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| 1 | Generation and characterization of stable pig pregastrulation epiblast stem cell lines显示文摘Pig epiblast-derived pluripotent stem cells are considered to have great potential and broad prospects for human therapeutic model developme nt and livestock breeding.Despite on going attempts since the 1990s,no stably defined pig epiblast-derived stem cell line has bee n established.Here,guided by in sights from a large-scale sin gle-cell tran scriptome an alysis of pig embryos from embryonic day(E)0 to E14,specifically,the tracing of pluripotency changes during epiblast development,we developed an in vitro culture medium for establishing and maintaining stable pluripotent stem cell lines from pig E10 pregastrulation epiblasts(pgEpiSCs).Enabled by chemical inhibition of WNT-related signaling in combination with growth factors in the FGF/ERK,JAK/STAT3,and Activin/Nodal pathways,pgEpiSCs maintain their pluripotency transcriptome features,similar to those of E10 epiblast cells,and normal karyotypes after more than 240 passages and have the potential to differentiate into three germ layers.Strikingly,ultradeep in situ Hi-C analysis revealed functional impacts of chromatin 3D-spatial associations on the transcriptional regulation of pluripote ncy marker genes in pgEpiSCs.I n practice,we con firmed that pgEpiSCs readily tolerate at least three rounds of successive gene editi ng and gene rated cloned gen e-edited live piglets.Our findings deliver on the long-a nticipated promise of pig pluripote nt stem cells and open new avenues for biological research,animal husbandry,and regenerative biomedicine. | Minglei Zhi Jinying Zhang Qianzi Tang Dawei Yu Shuai Gao Dengfeng Gao Pengliang Liu Jianxiong Guo Tang Hai Jie Gao Suying Cao Zimo Zhao Chongyang Li Xiaogang Weng Mengnan He Tianzhi Chen Yingjie Wang Keren Long Deling Jiao Guanglei Li Jiaman Zhang Yan Liu Yu Lin Daxin Pang Qianqian Zhu Naixin Chen Jingjing Huang Xinze Chen Yixuan Yao Jingcang Yang Zicong Xie Xianya Huang Mengxin Liu Ran Zhang Qiuyan Li Yiliang Miao Jianhui Tian Xingxu Huang Hongsheng Ouyang Bofeng Liu Wei Xie Qi Zhou Zhonghua Liu Caihong Zheng Mingzhou Li Jianyong Han | 2022 | Cell Research2022，32，4： | 3 |
| 2 | Challenges and strategies in high-accuracy manufacturing of the world’s largest SiC aspheric mirror显示文摘In the process of manufacturing the world’s largest silicon carbide(SiC)aspheric mirror,the primary difficulties are mirror blank preparation,asphere fabrication,and testing,as well as cladding and coating.Specifically,the challenges include the homogeneity of the complicated structure casting,accuracy and efficiency of the fabrication process,print-through effect,fidelity and precision of test procedure,stress and denseness of cladding process,the dynamic range of interferometric measurement,and air turbulence error due to the long optical path.To break through such a barrier of difficulties,we proposed the water-soluble room temperature vanishing mold and gel casting technology,homogeneous microstructure reaction-formed joint technology,nano-accuracy efficient compound fabrication,gravity unloading technology,high-denseness low-defect physical vapor deposition(PVD)Si-cladding technology,test data fusion method,and time-domain averaging method,etc.Based on the proposed technologies and methods,we have accomplished the world’s largest SiC aspheric mirror with a size of φ4.03 m.The impressive performance of the SiC aspheric mirror is validated by the characteristics of the fabricated SiC aspheric mirror.The aerial density of the SiC blank is less than 120 kg/m^(2),surface shape test accuracy is better than 6 nm RMS,thickness inhomogeneity of the cladding layer is less than 5%,and the final surface figure error and roughness are 15.2 nm RMS and 0.8 nm RMS,respectively. | Xuejun Zhang Haixiang Hu Xiaokun Wang Xiao Luo Ge Zhang Wenxing Zhao Xiaoyi Wang Zhenyu Liu Ling Xiong Erhui Qi Congcong Cui Yanchao Wang Yingjie Li Xu Wang Longxiang Li Yang Bai Qiang Cheng Zhiyu Zhang Ruigang Li Wa Tang Xuefeng Zeng Weijie Deng Feng Zhang | 2022 | Light(Science & Applications)2022，11，12： | 3 |
| 3 | Latency represents sound frequency in mouse IC显示文摘Frequency is one of the fundamental parameters of sound.The frequency of an acoustic stimulus can be represented by a neural response such as spike rate,and/or first spike latency(FSL)of a given neuron.The spike rates/frequency function of most neurons changes with different acoustic ampli-tudes,whereas FSL/frequency function is highly stable.This implies that FSL might represent the fre-quency of a sound stimulus more efficiently than spike rate.This study involved representations of acoustic frequency by spike rate and FSL of central inferior colliculus(IC)neurons responding to free-field pure-tone stimuli.We found that the FSLs of neurons responding to characteristic frequency(CF)of sound stimulus were usually the shortest,regardless of sound intensity,and that spike rates of most neurons showed a variety of function according to sound frequency,especially at high intensities.These results strongly suggest that FSL of auditory IC neurons can represent sound frequency more precisely than spike rate. | QIU Qiang TANG Jie YU ZuLin ZHANG Juan ZHOU YingJie XIAO ZhongJu SHEN JunXian | 2007 | Science China(Life Sciences)2007，50，2： | 3 |
| 4 | Flat multifunctional liquid crystal elements through multi-dimensional information multiplexing显示文摘Flat optical elements have attracted enormous attentions and act as promising candidates for the next generation of optical components.As one of the most outstanding representatives,liquid crystal(LC)has been widely applied in flat panel display industries and inspires the wavefront modulation with the development of LC alignment techniques.However,most LC elements perform only one type of optical manipulation and are difficult to realize the multifunctionality and light integration.Here,flat multifunctional liquid crystal elements(FMLCEs),merely composed of anisotropic LC molecules with space-variant orientations,are presented for multichannel information manipulation by means of polarization,space and wavelength multiplexing.Specifically,benefiting from the unique light response with the change of the incident polarization,observation plane,and working wavelength,a series of FMLCEs are demonstrated to achieve distinct near-and far-field display functions.The proposed strategy takes full advantage of basic optical parameters as the decrypted keys to improve the information capacity and security,and we expect it to find potential applications in information encryption,optical anti-counterfeiting,virtual/augmented reality,etc. | Dongliang Tang Zhenglong Shao Xin Xie Yingjie Zhou Xiaohu Zhang Fan Fan Shuangchun Wen | 2023 | Opto-Electronic Advances2023，6，4： | 2 |
| 5 | Computational fluid dynamics simulation of aerosol transport and deposition显示文摘In this article computational fluid dynamics(CFD)simulation of aerosol transport and deposition,i.e.the transport and deposition of particles in an aerosol,is reviewed.The review gives a brief account of the basics of aerosol mechanics,followed by a description of the general CFD approach for flow field simulation,turbulence modeling,wall treatments and simulation of particle motion and deposition.Then examples from the literature are presented,including CFD simulation of particle deposition in human respiratory tract and particle deposition in aerosol devices.CFD simulation of particle transport and deposition may provide information that is difficult to obtain through physical experiments,and it may help reduce the number of experiments needed for device design.Due to the difficulty of describing turbulent flow and particle-eddy interaction,turbulent dispersion of particles remains one of the greatest challenges for CFD simulation.However,it is possible to take a balanced approach toward quantitative description of aerosol dispersion using CFD simulation in conjunction with empirical relations. | Yingjie TANG Bing GUO | 2011 | Frontiers of Environmental Science & Engineering2011，5，3： | 2 |
| 6 | Biomarkers of aging显示文摘Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant. | Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu | 2023 | Science China(Life Sciences)2023，66，5： | 2 |
| 7 | Immunomodulation of RAW264.7 macrophages by GLIS, a proteopolysaccharide from Ganoderma lucidum显示文摘 | Zhe Ji Qingjiu Tang Jinsong Zhang Yan Yang Wei Jia Yingjie Pan | 2007 | Journal of Ethnopharmacology2007，，3： | 1 |
| 8 | 2,3,7,8-Tetrachlorodibenzo-p-dioxin promotes migration ability of primary cultured rat astrocytes via aryl hydrocarbon receptor显示文摘Emerging evidence showed that 2,3,7,8-Tetrachlorodibenzo-p-dioxin(TCDD) could induce expression of certain reactivation-associated genes in astrocytes, however, the consequent cellular effects and molecular mechanisms are still unclear. During the process of astrocyte reactivation, migration is a critical cellular event. In the present study, we employed woundhealing assay and Transwell? motility assay to explore the effects of TCDD on cell migration in primary cultured rat cortical astrocytes. We found that upon TCDD treatments at relative low concentrations(10^(-10) and/or 10^(-9) mol/L), the ability of primary astrocytes to migrate horizontally and vertically was promoted. In line with this cellular effect, the mR NA expression of two promigratory genes, including cell division cycle 42(CDC42) and matrix metalloproteinase 2(MMP2)was induced by TCDD treatment. Dioxin exerts its toxic effects mainly through aryl hydrocarbon receptor(AhR) pathway. So the role of AhR pathway in the pro-migratory effects of TCDD was examined using an AhR antagonist, CH223191. We found that application of CH223191 significantly reversed the pro-migratory effects of TCDD. Interestingly, the basal ability of horizontal migration as well as basal levels of CDC42 and MMP2 expression were dramatically reduced suggesting a possible physiological role of AhR in maintaining the endogenous migration ability of the primary astrocytes. These findings support the notion that dioxin promotes astrocyte reactivation at molecular and cellular levels. | Yangsheng Chen Rui Sha Li Xu Yingjie Xia Yiyun Liu Xuejun Li Heidi Qunhui Xie Naijun Tang Bin Zhao | 2019 | Journal of Environmental Sciences2019，31，2： | 1 |
| 9 | Suspending Control Scheme of 8/10 Bearingless SRM Based on Adaptive Fuzzy PID Controller显示文摘As a nonlinear,strong coupling and multi-variable system,the drive performance of bearingless switched reluctance motor(BLSRM)is always limited by its complicated electromagnetic properties.Generally,conventional PID methods are used to achieve the basic control requirement in wide industrial applications,however its inherent operating principle limits its use on suspending control of BLSRM.In this paper,the suspending force system,which is separately controlled from torque system,is built based on an adaptive fuzzy PID controller to limit the rotor eccentric displacement with proper generation of radial force.When compared with a system adopted using conventional PID method for suspending force control,the proposed adaptive fuzzy PID method has superior performance in shortening the response time,reducing the maximum eccentric displacement error and higher speed range of operation due to its online self-turning of controller parameters.Both in simulation and experimental cases,comparison of results of the above two methods validates the effectiveness of the adaptive fuzzy PID controller for BLSRM drive system. | Yingjie He Ying Tang Dong-Hee Lee Jin-Woo Ahn | 2016 | Chinese Journal of Electrical Engineering2016，2，2： | 1 |
| 10 | Evaluating the mechanical properties of anisotropic shale containing bedding and natural fractures with discrete element modeling显示文摘Natural fracture data from one of the Carboniferous shale masses in the eastern Qaidam Basin were used to establish a stochastic model of a discrete fracture network and to perform discrete element simulation research on the size efect and mechanical parameters of shale.Analytical solutions of fctitious joints in transversely isotropic media were derived,which made it possible for the proposed numerical model to simulate the bedding and natural fractures in shale masses.The results indicate that there are two main factors infuencing the representative elementary volume(REV)size of a shale mass.The frst and most decisive factor is the presence of natural fractures in the block itself.The second is the anisotropy ratio:the greater the anisotropy is,the larger the REV.The bedding angle has little infuence on the REV size,whereas it has a certain infuence on the mechanical parameters of the rock mass.When the bedding angle approaches the average orientation of the natural fractures,the mechanical parameters of the shale blocks decrease greatly.The REV representing the mechanical properties of the Carboniferous shale masses in the eastern Qaidam Basin were comprehensively identifed by considering the infuence of bedding and natural fractures.When the numerical model size is larger than the REV,the fractured rock mass discontinuities can be transformed into equivalent continuities,which provides a method for simulating shale with natural fractures and bedding to analyze the stability of a borehole wall in shale. | Yingjie Li Lihong Song Yuanjun Tang Jianping Zuo Dongjie Xue | 2022 | International Journal of Coal Science & Technology2022，9，2： | 1 |
| 11 | Deep global-attention based convolutional network with dense connections for text classification显示文摘Text classification is a classic task innatural language process(NLP).Convolutional neural networks(CNNs)have demonstrated its effectiveness in sentence and document modeling.However,most of existing CNN models are applied to the fixed-size convolution filters,thereby unable to adapt different local interdependency.To address this problem,a deep global-attention based convolutional network with dense connections(DGA-CCN)is proposed.In the framework,dense connections are applied to connect each convolution layer to each of the other layers which can accept information from all previous layers and get multiple sizes of local information.Then the local information extracted by the convolution layer is reweighted by deep global-attention to obtain a sequence representation with more valuable information of the whole sequence.A series of experiments are conducted on five text classification benchmarks,and the experimental results show that the proposed model improves upon the state of-the-art baselines on four of five datasets,which can show the effectiveness of our model for text classification. | Tang Xianlun Chen Yingjie Xu Jin Yu Xinxian | 2020 | The Journal of China Universities of Posts and Telecommunications2020，27，2： | 1 |
| 12 | MicroRNA 125a and its regulation of the p53 tumor suppressor gene显示文摘 | Yingjie Zhang Jin-Song Gao Xiaoli Tang Lynne D. Tucker Peter Quesenberry Isidore Rigoutsos Bharat Ramratnam | 2009 | FEBS Letters2009，，22： | 1 |
| 13 | Preparation morpbology and mechamical properties of acrylatemodified polyurethane/unsaturated polyester resin graftIPNs显示文摘 | Tang Dongyan Qiao Yingjie Zhao Liancheng | | 0，，01： | 1 |
| 14 | Endothelin-1 Inhibits Background Two-Pore Domain Channel TASK-1 in Primary Human Pulmonary Artery Smooth Muscle Cells显示文摘 | Tang Bi Li Yingji Nagaraj Chandran Morty Rory E Gabor Sabine Stacher Elvira Voswinckel Robert Weissmann Norbert Leithner Katharina Olschewski Horst Olschewski Andrea | 2009 | American Journal of Respiratory Cell and Molecular Biology2009，，4： | 1 |
| 15 | PTB7-Th based organic solar cell with a high V_(oc) of 1.05 V by modulating the LUMO energy level of benzotriazole-containing non-fullerene acceptor显示文摘The open-circuit voltage(V_(oc))of classical photovoltaic polymers,such as P3HT and PTB7-Th,are always restricted when combining with fullerene derivatives,due to the difficulty of modulating the energy levels of fullerene derivatives.Thus,design of new non-fullerene small molecule acceptor(NFSMA)is very significant to match with these mature polymer donors and improve the V_(oc)and power conversion efficiency(PCE).Here,a new benzotriazole(BTA)-based NFSMA,BTA7 was synthesized by adopting A_2@A_1ADAA_1@A_2type molecular backbone.By using a strong electron-accepting unit of malononitrile(M)as terminal segment A_2,BTA7 demonstrates strong crystallinity,red-shifted absorption spectrum and down-shifted lowest unoccupied molecular orbital(LUMO)energy levels in comparison with BTA_1and BTA_2.Organic solar cells(OSCs)based on PTB7-Th:BTA7 realized a high V_(oc)of 1.05 V with a moderate PCE of 4.60%.The energy loss(E_(loss)=E_gàe V_(oc))of 0.53 e V is lower than the experiential minimum value of0.6 e V,which indicates PTB7-Th still has large potential to improve the V_(oc)and photovoltaic performance after the development of novel electron acceptors. | Bo Xiao Yingjie Zhao Ailing Tang Haiqiao Wang Jing Yang Erjun Zhou | 2017 | Science Bulletin2017，62，18： | 1 |
| 16 | Structural elucidation of a neutral fucogalactan from the mycelium of Coprinus comatus显示文摘 | Fan Junmin Zhang Jingsong Tang Qingjiu Liu Yanfang Zhang Anqiang Pan Yingjie | 2006 | Carbohydrate Research2006，341，9： | 1 |
| 17 | A Computational Fluid Dynamics Study of Particle Penetration through an Omni-Directional Aerosol Inlet显示文摘 | TANG YINGJIE GUO BING ANDREW R MCFARLAND | 2010 | Aerosol Science and Technology2010，，44： | 1 |
| 18 | Awareness Towards Rabies and Exposure Rate and Treatment of Dog-Bite Injuries Among Rural Residents—Guangxi Zhuang Autonomous Region,China,2021显示文摘Summary What is already known about this topic?Although fatal once clinical signs appear,rabies is preventable through three proven,effective interventions including mass dog vaccination,postexposure prophylaxis(PEP),and,though sometimes neglected,awareness of rabies.What is added by this report?The total awareness rate of rabies-related knowledge among rural residents was only 57.9%in Guangxi Zhuang Autonomous Region,one of the provinciallevel administrative divisions(PLADs)with endemic rabies in China. | Mantong Zhu Di Mu Qiulan Chen Ning Chen Yanping Zhang Wenwu Yin Yu Li Yingjie Chen Yidan Deng Xianyan Tang | 2021 | China CDC weekly2021，3，53： | 1 |
| 19 | Cardiac progenitor-derived exosomes protect ischemic myocardium from acute ischemia/reperfusion injury显示文摘 | Lijuan Chen Yingjie Wang Yaohua Pan Lan Zhang Chengxing Shen Gangjian Qin Muhammad Ashraf Neal Weintraub Genshan Ma Yaoliang Tang | 2013 | Biochemical and Biophysical Research Communications2013，，3： | 1 |
| 20 | Assessing Impacting Factors of Dog Owners’Adoption of Dog Vaccination Against Rabies:A Cross-sectional Survey in Rural Areas—Guangxi Zhuang Autonomous Region,China,2021显示文摘Summary What is already known about this topic?Rabies is fatal while preventable.More than 99%of human rabies cases were caused by dog bites worldwide.Mass dog vaccination could interrupt dogmediated rabies if achieving and maintaining a minimum coverage rate of 70%.What does this report contribute?The results of this study show that roughly 23.7%of households owned dogs in Guangxi Zhuang Autonomous Region. | Ning Chen Qiulan Chen Yanping Zhang Mantong Zhu Wenwu Yin Di Mu Yu Li Yingjie Chen Yidan Deng Xianyan Tang | 2021 | China CDC weekly2021，3，42： | 0 |
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