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| 1 | Viral effector protein manipulates host hormone signaling to attract insect vectors显示文摘 | Dewei Wu Tiancong Qi Wan-Xiang Li Haixia Tian Hua Gao Jiaojiao Wang Jin Ge Ruifeng Yao Chunmei Ren Xian-Bing Wang Yule Liu Le Kang Shou-Wei Ding Daoxin Xie | 2017 | Cell Research2017，27，3： | 20 |
| 2 | Multi-scale image segmentation of coal piles on a belt based on the Hessian matrix显示文摘Segmenting images of coal piles on a belt is an unsolved problem in coal-based machine vision research,though it is an essential step for estimating size distribution and classifying coal.In this investigation,a new algorithm for segmenting images of coal piles on a belt is proposed.A multi-scale linear filter,constructed of a Hessian matrix and Gaussian function,forms the core of this algorithm and obtains an edge intensity image to form good seed regions for a watershed segmentation.Manual segmentation is used to define ground truth segmentation images to quantify the errors of the proposed method.Tests indicate that 12.76%of the visible regions are under- or over-segmented,and that this algorithm is feasible and effective in practical applications. | Zelin Zhang JianguoYang Xiaolan Su Lihua Ding Yuling Wang | 2013 | Particuology2013，11，5： | 9 |
| 3 | Study of peach freshness predictive method based on electronic nose显示文摘 | Hui Guohua Wu Yuling Ye Dandan Ding Wenwen Zhu Linshan Wang Lvye | 2012 | Food Control2012，，1： | 2 |
| 4 | High VHL Expression Reverses Warburg Phenotype and Enhances Immunogenicity in Kidney Tumor Cells显示文摘Clear cell renal cell carcinoma(ccRCC)is a frequently occurring renal cancer.The Von Hippel-Lindau disease tumor suppressor VHL,a known tumor suppressor gene,is frequently mutated in about 50%of patients with ccRCC.However,it is unclear whether VHL influences the progression of ccRCC tumors expressing wild-type VHL.In the present study,we found that higher expression of VHL was correlated with the better disease-free survival(DFS)in ccRCC patients using The Cancer Genome Atlas(TCGA)datasets.We revealed that VHL overexpression in ccRCC cells inhibited epithelial-mesenchymal transition(EMT),sterol regulatory elementbinding protein 1(SREBP1)-regulated triglyceride synthesis,and cell proliferation.Proteomic analysis provided us a global view that VHL regulated four biological processes,including metabolism,immune regulation,apoptosis,and cell movement.Importantly,we found that VHL overexpression led to up-regulated expression of proteins associated with antigen processing and interferonresponsive proteins,thus rendering ccRCC cells more sensitive to interferon treatment.We defined an interferon-responsive signature(IRS)composed of ten interferon-responsive proteins,whose m RNA expression levels were positively correlated with DFS in ccRCC patients.Taken together,our results propose that the subset of ccRCC patients with high VHL expression benefit from immunotherapy. | Songbiao Zhu Wenxi Ding Yuling Chen Weixuan Wang Renhua Xu Chongdong Liu Xiaohui Liu Haiteng Deng | 2022 | Genomics, Proteomics & Bioinformatics2022，20，4： | 1 |
| 5 | MicroRNA-137, a HMGA1 Target, Suppresses Colorectal Cancer Cell Invasion and Metastasis in Mice by Directly Targeting FMNL2显示文摘 | Li Liang Xianzheng Li Xiaojing Zhang Zhenbing Lv Guoyang He Wei Zhao Xiaoli Ren Yuling Li Xiuwu Bian Wenting Liao Wei Liu Guangying Yang Yanqing Ding | 2012 | Gastroenterology2012，，： | 1 |
| 6 | Improving the accuracy of genomic prediction for meat quality traits using whole genome sequence data in pigs显示文摘Background Pork quality can directly affect customer purchase tendency and meat quality traits have become valu-able in modern pork production.However,genetic improvement has been slow due to high phenotyping costs.In this study,whole genome sequence(WGS)data was used to evaluate the prediction accuracy of genomic best linear unbiased prediction(GBLUP)for meat quality in large-scale crossbred commercial pigs.Results We produced WGS data(18,695,907 SNPs and 2,106,902 INDELs exceed quality control)from 1,469 sequenced Duroc×(Landrace×Yorkshire)pigs and developed a reference panel for meat quality including meat color score,marbling score,L*(lightness),a*(redness),and b*(yellowness)of genomic prediction.The prediction accuracy was defined as the Pearson correlation coefficient between adjusted phenotypes and genomic estimated breeding values in the validation population.Using different marker density panels derived from WGS data,accuracy differed substantially among meat quality traits,varied from 0.08 to 0.47.Results showed that MultiBLUP outperform GBLUP and yielded accuracy increases ranging from 17.39%to 75%.We optimized the marker density and found medium-and high-density marker panels are beneficial for the estimation of heritability for meat quality.Moreover,we conducted genotype imputation from 50K chip to WGS level in the same population and found average concord-ance rate to exceed 95%and r^(2)=0.81.Conclusions Overall,estimation of heritability for meat quality traits can benefit from the use of WGS data.This study showed the superiority of using WGS data to genetically improve pork quality in genomic prediction. | Zhanwei Zhuang Jie Wu Yibin Qiu Donglin Ruan Rongrong Ding Cineng Xu Shenping Zhou Yuling Zhang Yiyi Liu Fucai Ma Jifei Yang Ying Sun Enqin Zheng Ming Yang Gengyuan Cai Jie Yang Zhenfang Wu | 2023 | Journal of Animal Science and Biotechnology2023，14，5： | 1 |
| 7 | A bilayer prototype vascular prosthesis with improved radial compliance显示文摘 | CHEN Ying DING Xin LI Yuling | 2012 | Journal of the Textile Institute2012，103，1： | 1 |
| 8 | The source of hydrothermal fluids for the Sarekoubu gold deposit in the southern Akai, Xinjiang, China:Evidence from fluid inclusions and geochemistry 显示文摘 | Xu Jiuhua Ding Rufu Xie Yuling | 2008 | Journal of Asian Earth Sciences2008，32，24： | 1 |
| 9 | A novel small-molecule near-infrared II fluorescence probe for orthotopic osteosarcoma imaging显示文摘Osteosarcoma is the most common primary malignant tumor of bone,particularly among children and adolescents.Advances in imaging,surgical techniques,and implants have dramatically reduced the need for amputation in the past three decades.Recently,in vivo fluorescence imaging in the second near-infrared window(NIR-II,1,000–1,700 nm)shows impressive advantages of deeper tissue penetration and higher spatial resolution,which makes it a promising tool for the early diagnosis and post-operative observation of Osteosarcoma.To the best of our knowledge,this paper is the first time to develop a novel NIR-II fluorescence probe conjugated with an osteosarcoma targeted oligopeptide for molecular tumor imaging in a xenograft orthotopic osteosarcoma mouse model. | Jiacheng Lin Qianqian Li Xiaodong Zeng Ziyang Chen Qihang Ding Yang Li Hui Zhou Xianli Meng Deliang Chen Zixin Deng Xuechuan Hong Yuling Xiao | 2020 | Science China Chemistry2020，63，6： | 1 |
| 10 | Meristem Biology Flourishes Under Mt. Tai显示文摘 | Yuling Jiao Olivier Hamant Zhaojun Ding Xian Sheng Zhang | 2016 | Molecular Plant2016，9，8： | 0 |
| 11 | Daicong solution effects on brain ultrastructure in a rat model of Alzheimer's disease显示文摘BACKGROUND: Infusion of kainic acid into the basal nuclei induces neuronal excitotoxicity, degeneration, and necrosis, resulting in disturbed learning and memory functions. OBJECTIVE: To explore the effects of different doses of traditional Chinese medicine Daicong solution on brain ultrastructure in a rat model of Alzheimer's disease. DESIGN, TIME AND SETTING: The randomized, controlled, cellular morphology experiment was performed at the Shandong Provincial Key Laboratory of Molecular Immunology of Weifang Medical University, China from October 2006 to March 2007. MATERIALS: Fifty healthy, Sprague Dawley rats, aged 22-months, were used to establish rat models of Alzheimer's disease. The Morris water maze was prepared at the Pharmacometrics Key Laboratory of Weifang Medical University in Shandong Province of China. Traditional Chinese medicine Daicong solution (crude drug 1 g/mL), composed of radix ginseng, rehmannia dried rhizome, anemarrhenae and radix astragali, was produced by the Department of Pharmacy of Hospital Affiliated to Weifang Medical University. Kainic acid was provided by Professor Xiuyan Li from Weifang Medical University. METHODS: A total of 40 model rats were equally and randomly divided into four groups: dementia model, low-dose Daicong solution (5 g/kg/d), moderate-dose Daicong solution (10 g/kg/d), and high-dose Daicong solution (20 g/kg/d). An additional 10 healthy rats served as the normal control group. Rats in the dementia model and normal control groups received saline (10 mL/kg/d). MAIN OUTCOME MEASURES: Neural cell ultrastructure was observed utilizing electron microscopy after 1 month of respective treatments. RESULTS: Compared with the normal control group, electron density and the number of ribosomes were significantly reduced in neuronal cytoplasm, and many lipofuscin grains and vacuole-like changes were observed in mitochondria in the dementia model group. In addition, nuclear chromatin presented with different sizes of plaque-shaped degenerative pathological changes. In the Alzheimer's disease rat model, neurons and neuroepithelial cells recovered to normal conditions following treatment with moderate- and high-dose Daicong solution. In the low-dose Daicong group, the condition was slightly improved, but the cytopathic effects were still significant. CONCLUSION: Daicong solution significantly improved neuronal and neuroepithelial pathological ultrastructure in a rat model of Alzheimer's disease. | Qi'an Yue Hongyan Wang Shumei Zhao Shengming Zhang Hongjuan Wu Yiguang Wang Fengjie Li Yuanyuan Yang Juanjuan Liu Yuling Ding | 2008 | Neural Regeneration Research2008，3，10： | 0 |
| 12 | Synthesis and Antioxidant Activity of(E)ω-Formylcamphene-Based Thiazole Hydrazone Derivatives显示文摘(E)ω-formylcamphene was synthesized fromα-pinene,the main component of turpentine,and then reacted with thiosemicarbazide to obtain(E)ω-formylcamphene thiosemicarbazide 3,which was reacted with 14α-bromoace-tophenone compounds to obtain 14(E)ω-formylcamphene thiazole hydrazone compounds 5a–5n;the yields were all above 80%.The structures of the target compounds were characterized by IR,^(1)H-NMR,^(13)C-NMR,and HR-MS analyses.Then,500,250,125,62.5,and 31.25 mg/L drug solutions were prepared.Free radical scavenging experi-ments of 1,1-diphenyl-2-picrylhydrazyl(DPPH)and 2,2-bis(3-ethyl-benzothiazole-6-sulfonic acid)diammonium salt(ABTS)were carried out with Trolox and L-ascorbic acid as the control samples.The scavenging rates of 14 compounds for DPPH and ABTS free radicals were obtained;the IC_(50) values of scavenging free radicals were fitted using SPSS software.The results show that 14(E)ω-formylcamphene-based thiazole hydrazone compounds exhibited good scavenging effects on the two free radicals,especially when the concentration of the drug solution was 125 and 62.5 mg/L;most compounds exceeded the scavenging efficiency of Trolox and L-ascorbic acid. | Jiayu Chang Qingying Ding Chong Zhong Yao Long Zhuanquan Xiao Hai Luo Yuling Yang Zongde Wang Shengliang Liao Jinzhu Chen Shangxing Chen Ji Zhang | 2023 | Journal of Renewable Materials2023，11，1： | 0 |
| 13 | Panoptic UAV:Panoptic Segmentation of UAV Images for Marine Environment Monitoring显示文摘UAV marine monitoring plays an essential role in marine environmental protection because of its flexibility and convenience,low cost and convenient maintenance.In marine environmental monitoring,the similarity between objects such as oil spill and sea surface,Spartina alterniflora and algae is high,and the effect of the general segmentation algorithm is poor,which brings new challenges to the segmentation of UAV marine images.Panoramic segmentation can do object detection and semantic segmentation at the same time,which can well solve the polymorphism problem of objects in UAV ocean images.Currently,there are few studies on UAV marine image recognition with panoptic segmentation.In addition,there are no publicly available panoptic segmentation datasets for UAV images.In this work,we collect and annotate UAV images to form a panoptic segmentation UAV dataset named UAV-OUC-SEG and propose a panoptic segmentation method named PanopticUAV.First,to deal with the large intraclass variability in scale,deformable convolution and CBAM attention mechanism are employed in the backbone to obtain more accurate features.Second,due to the complexity and diversity of marine images,boundary masks by the Laplacian operator equation from the ground truth are merged into feature maps to improve boundary segmentation precision.Experiments demonstrate the advantages of PanopticUAV beyond the most other advanced approaches on the UAV-OUC-SEG dataset. | Yuling Dou Fengqin Yao Xiandong Wang Liang Qu Long Chen Zhiwei Xu Laihui Ding Leon Bevan Bullock Guoqiang Zhong Shengke Wang | 2024 | Computer Modeling in Engineering & Sciences2024，138，1： | 0 |
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