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| 1 | Chinese Stroke Association guidelines for clinical management of cerebrovascular disorders: executive summary and 2019 update of clinical management of cerebral venous sinus thrombosis显示文摘Aim Cerebral venous sinus thrombosis(CVST)is a less common cerebrovascular disease that predominantly affects young patients.The incidence of CVST is 2-5/10000000/year,accounting for 0.5%-1%of all stroke.To reduce mortality and morbidity associated with CVST,Chinese Stroke Association commissioned the authors to write the current guideline on the management of CVST.Methods PubMed(MEDLINE),CNKI and Wanfang database were searched for studies related to CVST from 1 January 1990 to 31 July 2019.Data were synthesised by evidence tables.Each recommendation was fully discussed by the writing group members and reviewed by Chinese Stroke Association Stroke Fellow Committees.Levels of evidence grading algorithm of Chinese Stroke Association was used to grade each recommendation.results This guideline mainly focuses on the diagnostic evaluation,therapeutic strategies and secondary prevention of CVST.CT/CTV and MRI/MRV are recommended in the initial imaging evaluation of patients with suspected CVST.Anticoagulation therapy with low-molecular weight heparin should be initiated in patients with CVST immediately.After the acute stage,warfarin is recommended for 3-6 months to prevent the recurrence of CVST and other venous thromboembolic events.Conclusions The guideline summarises the current evidence regarding the management of CVST,and provides references for diagnosis,treatment and secondary prevention of CVST in China. | Yuhua Fan Jian Yu Hongbing Chen Jian Zhang Jiangang Duan Dapeng Mo Wenhao Zhu Bo Wang Fubing Ouyang Yicong Chen Linfang Lan Jinsheng Zeng Chinese Stroke Association Stroke Council CVST Guideline Writing Committee | 2020 | Stroke & Vascular Neurology2020，5，2： | 14 |
| 2 | Weighted Markov chains for forecasting and analysis in Incidence of infectious diseases in jiangsu Province,China显示文摘This paper first applies the sequential cluster method to set up the classification standard of infectious disease incidence state based on the fact that there are many uncertainty characteristics in the incidence course.Then the paper presents a weighted Markov chain,a method which is used to predict the future incidence state.This method assumes the standardized self-coefficients as weights based on the special characteristics of infectious disease incidence being a dependent stochastic variable.It also analyzes the characteristics of infectious diseases incidence via the Markov chain Monte Carlo method to make the long-term benefit of decision optimal.Our method is successfully validated using existing incidents data of infectious diseases in Jiangsu Province.In summation,this paper proposes ways to improve the accuracy of the weighted Markov chain,specifically in the field of infection epidemiology. | Zhihang Peng Changjun Bao Yang Zhao Honggang Yi Letian Xia Hao Yu Hongbing Shen Feng Chen | 2010 | The Journal of Biomedical Research2010，24，3： | 10 |
| 3 | Simulated-sunlight-activated photocatalysis of Methylene Blue using cerium-doped SiO_2/TiO_2 nanostructured fibers显示文摘Cerium-doped SiO 2 /TiO 2 nanostructured fibers were fabricated by electrospinning technology.The prepared fibers were characterized by thermogravimetric analysis(TGA),scanning electron microscopy(SEM),X-ray diffraction(XRD) and Fourier transform infrared spectroscopy(FT-IR).Using the fibers as catalysts,photocatalytic degradation of Methylene Blue(MB) aqueous solution was carried out under simulated sunlight.The 0.2% Ce doping proved to be the optimal concentration for the doping of TiO 2 /SiO 2,compared to other Ce-doped molar concentrations.The 0.2% Ce-doped SiO 2 /TiO 2 fibers exhibited higher photocatalytic activity than industrial Degussa P25 and the samples doped with only Ce or SiO 2.The reasons for improving the photocatalytic activity were also discussed.Several operational parameters were studied,which showed that the photocatalytic efficiency of MB was influenced by parameters such as the initial dye concentration,the initial pH,inorganic anions,and so on.In addition,the influences of an electron acceptor and a radical scavenger suggested that OH was the dominant photooxidant during the photocatalytic process.The reuse evaluation of the fibers indicated that their photocatalytic activity had good stability. | Yu Liu Hongbing Yu Zhenning Lv Sihui Zhan Jiangyao Yang Xinhong Peng Yixuan Ren Xiaoyan Wu | 2012 | Journal of Environmental Sciences2012，24，10： | 10 |
| 4 | Carbon Dioxide Captured from Flue Gas by Modified Ca-based Sorbents in Fixed-bed Reactor at High Temperature显示文摘Four kinds of Ca-based sorbents were prepared by calcination and hydration reactions using different precursors: calcium hydroxide, calcium carbonate, calcium acetate monohydrate and calcium oxide. The CO2 absorption capacity of those sorbents was investigated in a fixed-bed reactor in the temperature range of 350-650℃. It was found that all of those sorbents showed higher capacity for CO2 absorption when the operating temperature higher than 450℃. The CaAc2-CaO sorbent showed the highest CO2 absorption capacity of 299mg·g-1. The morphology of those sorbents was examined by scanning electron microscope (SEM), and the changes of composition before and after carbonation were also determined by X-ray diffraction (XRD). Results indicated that those sorbents have the similar chemical compositions and crystalline phases before carbonation reaction [mainly Ca(OH)2], and CaCO3 is the main component after carbonation reaction. The SEM morphology shows clearly that the sorbent pores were filled with reaction products after carbonation reaction, and became much denser than before. The N2 adsorption-desorption isotherms indicated that the CaAc2-CaO and CaCO3-CaO sorbents have higher specific surface area, larger pore volume and appropriate pore size distribution than that of CaO-CaO and Ca(OH)2-CaO. | YANG Lei YU Hongbing WANG Shengqiang WANG Haowen ZHOU Qibin | 2013 | Chinese Journal of Chemical Engineering2013，21，2： | 8 |
| 5 | Prediction of length-of-day using extreme learning machine显示文摘Traditional artificial neural networks(ANN) such as back-propagation neural networks(BPNN) provide good predictions of length-of-day(LOD). However, the determination of network topology is difficult and time consuming. Therefore, we propose a new type of neural network, extreme learning machine(ELM), to improve the efficiency of LOD predictions. Earth orientation parameters(EOP) C04 time-series provides daily values from International Earth Rotation and Reference Systems Service(IERS), which serves as our database. First, the known predictable effects that can be described by functional modelsdsuch as the effects of solid earth, ocean tides, or seasonal atmospheric variationsdare removed a priori from the C04 time-series. Only the residuals after the subtraction of a priori model from the observed LOD data(i.e., the irregular and quasi-periodic variations)are employed for training and predictions. The predicted LOD is the sum of a prior extrapolation model and the ELM predictions of the residuals. Different input patterns are discussed and compared to optimize the network solution. The prediction results are analyzed and compared with those obtained by other machine learning-based prediction methods, including BPNN, generalization regression neural networks(GRNN), and adaptive network-based fuzzy inference systems(ANFIS). It is shown that while achieving similar prediction accuracy, the developed method uses much less training time than other methods. Furthermore, to conduct a direct comparison with the existing prediction techniques, the mean-absolute-error(MAE) from the proposed method is compared with that from the EOP prediction comparison campaign(EOP PCC). The results indicate that the accuracy of the proposed method is comparable with that of the former techniques. The implementation of the proposed method is simple. | Lei Yu Zhao Danning Cai Hongbing | 2015 | Geodesy and Geodynamics2015，6，2： | 5 |
| 6 | Bevacizumab biosimilar LY01008 compared with bevacizumab(Avastin)as first-line treatment for Chinese patients with unresectable,metastatic,or recurrent non-squamous non-small-cell lung cancer:A multicenter,randomized,double-blinded,phase Ⅲ trial显示文摘Background:Previous studies have demonstrated the preclinical pharmacological and toxicological consistency,and clinical pharmacokinetic equivalence of bevacizumab biosimilar LY01008 with reference bevacizumab(Avastin).This randomized controlled trial aimed to compare the efficacy and safety of LY01008 with Avastin in first-line treatment of Chinese patients with advanced or recurrent non-squamous non-small cell lung cancer(NSCLC).Methods:StageⅢB-ⅣNSCLC patients with evaluable lesions,good physical status,and adequate organ functions from 67 centers across China were randomized in a ratio of 1:1 to receive LY01008 or Avastin 15 mg/kg intravenously in combination with paclitaxel/carboplatin(combined treatment)for 4-6 cycles,followed by maintenance monotherapy with LY01008 until disease progression,intolerable toxicity,or death.The primary endpoint was objective response rate(ORR)in accordance with Response Evaluation Criteria in Solid Tumors(RECIST)version 1.1 confirmed by independent radiological review committees(IRRC).Secondary endpoints included disease control rate(DCR),duration of response(DoR),progression-free survival(PFS),overall survival(OS),and safety.This study was registered in Clinical Trials.gov(NCT03533127).Results:Between December 15^(th),2017,and May 15^(th),2019,a total of 649 patients were randomized to the LY01008(n=324)or Avastin(n=325)group.As of September 25th,2019 for primary endpoint analysis,589 patients received ORR evaluation,with a median number of combined treatment cycles of 5(range 1-6)andmedian duration of treatment of 3.0(range 0.0-5.1)months.ORRof responseevaluable patients in the LY01008 and Avastin groups were 48.5% and 53.0%,respectively.The stratified ORR ratio was 0.91(90%CI 0.80-1.04,within the prespecified equivalence margin of 0.75-1.33).Up to May 15^(th),2020,with a median follow-up of 13.6(range 0.8-28.4)months,no notable differences in DCR,median DoR,median PFS,median OS,and 1-year OS rate were observed between the LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,or recurrent non-squamous NSCLC patients in the first-line setting. | Yuankai Shi Kaijian Lei Yuming Jia Bingqiang Ni Zhiyong He Minghong Bi Xicheng Wang Jianhua Shi Ming Zhou Qian Sun Guolei Wang Dongji Chen Yongqian Shu Lianke Liu Zhongliang Guo Yong Liu Junquan Yang Ke Wang Ke Xiao LinWu Tienan Yi Debin Sun Mafei Kang Tianjiang Ma Yimin Mao Jinsheng Shi Tiegang Tang Yan Wang Puyuan Xing Dongqing Lv Wangjun Liao Zhiguo Luo Bin Wang Xiaohong Wu Xiaoli Zhu Shuhua Han Qisen Guo Rongyu Liu Zhiwei Lu Jianyong Zhang Jian Fang Changlu Hu Yinghua Ji Guolong Liu Hong Lu Dedong Wu Junhong Zhang Shuyang Zhu Zheng Liu Wensheng Qiu Feng Ye Yan Yu Yanqiu Zhao Qinhong Zheng Jun Chen Zhanyu Pan Yiping Zhang Wenjuan Lian Bo Jiang Bo Qiu Guojun Zhang Hua Zhang Yanju Chen Yuan Chen Hongbing Duan Manxiang Li Shengming Liu Lijun Ma Hongming Pan Xia Yuan Xueli Yuan Yulong Zheng Emei Gao Li Zhao Shumin Wang Can Wu | 2021 | Cancer Communications2021，41，9： | 5 |
| 7 | The calcium uniporter regulates the permeability transition pore in isolated cortical mitochondria显示文摘To investigate the influence of the mitochondrial calcium uniporter on the mitochondrial permeability transition pore, the present study observed mitochondrial morphology in cortical neurons isolated from adult rats using transmission electron microscopy, and confirmed the morphology and activity of isolated mitochondria by detecting succinic dehydrogenase and monoamine oxidase, two mitochondrial enzymes. Isolated mitochondria were treated with either ruthenium red, an inhibitor of the uniporter, spermine, an activator of the uniporter, or in combination with cyclosporin A, an inhibitor of the mitochondrial permeability transition pore. Results showed that ruthenium red inhibited CaCl2-induced mitochondrial permeability transition pore opening, spermine enhanced opening, and cyclosporin A attenuated the effects of spermine. Results demonstrated that the mitochondrial calcium uniporter plays a role in regulating the mitochondrial permeability transition pore in mitochondria isolated from the rat brain cortex. | Ning Yu Shilei Wang Peng Wang Yu Li Shuhong Li Li Wang Hongbing Chen Yanting Wang | 2012 | Neural Regeneration Research2012，7，2： | 4 |
| 8 | SOLUTION OF A CLASS OF INVESTMENT DEVELOPMENTAL EQUATIONS显示文摘The paper discusses the solution of a class of assets developmental equations. We get the existence and uniqueness of global solution, and under the constancy of state obtain the stability of solution. | JIAO Hongbing (Department of Mathematics, Hebei Teacher’s University, Shijiazhuang 050016, China) YU Jingyuan (Beijing Institute of Information and Control, Beijing 100037, China) QI Chuanda (Henan Xinyang Teacher’s College, Xinyany 464000, China) | 2000 | Systems Science and Mathematical Sciences2000，13，2： | 4 |
| 9 | A novel structure of scalable air-cathode without Nafion and Pt by rolling activated carbon and PTFE as catalyst layer in microbial fuel cells显示文摘 | Heng Dong Hongbing Yu Xin Wang Qixing Zhou Junli Feng | 2012 | Water Research2012，，17： | 3 |
| 10 | Four recombinant pluripotency transcriptional factors containing a protein transduction domain maintained the in vitro pluripotency of chicken embryonic stem cells显示文摘Long-term in vitro maintenance of embryonic stem cell (ESC) pluripotency enables the pluripotency and differentiation of ESCs in animals to be investigated. The ability to successfully maintain and differentiate chicken embryonic stem cells (cESCs) would provide a useful tool for avian biology research and would be a resource directly applicable to agricultural production. In this study, endogenous chicken pluripotency transcription factors, POUV, Sox-2, Nanog and Lin28 were cloned and expressed as recombinant proteins containing a nine consecutive arginine protein transduction domain (PTD). cESCs were cultured with these recombinant proteins to maintain cESC pluripotency in vitro. Cultured cESCs exhibited typical characteristics of pluripotency, even after six generations of rapid doubling, including positive staining for stage-specific embryonic antigen I, and strong staining for alkaline phosphatase. Expression levels of the pluripotency markers, POUV, Nanog, C-Myc, Sox-2 and Lin28 were the same as in uncultured stage X blastoderm cells, and most significantly, the formation of embryoid bodies (EBs) by 6th generation cESCs confirmed the ability of these cultured cESCs to differentiate into cells of all three embryonic germ layers. Thus, transcription factors could be translocated through the cell membrane into the intracellular space of cESCs by using a PTD of nine consecutive arginines and the pluripotency of cESCs could be maintained in vitro for at least six generations. | YU MiaoYing LIAN Song HAN HongBing YU Kun LI GuiGuan LIAN ZhengXing LI Ning | 2013 | Science China(Life Sciences)2013，56，1： | 2 |
| 11 | Interfacial defective Ti^(3+) on Ti/TiO_(2) as visible-light responsive sites with promoted charge transfer and photocatalytic performance显示文摘Defect sites on oxide semiconductors play a crucial role in promoting photocatalytiperformance and mod-ulating the bandgap structure of photocatalysts.However,the role of interfacial coordinatively unsatu-rated defect sites between metal and oxide in photocatalysis is still under debate.So,we designed an experiment to probe the role of interfacial coordinatively unsaturated defect sites.In this work,a se-ries of Ti/TiO_(2) photocatalysts with varying concentrations of interfacial Ti^(3+)sites were prepared through an epitaxial growth method under hydrothermal conditions.Through experimental and computational investigations,the roles of interfacial defect sites were discussed in detail.On the one hand,the inter-facial coordinatively unsaturated Ti^(3+)sites could act as visible-light-responsive sites in photocatalytic reactions due to the overlap and hybridization of multiple electronic orbitals.On the other hand,the Ti/TiO_(2) interface exhibited a certain degree of metallic character near the Fermi level because of the par-tial delocalization and redistribution of electrons,facilitating the charge migration and separation across the metal-oxide interface.Consequently,the obtained Ti/TiO_(2) catalysts showed notably enhanced charge transfer efficiency and visible light photocatalytic activity compared to their pristine counterparts.This work may provide a new perspective to interfacial defect engineering in classic metal/oxide heterojunc-tion photocatalysts and figure a more precise direction to synthesize higher effective photocatalysts for environmental governance. | Yangfan Zhang Yao Li Han Yu Kai Yu Hongbing Yu | 2022 | Journal of Materials Science & Technology2022，，11： | 2 |
| 12 | Nonlinear and optical limiting properties of graphenefamilies显示文摘 | Feng Miao Zhan Hongbing Chen Yu | 2010 | Applied Phy- sics Letters2010，96，03： | 1 |
| 13 | The effectsof temperature and catalysts on the pyrolysis of industrial wastes (herb residue) 显示文摘 | Wang Pan Zhan Sihui Yu Hongbing | 2010 | Bioresource Technology2010，101，9： | 1 |
| 14 | Catalysis kinetics and porous analysis of roiling activated carbon-PTFE air- cathode in microbial fuel cells 显示文摘 | Dong Heng Yu Hongbing Wang Xin | 2012 | Environmental Science and Technology2012，46，13： | 1 |
| 15 | Epoxy-POSS/silicone rubber nanocomposites with excellent thermal stability and radiation resistance显示文摘Due to the rigid Si-O-Si backbone,silicone rubber(SR)have a widespread application in extreme environment such as high temperature and high-level radiation.However,the radiation stability of SR still does not meet the practical needs in special radiation environments.Herein we prepared epoxy POSS(e POSS)/SR nanocomposites with excellent thermal stability and radiation resistance.As a physical crosslinking point in the SR,addition of small amount of ePOSS not only enhanced the mechanical properties of the matrix,but also improved its thermal stability greatly due to their good compatibility.e POSS/SR had higher radiation stability in air than SR owing to the inhibition of radiation oxidation by ePOSS,and the yield of main gaseous radiolysis products(CH_(4),H_(2),CO and CO_(2))of SR and ePOSS/SR nanocomposites was determined.By analyzing the changes of chemical structure,thermal properties and mechanical properties of the ePOSS/SR nanocomposite,combined with the characteristics of gas products afterγ-irradiation,the radiation induced crosslinking and degradation mechanism of the nanocomposites was proposed comprehensively. | Mengni Shi Yinyong Ao Lei Yu Lang Sheng Shuangxiao Li Jing Peng Hongbing Chen Wei Huang Jiuqiang Li Maolin Zhai | 2022 | Chinese Chemical Letters2022，33，7： | 1 |
| 16 | Experimental study on a hybrid photovoltaic/heat pump system显示文摘 | Chen Hongbing Saffa B R Fu Yu | 2011 | Applied Thermal Engineering2011，31，： | 1 |
| 17 | Chemical Characteristics of Precipitation at Three Chinese Regional Background Stations from 2006 to 2007 显示文摘 | Yi Li Yu Xiaolan Cheng Hongbing | 2010 | Atmospheric Research2010，69，1： | 1 |
| 18 | Improvement of the prediction accuracy of polar motion using empirical mode decomposition显示文摘Previous studies revealed that the error of pole coordinate prediction will significantly increase for a prediction period longer than 100 days, and this is mainly caused by short period oscillations. Empirical mode decomposition(EMD), which is increasingly popular and has advantages over classical wavelet decomposition, can be used to remove short period variations from observed time series of pole coordinates. A hybrid model combing EMD and extreme learning machine(ELM), where high frequency signals are removed and processed time series is then modeled and predicted, is summarized in this paper. The prediction performance of the hybrid model is compared with that of the ELM-only method created from original time series. The results show that the proposed hybrid model outperforms the pure ELM method for both short-term and long-term prediction of pole coordinates. The improvement of prediction accuracy up to 360 days in the future is found to be 24.91% and 26.79% on average in terms of mean absolute error(MAE) for the x p and y p components of pole coordinates, respectively. | Yu Lei Hongbing Cai Danning Zhao | 2017 | Geodesy and Geodynamics2017，8，2： | 1 |
| 19 | Enhanced perfor-mance and capacitance behavior of anode by rolling Fe3O4 into activated carbon in microbial fuel cells显示文摘 | Peng Xinhong Yu Hongbing Wang Xin | 2012 | Bioresource Technology2012，121，： | 1 |
| 20 | Coastal geomorphic evolution at the Denglou Cape, the Leizhou Peninsula显示文摘 | Wang Lirong(王丽荣) Zhao Huanting(赵焕庭) Song Chaojing(宋朝景) Yuan Jiayi(袁家义) Yu Hongbing(于红兵) | 2002 | Acta Oceanologica Sinica2002，21，4： | 1 |
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