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| 1 | Effect of cholecystokinin octapeptide on tumor necrosis factor α transcription and nuclear factor-κB activity induced by lipopolysaccharide in rat pulmonary interstitial macrophages显示文摘AIM: To elucidate the anti-inflammatory mechanism ofan intestinal neuropeptide, sulfated cholecystokininoctapeptide (sCCK-8), the effects of sCCK-8 onlipopolysaccharide (LPS)-induced tumor necrosis factorpulmonary interstitial macrophages (PIMs) werestudied.METHODS: PIMs from rat were stimulated with LPS(:1mg @ L-1) in the presence or absence of sCCK-8 (10-8-:10-6mol@ L-1) or/and CCK receptor antagonistproglumide (2 mg @ L-1). The expression of TNF-α mRNAwas assayed by reverse transcription polymerase chainreaction (RT-PCR) at 3h of the stimulation, and nuclearelectrophoretic mobility shift assay (EMSA) at 1 h ofat 30 min of the stimulation was detected by Westernblot.RESULTS: sCCK-8, at concentrations from 10-8 mol @ L-1to 10-6 mol @ L-1 obviously inhibited LPS-induced TNF-αdependent manner, P<0.05, P<0.01. Stimulation PIMsP<0.01, which was elevated by sCCK-8, P<0.05. Thewere attenuated by CCK receptor antagonistproglumide, P<0.01.CONCLUSION: sCCK-8 inhibits LPS-induced TNF-α mRNAwhich is mediated through CCK receptors and inhibitinginflammatory mechanisms of sCCK-8. | Bin Cong Shu-Jin Li Yi-Ling Ling Department of Pathophysiology,Hebei Medical University,Shijiazhuang 050017,Hebei Province,China Yu-Xia Yao Molecular Biological Laboratory,Hebei Medical University,Shijiazhuang 050017,Hebei Province,China Gui-jun Zhu Department of chest surgey,The Fourth Hospital,Hebei Medical University,Shijiazhuang 050017,Hebei Province,China | 2002 | World Journal of Gastroenterology2002，8，4： | 31 |
| 2 | Scene text detection and recognition: recent advances and future trends显示文摘 | Yingying ZHU Cong YAO Xiang BAI | 2016 | Frontiers of Computer Science2016，10，1： | 20 |
| 3 | The Chromosome-Based Rubber Tree Genome Provides New Insights into Spurge Genome Evolution and Rubber Biosynthesis显示文摘The rubber tree,Hevea brasiliensis,produces natural rubber that serves as an essential industrial raw material.Here,we present a high-quality reference genome for a rubber tree cultivar GT1 using single-molecule real-time sequencing(SMRT)and Hi-C technologies to anchor the~1.47-Gb genome assembly into 18 pseudochromosomes.The chromosome-based genome analysis enabled us to establish a model of spurge chromosome evolution,since the common paleopolyploid event occurred before the split of Hevea and Manihot.We show recent and rapid bursts of the three Hevea-specific LTR-retrotransposon families during the last 10 million years,leading to the massive expansion by~65.88%(~970 Mbp)of the whole rubber tree genome since the divergence from Manihot.We identify large-scale expansion of genes associated with whole rubber biosynthesis processes,such as basal metabolic processes,ethylene biosynthesis,and the activation of polysaccharide and glycoprotein lectin,which are important properties for latex production.A map of genomic variation between the cultivated and wild rubber trees was obtained,which contains~15.7 million high-quality single-nucleotide polymorphisms.We identified hundreds of candidate domestication genes with drastically lowered genomic diversity in the cultivated but not wild rubber trees despite a relatively short domestication history of rubber tree,some of which are involved in rubber biosynthesis.This genome assembly represents key resources for future rubber tree research and breeding,providing novel targets for improving plant biotic and abiotic tolerance and rubber production. | Jin Liu Cong Shi Cheng-Cheng Shi Wei Li Qun-Jie Zhang Yun Zhang Kui Li Hui-Fang Lu Chao Shi Si-Tao Zhu Zai-Yun Xiao Hong Nan Yao Yue Xun-Ge Zhu Yu Wu Xiao-Ning Hong Guang-Yi Fan Yan Tong Dan Zhang Chang-Li Mao Yun-Long Liu Shi-Jie Hao Wei-Qing Liu Mei-Qi Lv Hai-Bin Zhang Yuan Liu Ge-Ran Hu-tang Jin-Peng Wang Jia-Hao Wang Ying-Huai Sun Shu-Bang Ni Wen-Bin Chen Xing-Cai Zhang Yuan-Nian Jiao Evan E.Eichler Guo-Hua Li Xin Liu Li-Zhi Gao | 2020 | Molecular Plant2020，13，2： | 15 |
| 4 | Design and test of operation parameters for rice air broadcasting by unmanned aerial vehicle显示文摘Considering the difficulty of broadcasting in the small plots and complex terrain in South China,this research aimed to explore a new efficient broadcasting way and figure out advisable operation parameters by using a hollow 12-axis,rotor-wing Unmanned Aerial Vehicle(UAV)which is typically made up of four groups of solid support structure,with each consisting of three axes and two rotor wings.A 3.7 L reverse pyramid-shape seed hopper with a 60 mm×13 mm rectangular outlet at the bottom was designed to realize self-gravity seeding.Rice seed firstly directly falls on the rotating disc driven by direct-current dynamo before being sown.The disc was located 120 mm above the ground,with a diameter of 350 mm.Under constant flight conditions,parameters of the on-board broadcasting devices(dropping speed referring to speed for the outlet and the broadcasting speed for the disc’s rotation speed)determine the uniformity of air broadcasting.The FUTABA T8FG transmitter and receiver system were employed as the remote control device.When the UAV flies at 3 m/s and 2 m above the ground with an expected seeding of 180 grain/m^(2),the RD(Right Down)knob marked 29 and LD(Left Down)knob marked-24 with a disc rotation speed of 900 r/min,the broadcasting lasts for 15 seconds with a 25%opening(1.95 cm^(2))of rectangular outlet.In order to verify the feasibility of air broadcasting parameters,the project team carried out a field broadcasting test by using a hollow multi-rotor UAV at Zhongluotan Test Base in Guangzhou in July,2014.In the square field plots of 0.09 hm^(2),flying path of air broadcasting operation was designed.The collected sampling data of broadcasting quantity per unit area after the test showed that there were,on average,187.4 grains/m^(2)of the five sampling points with a standard deviation of 22.77,and a coefficient of variation of 12.15%which was far smaller than that of artificial broadcasting.The average yield of field broadcasted by UAV is 7705.5 kg/hm^(2)in 2014,implying that rice air broadcasting by UAV is feasible. | Li Jiyu Lan Yubin Zhou Zhiyan Zeng Shan Huang Cong Yao Weixiang Zhang Yang Zhu Qiuyang | 2016 | International Journal of Agricultural and Biological Engineering2016，9，5： | 10 |
| 5 | Automatic extraction of lunar impact craters from Chang'E-1 satellite photographs显示文摘The distribution characteristics of the impact craters can provide a large amount of information on impact history and the lunar evolution process. In this research, based on the digital elevation model (DEM) data originating from Change'E-1 CCD stereo camera, three automatic extraction methods for the impact craters are implemented in two research areas: direct extraction from flooded DEM data (the Flooded method), object-oriented extraction from DEM data by using ENVI ZOOM function (the Object-Oriented method) and novel object-oriented extraction from flooded DEM data (the Flooded Object-Oriented method). Accuracy assessment, extracted degree computation, cumulative frequency analysis, shape and age analysis of the extracted craters combined display the following results. (1) The Flooded Object-Oriented method yields better accuracy than the other two methods in the two research areas; the extraction result of the Flooded method offers the similar accuracy to that of the Object-Oriented method. (2) The cumulative frequency curves for the extracted craters and the confirmed craters share a similar change trajectory. (3) The number of the impact craters extracted by the three methods in the Imbrian period is the largest and is of various types; as to their age earlier than Imbrain, it is difficult to extract because they could have been destroyed. | WAN Cong CHENG WeiMing ZHOU ZengPo ZHAO ShangMin XIA Yao | 2012 | Science China(Physics,Mechanics & Astronomy)2012，55，1： | 8 |
| 6 | Malnutrition and Quality of Life in Chinese Cancer Patients: a Clinical Study of 23,994 Subjects显示文摘Background Malnutrition is common in patients with cancer,and can negatively impact their quality of life(QoL)and even survival.However,there is currently no large data available on the prevalence of malnutrition in Chinese cancer patients.This study evaluated the prevalence of malnutrition and the QoL of Chinese patients with locoregional,recurrent or metastatic cancer.Methods We conducted a nationwide observational,multi-center,hospital-based cross-sectional study within the Chinese Society of Nutritional Oncology(CSNO)Network.All of the patients were diagnosed with one of the following 18 different types of malignant tumors:lung cancer,gastric cancer,liver cancer,colorectal cancer,breast cancer,esophageal cancer,cervical cancer,endometrial cancer,nasopharyngeal carcinoma,malignant lymphoma,leukemia,pancreatic cancer,ovarian cancer,prostate cancer,bladder cancer,brain cancer,biliary tract malignant tumors or gastrointestinal stromal tumors.These patients were enrolled from 72 hospitals located in different regions of China.The patients’nutritional status was evaluated based on the body mass index(BMI),loss of bodyweight,laboratory measurements and patient generated-subjective global assessment(PG-SGA)scores.The cancer patients’physical status and QoL were assessed by the Karnofsky Performance Status(KPS)questionnaire and the European Organization for Research and Treatment of Cancer(EORTC)QLQ-C30 questionnaire,respectively.Results From December 2013 to April 2016,23,994 patients hospitalized for cancer treatment(such as surgery,chemotherapy or radiotherapy)were enrolled in the study.The patients included 12,494(52.9%)males and 11,124(47.1%)females.The mean age was 55.8±13.7 years.The proportions of patients in cancer stagesⅠ,Ⅱ,Ⅲ,Ⅳand uncertain were 11.5%,20.3%,27.5%,30.2%and 10.5%,respectively.Among the 23,994 inpatients,the proportions of patients who were underweight(BMI<18.5 kg/m2),normal(18.5 kg/m2 | Hong Xia Xu Chun Hua Song Zhen Ming Fu Chang Wang Zeng Qing Guo Yuan Lin Ying Ying Shi Wen Hu Yi Ba Su Yi Li Zeng Ning Li Kun Hua Wang Jing Wu Ying He Jia Jun Yang Cong Hua Xie Fu Xiang Zhou Xin Xia Song Gong Yan Chen Wen Jun Ma Su Xia Luo Zi Hua Chen Ming Hua Cong Hu Ma Chun Ling Zhou Wei Wang Qi Luo Yong Mei Shi Yu Mei Qi Hai Ping Jiang Wen Xian Guan Jun Qiang Chen Jia Xin Chen Yu Fang Lan Zhou Yong Dong Feng Rong Shao Tan Tao Li Jun Wen Ou Qing Chuan Zhao Jian Xiong Wu Min Weng Qing Hua Yao Jiu Wei Cui Wei Li Han Ping Shi the Investigation on Nutrition Status and Clinical Outcome of Common Cancers(INSCOC)Group | 2021 | Journal of Nutritional Oncology2021，6，1： | 8 |
| 7 | Concentration level and distribution of polycyclic aromatic hydrocarbons in soil and grass around Mt. Qomolangma, China显示文摘High mountains may serve as a condenser for persistent organic pollutants. In the present study, soil and grass samples from Mt. Qomolangma region, China were collected from 4600 to 5620 m a.s.l and were analyzed for polycyclic aromatic hydrocarbons (PAHs) to determine if they are concentrated at colder, more elevated sites and to evaluate their possible resources and fractionation. The total PAHs concentration in soil samples was < 600 ng g?1, the critical value to differentiate PAHs levels in remote and urban regions. This implied the PAHs levels at Mt. Qomolangma are relatively low and what one might expect in such a remote region of the world. These low values may represent a soil background for mid-latitude Northern Hemisphere soils away from the direct influence of an anthropogenic source. As for the distribution pattern, the low molecular weight PAHs were prone to accumulate at higher altitude, while the high molecular weight PAHs inversely related or unrelated with elevation. Based on high concentration of phenanthrene at elevated sample site and the ratios of individual PAHs, we deduced that home-heating combustion and vehicle emission may result in the constitution trait of PAHs in this mountain region. Monsoon traveling over India, Pakistan and other countries with dense population may carry contaminant to Mt. Qomolangma region. | WANG XiaoPing YAO TanDong CONG ZhiYuan YAN XinLiang KANG ShiChang ZHANG Yong | 2007 | Chinese Science Bulletin2007，52，10： | 8 |
| 8 | A cohort autopsy study defines COVID-19 systemic pathogenesis显示文摘Severe COVID-19 disease caused by SARS-CoV-2 is frequently accompanied by dysfunction of the lungs and extrapulmonary organs.However,the organotropism of SARS-CoV-2 and the port of virus entry for systemic dissemination remain largely unknown.We profiled 26 COVID-19 autopsy cases from four cohorts in Wuhan,China,and determined the systemic distribution of SARS-CoV-2. | Xiao-Hong Yao Tao Luo Yu Shi Zhi-Cheng He Rui Tang Pei-Pei Zhang Jun Cai Xiang-Dong Zhou Dong-Po Jiang Xiao-Chun Fei Xue-Quan Huang Lei Zhao Heng Zhang Hai-Bo Wu Yong Ren Zhen-Hua Liu Hua-Rong Zhang Cong Chen Wen-Juan Fu Heng Li Xin-Yi Xia Rong Chen Yan Wang Xin-Dong Liu Chang-Lin Yin Ze-Xuan Yan Juan Wang Rui Jing Tai-Sheng Li Wei-Qin Li Chao-Fu Wang Yan-Qing Ding Qing Mao Ding-Yu Zhang Shu-Yang Zhang Yi-Fang Ping Xiu-Wu Bian | 2021 | Cell Research2021，31，8： | 7 |
| 9 | Effect of cholecystokinin octapeptide on diacylglyceroI-PKC signaling pathway in rat pulmonary interstitial macrophages stimulated by lipopolysaccharide显示文摘Aim:To investigate the effect of cholecystokinin octapeptide(CCK-8)on thediacylglycerol-protein kinase C(DAG-PKC)signaling pathway in rat pulmonaryinterstitial macrophages(PIM)stimulated by lipopolysaccaride(LPS).Methods:The PIM from rat lung tissues were isolated using the collagenase digestionmethod combined with alveolar lavage and pulmonary vessel perfusion.DAGcontent and PKC activity were measured by radioenzymatic assay.The transloca-tion of PKCζ was determined by semi-quantitative immunoblot analysis.Results:CCK-8,at high concentrations(1×10^(-6)-1×10^(-5)mol/L),decreased DAG content andinhibited PKC activity and PKCζ translocation compared with that in rat restingPIM of a control group(P<0.01).LPS increased DAG content,and promoted PKCactivity and PKC~ translocation(P<0.01).CCK-8 decreased LPS-induced DAGcontent and inhibited LPS-induced PKC activity and PKCζ translocation signifi-cantly at 1×10^(-8)-1×10^(-5)mol/L(P<0.01).This inhibitory effect of CCK-8 could beabrogated partly by proglumide(non-selective CCK receptor antagonist),CR-1409(selective CCK-A receptor antagonist),and CR-2945(selective CCK-Breceptor antagonist)in a concentration-dependent manner(P<0.01).Conclusion:CCK-8 was a negative modulator of the DAG-PKC signaling pathway in rat restingPIM,which is very important for maintaining body homeostasis.It significantlyinhibited LPS-induced DAG content,PKC activity and PKCζ translocation in aconcentration-dependent manner.The CCK receptor,especially the CCK-Areceptor,might play a major role in this process. | Shun-jiang XU Wei-juan GAO Bin CONG Chun-ling MA Shu-jin LI Yi-ling LING Zhen-yong GU Yu-xia YAO | 2005 | Acta Pharmacologica Sinica2005，26，12： | 6 |
| 10 | E-selectin and its ligand-sLeX in the metastasis of hepatocellular carcinoma显示文摘Objective: To study the significance of E-selectin andits ligand-sLeX in the metastasis of hepatocellularcarcinoma (HCC).Methods: Flow cytometry and immunohistochemistrywere used to detect the expression of E-selectin and itsligand-sLeX in both HCC cell lines and human HCCtissues.Results: The positive rate of E-selectin in vascular en-dothelial cells adjacent to cancer was 67.9% (19/28). Theexpression of E-selectin in tumors accompanied withemboli or satellite foci was significantly higher than thatin tumors without emboli or satellite foci (P<0.05),and it was not related to tumor size, tumor capsule,AFP content, and the degree of differentiation. Thepositive expression of sLeX in SMMU-7721, PLF/PRF/5 and HepGⅡ cell lines was 7.03%, 63.35% and97.29% respectively. The positive cells of sLeX mainlydistributed in the margin of tumor tissues. The positiveexpression of sLeX in HCC cells in emboli or invasivetumor tissues was much higher than in primary foci.Conclusion: E-selectin and its ligand-sLeX are closelycorrelated with the metastasis of HCC. | Bao-Hua Zhang Han Chen Xiao-Ping Yao Wen-Ming Cong Meng-Chao Wu From the Eastern Hepatobiliary Surgery Hospital, Second Military Medical University of PLA, Shanghai 200438, China | 2002 | Hepatobiliary & Pancreatic Diseases International2002，1，1： | 6 |
| 11 | Keyword Extraction for Contextual Advertising显示文摘Contextual advertising is a major revenue source for today’s companies.Keyword extraction is a key step in this kind of advertising,through which appropriate | LIU Jianyi WANG Cong YAO Wenbin | 2010 | China Communications2010，7，4： | 6 |
| 12 | SPARC expression and prognostic value in non-small cell lung cancer显示文摘Secreted protein,acidic and rich in cysteine(SPARC) is expressed in numerous types of tumors and is suggested to have prognostic value.Moreover,because of its strong affinity for albumin,and hence albumin-bound drugs,SPARC has increasingly become a focus for research.In this study,we aimed to determine SPARC expression in patients with non-small cell lung cancer(NSCLC) and investigate the association of SPARC with disease prognosis.Tissue microarrays were constructed with specimens from 105 patients with NSCLC treated at Sun Yat-sen University Cancer Center,and immunohistochemical analysis was performed on these tissue microarrays to assess SPARC expression.Our results showed that SPARC expression status did not significantly relate with age,gender,and tumor stage.However,SPARC was expressed more frequently in squamous cell carcinoma than in adenocarcinoma(75% vs.43.5%,P = 0.004).Patients with smoking history had higher SPARC expression than non-smokers(68.2% vs.33.3%,P = 0.002).In both univariate and multivariate analyses,SPARC was a prognostic factor of overall survival(HR = 0.32;95% CI:0.16-0.65) but not disease-free survival.Our study indicates that SPARC expression is higher in squamous cell carcinoma than in adenocarcinoma in NSCLC.Most notably,SPARC can be used as a prognostic factor for NSCLC. | Yan Huang Jing Zhang Yuan-Yuan Zhao Wei Jiang Cong Xue Fei Xu Hong-Yun Zhao Yang Zhang Li-Ping Zhao Zhi-Huang Hu Zhi-Wen Yao Qian-Yong Liu Li Zhang | 2012 | Chinese Journal of Cancer2012，31，11： | 6 |
| 13 | A complex structure of arrestin-2 bound to a G protein-coupled receptor显示文摘Arrestins comprise a family of signal regulators of G-protein-coupled receptors(GPCRs),which include arrestins 1 to 4.While arrestins 1 and 4 are visual arrestins dedicated to rhodopsin,arrestins 2 and 3(Arr2 and Arr3)areβ-arrestins known to regulate many nonvisual GPCRs.The dynamic and promiscuous coupling of Arr2 to nonvisual GPCRs has posed technical challenges to tackle the basis of arrestin binding to GPCRs.Here we report the structure of Arr2 in complex with neurotensin receptor 1(NTSR1),which reveals an overall assembly that is strikingly different from the visual arrestin–rhodopsin complex by a 90°rotation of Arr2 relative to the receptor.In this new configuration,intracellular loop 3(ICL3)and transmembrane helix 6(TM6)of the receptor are oriented toward the N-terminal domain of the arrestin,making it possible for GPCRs that lack the C-terminal tail to couple Arr2 through their ICL3.Molecular dynamics simulation and crosslinking data further support the assembly of the Arr2‒NTSR1 complex.Sequence analysis and homology modeling suggest that the Arr2‒NTSR1 complex structure may provide an alternative template for modeling arrestin–GPCR interactions. | Wanchao Yin Zhihai Li Mingliang Jin Yu-Ling Yin Parker Wde Waal Kuntal Pal Yanting Yin Xiang Gao Yuanzheng He Jing Gao Xiaoxi Wang Yan Zhang Hu Zhou Karsten Melcher Yi Jiang Yao Cong X.Edward Zhou Xuekui Yu H.Eric Xu | 2019 | Cell Research2019，29，12： | 4 |
| 14 | Apoptotic cell administration enhances pancreatic islet engraftment by induction of regulatory T cells and tolerogenic dendritic cells显示文摘Apoptotic 房间转移被发现了能便于 allograft 的嫁接。然而,内在的机制尚待充分被理解。这里,我们证明施主 apoptotic splenocytes 的静脉内的管理能由导致 tolerogenic 的产生支持胰腺的小岛嫁接树枝状的房间(Tol-DCs ) 和 CD4 + Foxp3 + 规章的 T 房间(Tregs ) 。在 vivo,树枝状的房间(DC ) 或 Tregs 的清理由 apoptotic 房间管理阻止了有免疫力的忍耐的正式就职。用 anti-CD25 的 Tregs 的短暂消除, monoclonal 抗体(mAb ) 在 apoptotic splenocytes 的管理以后废除了 Tol-DCs 的产生。相互地,在用白喉毒素(DT ) 的 CD11c 数据终端就绪老鼠以内的 DC 的弄空与 apoptotic splenocytes 的管理在接受者阻止了 Tregs 的产生。在二个房间之间的房间接触打的由直接要求,并且规划了死亡 1 ligand (PD-L1 ) 的 Tol-DCs 的 Tregs 的正式就职在 Tregs 扩大起了重要作用。Apoptotic 房间管理没能在 IL-10-deficient 和 Smad3 缺乏的老鼠导致 Tol-DCs,建议那 IL-10 和转变生长 factor-β(TGF-β) 被需要处于 tolerogenic 状态维持 DC。因此,我们证明 Tol-DCs 在他们的表面上并且相互地经由 PD-L1 支持 Tregs 的扩大 Tregs 便于 Tol-DCs 维持 apoptotic 房间经由 secreting IL-10 和 TGF-β 导致的移植忍耐;。 | Cong Wu Yi Zhang Yingnling Jiang Quanxing Wang Yao Long Chunmei Wang Xuetao Cao Guoyou Chen | 2013 | Cellular & Molecular Immunology2013，10，5： | 4 |
| 15 | Experimental Study on Measurement and Calculation of Heat Flux in Supersonic Combustor of Scramjet显示文摘An experimental measurement and calculation method which consist of thermal response model, convergence criteria and control algorithms, is proposed in this paper for the determination of heat flux in a scramjet combustor. Numerical simulations are done to evaluate the effectiveness of the proposed method, and experiments are made in the direct-connect hydrocarbon fueled scramjet combustor of Mach-6 flight for different equivalence ratios. The distribution of heat flux along the axial and circumferential directions can be obtained using the proposed method. The distribution of heat flux is uneven which is caused by the aerodynamic heating, combustion heat release and changes of section area, and the peak heat flux can be more than 2MW/m2 during the experiments. Heat flux increases with the increase in equivalence ratio for the same Mach number. And axial distribution of heat flux is uniform for different equivalence ratios. In addition, the combustion heat release area of the combustion chamber can therefore be concluded which is useful for guiding the structural design of the thermal protection system. | ZHANG Cong YAO Zhanli QIN Jiang BAO Wen | 2015 | Journal of Thermal Science2015，24，3： | 4 |
| 16 | CPPU may induce gibberellin-independent parthenocarpy associated with PbRR9 in‘Dangshansu’pear显示文摘Parthenocarpy is a valuable trait in self-incompatible plants,such as pear.N-(2-chloro-4-pyridyl)-N’-phenylurea(CPPU),a synthetic cytokinin analog,can induce parthenocarpy in pear(Pyrus spp.),but the mechanism of induction is unclear.To investigate the role of gibberellin in CPPU-induced parthenocarpy in pear,CPPU supplemented with paclobutrazol(PAC)was sprayed onto‘Dangshansu’pear.We found that the fruit set rate of pear treated with CPPU supplemented with PAC was identical to that in a CPPU-alone treatment group.In regard to cell development,CPPU mainly promoted hypanthium cell division and expansion,and PAC application had no influence on CPPU-induced cell development.RNA sequencing revealed that gibberellin 20 oxidase and gibberellin 3 oxidase genes were not differentially expressed following CPPU treatment.According to the analysis of fruit phytohormone content,the CPPU treatments did not induce gibberellin biosynthesis.These results suggest that CPPU-induced parthenocarpy may be gibberellin independent in‘Dangshansu’pear.After CPPU treatment,the indole acetic acid(IAA)content in fruit was significantly increased,and the abscisic acid(ABA)content was significantly decreased.Similarly,RNA sequencing revealed that many genes involved in the auxin and ABA pathways were significantly differentially expressed in the CPPU treatment groups;among them,indole-3-pyruvate monooxygenase(YUCCA)was significantly upregulated and 9-cis-epoxycarotenoid dioxygenase(NCED)was significantly downregulated.IAA and ABA may thus play important roles in CPPU-induced parthenocarpy.PbTwo-component response regulator9(PbRR9),PbYUCCA4,and PbNCED6 were then selected to further elucidate the mechanism of CPPU-induced parthenocarpy.A yeast one-hybrid assay indicated that PbRR9 can combine with the PbYUCCA4 and PbNCED6 promoters.Dual luciferase assays revealed that PbRR9 can promote and repress the activities of the PbYUCCA4 and PbNCED6 promoters,respectively.After the transient expression of PbRR9 in fruits,PbYUCCA4 expression was significantly upregulated,and PbNCED6 expression was significantly downregulated.This study uncovered a CPPU-induced parthenocarpy mechanism that is different from that in tomato.CPPU may upregulate PbYUCCA4 and downregulate PbNCED6 by upregulating PbRR9,thereby increasing IAA content and decreasing ABA content to ultimately induce parthenocarpy in‘Dangshansu’pear.However,because only a single time point was used and because‘botanical’and‘accessory’fruits have different structures,this conclusion is still preliminary. | Liu Cong Ting Wu Hanting Liu Huibin Wang Haiqi Zhang Guangping Zhao Yao Wen Qianrong Shi Lingfei Xu Zhigang Wang | 2020 | Horticulture Research2020，7，1： | 4 |
| 17 | Distributed Packet-Aware Routing Scheme Based on Dynamic Network Coding显示文摘In this paper, we study transmission of packets with time constraints in cooperative 5G wireless networks. As we know, the packets which are transmitted with large delay become useless and have to be dropped. In order to minimize packet dropping probability, we consider multiple transmission methods and integrate packet scheduling with adaptive network coding method selection. Firstly we introduce queue length to obtain the gain of network. Based on this, we present the dynamic coding-aware routing metric, which can increase potential coding opportunities. Moreover, we propose a distributed packet-aware transmission routing scheme based on the above routing metric, which can discover the available paths timely and efficiently. Simulation results show that the proposed method can reduce average packet dropping probability with lower computational complexity. | Yao Yu Yuhuai Peng Xiaoling Li Jinfeng Gao Xiaozhu Cong | 2016 | China Communications2016，13，10： | 4 |
| 18 | α1-AR overactivation induces cardiac inflammation through NLRP3 inflammasome activation显示文摘Acute sympathetic stress causes excessive secretion of catecholamines and induces cardiac injuries,which are mainly mediated byβ-adrenergic receptors(β-ARs).However,α1-adrenergic receptors(α1-ARs)are also expressed in the heart and are activated upon acute sympathetic stress.In the present study,we investigated whetherα1-AR activation induced cardiac inflammation and the underlying mechanisms.Male C57BL/6 mice were injected with a single dose ofα1-AR agonist phenylephrine(PE,5 or 10 mg/kg,s.c.)with or without pretreatment withα-AR antagonist prazosin(5 mg/kg,s.c.).PE injection caused cardiac dysfunction and cardiac inflammation,evidenced by the increased expression of inflammatory cytokine IL-6 and chemokines MCP-1 and MCP-5,as well as macrophage infiltration in myocardium.These effects were blocked by prazosin pretreatment.Furthermore,PE injection significantly increased the expression of NOD-like receptor protein 3(NLRP3)and the cleavage of caspase-1(p20)and interleukin-18 in the heart;similar results were observed in both Langendorff-perfused hearts and cultured cardiomyocytes following the treatment with PE(10μM).Moreover,PE-induced NLRP3 inflammasome activation and cardiac inflammation was blocked in Nlrp3-/-mice compared with wild-type mice.In conclusion,α1-AR overactivation induces cardiac inflammation by activating NLRP3 inflammasomes. | Jun-zhou Xin Ji-min Wu Guo-min Hu Hui-jun Gu Ye-nan Feng Shuai-xing Wang Wen-wen Cong Ming-zhe Li Wen-li Xu Yao Song Han Xiao You-yi Zhang Li Wang | 2020 | Acta Pharmacologica Sinica2020，41，3： | 4 |
| 19 | Extension Protocol for the Investigation on Nutrition Status and Clinical Outcome of Patients with Common Cancers in China(INSCOC)Study:2021 update显示文摘Background Malnutrition is common in patients with cancer,and this adversely affects the survival and quality of life of patients.Chinese Society for Nutritional Oncology issued a multi-center,large-scale,long-term follow-up prospective study,the Investigation on Nutrition Status and Clinical Outcome of Patients with Common Cancers in China(INSCOC study)since 2013.This is an extension to the previous 2013-2020 study protocol.This study still sought to:①address the prognostic impact of nutritional factors and quality of life on cancer patient survival;②describe the overall and cancer-specific incidence and/or distribution of malnutrition and different measurements of patient quality of life.Methods and study design This is an observational,multi-centered,hospital-based prospective cohort study.Data collection will be performed at baseline(within 48 hours after patient admission),during the hospital stay and 30 days after hospital admission.Follow-up will be conducted for 1-20 years after enrollment.The primary outcome will be the all-cause mortality/overall survival,and secondary outcomes will be the length of hospital stay and costs of hospitalization.Study factors will include demographic characteristics,tumor characteristics,information about chronic diseases,hematological measurements(e.g.,red blood cell count,total lymphocyte counts,hemoglobin,albumin,prealbumin,creatinine,C-reactive protein,IL-6),anthropometric measurements(e.g.,height,weight,arm circumference,arm muscle circumference,triceps skinfold thickness,and waist circumference),body composition parameters,PG-SGA scores,quality of life(as indicated by the QLQ-C30 questionnaire),muscle mass(as indicated by the calf circumference),muscle strength(as indicated by the handgrip strength),muscle function(as indicated by the six-meter walking speed test)and physical status assessments(as indicated by the Karnofsky Performance Status scores).This clinical study protocol was approved by local Ethics Committees of all the participating hospitals.Written informed consent is required for each subject included.Discussion This multi-center,large-scale,long-term follow up prospective study will help improve the diagnosis of malnutrition in cancer patients and identify the risk factors associated with adverse clinical outcomes.The anticipated results of this study will highlight the need for a truly scientific appraisal of nutrition therapy in Chinese oncology populations,and finally help treat the potentially reversible elements of malnutrition in cancer patients to improve their clinical outcomes in the future. | Hong Xia Xu Chun Hua Song Liang Yu Yin Chang Wang Zhen Ming Fu Zeng Qing Guo Yuan Lin Ying Ying Shi Wen Hu Yi Ba Su Yi Li Zeng Ning Li Kun Hua Wang Jing Wu Ying He Jia Jun Yang Cong Hua Xie Fu Xiang Zhou Xin Xia Song Gong Yan Chen Wen Jun Ma Su Xia Luo Zi Hua Chen Zhi Kang Chen Ming Hua Cong Hu Ma Chun Ling Zhou Wei Wang Qi Luo Yong Mei Shi Yu Mei Qi Hai Ping Jiang Wen Xian Guan Jun Qiang Chen Xiang Hua Wu Jia Xin Chen Yu Fang Lan Zhou Yong Dong Feng Rong Shao Tan Tao Li Jun Wen Ou Qing Chuan Zhao Jian Xiong Wu Min Weng Qing Hua Yao Ya Yin Yu Quan Jun Lyu Hong Qiu Ming Liu Wei Li Han Ping Shi The Investigation on Nutrition Status and Clinical Outcome of Common Cancers(INSCOC)Group | 2022 | Journal of Nutritional Oncology2022，7，2： | 3 |
| 20 | FOLFIRINOX for locally advanced and metastatic pancreatic cancer: single institution retrospective review of efficacy and toxicity显示文摘 | Krishna S. Gunturu Xiaopan Yao Xiangyu Cong Jaykumar R. Thumar Howard S. Hochster Stacey M. Stein Jill Lacy | 2013 | Medical Oncology2013，，1： | 3 |
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