|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Humoral immune response to circulating SARS-CoV-2 variants elicited by inactivated and RBD-subunit vaccines显示文摘SARS-CoV-2 variants could induce immune escape by mutations on the receptor-binding domain(RBD)and N-terminal domain(NTD).Here we report the humoral immune response to circulating SARS-CoV-2 variants,such as 501Y.V2(B.1.351),of the plasma and neutralizing antibodies(NAbs)elicited by CoronaVac(inactivated vaccine),ZF2001(RBD-subunit vaccine)and natural infection.Among 86 potent NAbs identified by high-throughput single-cell VDJ sequencing of peripheral blood mononuclear cells from vaccinees and convalescents,near half anti-RBD NAbs showed major neutralization reductions against the K417N/E484K/N501Y mutation combination,with E484K being the dominant cause.VH3-53/VH3-66 recurrent antibodies respond differently to RBD variants,and K417N compromises the majority of neutralizing activity through reduced polar contacts with complementarity determining regions.In contrast,the 242–244 deletion(242–244Δ)would abolish most neutralization activity of anti-NTD NAbs by interrupting the conformation of NTD antigenic supersite,indicating a much less diversity of anti-NTD NAbs than anti-RBD NAbs.Plasma of convalescents and CoronaVac vaccinees displayed comparable neutralization reductions against pseudo-and authentic 501Y.V2 variants,mainly caused by E484K/N501Y and 242–244Δ,with the effects being additive.Importantly,RBD-subunit vaccinees exhibit markedly higher tolerance to 501Y.V2 than convalescents,since the elicited anti-RBD NAbs display a high diversity and are unaffected by NTD mutations.Moreover,an extended gap between the third and second doses of ZF2001 leads to better neutralizing activity and tolerance to 501Y.V2 than the standard three-dose administration.Together,these results suggest that the deployment of RBD-vaccines,through a third-dose boost,may be ideal for combating SARS-CoV-2 variants when necessary,especially for those carrying mutations that disrupt the NTD supersite. | Yunlong Cao Ayijiang Yisimayi Yali Bai Weijin Huang Xiaofeng Li Zhiying Zhang Tianjiao Yuan Ran An Jing Wang Tianhe Xiao Shuo Du Wenping Ma Liyang Song Yongzheng Li Xiang Li Weiliang Song Jiajing Wu Shuo Liu Xuemei Li Yonghong Zhang Bin Su Xianghua Guo Yangyang Wei Chuanping Gao Nana Zhang Yifei Zhang Yang Dou Xiaoyu Xu Rui Shi Bai Lu Ronghua Jin Yingmin Ma Chengfeng Qin Youchun Wang Yingmei Feng Junyu Xiao Xiaoliang Sunney Xie | 2021 | Cell Research2021，31，7： | 12 |
| 2 | Immobilization of lead in anthropogenic contaminated soils using phosphates with/without oxalic acid显示文摘Understanding the effects of oxalic acid(OA) on the immobilization of Pb(Ⅱ) in contaminated soils by phosphate materials, has considerable benefits for risk assessment and remediation strategies for the soil. A series of phosphate amendments with/without oxalic acid were applied to two anthropogenic contaminated soils. We investigated the immobilization of Pb(Ⅱ) by KH2PO4, phosphate rock(PR), activated phosphate rock(APR) and synthetic hydroxyapatite(HAP) at different phosphate:Pb(P:Pb) molar ratios(0, 0.6, 2.0 and 4.0) in the presence/absence of 50 mmol oxalic acid/kg soil, respectively. The effects of treatments were evaluated using single extraction with deionized water or Ca Cl2, Community Bureau of Reference(BCR) sequential extraction and toxicity characteristic leaching procedure(TCLP)methods. Our results showed that the concentration of water extractable, exchangeable and TCLP-Pb all decreased with incubation time. The concentration of water-extractable Pb after120 days was reduced by 100% when soils were amended with APR, HAP and HAP + OA, and the TCLP-Pb was <5 mg/L for the red soil at P:Pb molar ratio 4.0. Water-soluble Pb could not be detected and the TCLP-Pb was <5 mg/L at all treatments applied to the yellow-brown soil. BCR results indicated that APR was most effective, although a slight enhancement of water-soluble phosphate was detected at the P:Pb molar ratio 4.0 at the beginning of incubation. Oxalic acid activated phosphates, and so mixing insoluble phosphates with oxalic acid may be a useful strategy to improve their effectiveness in reducing Pb bioavailability. | Xiaojuan Su Jun Zhu Qingling Fu Jichao Zuo Yonghong Liu Hongqing Hu | 2015 | Journal of Environmental Sciences2015，27，2： | 9 |
| 3 | Microclimatic characteristics of the Heihe oasis in the hyperarid zone of China显示文摘The microclimate of a desert oasis in hyperarid zone of China was monitored using micrometeorological methods and compared with those of areas adjacent to forested land. Differences in ground-level photosynthetically active radiation (PAR) on clear, cloudy and dust storm days and their subtending causes are analysed and discussed. Desert oases serve the ecological functions of altering solar radiation, adjusting near-ground and land surface temperatures, reducing soil temperature differences, lowering wind velocity, and increasing soil and atmospheric humidity. The total solar radiation in the interior of the oasis was roughly half of that outside a forest canopy. During the growing season, air temperatures in Populus euphratica Oliv. (poplar) and Tamarix ramosissima Ledeb. (tamarisk) forests were 1.62 °C and 0.83 °C lower respectively than those in the areas around the forests. Furthermore, the taller the forest cover, the greater the temperature drops; air temperatures in the upper storey were greater than those in the lower storey, i.e., air temperature rose with increasing height. Over the growing season, the relative humidities of the air in the poplar and tamarisk forests were 8.5% and 4.2% higher respectively than those in areas around the forests. Mean wind velocity in poplar-forested lands was 0.33 m s-1, 2.31 m s-1 lower than that in the surrounding area. During dust storm days the PAR was significantly lower than that on cloudy or clear days, when it was high and varied in an irregular manner. | FENG Qi SI Jianhua ZHANG Yanwu YAO Jiming LIU Wei SU Yonghong | 2006 | Journal of Geographical Sciences2006，16，1： | 4 |
| 4 | Contents Variation Analysis ofγ-Amino Butyric Acid in Semen sojae praeparatum Fermentation Using Online Pre-Column Derivatization-HPLC显示文摘This paper reported the contents variation analysis ofγ-amino butyric acid(GABA)in Semen sojae praeparatum(SSP)which is a famous traditional Chinese medicine.High performance liquid chromatography(HPLC)was used and GABA was derivatized by online pre-column derivatization with o-phthalaldehyde(OPA).To validate this method,the precision,stability,repeatability and recovery were discussed.In the concentration range from 0.0125 to 0.400 mg/m L,the calibration curve for GABA was linear and the regression equation was obtained with correlation coefficient(R2)of 0.9999.Relatively high levels of GABA exist in SSP and the content changes of GABA at different time points during the fermenting process were detected.At the'yellow cladding'stage,GABA level was very low or even undetectable;the'secondary fermentation'stage witnessed a rapid increase of GABA content to 1.39-5.52 mg/g,which remained stable after 18 days of'secondary fermentation'.This study demonstrated that GABA was generated at the'secondary fermentation'stage,revealing the significance and rationality of the'secondary fermentation'stage in the fermenting process of SSP.On the other hand,it suggested the downside of taking soy isoflavones as the only measurement in existing quality assessment and optimization approach for the fermenting process of SSP. | WENG Meizhi HE Jing REN Jiaxiu LIANG Yonghong CHEN Qingfeng SU Mingsheng WANG Liyuan XIE Xiaomei | 2021 | Wuhan University Journal of Natural Sciences2021，26，1： | 2 |
| 5 | Sap-flow measurement and scale transferring from sample trees to entire forest stand of Populus euphratica in desert riparian forest in extreme arid region显示文摘Understanding how the transpiration of this vegetation type responds to environmental stress is important for determining the wa-ter-balance dynamics of the riparian ecosystem threatened by groundwater depletion. Transpiration and sap flow were measured using the heat-pulse technique. The results were then projected up to the stand level to investigate the stand's water-use in relation to climate forcing in the desert riparian forest in an extreme arid region. This study took place from April through October 2003 and from May through October 2004. The experimental site was selected in the Populus euphratica Forest Reserve (101o10' E, 41o59' N) in Ejina county, in the lower Heihe River basin, China. The sapwood area was used as a scalar to extrapolate the stand-water consumption from the whole trees' water consumption measured by the heat-pulse velocity recorder (HPVR). Scale transferring from a series of individual trees to a stand was done according to the existing natural variations between trees under given environmental conditions. The application of the biometric parameters available from individual tree and stand levels was proved suitable for this purpose. A significant correlation between the sapwood area and tree diameter at breast height (DBH) was found. The prediction model is well fitted by the power model. On the basis of the prediction model, the sapwood area can be cal-culated by DBH. The sap-flow density can then be used to extrapolate the stand-water use by means of a series of mathematical models. | JianHua Si 1, Qi Feng 1, HaiYang Xi 1, ZongQiang Chang 1, YongHong Su 1, Kai Zhang 1,2 1. Cold and Arid Regions Environmental and Engineering Research Institute, Chinese Academy of Sciences, Lanzhou, Gansu 730000, China. 2. Institute of Arid Meteorology, China Meteorological Administration, Lanzhou, Gansu 730020, China. | 2009 | Research in Cold and Arid Regions2009，1，3： | 2 |
| 6 | Environmental iso-topic and hydrochemical study of groundwater in the Ejina Basin, northwest China 显示文摘 | Su Yonghong Zhu Gaofeng Feng Qi | 2009 | Environmental Geology2009，58，3： | 1 |
| 7 | Estimating actual evapotranspiration from an alpine grassland on Qinghai-Tibetan plateau using a two-source model and parameter uncertainty analysis by Bayesian approach显示文摘 | Gaofeng Zhu Yonghong Su Xin Li Kun Zhang Changbin Li | 2013 | Journal of Hydrology2013，，： | 1 |
| 8 | Modeling of hysteresis in piezoelectric actuators using neural networks 显示文摘 | Zhang Xinliang Tan Yonghong Su Miyong | 2009 | Mechanical Systems and Signal Processing2009，23，： | 1 |
| 9 | Modelling evapo- transpiration in an alpine grassland ecosystem on Qinghai-Tibetan Plateau 显示文摘 | Zhu Gaofeng Su Yonghong Li Xin | 2014 | Hydrological Processes2014，28，3： | 1 |
| 10 | Estimating actual e- vapotranspiration from an alpine grassland on Qinghai-Tibetan Plateau using a two-source model and parameter uncertainty anal- ysis by Bayesian approach 显示文摘 | Zhu Gaofeng Su Yonghong Li Xin | 2013 | Journal of Hydrology2013，476，： | 1 |
| 11 | The hydrochemical characteristics and evolution of groundwater and surface water in the Heihe River Basin, northwest China 显示文摘 | ZHU Gaofeng SU Yonghong FENG Qi | 2008 | Hydrogeology Journal2008，16，： | 1 |
| 12 | Immobilization of lead in anthropogenic contaminated soils using phosphates with/without oxalic acid显示文摘 | Xiaojuan Su Jun Zhu Qingling Fu Jichao Zuo Yonghong Liu Hongqing Hu | 2014 | Journal of Environmental Sciences2014，，： | 1 |
| 13 | Major ion chemistry of groundwater in the extreme arid region northwest China显示文摘 | Si Jianhua Feng Qi Wen Xiaohu Su Yonghong Xi Haiyang Chang Zongqiang | 2009 | Environmental Geology2009，，5： | 1 |
| 14 | Non-growing season soil CO_2 efflux and its changes in an alpine meadow ecosystem of the Qilian Mountains,Northwest China显示文摘Most soil respiration measurements are conducted during the growing season.In tundra and boreal forest ecosystems,cumulative,non-growing season soil CO2 fluxes are reported to be a significant component of these systems' annual carbon budgets.However,little information exists on soil CO2 efflux during the non-growing season from alpine ecosystems.Therefore,comparing measurements of soil respiration taken annually versus during the growing season will improve the accuracy of estimating ecosystem carbon budgets,as well as predicting the response of soil CO2 efflux to climate changes.In this study,we measured soil CO2 efflux and its spatial and temporal changes for different altitudes during the non-growing season in an alpine meadow located in the Qilian Mountains,Northwest ChinaField experiments on the soil CO2 efflux of alpine meadow from the Qilian Mountains were conducted along an elevation gradient from October 2010 to April 2011.We measured the soil CO2 efflux,and analyzed the effects of soil water content and soil temperature on this measure.The results show that soil CO2 efflux gradually decreased along the elevation gradient during the non-growing season.The daily variation of soil CO2 efflux appeared as a single-peak curve.The soil CO2 efflux was low at night,with the lowest value occurring between 02:00-06:00.Then,values started to rise rapidly between 07:00-08:30,and then descend again between 16:00-18:30.The peak soil CO2 efflux appeared from 11:00 to 16:00.The soil CO2 efflux values gradually decreased from October to February of the next year and started to increase in March.Non-growing season Q10(the multiplier to the respiration rate for a 10℃ increase in temperature) was increased with raising altitude and average Q10 of the Qilian Mountains was generally higher than the average growing season Q10 of the Heihe River Basin.Seasonally,non-growing season soil CO2 efflux was relatively high in October and early spring and low in the winter.The soil CO2 efflux was positively correlated with soil temperature and soil water content.Our results indicate that in alpine ecosystems,soil CO2 efflux continues throughout the non-growing season,and soil respiration is an important component of annual soil CO2 efflux. | ZongQiang CHANG XiaoQing LIU Qi FENG ZongXi CHE HaiYang XI YongHong SU JianHua SI | 2013 | Journal of Arid Land2013，5，4： | 1 |
| 15 | An Improved Turn-On Aptasensor for Thrombin Detection Using Split Aptamer Fragments and Graphene Oxide显示文摘为凝血酵素察觉使用的改进刺激 aptasensor 切开了 aptamer 碎片和 graphene 氧化物(去) 被报导。凝血酵素绑定 aptamer (Apt15 ) 被分成为目标识别,用荧光黄(FAM-Apt-A ) 标记的一个 8 底序列和 7 底 oligonucleotide 的二部分定序(Apt-B ) 。当目标蛋白质不在时, FAM-Apt-A/Apt-B 的荧光被熄灭由通过 Π-Π 叠在之间去并且搁浅单人赛的 DNA。不管多么当凝血酵素被介绍进系统时,一有二裂口 aptamer 碎片和凝血酵素的导致目标的 G 四倍的形式。荧光由于在之间的弱相互作用恢复了 G 四倍并且去。用未经触动的 aptamer 比作策略,探查集中被降低,并且改进敏感被获得。而且,加热过程避免相反的第二等的结构由于更短的裂口 aptamer 碎片的使用被避免。 | Xingfen Liu Yonghong Yang Xiaoxiao Hua Xiaomiao Feng Shao Su Yanqin Huang Quli Fan Lianhui Wang Wei Huang | 2015 | Chinese Journal of Chemistry2015，33，8： | 1 |
| 16 | Nucleosome?binding protein HMGN2 exhibits antitumor activity in oralsquamous cell carcinoma显示文摘 | Ankang Hu Xiaoqian Dong Xiqian Liu Ping Zhang Yonghong Zhang Ning Su Qianming Chen Yun Feng | 2014 | Oncology Letters2014，，1： | 1 |
| 17 | The hydrochemical char- acteristics and evolution of groundwater and surface water in the Heihe River Basin, northwest China显示文摘 | Zhu Gaofeng Su Yonghong Feng Qi | 2008 | Hydrogeology Jour- nal2008，16，1： | 1 |
| 18 | Neural networks based identification and compensation of rate-dependent hysteresis in piezoelectric actuators显示文摘 | Xinliang Zhang Yonghong Tan Miyong Su Yangqiu Xie | 2010 | Physica B: Physics of Condensed Matter2010，，12： | 1 |
| 19 | The Disastrous 23 July 2009 Debris Flow in Xiangshui Gully, Kangding County, Southwestern China显示文摘On 23 July 2009, a catastrophic debris flows were triggered by heavy rainfall in Xiangshui gully, Kangding county, southwestern China. This debris flow originating shortly after a rainstorm with an intensity of 28 mm per hour transported a total volume of more than 480×103 m3 debris, depositing the poorly sorted sediment including boulders up to 2-3 m in diameter both onto an existing debris fans and into the river. Our primary objective for this study was to analyze the characteristics of the triggering rainfall and the debris supply conditions, and to estimate debris-flow volume, mean velocity, and discharge. A comparison with adjacent rain-gage records indicates that debris flows in this setting can be produced in response to as little as 17 mm/hour or 3.5 mm/10-minute of rainfall intensity with relatively lower amount of cumulative antecedent rainfall. The field measurement and the interpretation of the Worldview image indicate that abundant landslides occurred on steep slopes within areas underlain by highly weathered granite. Using empirical equations that combine flow depth and channel slope, the mean velocity and discharge of the debris flow were estimated to be 9.2 m/s and 2150 m3/s, respectively. The results contribute to a better understanding of the conditions leading to catastrophic debris flows. | TANG Chuan YANG Yonghong SU Yongchao DING Jun HUANG Wenjie | 2011 | Journal of Mountain Science2011，8，2： | 1 |
| 20 | Influence of environmental,root,and stand parameters on soil surface CO_2 efflux in a Populus euphratica of desert forest in extreme arid region显示文摘Spatial variation in soil surface CO2 efflux was measured in a stand of Populus euphratica in the Ejina Oasis of desert riparian forest in the extreme arid region in northwestern China from April 2007 through October 2007.Measurements were taken with a gas-exchange analyzer linked to a soil-respiration chamber.The mean soil CO2 efflux in the stand was 2.71 μmol/(m2·s) during the growing season and 1.38 μmol/(m2·s) in the nongrowing season.The seasonal maximum (end of May through early June) andminimum (October) CO2 efflux were 3.38 and 0.69 μmol/(m2·s),respectively.The diurnal fluctuation of CO2 efflux was relatively small (< 20 percent),with theminimum appearing around 05:00 and the maximum around 15:00.Linear regression analysis showed soil-surface CO2 efflux to be most highly correlated with soil temperature (R2=0.435) and soil moisture (R2=0.213).When all variables were considered simultaneously,only soil temperature (R2=0.378),soil moisture (R2=0.147),and root volume density (R2=0.021) explained a significant amount of variance in soil surface CO2 efflux.Stand volumes were not correlated with soil CO2 efflux on our sites. | ZongQiang Chang,Qi Feng,YongHong Su,JianHua Si, HaiYang Xi,ShengKui Cao,Rui Guo Alashan Desert Eco-Hydrology Experimental Research Station,Cold and Arid Regions Environmental and Engineering Research Institute,Chinese Academy of Sciences,Lanzhou 730000,China. | 2009 | Research in Cold and Arid Regions2009，1，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员