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| 1 | In vivo theranostics with near-infraredemitting carbon dots—highly efficient photothermal therapy based on passive targeting after intravenous administration显示文摘Carbon dots that exhibit near-infrared fluorescence(NIR CDs)are considered emerging nanomaterials for advanced biomedical applications with low toxicity and superior photostability and targeting compared to currently used photoluminescence agents.Despite progress in the synthesis of NIR CDs,there remains a key obstacle to using them as an in vivo theranostic agent.This work demonstrates that the newly developed sulfur and nitrogen codoped NIR CDs are highly efficient in photothermal therapy(PTT)in mouse models(conversion efficiency of 59%)and can be readily visualized by photoluminescence and photoacoustic imaging.The real theranostic potential of NIR CDs is enhanced by their unique biodistribution and targeting.Contrary to all other nanomaterials that have been tested in biomedicine,they are excreted through the body’s renal filtration system.Moreover,after intravenous injection,NIR CDs are accumulated in tumor tissue via passive targeting,without any active species such as antibodies.Due to their accumulation in tumor tissue without the need for intratumor injection,high photothermal conversion,excellent optical and photoacoustic imaging performance,and renal excretion,the developed CDs are suitable for transfer to clinical biomedical practice. | Xin Bao Ye Yuan Jingqin Chen Bohan Zhang Di Li Ding Zhou Pengtao Jing Guiying Xu Yingli Wang Kateřina Holá Dezhen Shen Changfeng Wu Liang Song Chengbo Liu Radek Zbořil Songnan Qu | 2018 | Light(Science & Applications)2018，7，1： | 13 |
| 2 | Differential gene expression profiling of human epidermal growth factor receptor 2- overexpressing mammary tumor显示文摘(HER2 ) 人的表皮的生长因素受体 2 高度在约 30% 乳癌病人被表示,并且实质的证据支持在 HER2 overexpression 和差的全面幸存之间的关系。然而, HER2 信号 transduction 小径的生物功能不是完全清楚的。在小径以内调查基因激活,我们屏蔽了差别在 HER2 积极的老鼠的表示基因用减少性的杂交与反向的弄污点的分析相结合的二方向性的抑制的乳房的肿瘤。与 transduction,房间 proliferation/growth/apoptosis 和 secreted/extracellular 矩阵蛋白质有关的四十基因和表示顺序标签是在 HER2 积极的乳房的肿瘤织物表示的差别。在这些之中, 19 已经被报导是在乳房的肿瘤表示的差别, 11 首先被识别是在这研究在乳房的肿瘤表示,但是是的差别已经在另外的肿瘤报导了,并且 10 与另外的癌症相关。这些基因能便于在乳癌发信号的 HER2 的角色的理解。 | Yan Wang Haining Peng Yingli Zhong Daiqiang Li Mi Tang Xiaofeng Ding Jian Zhang | 2008 | Acta Biochimica et Biophysica Sinica2008，40，5： | 1 |
| 3 | Direct regulation of caspase?3 by the transcription factor AP?2α isinvolved in aspirin?induced apoptosis in MDA?MB?453 breast cancer cells显示文摘 | Feng Yan Qiongzhi He Xiang Hu Wen Li Ke Wei Li Li Yingli Zhong Xiaofeng Ding Shuanglin Xiang Jian Zhang | 2013 | Molecular Medicine Reports2013，，3： | 1 |
| 4 | LIM domain protein TES changes its conformational states in different cellular compartments显示文摘 | Yingli Zhong Jiaolian Zhu Yan Wang Jianlin Zhou Kaiqun Ren Xiaofeng Ding Jian Zhang | 2009 | Molecular and Cellular Biochemistry . 2009 (1-2)2009，，： | 1 |
| 5 | Cryo-EM structures of PAC1 receptor reveal ligand binding mechanism显示文摘The pituitary adenylate cyclase-activating polypeptide type I receptor(PAC1R)belongs to the secretin receptor family and is widely distributed in the central neural system and peripheral organs.Abnormal activation of the receptor mediates trigeminovascular activation and sensitization,which is highly related to migraine,making PAC1R a potential therapeutic target.Elucidation of PAC1R activation mechanism would benefit discovery of therapeutic drugs for neuronal disorders.PAC1R activity is governed by pituitary adenylate cyclase-activating polypeptide(PACAP),known as a major vasodilator neuropeptide,and maxadilan,a native peptide from the sand fly,which is also capable of activating the receptor with similar potency.These peptide ligands have divergent sequences yet initiate convergent PAC1R activity.It is of interest to understand the mechanism of PAC1R ligand recognition and receptor activity regulation through structural biology.Here we report two near-atomic resolution cryo-EM structures of PAC1R activated by PACAP38 or maxadilan,providing structural insights into two distinct ligand binding modes.The structures illustrate flexibility of the extracellular domain(ECD)for ligands with distinct conformations,where ECD accommodates ligands in different orientations while extracellular loop 1(ECU)protrudes to further anchor the ligand bound in the orthosteric site.By structureguided molecular modeling and mutagenesis,we tested residues in the ligand-binding pockets and identified clusters of residues that are critical for receptor activity.The structures reported here for the first time elucidate the mechanism of specificity and flexibility of ligand recognition and binding for PACT R,and provide insights toward the design of therapeutic molecules targeting PAC1R. | Jia Wang Xianqiang Song Dandan Zhang Xiaoqing Chen Xun Li Yaping Sun Cui Li Yunpeng Song Yao Ding Ruobing Ren Essa Hu Harrington Liaoyuan AHu Wenge Zhong Cen Xu Xin Huang Hong-Wei Wang Yingli Ma | 2020 | Cell Research2020，30，5： | 1 |
| 6 | Author Correction: Cryo-EM structures of PAC1 receptor reveal ligand binding mechanism显示文摘We noticed the missing structure deposition information in our manuscript published online on February 11,2020,which are the PDB codes and EMDB map entries of the structure PACAP38-PAC1R-GS(PDB code:6M1I and EMDB entry:EMD-30048)and maxadilan-PAC1R-Gs(PDB code:6M1H and EMDB entry:EMD-30047).We apologize for any inconvenience this missing information has caused.This correction does not affect the description of the results or the conclusion of this work. | Jia Wang Xianqiang Song Dandan Zhang Xiaoqing Chen Xun Li Yaping Sun Cui Li Yunpeng Song Yao Ding Ruobing Ren Essa Hu Harrington Liaoyuan AHu Wenge Zhong Cen Xu Xin Huang Hong-Wei Wang Yingli Ma | 2020 | Cell Research2020，30，5： | 0 |
| 7 | Novel Designed PEG-Dicationic Imidazolium-Based Ionic Liquids as Effective Plasticizers for Sustainable Polylactide显示文摘A series of novel polyethylene glycol-dicationic imidazolium-based ionic liquids(mPEG-ILs)were synthesized by facile quaternization reaction from various elaborately designed di-imidazoles and PEG,which were then studied as green plasticizers for sustainable polylactide(PLA)material. | Huijie Zuo Xiangjian Chen Yingli Ding Liang Cui Baomin Fan Li Pan Kunyu Zhang | 2021 | Chinese Journal of Chemistry2021，39，8： | 0 |
| 8 | Optimising multi-vent module-based adaptive ventilation using a novel parameter for improved indoor air quality and health protection显示文摘As infectious respiratory diseases are highly transmissible through the air,researchers have improved traditional total volume air distribution systems to reduce infection risk.Multi-vent module-based adaptive ventilation(MAV)is a novel ventilation type that facilitates the switching of inlets and outlets to suit different indoor scenarios without changing ductwork layout.However,little research has evaluated MAV module sizing and air velocity selection,both related to MAV system efficiency in removing contaminants and the corresponding level of protection for occupants in the ventilated room.Therefore,the module-source offset ratio(MSOR)is proposed,based on the MAV module size and its distance from an infected occupant,to inform selection of optimal MAV module parameters.Computational fluid dynamics simulations illustrated contaminant distribution in a two-person MAV equipped office.Discrete phase particles modelled respiratory contaminants from the infected occupant,and contaminant concentration distributions were compared under four MAV air distribution layouts,three air velocities,and three module sizes considered using the MsOR.Results indicate that lower air velocities favour rising contaminant levels,provided the ventilation rate is met.Optimal contaminant discharge can be achieved when the line of outlets is located directly above the infected occupant.Using this parameter to guide MAV system design,85.7% of contaminants may be rendered harmless to the human body within 120 s using the default air vent layout.A more appropriate supply air velocity and air vent layout increases this value to 91.4%.These results are expected to inform the deployment of MAV systems to reduce airborne infection risk. | Haotian Zhang Xiaoxiao Ding Weirong Zhang Weijia Zhang Yingli Xuan | 2024 | Building Simulation2024，17，1： | 0 |
| 9 | Declines in Blood Lead Levels Among General Population-China,2000–2018显示文摘What is already known about this topic?Environmental and occupational lead exposure has generally declined in the past two decades.However,there is no large-scale monitoring of blood lead levels(BLLs)in the Chinese general population.What is added by this report?This nationally representative study showed declines of BLLs in all ages of participants;for children aged 3–5 years,down from 78.1μg/L to 16.9μg/L,corresponding to 78.4%decrease in the past two decades(2000–2018).What are the implications for public health practice?Recommendations for elevated BLLs on screening children at high risk now need to be revisited and updated from 100μg/L to 50μg/L in guidelines to conform with the substantial declines in China. | Yuebin Lyu Jing Chen Zheng Li Liang Ding Feng Zhao Yingli Qu Xulin Zheng Zheng Zhang Xiaojian Hu Saisai Ji Yifu Lu Yawei Li Yuanduo Zhu Yanwei Yang Yidan Qiu Haocan Song Wenli Zhang Bing Wu Jiayi Cai Miao Zhang Fangyu Li Ying Zhu Zhaojin Cao John Ji Xiaoyuan Yao Yuxin Zheng Xiaoming Shi | 2022 | China CDC weekly2022，4，50： | 0 |
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