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| 1 | Suppression of m6A reader Ythdf2 promotes hematopoietic stem cell expansion显示文摘 | Zhenrui Li Pengxu Qian Wanqing Shao Hailing Shi Xi C. He Madelaine Gogol Zulin Yu Yongfu Wang Meijie Qi Yunfei Zhu John M. Perry Kai Zhang Fang Tao Kun Zhou Deqing Hu Yingli Han Chongbei Zhao Richard Alexander Hanzhang Xu Shiyuan Chen Allison Peak Kathyrn Hall Michael Peterson Anoja Perera Jeffrey S. Haug Tari Parmely Hua Li Bin Shen Julia Zeitlinger Chuan He Linheng Li | 2018 | Cell Research2018，28，9： | 18 |
| 2 | Rb-Sr and Sm-Nd Isochron Ages of the Dongmozhazhua and Mohailaheng Pb-Zn Ore Deposits in the Yushu area, southern Qinghai and Their Geological Implications显示文摘Located on the northeast margin of the Qiangtang terrane between the Jinshajiang suture zone and Bangonghu-Nujiang suture zone, the Dongmozhazhua and Mohailaheng Pb-Zn deposits in the Yushu area of Qinghai Province are representative Pb-Zn deposits of the Pb-Zn-Cu polymetallic mineralization belt in the northern part of the Nujiang-Lancangjiang-Jinshajiang area, which are in the front belt of the Yushu thrust nappe system. The formed environments of these two deposits are different from those of sediment-hosted base metal deposits elsewhere in the world. The authors hold that they were formed during the Indian-Asian continental collision and developed within the foldthrust belt combined with thrust and strike-slip-related Cenozoic basins in the interior of the collisional zone. Studying on the metallogenic epochs of these two deposits is helpful to the understanding of ore-forming regularity of the regional Pb-Zn-Cu mineralization belt and also to the search for new deposits in this region. The age of the Dongmozhazhua deposit has been determined by the Rb-Sr isochron method for sphalerite residues, whereas the age of the Mohailaheng deposit has been determined by the Rb-Sr isochron method for sphalerite residues and the Sm-Nd isochron method for fluorite. The age of the Dongmozhazhua deposit is 35.0±0.0 Ma((87Sr/86Sr)0=0.708807) for sphalerite residues. The age of the Mohailaheng deposit is 32.2±0.4 Ma((87Sr/86Sr)0=0.708514) for sphalerite residues and 31.8±0.3 Ma((143Nd/144Nd)0=0.512362) for fluorite with an average of 32.0 Ma. Together with the regional geological setting during mineralization, a possible tectonic model for metallogeny of the Dongmozhazhua and Mohailaheng Pb-Zn deposits has been established. These two ages are close to the ages of the Pb-Zn deposits in the Lanping and Tuotuohe basins, indicating that it is possible that the narrow 1000-kilometer-long belt controlled by a thrust nappe system on the eastern and northern margins of the Tibetan plateau could be a giant Pb-Zn mineralized belt. | TIAN Shihong GONG Yingli YANG Zhusen HOU Zengqian LIU Yingchao SONG Yucai XUE Wanwen LU Haifeng WANG Fuchun ZHANG Yubao ZHU Tian YU Changjie | 2014 | Acta Geologica Sinica(English Edition)2014，88，2： | 8 |
| 3 | Research review of the cement sand and gravel(CSG)dam显示文摘The cement sand and gravel(CSG)dam is a new style of dam that owes the advantages both of the concrete faced rock-fill dam(CRFD)and roller compacted concrete(RCC)gravity dam,because of which it has attracted much attention of experts home and abroad.At present,some researches on physic-mechanical property of CSG material and work behavior of CSG dam have been done.This papcr introduces the development and characteristics of CSG dam systematically,and summarizes the progress of the study on basic tests,constitutive relation of CSG material and numerical analysis of CSG dam,in addition,indicates research and application aspect of the dam. | Xin CAI Yingli WU Xingwen GUO Yu MING | 2012 | Frontiers of Structural and Civil Engineering2012，6，1： | 7 |
| 4 | Models for estimating the leaf NDVI of japonica rice on a canopy scale by combining canopy NDVI and multisource environmental data in Northeast China显示文摘Remote sensing of rice traits has advanced significantly with regard to the capacity to retrieve useful plant biochemical,physiological and structural quantities across spatial scales.The rice leaf NDVI(normalized difference vegetation index)has been developed and applied in monitoring rice growth,yield prediction and disease status to guide agricultural management practices.This study combined rice canopy NDVI and environmental data to estimate rice leaf NDVI.The test site was a japonica rice experiment located in the eastern city of Shenyang,Liaoning Province,China.This paper describes(1)the use of multiple linear regression to establish four periods of rice leaf NDVI models with good accuracy(R2=0.782–0.903),and(2)how the key point of the rice growth period based on these models was determined.The techniques for modeling leaf NDVI at the point of remote canopy sensing were also presented.The results indicate that the rice leaf NDVI has a high correlation with the canopy NDVI and multisource environmental data.This research can provide an efficient method to detect rice leaf growth at the canopy scale in the future. | Yu Fenghua Xu Tongyu Cao Yingli Yang Guijun Du Wen Wang Shu | 2016 | International Journal of Agricultural and Biological Engineering2016，9，5： | 6 |
| 5 | Recent Progress of Aerosol Light-scattering Enhancement Factor Studies in China显示文摘Assessment of the radiative forcing of aerosols in models still lacks sufficient input data for aerosol hygroscopicity. The light scattering enhancement factor [ f(RH, λ)] is a crucial parameter for describing aerosol hygroscopic growth properties.In this paper, we provide a survey of f(RH, λ) studies in China for the past seven years, including instrument developments of humidified nephelometers, ambient f(RH, λ) measurements in China, f(RH, λ) parameterization schemes, and f(RH, λ)applications in aerosol measurements. Comparisons of different f(RH, λ) parameterizations are carried out to check their performance in China using field measurement datasets. We also summary the parameterization schemes for predicting f(RH, λ)with aerosol chemical compositions. The recently developed methods to observe other aerosol properties using f(RH, λ)measurements, such as calculating the aerosol hygroscopicity parameter, cloud condensation nuclei number concentration,aerosol liquid water content, and aerosol asymmetry factor, are introduced. Suggestions for further research on f(RH, λ) in China are given. | Chunsheng ZHAO Yingli YU Ye KUANG Jiangchuan TAO Gang ZHAO | 2019 | Advances in Atmospheric Sciences2019，36，9： | 5 |
| 6 | 7, 8-dihydroxycoumarin improves neurological function in a mouse model of sciatic nerve injury显示文摘In the present study, a mouse model of sciatic nerve injury was treated with intraperitoneal injection of 7, 8-dihydroxycoumarin (10, 5, or 2.5 mg/kg per day). Western blot and real-time PCR results showed that growth associated protein 43 expression was significantly increased in the L4-6 seg-ments of the spinal cord. The amplitude and velocity of motor nerve conduction in the sciatic nerve were significantly increased in model mice. In addition, the appearance of the myelin sheath in the injured sciatic nerve was regular, with an even thickness and clear outline, and the surrounding fi-broplasia was not obvious. Our results indicate that 7, 8-dihydroxycoumarin can promote the repair of injured nerve by upregulating growth associated protein 43 expression in the corresponding spinal cord segments of mice with sciatic nerve injury. | Jianshi Du Qing Zhao Yingli Zhang Yu Wang Ming Ma | 2012 | Neural Regeneration Research2012，7，6： | 2 |
| 7 | 4 - 18 Shell Effect on Subsequent Stabilization of Multi-electron Transfer in Slow Arq +-Ar ( q = 6 - 9, 11 ) Collisions显示文摘 | Lu Rongchun Yu Deyang Shao Caojie Ruan Fangfang Xue Yingli Cai Xiaohong | 2010 | IMP & HIRFL Annual Report2010，，1： | 1 |
| 8 | Metagenomic insights into the effects of submerged plants on functional potential of microbial communities in wetland sediments显示文摘Submerged plants in wetlands play important roles as ecosystem engineers to improve self-purification and promote elemental cycling.However,their effects on the functional capacity of microbial communities in wetland sediments remain poorly understood.Here,we provide detailed metagenomic insights into the biogeochemical potential of microbial communities in wetland sediments with and without submerged plants(i.e.,Vallisneria natans).A large number of functional genes involved in carbon(C),nitrogen(N)and sulfur(S)cycling were detected in the wetland sediments.However,most functional genes showed higher abundance in sediments with submerged plants than in those without plants.Based on the comparison of annotated functional genes in the N and S cycling databases(i.e.,NCycDB and SCycDB),we found that genes involved in nitrogen fixation(e.g.,nifD/H/K/W),assimilatory nitrate reduction(e.g.,nasA and nirA),denitrification(e.g.,nirK/S and nosZ),assimilatory sulfate reduction(e.g.,cysD/H/J/N/Q and sir),and sulfur oxidation(e.g.,glpE,soeA,sqr and sseA)were significantly higher(correctedp<0.05)in vegetated vs.unvegetated sediments.This could be mainly driven by environmental factors including total phosphorus,total nitrogen,and C:N ratio.The binning of metagenomes further revealed that some archaeal taxa could have the potential of methane metabolism including hydrogenotrophic,acetoclastic,and methylotrophic methanogenesis,which are crucial to the wetland methane budget and carbon cycling.This study opens a new avenue for linking submerged plants with microbial functions,and has further implications for understanding global carbon,nitrogen and sulfur cycling in wetland ecosystems. | Binhao Wang Xiafei Zheng Hangjun Zhang Xiaoli Yu Yingli Lian Xueqin Yang Huang Yu Ruiwen Hu Zhili He Fanshu Xiao Qingyun Yan | 2021 | Marine Life Science & Technology2021，3，4： | 1 |
| 9 | Observation of K- and L-REC in 200 MeV/u Xe54+ N2 collisions at HIRFL-CSR显示文摘 | Yu Deyang Xue Yingli Shao Cajie | 2011 | Nuclear Instruments and Methods in Physics Research B2011，269，7： | 1 |
| 10 | Sulfur poisoning resistant mesoporous Mn-base catalyst for low-temperature SCR of NO with NH3显示文摘 | Yu Jian Guo Feng Wang Yingli Zhu Jianhong Liu Yunyi Su Fabing Gao Shiqiu Guangwen Xu | | 0，，： | 1 |
| 11 | JaponiconeA induces apoptosis of bortezomib-sensitive and -resistant myeloma cells in vitro and in vivo by targeting IKKβ显示文摘Objective:Multiple myeloma(MM)remains incurable with high rates of relapse.New therapeutic drugs are therefore urgently needed to improve the prognosis.JaponiconeA(JA),a natural product isolated from Inula japonica Thunb,has shown good anti-MM potential.A comprehensive study should therefore be conducted to identify both the in vitro and in vivo mechanisms of the anti-MM effects of JA.Methods:CCK8 assays and flow cytometry were used to detect the proliferation,apoptosis,and cell cycle of MM cell lines when treated with JA.In vivo experiments were conducted using subcutaneous xenograft mouse models.We also identified possible targets and the mechanism of JA using RNA-seq and c-Map databases,and identified the specific targets of JA in bortezomib-sensitive and-resistant MM cell lines using CETSA,DARTS,and rescue experiments.Furthermore,JA and bortezomib were used separately or together to characterize their possible synergistic effects.Results:In vitro,JA inhibited proliferation,and induced apoptosis and G2/M phase arrest in MM cell lines,and selectively killed primary CD138+MM cells.In vivo,JA also demonstrated a strong anti-tumor effect with no observable toxicity.In addition,JA showed synergetic effects in combination with bortezomib,and enhanced the anti-tumor effect of bortezomib in bortezomibresistant cells.CETSA and DARTS confirmed direct binding of JA to NF-κB inhibitor kinase beta(IKKβ),and overexpression of IKKβor knockdown of IκBαpartially rescued the apoptosis induced by JA.Conclusions:JA exhibited strong anti-tumor effects in MM.It sensitized myeloma cells to bortezomib and overcame NF-κB-induced drug resistance by inhibiting IKKβ,providing a new treatment strategy for MM patients. | Zilu Zhang Chenjing Ye Jia Liu Wenbin Xu Chao Wu Qing Yu Xiaoguang Xu Xinyi Zeng Huizi Jin Yingli Wu Hua Yan | 2022 | Cancer Biology & Medicine2022，19，5： | 1 |
| 12 | Variable valence Mo^(5+)/Mo^(6+)ionic bridge in hollow spherical g-C_(3)N_(4)/Bi_(2)MoO_(6) catalysts for promoting selective visible light-driven CO_(2)photoreduction into CO显示文摘Herein,the catalysts of ultrathin g-C_(3)N_(4)surface-modified hollow spherical Bi2MoO6(g-C_(3)N_(4)/Bi2MoO6,abbreviated as CN/BMO)were fabricated by the co-solvothermal method.The variable valence Mo^(5+)/Mo^(6+)ionic bridge in CN/BMO catalysts can boost the rapid transfer of photogenerated electrons from Bi2MoO6to g-C_(3)N_(4).And the synergy effect of g-C_(3)N_(4)and Bi2MoO6components remarkably enhance CO_(2)adsorption capability.CN/BMO-2 catalyst has the best performances for visible light-driven CO_(2)reduction compared with single Bi2MoO6and g-C_(3)N_(4),i.e.,its amount and selectivity of CO product are 139.50μmol g-1and 96.88%for 9 h,respectively.Based on the results of characterizations and density functional theory calculation,the photocatalytic mechanism for CO_(2)reduction is proposed.The high-efficient separation efficiency of photogenerated electron-hole pairs,induced by variable valence Mo^(5+)/Mo^(6+)ionic bridge,can boost the rate-limiting steps(COOH*-to-CO*and CO*desorption)of selective visible light-driven CO_(2)conversion into CO.It inspires the establishment of efficient photocatalysts for CO_(2)conversion. | Wenjie He Yuechang Wei Jing Xiong Zhiling Tang Yingli Wang Xiong Wang Hui Xu Xiao Zhang Xiaolin Yu Zhen Zhao Jian Liu | 2023 | Journal of Energy Chemistry2023，，5： | 1 |
| 13 | Total aralosides of aralia elata (Miq) seem (TASAES) ameliorate nonalcoholic steatohepatitis by modulating IRE1α-mediated JNK and NF-κB pathways in ApoE–/– mice显示文摘 | Yun Luo Xi Dong Yingli Yu Guibo Sun Xiaobo Sun | 2015 | Journal of Ethnopharmacology2015，，： | 1 |
| 14 | MicroRNA-146a negatively regulates PTGS2 expression induced by Helicobacter pylori in human gastric epithelial cells显示文摘 | Zhen Liu Di Wang Yongliang Hu Guoyong Zhou Chaohui Zhu Qi Yu Yingchun Chi Yingli Cao Chiyu Jia Quanming Zou | 2013 | Journal of Gastroenterology2013，，1： | 1 |
| 15 | Total aralosides of aralia elata (Miq) seem (TASAES) ameliorate nonalcoholic steatohepatitis by modulating IREla-mediated JNK and NF- KB pathways in ApoE-/- mice显示文摘 | LUO Yun DONG Xi YU Yingli | 2015 | Journal of Ethnopharma- cology2015，163，： | 1 |
| 16 | Progress in the Study of the Left Atrial Function Index in Cardiovascular Disease:A Literature Review显示文摘Some studies have shown that left ventricular structure and function play an important role in the risk stratifi cation and prognosis of cardiovascular disease.The clinical application of left atrial function in cardiovascular disease has gradually attracted attention in the cardiovascular fi eld.There are many traditional methods to evaluate left atrial function.Left atrial function related indexes measured by echocardiography has been identifi ed as a powerful predictor of cardiovascular disease in recent years,but they have some limitations.The left atrial function index has been found to evaluate left atrial function more effectively than traditional parameters.Furthermore,it is a valuable predictor of the risk stratifi cation and prognosis in patients with clinical cardiovascular disease such as heart failure,atrial fi brillation,hypertension,and coronary heart disease. | Pei Huang Yi Zhang Yi Tang Qinghua Fu Zhaofen Zheng Xiaoyan Yang Yingli Yu | 2021 | Cardiovascular Innovations and Applications2021，，2： | 1 |
| 17 | In vitro/vivo assessment of praziquantel nanocrystals: Formulation, characterization, and pharmacokinetics in beagle dogs显示文摘To investigate the impact of particle size on in vitro/vivo performance of praziquantel(PZQ), nanocrystals(NCs) and microcrystals(MCs) of PZQ were prepared using the methods of wet milling and jet milling, respectively. PZQ NCs and MCs were characterized with dynamic light scattering, laser particle size analyzer, transmission electron microscopy, differential scanning calorimetry, X-ray powder diffraction and fourier transform infrared spectroscopy. The average diameters of PZQ NCs and MCs were 364.4 nm and 3.7 μm, respectively. No change in crystalline form was observed. Dissolution tests were performed in two different media, where the cumulative dissolution and dissolution rate of NCs were significantly improved in comparison with those of MCs and KANGQING~? in non-sink condition. Similarly, oral bioavailability of PZQ NCs in beagle dogs was 1.68( P < 0.05) and 1.83 fold( P < 0.01) higher than that of MCs and KANGQING~? . Considering the advantages of in vitro/vivo performance and facile preparation, PZQ NCs may have a great application in the treatment of schistosomiasis. | Ruyi Yang Tao Zhang Jiang Yu Yan Liu Yingli Wang Zhonggui He | 2019 | Asian Journal of Pharmaceutical Sciences2019，14，3： | 1 |
| 18 | Lipid nanomaterials-based RNA therapy and cancer treatment显示文摘We summarize the most important advances in RNA delivery and nanomedicine.We describe lipid nanoparticle-based RNA therapeutics and the impacts on the development of novel drugs.The fundamental properties of the key RNA members are described.We introduced recent advances in the nanoparticles to deliver RNA to defined targets,with a focus on lipid nanoparticles(LNPs).We review recent advances in biomedical therapy based on RNA drug delivery and state-of-the-art RNA application platforms,including the treatment of different types of cancer.This review presents an overview of current LNPs based RNA therapies in cancer treatment and provides deep insight into the development of future nanomedicines sophisticatedly combining the unparalleled functions of RNA therapeutics and nanotechnology. | Xingcai Zhang Luo Hai Yibo Gao Guocan Yu Yingli Sun | 2023 | Acta Pharmaceutica Sinica B2023，13，3： | 1 |
| 19 | Effects of plant protection UAV-based spraying on the vertical distribution of droplet deposition on Japonica rice plants in Northeast China显示文摘In order to study the regularity of the vertical distribution of droplet deposition on rice plants during pesticide spraying operated by a low-flying multi-rotor plant protection unmanned aviation vehicle(UAV),water-sensitive spray cards were placed on the leaves at the top,in the middle,and at the bottom of rice plants to acquire data on droplet deposition.In this study,a suspension containing tricylazole and hexaconazole was used in the spraying.The water-sensitive spray cards were analyzed by the droplet deposition processing software iDAS to obtain the vertical distribution of the droplets sprayed by the plant protection UAV.The results showed that (1)significant variation was found in the coverage of the droplets in different vertical positions of the rice plants.Within the effective spray width,the best coverage of the droplets was found in the area just below the rotors,whereas the coverage of areas farther away from the rotors was poor.For the different vertical positions of the rice plants,the overall droplet coverage was 58.38%at the top,33.55%in the middle,and 11.34%at the bottom of the plants;(2)for all vertical positions,the average size of the droplets ranged between 110μm and 140μm,which was suitable for the control of plant diseases and insect pests.The highest droplet density was found at the top of the plants,and the distribution of the droplet density was similar in the middle and at the bottom of the rice plants;(3)the diffusion ratio at the top of the rice plants(0.84)was better than that in the middle(0.57)and at the bottom(0.37).The overall relative span could meet the requirements for the actual application.Except for the position in the middle of the plants,the relative span for the other positions of the plants was over 0.67,which is the standard value.This study demonstrated the distribution regularity of droplet deposition along with the vertical direction of rice plants during UAV-based spraying,which is of guiding significance for the use of UAVs in plant protection,the improvement of chemical utilization efficiency,and the reduction of pesticide and fertilizer pollution. | Yingli Cao Fenghua Yu Tongyu Xu Wen Du Zhonghui Guo Haiyan Zhang | 2021 | International Journal of Agricultural and Biological Engineering2021，14，5： | 1 |
| 20 | Research review of the cement sand and gravel(CSG)dam显示文摘 | Xin CAI Yingli WU Xingwen GUO Yu MING | | 0，，01： | 1 |
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