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| 1 | Biodegradation behavior of magnesium and ZK60 alloy in artificial urine and rat models显示文摘In this work, the biodegradable and histocompatibility properties of pure Mg and ZK60 alloy wereinvestigated as new temporary implants for urinary applications. The corrosion mechanism in artificialurine was proposed using electrochemical impedance spectroscopy and potentiodynamic polarizationtests. The corrosion potential of pure magnesium and ZK60 alloy were -1820 and -1561 mV, respectively,and the corrosion current densities were 59.66 ± 6.41 and 41.94 ± 0.53 μA cm^-2, respectively. Thein vitro degradation rates for pure Mg and ZK60 alloy in artificial urine were 0.382 and 1.023 mm/y,respectively, determined from immersion tests. The ZK60 alloy degraded faster than the pure Mg in bothartificial urine and in rat bladders (the implants of both samples are ø 3 mm × 5 mm). Histocompatibilityevaluations showed good histocompatibility for the pure Mg and ZK60 alloy during the 3 weeks postimplantationin rat bladders, and no harm was observed in the bladder, liver and kidney tissues. Theresults provide key information on the degradation properties and corrosion mechanism of pure Mg andZK60 alloy in the urinary system. | Shiying Zhang Yanze Bi Jianye Li Zhenguo Wang Jingmin Yan Jiawang Song Haibo Sheng Heqing Guo Yan Li | 2017 | Bioactive Materials2017，2，2： | 4 |
| 2 | High-gain integrated in-line few-mode amplifier enabling 3840-km long-haul transmission显示文摘An integrated few-mode erbium-doped fiber amplifier(FM-EDFA)with high modal gain is suitable for the in-line amplification in mode-division multiplexing transmission(MDM)systems.We first experimentally demonstrate a dual-stage integrated FM-EDFA supporting three linear polarization modes.Consisting of integrated passive components with low insertion losses,the FM-EDFA has a similar structure and performance to widely used commercial single-mode EDFAs.The averaged modal gain of 25 dB,the differential modal gain(DMG)of<1.1 dB,and noise figures of 5–7 dB are simultaneously achieved.In addition,the DMG of the 3M-EDF itself is~0.3 dB.Moreover,an MDM transmission experiment with the in-line few-mode amplification by our proposed FM-EDFA over a 3840-km few-mode fiber link for a 28-Gbaud quadrature phase-shift keying(QPSK)signal is demonstrated. | TAo Xu TIANYU GAO YANZE WANG WENHAO LI WEI LI CHENG Du ZHIQUN YANG YAPING LIU LIN ZHANG | 2022 | Photonics Research2022，10，12： | 2 |
| 3 | Efficient X-ray luminescence imaging with ultrastable and eco-friendly copper(Ⅰ)-iodide cluster microcubes显示文摘The advancement of contemporary X-ray imaging heavily depends on discovering scintillators that possess high sensitivity,robust stability,low toxicity,and a uniform size distribution.Despite significant progress in this field,the discovery of a material that satisfies all of these criteria remains a challenge.In this study,we report the synthesis of monodisperse copper(Ⅰ)-iodide cluster microcubes as a new class of X-ray scintillators.The as-prepared microcubes exhibit remarkable sensitivity to X-rays and exceptional stability under moisture and X-ray exposure.The uniform size distribution and high scintillation performance of the copper(Ⅰ)-iodide cluster microcubes make them suitable for the fabrication of large-area,flexible scintillating films for X-ray imaging applications in both static and dynamic settings. | Yanze Wang Wenjing Zhao Yuanyuan Guo Wenbo Hu Chenxi Peng Lei Li Yuan Wei Zhongbin Wu Weidong Xu Xiyan Li Yung Doug Suh Xiaowang Liu Wei Huang | 2023 | Light(Science & Applications)2023，12，8： | 1 |
| 4 | Cooperative planning ofmulti-agent systems based on task-oriented knowledge fusion with graph neural networks显示文摘Cooperative planning is one of the critical problems in the field of multi-agent system gaming.This work focuses on cooperative planning when each agent has only a local observation range and local communication.We propose a novel cooperative planning architecture that combines a graph neural network with a task-oriented knowledge fusion sampling method.Two main contributions of this paper are based on the comparisons with previous work:(1)we realize feasible and dynamic adjacent information fusion using GraphSAGE(i.e.,Graph SAmple and aggreGatE),which is the first time this method has been used to deal with the cooperative planning problem,and(2)a task-oriented sampling method is proposed to aggregate the available knowledge from a particular orientation,to obtain an effective and stable training process in our model.Experimental results demonstrate the good performance of our proposed method. | Hanqi DAI Weining LU Xianglong LI Jun YANG Deshan MENG Yanze LIU Bin LIANG | 2022 | Frontiers of Information Technology & Electronic Engineering2022，23，7： | 0 |
| 5 | Consistent Alterations of Human Fecal Microbes After Transplantation into Germ-free Mice显示文摘Fecal microbiota transplantation(FMT)of human fecal samples into germ-free(GF)mice is useful for establishing causal relationships between the gut microbiota and human phenotypes.However,due to the intrinsic differences between human and mouse intestines and the different diets of the two organisms,it may not be possible to replicate human phenotypes in mice through FMT;similarly,treatments that are effective in mouse models may not be effective in humans.In this study,we aimed to identify human gut microbes that undergo significant and consistent changes(i.e.,in relative abundances)after transplantation into GF mice in multiple experimental settings.We collected 16S rDNA-seq data from four published studies and analyzed the gut microbiota profiles from 1713 human–mouse pairs.Strikingly,on average,we found that only 47%of the human gut microbes could be re-established in mice at the species level,among which more than 1/3 underwent significant changes(referred to as“variable taxa”).Most of the human gut microbes that underwent significant changes were consistent across multiple human–mouse pairs and experimental settings.Consequently,about 1/3 of human samples changed their enterotypes,i.e.,significant changes in their leading species after FMT.Mice fed with a controlled diet showed a lower enterotype change rate(23.5%)than those fed with a noncontrolled diet(49.0%),suggesting a possible solution for rescue.Most of the variable taxa have been reported to be implicated in human diseases,with some recognized as the causative species.Our results highlight the challenges of using a mouse model to replicate human gut microbiota-associated phenotypes,provide useful information for researchers using mice in gut microbiota studies,and call for additional validations after FMT.An online database named FMT-DB is publicly available at http://gffzz31fc3efd07a444b1h0qpuxpxwbpkv6vkq.ffgz.tsg.suse.edu.cn/#/. | Yanze Li Wenming Cao Na L Gao Xing-Ming Zhao Wei-Hua Chen | 2022 | Genomics, Proteomics & Bioinformatics2022，20，2： | 0 |
| 6 | Structural insights reveal the specific recognition of meiRNA by the Mei2 protein显示文摘In the fission yeast Schizosaccharomyces pombe,Mei2,an RNA-binding protein essential for entry into meiosis,regulates meiosis initiation.Mei2 binds to a specific non-coding RNA species,meiRNA,and accumulates at the sme2 gene locus,which encodes meiRNA.Previous research has shown that the Mei2 C-terminal RNA recognition motif(RRM3)physically interacts with the meiRNA 5'region in vitro and stimulates meiosis in vivo.However,the underlying mechanisms still remain elusive.We first employed an in vitro crosslinking and immunoprecipitation sequencing(CLIP-seq)assay and demonstrated a preference for U-rich motifs of meiRNA by Mei2 RRM3.We then solved the crystal structures of Mei2 RRM3 in the apo form and complex with an 8 mer RNA fragment,derived from meiRNA,as detected by in vitro CLIP-seq.These results provide structural insights into the Mei2 RRM3-meiRNA complex and reveal that Mei2 RRM3 binds specifically to the Uuc(U)sequence.Furthermore,a structure-based Mei2 mutation,Mei2F644A causes defective karyogamy,suggesting an essential role of the RNA-binding ability of Mei2 in regulating meiosis. | Siyuan Shen Yanze jian Zhaokui Cai Fudong Li Mengqi Lv Yongrui Liu Jihui Wu Chuanhai Fu Yunyu Shi | 2022 | Journal of Molecular Cell Biology2022，14，5： | 0 |
| 7 | Anticorrosive and antibacterial smart integrated strategy for biomedical magnesium显示文摘Biomedical magnesium is an ideal material for hard tissue repair and replacement.However,its rapid degradation and infection after implantation significantly hindersclinical applications.To overcome these two critical drawbacks,we describe an integrated strategybased on the changes in pH and Mg^(2+)triggered by magnesiumdegradation.This system can simultaneously offer anticorrosion and antibacterial activity.First,nanoengineered peptide-grafted hyperbranched polymers(NPGHPs)with excellent antibacterial activity were introduced to sodium alginate(SA)to construct a sensitive NPGHPs/SA hydrogel.The swelling degree,responsiveness,and antibacterial activity were then investigated,indicating that the system can perform dual stimulation of pH and Mg^(2+)with controllable antimicrobial properties.Furthermore,an intelligent platform was constructed by coating hydrogels on magnesium with polydopamine as the transition layer.The alkaline environment generated by the corrosion of magnesium reduces the swelling degree of the coatingso that the liquid is unfavorable for contacting the substrate,thus exhibiting superior corrosion resistance.Antibacterial testing shows that the material can effectively fight against bacteria,while hemolytic and cytotoxicity testing suggest that it is highly biocompatible.Thus,this work realizes the smart integration of anticorrosion and antibacterial properties of biomedical magnesium,thereby providing broader prospects for the use of magnesium. | JianLiang Zhao HanRui Cui ZeYu Gao YanZe Bi ZhenZhen Dong Yan Li CaiQi Wang | 2023 | Journal of Magnesium and Alloys2023，11，8： | 0 |
| 8 | Arabidopsis ROOT ELONGATION RECEPTOR KINASES negatively regulate root growth putatively via altering cell wall remodeling gene expression显示文摘Receptor-like kinases(RLKs)play key roles in regulating various physiological aspects in plant growth and development.In Arabidopsis thaliana,there are at least 223 leucine-rich repeat(LRR)RLKs.The functions of the majority of RLKs in the LRR XI subfamily were previously revealed.Only three RLKs were not characterized.Here we report that two independent triple mutants of these RLKs,named ROOT ELONGATION RECEPTOR KINASES(REKs),exhibit increased cell numbers in the root apical meristem and enhanced cell size in the elongation and maturation zones.The promoter activities of a number of Quiescent Center marker genes are significantly up-regulated in the triple mutant.However,the promoter activities of several marker genes known to control root stem cell niche activities are not altered.RNA-seq analysis revealed that a number of cell wall remodeling genes are significantly up-regulated in the triple mutant.Our results suggest that these REKs play key roles in regulating root development likely via negatively regulating the expression of a number of key cell wall remodeling genes. | Yanze Wang Weiyue Chen Yang Ou Yingying Zhu Jia Li | 2022 | Journal of Integrative Plant Biology2022，64，8： | 0 |
| 9 | Optimal dispatch approach for rural multi-energy supply systems considering virtual energy storage显示文摘In response to the underutilization of energy and insufficient flexible operation capability of rural energy supply systems in China,this study proposes an optimal dispatch approach for a rural multi-energy supply system(RMESS)considering virtual energy storage(VES).First,to enable the flexible utilization of rural biomass resources and the thermal inertia of residential building envelopes,this study constructed VES-I and VES-II models that describe electrical-thermal and electrical-gas coupling from an electrical viewpoint.Subsequently,an RMESS model encompassing these two types of VES was formulated.This model delineates the intricate interplay of multi-energy components within the RMESS framework and facilitates the precise assessment of the adjustable potential for optimizing RMESS operations.Based on the above models,a day-ahead optimal dispatch model for an RMESS considering a VES is proposed to achieve optimal economic performance while ensuring efficient energy allocation.Comparative simulations validated the effectiveness of the VES modeling and the day-ahead optimal dispatch approach for the RMESS. | Yanze Xu Yunfei Mu Haijie Qi Hairun Li Peng Yu Shumin Sun | 2023 | Global Energy Interconnection2023，6，6： | 0 |
| 10 | Acidity Evaluation of Industrially Dealuminated Y Zeolite via Methylcyclohexane Transformation显示文摘The catalytic transformation of methylcyclohexane as an accepted probe reaction to evaluate zeolitic acidity(concentration,strength,and accessibility)is employed to study the acidity and the reactivity of three commercial dealuminated Y zeolites(DAY)with different Si/Al ratios and meso/microporosities,with their properties analyzed by N_(2) adsorption/desorption,pyridine-IR,and hydroxyl-IR spectroscopy technologies.The global activity(conversion)is largely dependent on the concentration of the acid sites,and the activity of the protonic sites in terms of turnover frequency(TOF)reflects the accessibility of acid sites.The products of aromatics and isomers,and the yield of cracking products increase with the increase of concentration of strong protonic sites in zeolite micropores.Moreover,the decrease of aromatics with the reduction of the concentration of acid sites and the diffusion length within DAY zeolites are observed due to the decrease of the secondary reaction.For the same reason,it results in the increasing of C_(7)products and alkenes/alkanes ratios in the cracking products.The high i-C_(4)product selectivity is a unique reflection of the high percentage of very strong acid sites,which is characterized by the hydroxyl-IR band at 3600 cm^(-1). | Hou Kaige Qin Bo Han Junjie Du Yanze Ma Jinghong Li Ruifeng | 2021 | China Petroleum Processing & Petrochemical Technology2021，23，3： | 0 |
| 11 | Novel phthalimides regulating PD-1/PD-L1 interaction as potential immunotherapy agents显示文摘Programmed cell death 1(PD-1)/programmed cell death ligand 1(PD-L1)have emerged as one of the most promising immune checkpoint targets for cancer immunotherapy.Despite the inherent advantages of small-molecule inhibitors over antibodies,the discovery of small-molecule inhibitors has fallen behind that of antibody drugs.Based on docking studies between small molecule inhibitor and PD-L1 protein,changing the chemical linker of inhibitor from a flexible chain to an aromatic ring may improve its binding capacity to PD-L1 protein,which was not reported before.A series of novel phthalimide derivatives from structure-based rational design was synthesized.P39 was identified as the best inhibitor with promising activity,which not only inhibited PD-1/PD-L1 interaction(IC_(50)=8.9 nmol/L),but also enhanced killing efficacy of immune cells on cancer cells.Co-crystal data demonstrated that P39 induced the dimerization of PD-L1 proteins,thereby blocking the binding of PD-1/PD-L1.Moreover,P39 exhibited a favorable safety profile with a LD_(50)>5000 mg/kg and showed significant in vivo antitumor activity through promoting CD8^(+)T cell activation.All these data suggest that P39 acts as a promising small chemical inhibitor against the PD-1/PD-L1 axis and has the potential to improve the immunotherapy efficacy of T-cells. | Chengliang Sun Yao Cheng Xiaojia Liu Gefei Wang Wenjian Min Xiao Wang Kai Yuan Yi Hou Jiaxing Li Haolin Zhang Haojie Dong Liping Wang Chenguang Lou Yanze Sun Xinmiao Yu Hongbin Deng Yibei Xiao Peng Yang | 2022 | Acta Pharmaceutica Sinica B2022，12，12： | 0 |
| 12 | Nitrogen Removal Performance of Denitrifying Ammonium Oxidation System in Treating Sulfamethoxazole-laden Secondary Wastewater Effluent显示文摘In this study,nitrogen removal performance of the denitrifying ammonium oxidation(DAO)process was investigated when treating sulfamethoxazole(SMX)-laden secondary wastewater effluent.The influent SMX concentration showed negligible effect on efficiencies for removal of nitrate and COD.However,the ammonium ions removal rate was moderately reduced,when the influent SMX concentration in wastewater reached 6 mg/L.Total nitrogen removal efficiency remained as high as 76.77%towards the day 158 at the end of experiment.Candidatus_Brocadia and Candidatus_Kuenenia were the functional anammox strains.The unclassified_f__Rhodobacteraceae sp.was predominant heterotrophic denitrifying strain in the studied reactor.The concentrations of soluble extracellular polymeric substances in sludge obviously increased from 16.76 mg/g VSS to 32.31 mg/g VSS,which might protect the nitrogen removal strains from high-concentration SMX.This result provides a theoretical and technical foundation for the application of denitrifying ammonium oxidation process in treating sulfamethoxazole-laden secondary wastewater effluent. | Liu Chunshuang Li Wei Duan Weichao Huiyun Zhong Yu Haitong Li Yanze Liu Fang Zhao Chaocheng | 2021 | China Petroleum Processing & Petrochemical Technology2021，23，1： | 0 |
| 13 | Accelerating hybrid and compact neural networks targeting perception and control domains with coarse-grained dataflow reconfiguration显示文摘Driven by continuous scaling of nanoscale semiconductor technologies,the past years have witnessed the progressive advancement of machine learning techniques and applications.Recently,dedicated machine learning accelerators,especially for neural networks,have attracted the research interests of computer architects and VLSI designers.State-of-the-art accelerators increase performance by deploying a huge amount of processing elements,however still face the issue of degraded resource utilization across hybrid and non-standard algorithmic kernels.In this work,we exploit the properties of important neural network kernels for both perception and control to propose a reconfigurable dataflow processor,which adjusts the patterns of data flowing,functionalities of processing elements and on-chip storages according to network kernels.In contrast to stateof-the-art fine-grained data flowing techniques,the proposed coarse-grained dataflow reconfiguration approach enables extensive sharing of computing and storage resources.Three hybrid networks for MobileNet,deep reinforcement learning and sequence classification are constructed and analyzed with customized instruction sets and toolchain.A test chip has been designed and fabricated under UMC 65 nm CMOS technology,with the measured power consumption of 7.51 mW under 100 MHz frequency on a die size of 1.8×1.8 mm^2. | Zheng Wang Libing Zhou Wenting Xie Weiguang Chen Jinyuan Su Wenxuan Chen Anhua Du Shanliao Li Minglan Liang Yuejin Lin Wei Zhao Yanze Wu Tianfu Sun Wenqi Fang Zhibin Yu | 2020 | Journal of Semiconductors2020，41，2： | 0 |
| 14 | The bioelectrical properties of bone tissue显示文摘Understanding the bioelectrical properties of bone tissue is key to developing new treatment strategies for bone diseases and injuries,as well as improving the design and fabrication of scaffold implants for bone tissue engineering.The bioelectrical properties of bone tissue can be attributed to the interaction of its various cell lineages(osteocyte,osteoblast and osteoclast)with the surrounding extracellular matrix,in the presence of various biomechanical stimuli arising from routine physical activities;and is best described as a combination and overlap of dielectric,piezoelectric,pyroelectric and ferroelectric properties,together with streaming potential and electro-osmosis.There is close interdependence and interaction of the various electroactive and electrosensitive components of bone tissue,including cell membrane potential,voltage-gated ion channels,intracellular signaling pathways,and cell surface receptors,together with various matrix components such as collagen,hydroxyapatite,proteoglycans and glycosaminoglycans.It is the remarkably complex web of interactive cross-talk between the organic and non-organic components of bone that define its electrophysiological properties,which in turn exerts a profound influence on its metabolism,homeostasis and regeneration in health and disease.This has spurred increasing interest in application of electroactive scaffolds in bone tissue engineering,to recapitulate the natural electrophysiological microenvironment of healthy bone tissue to facilitate bone defect repair. | Boon Chin Heng Yunyang Bai Xiaochan Li Yanze Meng Yanhui Lu Xuehui Zhang Xuliang Deng | 2023 | Animal Models and Experimental Medicine2023，6，2： | 0 |
| 15 | Numerical Simulation of the Flat Ribbon Wound Explosion Containment Vessels Subjected to Internal Blast Loading显示文摘In order to constitute engineering design methods of the flat ribbon wound explosion containment vessels, the dynamic response of such vessels subjected to internal explosion loading is simulated using LS-DYNA3D. Three winding angles, 10°, 15°and 20°, are considered. It is shown that among ribbon vessels investigated, the center displacement of outermost ribbons of the vessel with 10°winding angle is the smallest under the same blast loading. The response of vessels loaded in inner core is local. From the center of the cylindrical shell to the bottom cover, the maximum strain gradually decreases. The ribbons are subjected to tension in the length direction and compression in the width direction. Blasting shock energy concentrates on where is close to center section of blasting. For comparison, numerical simulation of a monobloc thick-walled explosion containment vessel is also investigated. It can be found that the biggest deformation of the flat ribbon wound explosion containment vessels is bigger than that of the monobloc thick-walled explosion containment vessel in the center section of blasting under the same TNT. Numerical results are approximately in agreement with experimental ones. It is proved that the ribbon vessels have the valuable properties of ' leak before burst at worst' compared with the monobloc vessels through numerical simulation. | SONG Yanze LI Zhiqiang ZHAO Longmao ZHENG Jinyang | 2006 | Transactions of Tianjin University2006，12，B09： | 0 |
| 16 | An error analysis and optimization method for combined measurement with binocular vision显示文摘The accurate measurement of surfaces of large aviation components is vital for the assessment of manufacturing and assembly quality of such components.To satisfy the measurement requirement of large-size components,most current researches pay more attention to combined measurement methods utilizing different measuring instruments,but the related researches on error analysis and optimization methods are not taken enough attention.This paper proposes a combined laser-assisted measurement method with feature enhancement techniques,and it also develops an error propagation model of the main factors affecting the overall measurement error in detail.Firstly,the surface of a large-size component is measured by the measurement system at multiple stations.Secondly,a control point coordinate system is established as a bridge to unify all local measurement data into the global coordinate system.To improve the overall measurement accuracy,the pixel extraction error as a key factor causing the overall measurement error is analyzed in detail.Next,the error propagation model is established,and some optimization strategies of layout for minimizing measurement error and transformation error are researched.Finally,experiments are carried out to verify the effectiveness of the proposed method.The results show that the measurement error of the proposed method reaches 0.073%and 0.14%with a 1 D standard ruler and a flat plate,respectively. | Yongkang LU Wei LIU Yang ZHANG Junqing LI Weiqi LUO Yanze ZHANG Hongwen XINGb Lei ZHANG | 2021 | Chinese Journal of Aeronautics2021，34，10： | 0 |
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