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| 1 | 5-Hydroxymethylcytosine signatures in circulating cell-free DNA as diagnostic biomarkers for human cancers显示文摘象 5-methylcytosine (5mC ) 和 5-hydroxymethylcytosine (5hmC ) 那样的 DNA 修正是知道在哺乳动物影响全球基因表示的 epigenetic 标记。在人的染色体,与基因表示的靠近的关联和高化学的稳定性给他们的流行,这些 DNA epigenetic 标记能为癌症用作理想的 biomarkers 诊断。利用一种高度敏感、选择的化学标记技术,我们这里报导在传播没有房间的 DNA ( cfDNA )并且在从最近与 colorectal 诊断的 260 个病人的一个队收集的配对的肿瘤和邻近的纸巾的 genomic DNA ( gDNA )的 5hmC 的染色体宽的介绍,胃,胰腺,从 90 个健康个人的肝或甲状腺癌症和正常纸巾。5hmC 主要在与开的染色质和容许的 histone 修正重合的 transcriptionally 活跃的区域被散布。柔韧的联系癌症的 5hmC 签名在 cfDNA 被识别为特定的癌症类型是特征的。传播 cfDNA 的 5hmC 底 biomarkers colorectal 和胃的癌症是高度预兆的并且比常规 biomarkers 优异并且比得上从织物活体检视的 5hmC biomarkers。因此,这新策略能从血样品的分析为癌症的诊断和预后导致有效、最低限度地侵略的方法的发展。 | Wenshuai Li Xu Zhang Xingyu Lu Lei You Yanqun Song Zhongguang Luo Jun Zhang Ji Nie Wanwei Zheng Diannan Xu Yaping Wang Yuanqiang Dong Shulin Yu Jun Hong Jianping Shi Hankun Hao Fen Luo Luchun Hua Peng Wang Xiaoping Qian Fang Yuan Lianhuan Wei Ming Cui Taiping Zhang Quan Liao Menghua Dai Ziwen Liu Ge Chen Katherine Meckel Sarbani Adhikari Guifang Jia Marc B Bissonnette Xinxiang Zhang Yupei Zhao Wei Zhang Chuan He Jie Liu | 2017 | Cell Research2017，27，10： | 30 |
| 2 | RNA interference targeting CD147 inhibits metastasis and invasion of human breast cancer MCF-7 cells by downregulating MIVIP-9/VEGF expression显示文摘 | Fang Li Junping Zhang Jiqiang Guo Yuan Jia Yaping Han Zhuanhua Wang | 2018 | Acta Biochimica et Biophysica Sinica2018，50，7： | 7 |
| 3 | The effect of V-Nb on the growth of austenite grains in 17CrNiMo6 gear steel显示文摘This study researches the effect of V-Nb on the growth of austenite grains in 17CrNiMo6 carburized gear steel.Results show that the carbonitride in V and Nb acts as second-phase particles in the steel,which can be used to block the migration of grain boundaries and the thinning of the austenite grains.This causes the crystals in the V-Nb microalloy 17CrNiMo6 steel to coarsen and the temperature to rise,thus reducing the cost of the carbonization that follows processing on the gears. | Zhao Yaping Wang Maoqiu Yuan Jiguo | 2008 | Baosteel Technical Research2008，2，2： | 5 |
| 4 | Preliminary observation results of the Coherent Beacon Systemonboard the China Seismo-Electromagnetic Satellite-1显示文摘This paper reports, for the first time, observation results of the Coherent Beacon System(CBS) onboard the China SeismoElectromagnetic Satellite-1(CSES-1). We describe the CBS, and the Computerized Ionospheric Tomography(CIT) algorithm program is validated by numerical experiment. Two examples are shown, for daytime and nighttime respectively. The Equatorial Ionization Anomaly(EIA) can be seen, and the northern crest core is located at ~20°N in the reconstruction image at 07:28 UTC on 20 July 2018(daytime).Disturbances are shown in the reconstruction image at 18:40 UTC on 13 July 2018(nighttime). We find that beacon measurements are more consistent with ionosonde measurements than model results, by comparing Nm F2 at three sites at Lanzhou, Chongqing, and Kunming; consistency with ionosonde measurements validates beacon measurements. Finally, we have studied Vertical Total Electron Content(VTEC) variations from ground to ~500 km(the height of CSES-1 orbit) and ratios of VTEC between beacon measurements and CODE(Center for Orbit Determination in Europe) data. VTEC variation from ground to ~500 km has a range of 7.2–16.5 TECU for the daytime case and a range of 1.1–1.7 TECU for the nighttime case. The Beacon/CODE ratio of VTEC varies with latitude and time. The mean Beacon/CODE ratio is 0.69 for the daytime case and 0.26 for the nighttime case. The fact that the nighttime case yields lower ratios indicates the higher altitude of the ionosphere during nighttime when the ionosphere is assumed to be a thin layer. | Liang Chen Ming Ou YaPing Yuan Fang Sun Xiao Yu WeiMin Zhen | 2018 | Earth and Planetary Physics2018，2，6： | 3 |
| 5 | Phylogenetic relationship and morphological evolution in the subfamily Limenitidinae(Lepidoptera:Nymphalidae)显示文摘mitochondrial 细胞色素氧子单元我(COI ) 基因和原子延伸因子 1 α(EF-1 α) 基因从 Nymphalidae 的 29 种类被定序(Nymphalidae,鳞翅目) 。种系发生的树基于从 29 种类决定的序列和在 GenBank 扔用的另外的 36 种类的序列被构造加入邻居(NJ ) ,最大的可能性(ML ) 和有 Libythea celtis (Libytheinae ) 的贝叶斯的方法作为外集团。我们的种系发生的树显示了四主要 clades。Clade A 包括三个亚科:Apaturinae, Nymphalinae,和 Limenitidinae,排除部落 Limenitidini;Clade B 包括亚科 Heliconiinae 和部落 Limenitidini;Clade C 包括 Satyrinae, Calinaginae, Charaxinae 和 Morphinae;并且 Clade D 包括亚科 Danainae。我们的学习建议部落 Pseudergolini, Biblidini, Limenitidini 和 Cyrestidini 应该被看作亚科并且在亚科 Pseudergolinae 以内证实了种间的关系,也就是 Amnosia +(Pseudergolis +(Stibochiona + Dichorragia )) 。我们然后印射三个词法字符(从后部的翅膀的外部边缘的肛门角度,视觉器官,和过程的点) 到 ML 分析用联合顺序数据构造的种系发生的树上。把这些词法人物的进化模式基于这被识别,他们显示三个人物在家庭 Nymphalidae 反复演变。 | Min Zhang Yang Zhong Tianwen Cao Yupeng Geng Yuan Zhang Ke Jin Zhumei Ren Rui Zhang Yaping Guo Enbo Ma | 2008 | Progress in Natural Science:Materials International2008，18，11： | 2 |
| 6 | Genomic and transcriptomic analysis unveils population evolution and development of pesticide resistance in fall armyworm Spodoptera frugiperda显示文摘The fall armyworm(FAW),Spodoptera frugiperda,is a destructive pest native to America and has recently become an invasive insect pest in China.Because of its rapid spread and great risks in China,understanding of FAW genetic background and pesticide resistance is urgent and essential to develop effective management strategies.Here,we assembled a chromosome-level genome of a male FAW(SFynMstLFR)and compared re-sequencing results of the populations from America,Africa,and China.Strain identification of 163 individuals collected from America,Africa and China showed that both C and R strains were found in the American pop-ulations,while only C strain was found in the Chinese and African populations.Moreover,population geno-mics analysis showed that populations from Africa and China have close relationship with significantly genetic differentiation from American populations.Taken toge-ther,FAWs invaded into China were most likely origi-nated from Africa.Comparative genomics analysis displayed that the cytochrome p450 gene family is extremely expanded to 425 members in FAW,of which 283 genes are specific to FAW.Treatments of Chinese populations with twenty-three pesticides showed the variant patterns of transcriptome profiles,and several detoxification genes such as AOX,UGT and GST spe-cially responded to the pesticides.These findings will be useful in developing effective strategies for manage-ment of FAW in China and other invaded areas. | Furong Gui Tianming Lan Yue Zhao Wei Guo Yang Dong Dongming Fang Huan Liu Haimeng Li Hongli Wang Ruoshi Hao Xiaofang Cheng Yahong Li Pengcheng Yang Sunil Kumar Sahu Yaping Chen Le Cheng Shuqi He Ping Liu Guangyi Fan Haorong Lu Guohai Hu Wei Dong Bin Chen Yuan Jiang Yongwei Zhang Hanhong Xu Fei Lin Bernard Slippers Alisa Postma Matthew Jackson Birhan Addisie Abate Kassahun Tesfaye Aschalew Lemma Demie Meseret Destaw Bayeleygne Dawit Tesfaye Degefu Feng Chen Paul K.Kuria Zachary M.Kinyua Tong-Xian Liu Huanming Yang Fangneng Huang Xin Liu Jun Sheng Le Kang | 2022 | Protein & Cell2022，13，7： | 2 |
| 7 | Extremely low penetrance of deafness associated with the mitochondrial 12S rRNA mutation in 16 Chinese families: Implication for early detection and prevention of deafness显示文摘 | Pu Dai Xin Liu Dongyi Han Yaping Qian Deliang Huang Huijun Yuan Weiming Li Fei Yu Ruining Zhang Hongyan Lin Yong He Youjun Yu Quanzhu Sun Huaiyi Qin Ronghua Li Xin Zhang Dongyang Kang Juyang Cao Wie-Yen Young Min-Xin Guan | 2005 | Biochemical and Biophysical Research Communications2005，，1： | 2 |
| 8 | Electrochemical hydrogen storage performance of AB_(5-)CoB composites synthesized by a simple mixing method显示文摘AB5 (MlNi4.0Al0.3Cu0.5Zn0.2) alloy and CoB alloy were prepared by arc melting. AB5-CoB composites were synthesized by simple mixing of AB5 alloy powders and CoB alloy powders, and their electrochemical hydrogen storage properties were studied as negative electrodes in KOH aqueous solution. The maximum discharge capacity of the AB5-CoB(50%) composite (the content of CoB in the composite is 50 wt.%) reached 365.3 mAh·g-1. After 100 charge-discharge cycles, the discharge capacity of the AB5-CoB(50%) composite was still much higher than that of the AB5 alloy. The high rate discharge capability (HRD) and potentiodynamic polarization were also tested. | SONG Dawei WANG Yijing WANG Yaping JIAO Lifang YUAN Huatang | 2009 | Rare Metals2009，28，6： | 2 |
| 9 | Effects on Decreasing Upper-Limb Poststroke Muscle Tone Using Transcranial Direct Current Stimulation: A Randomized Sham-Controlled Study显示文摘 | Dongyu Wu Long Qian Richard D. Zorowitz Lei Zhang Yaping Qu Ying Yuan | 2013 | Archives of Physical Medicine and Rehabilitation2013，，1： | 1 |
| 10 | Adenocarcinoma transformed into squamous cell carcinoma in non-small cell lung cancer显示文摘Non-small cell lung cancer(NSCLC)is the most common form of lung cancer which remains the deadliest malignancy worldwide(Siegel et al.,2019).In general,NSCLC can be divided into several subtypes,including adenocarcinoma(ADC),squamous cell carcinoma(SCC),adeno-squamous cell carcinoma(AD-SCC)and large cell carcinoma(LCC). | Yueqiang Jiang Jun Zhang Jin Feng Yaping Lu Yuan Fan Ling Cheng Xin Liao Liya Hu Shiying Yu Tiejun Yin | 2021 | Journal of Genetics and Genomics2021，48，7： | 1 |
| 11 | Identification of liver metastasis-associated genes in human colon carcinoma by mRNA profiling显示文摘Objective: Liver metastasis,which contributes substantially to high mortality,is the most common recurrent mode of colon carcinoma.Thus,it is necessary to identify genes implicated in metastatic colonization of the liver in colon carcinoma.Methods: We compared mRNA profiling in 18 normal colon mucosa(N),20 primary tumors(T) and 19 liver metastases(M) samples from the dataset GSE49355 and GSE62321 of Gene Expression Omnibus(GEO) database.Gene ontology(GO) and pathways of the identified genes were analyzed.Co-expression network and proteinprotein interaction(PPI) network were employed to identify the interaction relationship.Survival analyses based on The Cancer Genome Atlas(TCGA) database were used to further screening.Then,the candidate genes were validated by our data.Results: We identified 22 specific genes related to liver metastasis and they were strongly associated with cell migration,adhesion,proliferation and immune response.Simultaneously,the results showed that C-X-C motif chemokine ligand 14(CXCL14) might be a favorable prediction factor for survival of patients with colon carcinoma.Importantly,our validated data further suggested that lower CXCL14 represented poorer outcome and contributed to metastasis.Gene set enrichment analysis(GSEA) showed that CXCL14 was negatively related to the regulation of stem cell proliferation and epithelial to mesenchymal transition(EMT).Conclusions: CXCL14 was identified as a crucial anti-metastasis regulator of colon carcinoma for the first time,and might provide novel therapeutic strategies for colon carcinoma patients to improve prognosis and prevent metastasis. | Jianling Liu Dan Wang Chaoqi Zhang Zhen Zhang Xinfeng Chen Jingyao Lian Jinbo Liu Guixian Wang Weitang Yuan Zhenqiang Sun Weijia Wang Mengjia Song Yaping Wang Qian Wu Ling Cao Dong Wang Yi Zhang | 2018 | Chinese Journal of Cancer Research2018，30，6： | 1 |
| 12 | Clinical and molecular analysis of a four-generation Chinese family with aminoglycoside-induced and nonsyndromic hearing loss associated with the mitochondrial 12S rRNA C1494T mutation显示文摘 | Qiuju Wang Qing-Zhong Li Dongyi Han Yali Zhao Lidong Zhao Yaping Qian Hu Yuan Ronghua Li Suoqiang Zhai Wie-Yen Young Min-Xin Guan | 2005 | Biochemical and Biophysical Research Communications2005，，2： | 1 |
| 13 | A facile two-step synthesis and dehydrogenation properties of NaAlH 4 catalyzed with Co–B显示文摘 | Yaping Wang Qiuli Ren Yijing Wang Li Li Dawei Song Lifang Jiao Huatang Yuan | 2010 | International Journal of Hydrogen Energy2010，，20： | 1 |
| 14 | Author Correction: 5-Hydroxymethylcytosine signatures in circulating cell-free DNA as diagnostic biomarkers for human cancers显示文摘In the initial published version of this article, there was a mistake in the P value for the correlation between gene-expression changes and 5 hmC changes in tumors. The correct P value should be same as the P value shown in Fig. S6A: 9.8?×?10?6 (mistakenly shown as “9.8?×?106” in the main text). This correction does not affect the description of results or the conclusions of this study, since the range of P value is between 0 and 1. | Wenshuai Li Xu Zhang Xingyu Lu Lei You Yanqun Song Zhongguang Luo Jun Zhang Ji Nie Wanwei Zheng Diannan Xu Yaping Wang Yuanqiang Dong Shulin Yu Jun Hong Jianping Shi Hankun Hao Fen Luo Luchun Hua Peng Wang Xiaoping Qian Fang Yuan Lianhuan Wei Ming Cui Taiping Zhang Quan Liao Menghua Dai Ziwen Liu Ge Chen Katherine Meckel Sarbani Adhikari Guifang Jia Marc B Bissonnette Xinxiang Zhang Yupei Zhao Wei Zhang Chuan He Jie Liu | 2019 | Cell Research2019，29，7： | 1 |
| 15 | Regulation of B7-H1 expression on peripheral monocytes and IFN-γ secretion in T lymphocytes by HBeAg显示文摘 | Yaping Han Jun Li Longfeng Jiang Qingqing Xu Bo Liu Ke Jin Yuan Liu Zuhu Huang | 2013 | Cellular Immunology . 2013 (1-2)2013，，1： | 1 |
| 16 | Overexpression of high mobility group box 1 with poor prognosis in patients after radical prostatectomy显示文摘 | Tao Li Yaping Gui Tao Yuan Guoqiang Liao Cuidong Bian Qiquan Jiang Shengsong Huang Bo Liu Denglong Wu | 2012 | BJU International . 2012 (11c)2012，，： | 1 |
| 17 | Ceiling Degree of Polymerization for Brush Polymers Prepared via ROMP of Poly(tert-Butyl Acrylate) Macromonomers显示文摘 | QIAO Yaping YUAN Xiaoyan ZHAO Yunhui REN Lixia | 2018 | Chemical Research in Chinese Universities2018，34，5： | 1 |
| 18 | Study of the effects of total flavonoids of Astragalus on atherosclerosis formation and potential mechanisms 显示文摘 | Wang Deqing Zhuang Yuan Tian Yaping | 2012 | Oxidative medicine and cellular longevity2012，11，10： | 1 |
| 19 | A model for aircraft cabin evacuation considering passenger type显示文摘Pedestrian safety evacuation in aircraft cabins has been a challenging problem because of the aircraft’s unique characteristics,such as the diversity of passengers and the restricted evacuation environment.It is difficult to reproduce evacuation activities in aircraft cabin due to safety concerns and cost constraints.To fill this gap,an improved cellular automaton model of crowd evacuation for aircraft cabin is established by incorporating the characteristics of cabin space structures and passenger attributes.Passengers are divided into healthy individual passengers and disabled-healthy group passengers,whose movement mechanisms are quantified.Based on the constructed model,simulation experiments are conducted using the configuration cabin layout of B737-800 as an example.The results show that the evacuation time is prolonged with increased passenger density and the number of disabled passengers.Moreover,the overall evacuation time is insignificantly affected by whether disabled-healthy group passengers’seats are close to the aisle or window,and the evacuation efficiency is best when their seats are evenly distributed in the cabin.The evacuation time is the shortest when all cabin doors are open,and pedestrians are evacuated the slowest when the central emergency doors are closed.This study pro-vides valuable insights into effective strategies for pedestrian evacuation and crowd emergency management of civil aircraft. | Yaping Ma Jinfeng Yuan Lingling Tan Quanyi Liu Mengling Li | 2024 | Journal of Safety Science and Resilience2024，5，1： | 0 |
| 20 | Construction of a recombinant yeast strain converting xylose and glucose to ethanol显示文摘Candida shehatae gene xyl1 and Pichia stipitis gene xyl2,encoding xylose reductase(XR)and xylitol dehydrogenase(XD)respectively,were amplified by PCR.The genes xyl1 and xyl2 were placed under the control of promoter GAL in vector pYES2 to construct the recombinant expression vector pYES2-P12.Subsequently the vector pYES2-P12 was transformed into S.cerevisiae YS58 by LiAc to produce the recombinant yeast YS58-12.The alcoholic ferment indicated that the recombinant yeast YS58-12 could convert xylose to ethanol with the xylose consumption rate of 81.3%. | Shen TIAN Jinxin ZANG Yaping PAN Jikai LIU Zhenhong YUAN Yongjie YAN Xiushan YANG | 2008 | Frontiers in Biology2008，3，2： | 0 |
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