu Tingang Ma Suling Wang Minzheng Jiang Yanling Guo Ting Jiang Shuaiqi Huang Ziming Zheng Bo Yan Jiyuan Lv | 2023 | Journal of Renewable Materials2023，11，1： | 1 |
| 13 | Preparation and selective laser sintering of rice husk-plastic composite powder and post processing显示文摘 | Zeng Weiliang Guo Yanling Jiang Kaiyi | 2012 | Digest Journal of Nanomaterials and Biostrue- tures2012，7，3： | 1 |
| 14 | Preparation and laser sintering of limestone PAl2 composite 显示文摘 | Guo Yanling Jiang Kaiyi Bourell David L | 2014 | Polymer Testing2014，37，： | 1 |
| 15 | Versatile Functionalization of the Micropatterned Hydrogel of Hyperbranched Poly(ether amine) Based on “Thiol‐yne” Chemistry显示文摘 | Yanling Xu Hongjie Xu Xuesong Jiang Jie Yin | 2014 | Adv Funct Mater2014，，12： | 1 |
| 16 | Estimating biomass and net primary production from forest inventory data: A case study of China’s Larix forests显示文摘 | Zhou Guangsheng Wang Yuhui Jiang Yanling | 2002 | Ecology Manage2002，169，12： | 1 |
| 17 | Efficient generation and transportation of energetic electrons in a carbon nanotube array target 显示文摘 | Ji Yanling Jiang Gang Wu Weidong | 2010 | Appl Phys Lett2010，96，4： | 1 |
| 18 | Construction of an Infectious Clone for Mosquito-Derived Tembusu Virus Prototypical Strain显示文摘Dear Editor,Duck Tembusu virus(DTMUV),a member of the Flavivirus genus within the Flaviviridae family,has caused huge economic losses to the poultry industry in China and even in Asia since 2010(Zhang et al.2017).The first strain of Tembusu virus(TMUV)MM_1775 was isolated from mosquitoes in 1955 in Malaysia(Platt et al.1975).DTMUV CQW1 strain(GenBank:KM233707.1)was isolated from the liver tissue of Cherry Valley ducks in southwest China in 2015(Zhu et al.2015).The positive control rCQW1 was rescued from an infectious clone that contained the full-length cDNA of CQW1.And the complete cDNA was positioned under the control of the T7 promoter elements for in vitro transcription(Chen et al.2018).The relationship between TMUV evolution and pathogenic variants has not been revealed.The fundamental reason is the lack of the in vitro operation platform for the prototypical strain genome. | Xiaoli Wang Yu He Jiaqi Guo Bowen Jiang Mingshu Wang Renyong Jia Dekang Zhu Mafeng Liu Xinxin Zhao Qiao Yang Ying Wu Shaqiu Zhang Yunya Liu Ling Zhang Yanling Yu Anchun Cheng Shun Chen | 2021 | Virologica Sinica2021，36，6： | 1 |
| 19 | A non-ACE2 competing human single-domain antibody confers broad neutralization against SARS-CoV-2 and circulating variants显示文摘The current COVID-19 pandemic has heavily burdened the global public health system and may keep simmering for years.The frequent emergence of immune escape variants have spurred the search for prophylactic vaccines and therapeutic antibodies that confer broad protection against SARS-CoV-2 variants.Here we show that the bivalency of an affinity maturated fully human singledomain antibody(n3113.1-Fc)exhibits exquisite neutralizing potency against SARS-CoV-2 pseudovirus,and confers effective prophylactic and therapeutic protection against authentic SARS-CoV-2 in the host cell receptor angiotensin-converting enzyme 2(ACE2)humanized mice.The crystal structure of n3113 in complex with the receptor-binding domain(RBD)of SARS-CoV-2,combined with the cryo-EM structures of n3113 and spike ecto-domain,reveals that n3113 binds to the side surface of up-state RBD with no competition with ACE2.The binding of n3113 to this novel epitope stabilizes spike in up-state conformations but inhibits SARS-CoV-2 S mediated membrane fusion,expanding our recognition of neutralization by antibodies against SARS-CoV-2.Binding assay and pseudovirus neutralization assay show no evasion of recently prevalent SARS-CoV-2 lineages,including Alpha(B.1.1.7),Beta(B.1.351),Gamma(P.1),and Delta(B.1.617.2)for n3113.1-Fc with Y58L mutation,demonstrating the potential of n3113.1-Fc(Y58L)as a promising candidate for clinical development to treat COVID-19. | Zhenlin Yang Yulu Wang Yujia Jin Yuanfei Zhu Yanling Wu Cheng Li Yu Kong Wenping Song Xiaolong Tian Wuqiang Zhan Ailing Huang Shanshan Zhou Shuai Xia Xiaoxu Tian Chao Peng Cuicui Chen Yibing Shi Gaowei Hu Shujuan Du Yuyan Wang Youhua Xie Shibo Jiang Lu Lu Lei Sun Yuanlin Song Tianlei Ying | 2021 | Signal Transduction and Targeted Therapy2021，6，12： | 1 |
| 20 | Organization of serpin gene-1 from Mandeca sexta 显示文摘 | Hao Be Jiang Yang Wang Yanling | 1996 | Biol Chem1996，271，28： | 1 |
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