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| 1 | Development of a Haploid-Inducer Mediated Genome Editing System for Accelerating Maize Breeding显示文摘Crop breeding aims to generate pure in bred lines with multiple desired traits. Doubled haploid (DH) and genome editing using CRISPR/Cas9 are two powerful game-changing technologies in crop breeding. However, both of them still fall short for rapid generation of pure elite lines with integrated favorable traits. Here, we report the development of a Haploid-Inducer Mediated Genome Editing (IMGE) approach, which utilizes a maize haploid inducer line carrying a CRISPR/Cas9 cassette targeting for a desired agronomic trait to pollinate an elite maize in bred line and to generate genome-edited haploids in the elite maize background. Homozygous pure DH lines with the desired trait improvement could be generated within two generations, thus bypassing the lengthy procedure of repeated crossing and backcrossing used in conventional breeding for integrating a desirable trait into elite commercial backgrounds. | Baobao Wang Lei Zhu Binbin Zhao Yongping Zhao Yurong Xie Zhigang Zheng Yaoyao Li Juan Sun Haiyang Wang | 2019 | Molecular Plant2019，12，4： | 32 |
| 2 | Eco-environment range in the source regions of the Yangtze and Yellow rivers显示文摘Based on geographical and hydrological extents delimited, four principles are identified, as the bases for delineating the ranges of the source regions of the Yangtze and Yellow rivers in the paper. According to the comprehensive analysis of topographical characteristics, climate conditions, vegetation distribution and hydrological features, the source region ranges for eco-environmental study are defined. The eastern boundary point is Dari hydrological station in the upper reach of the Yellow River. The watershed above Dari hydrological station is the source region of the Yellow River which drains an area of 4.49×10 4 km 2 . Natural environment is characterized by the major topographical types of plateau lakes and marshland, gentle landforms, alpine cold semi-arid climate, and steppe and meadow vegetation in the source region of the Yellow River. The eastern boundary point is the convergent site of the Nieqiaqu and the Tongtian River in the upstream of the Yangtze River. The watershed above the convergent site is the source region of the Yangtze River, with a watershed area of 12.24×10 4 km 2 . Hills and alpine plain topography, gentle terrain, alpine cold arid and semi-arid climate, and alpine cold grassland and meadow are natural conditions in the source region of the Yangtze River. | DING Yongjian,YANG Jianping,LIU Shiyin,CHEN Rensheng,WANG Genxu,SHEN Yongping,WANG Jian,XIE Changwei,ZHANG Shiqing(Cold and Arid Regions Environmental and Engineering Research Institute, CAS, Lanzhou 730000, China) | 2003 | Journal of Geographical Sciences2003，13，2： | 18 |
| 3 | FHY3 and FAR1 Integrate Light Signals with the miR156-SPL Module-Mediated Aging Pathway to Regulate Arabidopsis Flowering显示文摘In response to competition for light from their neighbors,shade-intolerant plants flower precociously to ensure reproductive success and survival.However,the molecular mechanisms underlying this key developmental switch are not well understood.Here,we show that a pair of Arabidopsis transcription factors essential for phytochrome A signaling,FAR-RED ELONGATED HYPOCOTYL3(FHY3)and FAR-RED IMPAIRED RESPONSE1(FAR1),regulate flowering time by integrating environmental light signals with the miR156-SPL module-mediated aging pathway.We found that FHY3 and FAR1 directly interact with three flowering-promoting SQUAMOSA-PROMOTER BINDING PROTEIN-LIKE(SPL)transcription factors,SPL3,SPL4,and SPL5,and inhibit their binding to the promoters of several key flowering regulatory genes,including FRUITFUL(FUL),LEAFY(LFY),APETALA1(AP1),and MIR172C,thus downregulating their transcript levels and delaying flowering.Under simulated shade conditions,levels of SPL3/4/5 proteins increase,whereas levels of FHY3 and FAR1 proteins decline,thus releasing SPL3/4/5 from FHY3/FAR1 inhibition to allow activation of FUL,LFY,AP1,and MIR172C and,consequently,early flowering.Taken together,these results unravel a novel mechanism whereby plants regulate flowering time by integrating environmental cues(such as light conditions)and an internal developmental program(the miR156-SPL module-mediated aging pathway). | Yurong Xie Qin Zhou Yongping Zhao Quanquan Li Yang Liu Mengdi Ma Baobao Wang Rongxin Shen Zhigang Zheng Haiyang Wang | 2020 | Molecular Plant2020，13，3： | 8 |
| 4 | Modeling permafrost properties in the Qinghai-Xizang(Tibet) Plateau显示文摘Water and heat dynamics in the active layer at a monitoring site in the Tanggula Mountains, located in the permafrost region of the Qinghai-Xizang(Tibet) Plateau(QXP), were studied using the physical-process-based COUPMODEL model, including the interaction between soil temperature and moisture under freeze-thaw cycles. Meteorological, ground temperature and moisture data from different depths within the active layer were used to calibrate and validate the model. The results indicate that the calibrated model satisfactorily simulates the soil temperatures from the top to the bottom of the soil layers as well as the moisture content of the active layer in permafrost regions. The simulated soil heat flux at depths of 0 to 20 cm was consistent with the monitoring data, and the simulations of the radiation balance components were reasonable. Energy consumed for phase change was estimated from the simulated ice content during the freeze/thaw processes from 2007 to 2008. Using this model, the active layer thickness and the energy consumed for phase change were predicted for future climate warming scenarios. The model predicts an increase of the active layer thickness from the current 330 cm to approximately 350–390 cm as a result of a 1–2°C warming. However, the effect active layer thickness of more precipitation is limited when the precipitation is increased by 20%–50%. The COUPMODEL provides a useful tool for predicting and understanding the fate of permafrost in the QXP under a warming climate. | HU GuoJie ZHAO Lin WU XiaoDong LI Ren WU TongHua XIE ChangWei PANG QiangQiang XIAO Yao LI WangPing QIAO YongPing SHI JianZong | 2015 | Science China Earth Sciences2015，58，12： | 7 |
| 5 | An analytical model for estimating soil temperature profiles on the Qinghai-Tibet Plateau of China显示文摘Soil temperature is a key variable in the control of underground hydro-thermal processes. To estimate soil temperature more accurately, this study proposed a solution method of the heat conduction equation of soil temperature(improved heat conduction model) by applying boundary conditions that incorporate the annual and diurnal variations of soil surface temperature and the temporal variation of daily temperature amplitude, as well as the temperature difference between two soil layers in the Tanggula observation site of the Qinghai-Tibet Plateau of China. We employed both the improved heat conduction model and the classical heat conduction model to fit soil temperature by using the 5 cm soil layer as the upper boundary for soil depth. The results indicated that the daily soil temperature amplitude can be better described by the sinusoidal function in the improved model, which then yielded more accurate soil temperature simulating effect at the depth of 5 cm. The simulated soil temperature values generated by the improved model and classical heat conduction model were then compared to the observed soil temperature values at different soil depths. Statistical analyses of the root mean square error(RMSE), the normalized standard error(NSEE) and the bias demonstrated that the improved model showed higher accuracy, and the average values of RMSE, bias and NSEE at the soil depth of 10–105 cm were 1.41°C, 1.15°C and 22.40%, respectively. These results indicated that the improved heat conduction model can better estimate soil temperature profiles compared to the traditional model. | HU Guojie ZHAO Lin WU Xiaodong LI Ren WU Tonghua XIE Changwei QIAO Yongping SHI Jianzong CHENG Guodong | 2016 | Journal of Arid Land2016，8，2： | 4 |
| 6 | Surface-deformation monitoring in the permafrost regions over the Tibetan Plateau,using Sentinel-1 data显示文摘Differential Interferometric Synthetic Aperture Radar(D-In SAR) has been widely used to measure surface deformation over the Tibetan Plateau. However, the accuracy and applicability of the D-In SAR method are not well estimated due to the lack of in-situ validation. In this paper, we mapped the seasonal and long-term displacement of Tanggula(TGL) and Liangdaohe(LDH) permafrost regions with a stack of Sentinel-1 acquisitions using the Small Baseline Subset In SAR(SBAS-In SAR) method. In the TGL region, with its dry soils and sparse vegetation, the In SAR-derived surface-deformation trend was consistent with ground-based leveling results; long-term changes of the active layer showed a settlement rate of around 1 to 3 mm/a due to the melting of ground ice, indicating a degrading permafrost in this area. Around half of the deformation was picked up on monitoring, in contrast with in-situ measurements in LDH, implying that the D-In SAR method remarkably underestimated the surface-deformation. This phenomenon may be induced by the large soil-water content, high vegetation coverage, or a combination of these two factors in this region. This study demonstrates that surface deformation could be mapped accurately for a specific region with Sentinel-1 C-band data, such as in the TGL region.Moreover, although the D-In SAR technology provides an efficient solution for broad surface-deformation monitoring in permafrost regions, it shows a poor performance in the region with high soil-water content and dense vegetation coverage. | ZhenMing Wu Lin Zhao Lin Liu Rui Zhu ZeShen Gao YongPing Qiao LiMing Tian HuaYun Zhou MeiZhen Xie | 2018 | Research in Cold and Arid Regions2018，10，2： | 2 |
| 7 | Identification of NBS-Type Resistance Gene Homologs in Tobacco Genome显示文摘 | Xiaodong Leng Bingguang Xiao Sheng Wang Yijie Gui Yu Wang Xiuping Lu Jiahua Xie Yongping Li Longjiang Fan | 2010 | Plant Molecular Biology Reporter2010，，1： | 1 |
| 8 | A comparative study of pattern synchronization detection between neural signals using different cross-entropy measures显示文摘 | Xie Hongbo Guo Jingyi Zheng Yongping | 2010 | Biological Cybernetics2010，102，2： | 1 |
| 9 | Multi-drug resistant Pseudomonas aeruginosa resistance and resistance gene detection analysis显示文摘 | XIE Yongping LUN Xiuhong HE Jiaying | 2012 | Chin J Mieroeeol2012，24，4： | 1 |
| 10 | Effect of surface modification on microwave absorbing properties of magnetic metal fibers显示文摘 | Wei Xie Ph D Candidate Haifeng Cheng Zengyong Chu Yongjiang Zhou Gengping Tang Yongping Xu | 2007 | Journal of Wuhan University of Technology - Mater Sci Ed2007，，2： | 1 |
| 11 | Classification of the mechanomyogram signal using awavelet packet transform and singular valuedecomposition for multifunction prosthesis control显示文摘 | XIE Hongbo ZHENG Yongping GUO Jingyi | 2009 | Physiological Measurement2009，30，5： | 1 |
| 12 | MicroRNA-281 regulates the expression of ecdysone receptor (EcR) isoform B in the silkworm, Bombyx mori显示文摘 | Jianhao Jiang Xie Ge Zhiqian Li Yueqiang Wang Qisheng Song David W. Stanley Anjiang Tan Yongping Huang | 2013 | Insect Biochemistry and Molecular Biology2013，，8： | 1 |
| 13 | Growth and spectral properties of Er^3+ : GdVO4 crystal显示文摘 | Xiong Wei Lin Shukun Xie Yongping | 2004 | Journal of Crystal Growth2004，263，： | 1 |
| 14 | Developmental and reproductive characteristics of western mosquito fish(Gambusia affinis)exposed to paper mill effluent in the Dengcun River,Sihui,South China显示文摘 | Liping Hou Yongping Xie Guangguo Ying | 2011 | Aquatic Toxicology2011，103，34： | 1 |
| 15 | Overcoming cancer therapeutic bottleneck by drug repurposing显示文摘Ever present hurdles for the discovery of new drugs for cancer therapy have necessitated the development of the alternative strategy of drug repurposing,the development of old drugs for new therapeutic purposes.This strategy with a cost-effective way offers a rare opportunity for the treatment of human neoplastic disease,facilitating rapid clinical translation.With an increased understanding of the hallmarks of cancer and the development of various data-driven approaches,drug repurposing further promotes the holistic productivity of drug discovery and reasonably focuses on target-defined antineoplastic compounds.The“treasure trove”of non-oncology drugs should not be ignored since they could target not only known but also hitherto unknown vulnerabilities of cancer.Indeed,different from targeted drugs,these old generic drugs,usually used in a multi-target strategy may bring benefit to patients.In this review,aiming to demonstrate the full potential of drug repurposing,we present various promising repurposed non-oncology drugs for clinical cancer management and classify these candidates into their proposed administration for either mono-or drug combination therapy.We also summarize approaches used for drug repurposing and discuss the main barriers to its uptake. | Zhe Zhang Li Zhou Na Xie Edouard CNice Tao Zhang Yongping Cui Canhua Huang | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 1 |
| 16 | Classif- ication of the mechanomyogram signal using a wavelet packet transform and singular value decomposition for multifunction prosthesis control显示文摘 | XIE Hongbo ZHENG Yongping GUO Jingyi | 2009 | Physiological Measurement2009，30，5： | 1 |
| 17 | Classification ofthe mechanomyogram signal using a wave-let packet trans-form and singular value deco-mposition for multifunctionprosthesis control显示文摘 | Xie Hongbo Zheng Yongping Guo Jingyi | 2009 | Physiological Measurement2009，30，5： | 1 |
| 18 | Progress of electroplating and electroless plating on Mg alloy 显示文摘 | Wu Liping Zhao Jingjing Xie Yongping | 2010 | Transactions of Nonferrous Metals Society of China2010，20，2： | 1 |
| 19 | Growth and spectral properties of Er3+:GdVO4 crystal显示文摘 | Xiong Wei Lin Shukun Xie Yongping | 2004 | Journal of Crystal Growth2004，263，： | 1 |
| 20 | Variational bounds of the effective moduli of piezoelectric composites显示文摘The classical Hashin-Shtrikman variational principle was re-generalized to the heterogeneous piezoelectric materials.The auxiliary problem is very much simplified by selecting the reference medium as a linearly isotropic elastic medium.The electromechanical fields in the inhomogeneous piezoelectrics are simulated by introducing into the homogeneous reference medium certain eigenstresses and eigen electric fields.A closed-form solution can be obtained for the disturbance fields,which is convenient for the manipulation of the energy functional.As an application,a two-phase piezoelectric composite with nonpiezoelectric matrix is considered.Expressions of upper and lower bounds for the overall electromechanical moduli of the composite can be developed.These bounds are shown better than the Voigt-Reuss type ones. | WAN YongPing XIE LongTao ZHONG Zheng | 2012 | Science China(Physics,Mechanics & Astronomy)2012，55，11： | 0 |
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