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| 1 | Detumbling strategy based on friction control of dual-arm space robot for capturing tumbling target显示文摘The rotational motion of a tumbling target brings great challenges to space robot on successfully capturing the tumbling target.Therefore,it is necessary to reduce the target's rotation to a rate at which capture can be accomplished by the space robot.In this paper,a detumbling strategy based on friction control of dual-arm space robot for capturing tumbling target is proposed.This strategy can reduce the target's rotational velocity while maintaining base attitude stability through the establishment of the rotation attenuation controller and base attitude adjustment controller.The rotation attenuation controller adopts the multi-space hybrid impedance control method to control the friction precisely.The base attitude adjustment controller applies the dual-arm extended Jacobian matrix to stabilize the base attitude.The main contributions of this paper are as follows:(1)The compliant control method is adopted to achieve a precise friction control,which can reduce the target angular velocity steadily;(2)The dual-arm extended Jacobian matrix is applied to stabilize the base attitude without affecting the target capture task;(3)The detumbling strategy of dualarm space robot is designed considering base attitude stabilization,realizing coordinated planning of the base attitude and the arms.The strategy is verified by a dual-arm space robot with two 7-DOF(degrees of freedom)arms.Simulation results show that,target with a rotation velocity of 20(°)/s can be effectively controlled to stop within 30 s,and the final deflection of the base attitude is less than 0.15°without affecting the target capture task,verifying the correctness and effectiveness of the strategy.Except to the tumbling target capture task,the control strategy can also be applied to other typical on-orbit operation tasks such as space debris removal and spacecraft maintenance. | Gang CHEN Yuqi WANG Yifan WANG Ji LIANG Long ZHANG Guangtang PAN | 2020 | Chinese Journal of Aeronautics2020，33，3： | 9 |
| 2 | Genome of Plant Maca (Lepidium meyenil) Illuminates Genomic Basis for High-Altitude Adaptation in the Central Andes显示文摘Maca (Lepidium meyenii Walp, 2n = 8x = 64 ) ,属于 Brassicaceae 家庭,经济植物在秘鲁(4000-4500 m ) 在中央安第斯山脉岭被栽培。认为快速中央安第斯山脉高举发生 5-10 百万年以前(妈) ,一个进化问题关于象 maca 那样的植物怎么在一个短地质的时期以内获得高高度的改编产生。这里,我们报导 maca 的高质量的染色体集会,在里面它二仔细 spaced maca 特定的整个染色体的复制(WGD;6.7 妈) 被识别。在 maca 和密切相关的 Brassicaceae 种类之间的比较 genomic 分析揭示了经由 WGD 涉及不能生活的压力反应,荷尔蒙发信号小径,和第二等的代谢物生合成的 maca 基因和基因家庭的扩大。保留和许多复制基因的随后的功能的分叉可以说明词法、生理的变化(即,小叶形状和自我富饶) 在在高高度的环境的 maca。另外,一些复制 maca 基因在词法改编与功能被识别(即,叶卷应答) 并且不能生活的压力反应(即, GLYCINE 富有的 RNA 有约束力的蛋白质和 DNA-DAMAGE-REPAIR/TOLERATION 2 ) 在积极选择下面。一起, maca 染色体提供有用信息在安第斯山脉在植物的高高度的改编理解 WGD 的重要角色。 | Jing Zhang Yang Tian Liang Yan GuanghuiZhang Xiao Wang Yan Zeng Jiajin Zhang Xiao Ma Yuntao Tan Ni Long Yangzi Wang Yujin Ma Yuqi He Yu Xue Shumei Hao Shengchao Yang Wen Wang Liangsheng Zhang Yang Dong Wei Chen Jun Sheng | 2016 | Molecular Plant2016，9，7： | 9 |
| 3 | Cenozoic tectonic and geomorphic evolution of the Longxi region in northeastern Tibetan Plateau interpreted from detrital zircon显示文摘The Longxi region contains different kinds of Cenozoic sediments,including eolian deposits,reworked loess,fluvial and lacustrine deposits.The provenance evolution of these sediments is of great significance in exploring the uplift,tectonic deformation and associated with geomorphic evolution of the Northeastern Tibetan Plateau.In this paper,we used the single-grain zircon provenance analysis to constrain the provenances for the Paleogene alluvial conglomerates and for the Neogene fluvial-lacustrine sediments,and compared them with results from the loess deposits since the Miocene.The results show that:(1)the Paleogene alluvial conglomerates contain a large number of detrital zircons ranging from 560 to 1100 Ma that were derived from the Yangzi Block.However,the sediments of early Miocene have much fewer zircons of this age span,which are characterized by an abundance of zircon ages in the ranges of 200-360 Ma.This indicates that the Paleogene alluvial conglomerates mainly come from the middle and/or southern West Qinling,and the early Miocene sediments are primarily from the northern West Qinling;(2)Late Neogene fluvial sediments(11.5 Ma onward)in Tianshui-Qinan region are dominated by zircon ages of 3 80-450 Ma.This zircon population is similar to that of the exposed intrusive rocks of southern part of the Liupan Mountains,implying that the southern part of Liupan Mountains probably had already uplifted by 11.5 Ma;(3)Late Miocene lacustrine sediments in Tianshui region have a zircon age spectra that is remarkably different from coeval fluvial deposits,but is similar to the zircon age distributions of the Miocene loess in Qinan region,late Miocene-Pliocene Hipparion red clay and Quaternary loess.This indicates that fine particles within these Miocene lacustrine sediments in Tianshui region may be dominated by aeolian materials.This study reveals that provenance changes of Cenozoic sediments in Tianshui-Qinan region and its geomorphic evolution are closely related to the multi-stage uplift of the Northeastern Tibetan Plateau.In particular,the major uplift of the Northern Tibetan Plateau during late Oligocene-early Miocene may have not only provided the source areas and wind dynamic conditions for the deposits of the Miocene loess,but also provided the geomorphic conditions for its accumulation. | WANG ZhiXiang LIANG MeiYan SUN YuQi DAI GaoWen | 2017 | Science China Earth Sciences2017，60，2： | 4 |
| 4 | Natural exosome-like nanovesicles from edible tea flowers suppress metastatic breast cancer via ROS generation and microbiota modulation显示文摘Although several artificial nanotherapeutics have been approved for practical treatment of metastatic breast cancer,their inefficient therapeutic outcomes,serious adverse effects,and high cost of mass production remain crucial challenges.Herein,we developed an alternative strategy to specifically trigger apoptosis of breast tumors and inhibit their lung metastasis by using natural nanovehicles from tea flowers(TFENs).These nanovehicles had desirable particle sizes(131 nm),exosome-like morphology,and negative zeta potentials.Furthermore,TFENs were found to contain large amounts of polyphenols,flavonoids,functional proteins,and lipids.Cell experiments revealed that TFENs showed strong cytotoxicities against cancer cells due to the stimulation of reactive oxygen species(ROS)amplification.The increased intracellular ROS amounts could not only trigger mitochondrial damage,but also arrest cell cycle,resulting in the in vitro anti-proliferation,anti-migration,and anti-invasion activities against breast cancer cells.Further mice investigations demonstrated that TFENs after intravenous(i.v.)injection or oral administration could accumulate in breast tumors and lung metastatic sites,inhibit the growth and metastasis of breast cancer,and modulate gut microbiota.This study brings new insights to the green production of natural exosome-like nanoplatform for the inhibition of breast cancer and its lung metastasis via i.v.and oral routes. | Qiubing Chen Qian Li Yuqi Liang Menghang Zu Nanxi Chen Brandon S.B.Canup Liyong Luo Chenhui Wang Liang Zeng Bo Xiao | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 4 |
| 5 | Study on Unstable Characteristics of Centrifugal Pump under Different Cavitation Stages显示文摘In order to reveal the regularity of unsteady flow of centrifugal pump under different cavitation stages,a visual closed test-bed is built to collect signals such as the distribution of cavitation bubbles at the impeller inlet and external characteristics,etc.in the process of cavitation of centrifugal pumps.Combined with the shape and distribution of bubbles captured by high-speed photography,the cavitation stage of the centrifugal pump is divided.In addition,the variation of vorticity distribution,pressure pulsation and radial force of centrifugal pump under different cavitation stages are studied using the standard κ-ε turbulence model and the Kunz cavitation model.Main contributions are as follows:The cavitation bubbles can absorb the energy of vortex core to a certain extent and increase the volume of vortex core.Cavitation bubbles can also block the flow-path and induce the distortion of the internal flow field,resulting in unstable pressure waves that cause a significant increase in pressure pulsation rate.Besides,with the development of cavitation,the radial force on the impeller tends to remain invariable first and then decrease,and trajectory of the radial force changes from closed to open. | DONG Liang SHANG Huanhuan ZHAO Yuqi LIU Houlin DAI Cui WANG Ying | 2019 | Journal of Thermal Science2019，28，4： | 4 |
| 6 | Development of powdery mildew resistant derivatives of wheat variety Fielder for use in genetic transformation显示文摘Genetic transformation is widely used to improve target traits and to study gene function in wheat.However,transformation efficiency depends on the physiological status of the recipient genotype and that is affected by several factors including powdery mildew(PM)infection.The widely used recipient variety Fielder is very susceptible to PM.Therefore,it would be beneficial to develop PM resistant derivatives with high regeneration ability for use in genetic transformation.In the present study PM resistant lines CB037 and Pm97033 carrying genes Pm21 and PmV,respectively,were backcrossed to Fielder with selection for PM resistance.Five lines,NT89,NT90,NT154,and WT48 with Pm21 and line FL347 with PmV were developed,identified by molecular markers and genomic in situ hybridization(GISH)or fluorescent in situ hybridization(FISH),and further subjected to detailed assessment of agronomic traits and regeneration ability following genetic transformation capacity.Lines FL347,WT48,NT89 and NT154 assessed as being equal to,or superior,to Fielder in regeneration and transformation ability are recommended as suitable materials for the replacement of Fielder for wheat gene transfer and genome editing study. | Xiaona Liang Xiaomin Bie Yuliang Qiu Ke Wang Zujun Yang Yuqi Jia Zhiying Xu Mei Yu Lipu Du Zhishan Lin Xingguo Ye | 2023 | The Crop Journal2023，11，2： | 2 |
| 7 | Environmental biogeochemical behaviors of rare earth elements in soil–plant systems显示文摘 | Tao Liang Shen Zhang Lijun Wang Hsiang-Te Kung Yuqi Wang Aitang Hu Shiming Ding | 2005 | Environmental Geochemistry and Health2005，，4： | 2 |
| 8 | Dispersion behaviour of laser-synthesized nanometric SiC powders in aqueous medium with ammonium polyacrylate 显示文摘 | Zhou Rongcan Jiang Yuqi Liang Yong | 2002 | Ceram Inter2002，28，8： | 2 |
| 9 | Traditional Chinese Medicine guidelines for coronavirus disease 2019显示文摘OBJECTIVE:To summarize the evidence from Traditional Chinese Medicine(TCM)practice in the treatment of coronavirus disease 2019(COVID-19)and provide timely clinical practice guidance.METHODS:The guidelines were developed in accordance with the World Health Organization rapid guideline process.The evidence on TCM for COVID-19 from published guidelines,direct and indirect published clinical evidence,first hand clinical data,and expert experience and consensus were collected.The grading of recommendations assessment,development and evaluation(GRADE)method was used to grade the evidence and make the recommendations.RESULTS:Based on the available evidence,the guidelines recommended 17 Chinese medicines for COVID-19:2 Chinese herbal granules,7 Chinese patent medicines,and 8 Chinese herbal injections.CONCLUSION:As the literature search was conducted on March,any subsequent versions of these guidelines require an up-to-date literature review.We hope that the evidence summary in these guidelines will be helpful in global efforts to address COVID-19. | Liang Ning Ma Yanfang Wang Jingya Li Huizhen Wang Xiaohui Jiao Liwen Liu Bin Ma Yan Zhao Chen Luo Xufei Zhao Siya Lu Meng Cao Jin Hu Wenpin Zhang Hairong Liu Guoxiu Lu Cheng Liu Mengyu Li Li Han Xuejie Liu Yuqi Wang Liying Zhao Xueyao Wei Dongfeng Bai Jing Sun Mingyu Yang Yong Wu Xiaodan Chen Yaolong Shi Nannan Wang Yanping Wang Yongyan | 2020 | Journal of Traditional Chinese Medicine2020，40，6： | 2 |
| 10 | 显示文摘 | Yuqi Jiang Yong Liang | 2002 | Ceramics International2002，28，： | 1 |
| 11 | 内侧缰核胆碱能神经元GABAB受体通过突触前兴奋作用调控动物恐惧记忆显示文摘动物的生存依赖于将预警信号和危险联系起来.对预警信号形成恐惧记忆,以便提前做出反应。当预警信号不再与危险相关时,动物逐渐解除这种联系,消退恐惧记忆,以适应新的生存环境。恐惧记忆消退缺陷被认为和人类创伤后应激障碍(PTSD)等精神障碍有紧密关系。目前关于动物恐惧记忆的研究主要集中在杏仁核及其相关脑区。 | 张举恩 Lubin Tan Yuqi Ren Jingwen Liang Rui Lin Qiru Feng Jingfeng Zhou Fei Hu Jing Ren Chao Wei Tao Yu Yinghua Zhuang Bernhard Bettler Fengchao Wang 罗敏敏 | 2017 | 科学新闻2017，19，4： | 1 |
| 12 | Role of local coordination in bimetallic sites for oxygen reduction: A theoretical analysis显示文摘Understanding of the oxygen reduction reaction(ORR)mechanism for single atom catalysts is pivotal for the rational design of non-precious metal cathode materials and the commercialization of fuel cells.Herein,a series of non-precious metal electrocatalysts based on nitrogen-doped bimetallic(Fe and Co)carbide were modeled by density functional theory calculations to predict the corresponding reaction pathways.The study elucidated prior oxygen adsorption on the Fe atom in the dual site and the modifier role of Co atoms to tune the electronic structures of Fe.The reaction activity was highly correlated with the bimetallic center and the coordination environment of the adjacent nitrogen.Interestingly,the preadsorption of*OH resulted in the apparent change of metal atoms'electronic states with the d-band center shifting toward the Fermi level,thereby boosting reaction activity.The result should help promote the fundamental understanding of active sites in ORR catalysts and provide an effective approach to the design of highly efficient ORR catalysts on an atomic scale. | Yuqi Yang Hao Zhang Zhaofeng Liang Yaru Yin Bingbao Mei Fei Song Fanfei Sun Songqi Gu Zheng Jiang Yuen Wu Zhiyuan Zhu | 2020 | Journal of Energy Chemistry2020，29，5： | 1 |
| 13 | Ample dietary fat reduced the risk of primary vesical calculi by inducing macrophages to engulf budding crystals in mice显示文摘Although primary vesical calculi is an ancient disease,the mechanism of calculi formation remains unclear.In this study,we established a novel primary vesical calculi model with D,L-choline tartrate in mice.Compared with commonly used melamine and ethylene glycol models,our model was the only approach that induced vesical calculi without causing kidney injury.Previous studies suggest that proteins in the daily diet are the main contributors to the prevention of vesical calculi,yet the effect of fat is overlooked.To assay the relationship of dietary fat with the formation of primary vesical calculi,D,L-choline tartrate-treated mice were fed a high-fat,low-fat,or normal-fat diet.Genetic changes in the mouse bladder were detected with transcriptome analysis.A high-fat diet remarkably reduced the morbidity of primary vesical calculi.Higher fatty acid levels in serum and urine were observed in the high-fat diet group,and more intact epithelia in bladder were observed in the same group compared with the normal-and low-fat diet groups,suggesting the protective effect of fatty acids on bladder epithelia to maintain its normal histological structure.Transcriptome analysis revealed that the macrophage differentiation-related gene C-X-C motif chemokine ligand 14(Cxcl14)was upregulated in the bladders of high-fat diet-fed mice compared with those of normal-or low-fat diet-fed mice,which was consistent with histological observations.The expression of CXCL14 significantly increased in the bladder in the high-fat diet group.CXCL14 enhanced the recruitment of macrophages to the crystal nucleus and induced the transformation of M2 macrophages,which led to phagocytosis of budding crystals and prevented accumulation of calculi.In human bladder epithelia(HCV-29)cells,high fatty acid supplementation significantly increased the expression of CXCL14.Dietary fat is essential for the maintenance of physiological functions of the bladder and for the prevention of primary vesical calculi,which provides new ideas for the reduction of morbidity of primary vesical calculi. | Huiling Chen Kaiqiang Hu Yaru Liang Yuqi Gao Chenye Zeng Kang Xu Xiaojin Shi Liyuan Li Yuemiao Yin Yi Qiao Ying Qiu Qingfei Liu Zhao Wang | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 1 |
| 14 | Allogeneic gene-edited HIV-specific CAR-T cells secreting PD-1 blocking scFv enhance specific cytotoxic activity against HIV Envt cells in vivo显示文摘HIV-specific chimeric antigen receptor(CAR)T-cells have been developed to target HIV-1 infected CD4t T-cells that express HIV Env proteins.However,T cell exhaustion and the patient-specific autologous paradigm of CAR-T cell hurdled clinical applications.Here,we created HIV-specific CAR-T cells using human peripheral blood mononuclear cells and a 3BNC117-E27(3BE)CAR construct that enabled the expression of programmed cell death protein(PD-1)-blocking scFv E27 and the single-chain variable fragment of the HIV-1-specific broadly neutralizing antibody 3BNC117 to target native HIV Env.Compared with T cells expressing 3BNC117-CAR alone,3BE CAR-T cells showed greater cytotoxic activity against HIV Envt cells with stronger proliferation capability,higher killing efficiency,and enhanced cytokine secretion in the presence of HIV Env-expressing cells.Furthermore,we manufactured TCR-deficient 3BE CAR-T cells through gene editing and demonstrated that these CAR-T cells could effectively kill HIV Env^(+) cells in vivo without the occurrence of severe graft-versus-host disease(GvHD)in NSG mice.These data suggest that we have provided a feasible approach to the generation of“off-theshelf”anti-HIV CAR-T cells in combination with PD-1 checkpoint blockade immunotherapy,which can be a powerful therapeutic candidate for the functional cure of HIV. | Hanyu Pan Xinyi Yang Jing Wang Huitong Liang Zhengtao Jiang Lin Zhao Yanan Wang Zhiming Liang Xiaoting Shen Qinru Lin Yue Liang Jinglong Yang Panpan Lu Yuqi Zhu Min Li Pengfei Wang Jianqing Xu Hongzhou Lu Huanzhang Zhu | 2023 | Virologica Sinica2023，38，2： | 0 |
| 15 | Detecting Domain Generation Algorithms with Bi-LSTM显示文摘Botnets often use domain generation algorithms(DGA)to connect to a command and control(C2)server,which enables the compromised hosts connect to the C2 server for accessing many domains.The detection of DGA domains is critical for blocking the C2 server,and for identifying the compromised hosts as well.However,the detection is difficult,because some DGA domain names look normal.Much of the previous work based on statistical analysis of machine learning relies on manual features and contextual information,which causes long response time and cannot be used for real-time detection.In addition,when a new family of DGA appears,the classifier has to be re-trained from the very beginning.This paper presents a deep learning approach based on bidirectional long short-term memory(Bi-LSTM)model for DGA domain detection.The classifier can extract features without the need for manual feature extraction,and the trainable model can effectively deal with new unknown DGA family members.In addition,the proposed model only needs the domain name without any additional context information.All domain names are preprocessed by bigram and the length of each processed domain name is set as a value longer than the most samples.Bidirectional LSTM model receives the encoded data and returns labels to check whether domain names are normal or not.Experiments show that our model outperforms state-of-the-art approaches and is able to detect new DGA families reliably. | Liang Ding Lunjie Li Jianghong Han Yuqi Fan Donghui Hu | 2019 | Computers, Materials & Continua2019，，9： | 0 |
| 16 | Malignant transformation and treatment of cystic mixed germ cell tumor显示文摘Objective:The authors report an extremely unusual presentation and management of a children pineal mixed germ cell tumor mainly composed of immature teratoma,aiming to summarize main theraptic points by literature review.Methods:A cystic lesion located in the rear of third ventricle in a child was detected3 years ago with no other therapy performed except for a ventriculo-peritoneal shunt.During the following 3 years,intermitted regular brain MRI demonstrated no evidence of lesion aggrandizement.However from 20 days before admission to our institute the patient began to present acutely with exacerbating clinical symptoms meanwhile brain MRI showed signs of abrupt revulsions of initial lesion without any incentive cause.Neurological examination revealed a significant rising of serum tumor marker level.Then surgical resection was performed immediately after admission which was followed by correlative two-course chemotherapy.Results:Postoperative brain MRI demonstrated totally removing of the lesion in rear of third ventricle.Serum tumor marker level decreased remarkably after surgery and declined to normal level after two-course chemotherapy.No obvious neurological deficit occurred except for short-term memory difficulty which gradually recovered within two weeks.Soon after the second course chemotherapy the patient was currently asymptomatic and returned to school.Conclusions:(1)To ensure definitive diagnosis and proper therapecutic protocols benefit from grasping clinical features of mixed germ cell tumor.(2)Overall preoperative investigation including serum tumor marker level is as critical as neurological imaging examination.(3)Surgical excision is confirmed to be the key modality of treatment.With the regarding of mixed germ cell tumor,never highlight total resection too much.(4)Postoperative adjuvant chemotherapy is recommended as further intensive treatment to improve the prognosis of mix germ cell tumor. | Yapeng Zhao Hongyu Duan Qinghui Zhang Bingxin Shi Hui Liang Yuqi Zhang | 2016 | Translational Neuroscience and Clinics2016，2，1： | 0 |
| 17 | How silicon fertilizer improves nitrogen and phosphorus nutrient availability in paddy soil?显示文摘In order to reveal the mechanism of silicon(Si)fertilizer in improving nitrogen(N)and phosphorus(P)nutrient availability in paddy soil,we designed a series of soil culture experiments by combining application of varying Si fertilizer concentrations with fixed N and P fertilizer concentrations.Following the recommendations of fertilizer manufacturers and local farmers,we applied Si in concentrations of 0,5.2,10.4,15.6,and 20.8μg/kg.At each concentration of added Si,the availability of soil N and P nutrients,soil microbial activity,numbers of ammonia-oxidizing bacteria and P-decomposing bacteria which means that the organic P is decomposed into inorganic nutrients which can be absorbed and utilized by plants,and urease and phosphatase activity first increased,and then decreased,as Si was added to the soil.These indicators reached their highest levels with a Si application rate of 15.6μg/kg,showing values respectively 19.78%,105.09%,8.34%,73.12%,130.36%,28.12%,and 20.15%higher than those of the controls.Appropriate Si application(10.4 to 15.6µg/kg)could significantly increase the richness of the soil microbial community involved in cycling of N and P nutrients in the soil.When the Si application rate was 15.6μg/kg,parameters for characterizing microbial abundance such as sequence numbers,operational taxonomic unit(OTU)number,and correlation indices of microbial community richness such as Chao1 index,the adaptive coherence estimator(ACE)index,Shannon index,and Simpson index all reached maximum values,with amounts increased by 14.46%,10.01%,23.80%,30.54%,0.18%,and 2.64%,respectively,compared with the control group.There is also a good correlation between N and P mineralization and addition of Si fertilizer.The correlation coefficients between the ratio of available P/total P(AP/TP)and the number of ammonia-oxidizing bacteria,AP/TP and acid phosphatase activity(AcPA),AP/TP and the Shannon index,the ratio of available N/total amount of N(AN/TN)and the number of ammoniated bacteria,and AN/TN and AcPA were 0.9290,0.9508,0.9202,0.9140,and 0.9366,respectively.In summary,these results revealed that enhancement of soil microbial community structure diversity and soil microbial activity by appropriate application of Si is the key ecological mechanism by which application of Si fertilizer improves N and P nutrient availability. | Yuqi LIANG Min LIAO Zhiping FANG Jiawen GUO Xiaomei XIE Changxu XU | 2021 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2021，22，7： | 0 |
| 18 | Inflammatory risk stratification individualizes anti-inflammatory pharmacotherapy for acute type A aortic dissection显示文摘The systemic benefits of anti-inflammatory pharmacotherapy vary across cardiovascular diseases in clinical practice.We aimed to evaluate the application of artificial intelligence to acute type A aortic dissection(ATAAD)patients to determine the optimal target population who would benefit from urinary trypsin inhibitor use(ulinastatin).Patient characteristics at admission in the Chinese multicenter 5A study database(2016-2022)were used to develop an inflammatory risk model to predict multiple organ dysfunction syndrome(MODS). | Hong Liu Haiyang Li Lu Han Yingyuan Zhang Ying Wu Liang Hong Jinong Yang Jisheng Zhong Yuqi Wang Dongkai Wu Guoliang Fan Junquan Chen Shengqiang Zhang Xingxing Peng Zhihua Zeng Zhiwei Tang Zhanjie Lu Lizhong Sun Sichong Qian Yongfeng Shao Hongjia Zhang on behalf of the Additive Anti-inflammatory Action for Aortopathy&Arteriopathy(A)Investigators | 2023 | The Innovation2023，4，4： | 0 |
| 19 | H_(2)O_(2)-sensitive nanoscale coordination polymers for photoacoustic tumors imaging via in vivo chromogenic assay显示文摘Photoacoustic(PA)imaging with much deeper tissue penetration and better spatial resolution had been widely employed for the prevention and diagnosis of many diseases.In this study,a new type of hydrogen peroxide(H_(2)O_(2)T-activated photoacoustic nanoprobe[Mn-AH nanoscale coordination polymer nanodots(NCPs)]was successfully synthesized by a simple one-step method in water phase containing 2,20-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)(ABTS),horse radish peroxidase(HRP),and manganese ion(Mn^(2+).After modification by polyethylene glycol(PEG),Mn-AH NCPs exhibited excellent stability and biocompatibility for in vivo H_(2)O_(2)-responsive chromogenic assay with great speci¯city and sensitivity.In the presence of H_(2)O_(2),colorless ABTS would be converted by HRP into the oxidized form with strong near-infrared(NIR)absorbance,enabling photoacoustic detection of endogenous H_(2)O_(2).Using H_(2)O_(2)-activated Mn-AH NCPs,we have successfully performed PA imaging and H_(2)O_(2)detection of subcutaneous murine colon CT26 tumor and deep-seated orthotopic bladder tumor.Due to the inherent Mn element existence inside the Mn-AH,this nanoprobe also serves as a good T1-weighted magnetic resonance imaging(MRI)contrast agent simultaneously.Lastly,after accomplishing its imaging functions,the Mn-AH NCPs could be cleared out from the body without any long-term toxicity,providing a new opportunity for cancer diagnosis and treatment. | Jiayue Zhao Fei Gong Nailin Yang Huali Lei Zhihui Han Yuqi Yang Liang Cheng | 2022 | Journal of Innovative Optical Health Sciences2022，15，5： | 0 |
| 20 | Pulmonary delivery of mucus-traversing PF127-modified silk fibroin nanoparticles loading with quercetin for lung cancer therapy显示文摘The mucosal barrier remains a major barrier in the pulmonary drug delivery system,as mucociliary clearance in the airway accelerates the removal of inhaled nanoparticles(NPs).Herein,we designed and developed the inhalable Pluronic F127-modified silk fibroin NPs loading with quercetin(marked as QR-SF(PF127)NPs),aiming to solve the airway mucus barrier and improve the cancer therapeutic effect of QR.The PF127 coating on the SF NPs could attenuate the interaction between NPs and mucin proteins,thus facilitating the diffusion of SF(PF127)NPs in the mucus layer.The QR-SF(PF127)NPs had particle sizes of approximately 200 nm with negatively charged surfaces and showed constant drug release properties.Fluorescence recovery after photobleaching(FRAP)assay and transepithelial transport test showed that QR-SF(PF127)NPs exhibited superior mucus-penetrating ability in artificial mucus and monolayer Calu-3 cell model.Notably,a large amount of QR-SF(PF127)NPs distributed uniformly in the mice airway section,indicating the good retention of NPs in the respiratory tract.Themicemelanoma lungmetastasismodel was established,and the therapeutic effect of QR-SF(PF127)NPs was significantly improved in vivo.PF127-modified SF NPs may be a promising strategy to attenuate the interaction with mucin proteins and enhancemucus penetration efficiency in the pulmonary drug delivery system. | Yu Tang Lanfang Zhang Rui Sun Baiyi Luo Yu Zhou Yan Zhang Yuqi Liang Bo Xiao Chenhui Wang | 2023 | Asian Journal of Pharmaceutical Sciences2023，18，4： | 0 |
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