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| 1 | Sm-Nd isotope dating of hydrothermal calcites from the Xikuangshan antimony deposit,Central Hunan显示文摘The research on Samarium-Neodymium isotope systematics of hydrothermal calcites from the Xi-kuangshan antimony deposit, Central Hunan, places precise timing constraints on the Sb mineralization in this area. It is revealed that the Xikuangshan deposit formed during the late Jurassic-early Cretaceous Period, the early- and late-stage mineralization took place at (155.5±1.1) Ma and (124.1±3.7) Ma, respectively. The accurate age determination of mineralization is very crucial for revealing the super-enrichment mechanism of the element Sb at the Xikuangshan mine, and lays some foundations for the further understandings of its ore genesis and mineralization mechanism. | PENG Jiantang HU Ruizhong LIN Yuanxian ZHAO Junhong | 2002 | Chinese Science Bulletin2002，47，13： | 19 |
| 2 | A comprehensive review of integrative pharmacology-based investigation:A paradigm shift in traditional Chinese medicine显示文摘Over the past decade,traditional Chinese medicine(TCM) has widely embraced systems biology and its various data integration approaches to promote its modernization.Thus,integrative pharmacology-based traditional Chinese medicine(TCMIP) was proposed as a paradigm shift in TCM.This review focuses on the presentation of this novel concept and the main research contents,methodologies and applications of TCMIP.First,TCMIP is an interdisciplinary science that can establish qualitative and quantitative pharmacokinetics-pharmacodynamics(PK-PD) correlations through the integration of knowledge from multiple disciplines and techniques and from different PK-PD processes in vivo.Then,the main research contents of TCMIP are introduced as follows:chemical and ADME/PK profiles of TCM formulas;confirming the three forms of active substances and the three action modes;establishing the qualitative PK-PD correlation;and building the quantitative PK-PD correlations,etc.After that,we summarize the existing data resources,computational models and experimental methods of TCMIP and highlight the urgent establishment of mathematical modeling and experimental methods.Finally,we further discuss the applications of TCMIP for the improvement of TCM quality control,clarification of the molecular mechanisms underlying the actions of TCMs and discovery of potential new drugs,especially TCM-related combination drug disco very. | Haiyu Xu Yanqiong Zhang Ping Wang Junhong Zhang Hong Chen Luoqi Zhang Xia Du Chunhui Zhao Dan Wu Feng Liu Hongjun Yang Changxiao Liu | 2021 | Acta Pharmaceutica Sinica B2021，11，6： | 18 |
| 3 | Petrogenesis of the Xihuashan Granite in Southern Jiangxi Province,South China:Constraints from Zircon U-Pb Geochronology,Geochemistry and Nd Isotopes显示文摘Mesozoic granitic intrusions are widely distributed in the Nanling region,South China.Yanshanian granites are closely connected with the formation of tungsten deposits.The Xihuashan granite is a typical representative of tungsten-bearing granite.The Xihuashan granite consists mainly of medium-grained porphyritic biotite granite,medium-grained biotite granite and fine-grained two-mica granite,which correspond to LA-ICP-MS zircon U-Pb ages of 155.5±0.4 Ma,153.0±0.6 Ma and 152.8±0.9 Ma,respectively.Rocks from the Xihuashan mining area displays high SiO2(73.85% to 76.49%) and Na2O+K2O contents(8.09% to 9.43%),belonging to high-K calc-alkaline series.They are metaluminous to weakly peraluminous with A/CNK values ranging from 0.96 to 1.06.All granites in this study area are rich in Rb,Th,U and Pb,and depleted in Ba,Sr,P,Ti,Nb and Eu,especially depleted in medium-grained biotite granite and fine-grained two-mica granite.The medium-grained porphyritic biotite granites usually have high LREE concentrations,whereas medium-grained biotite granite and fine-grained two-mica granite displays high HREE contents.Our geochemical data reveal that the studied rocks are highly fractionated I-type granite.The magma underwent strong magma differentiation with decreasing temperature and increasing oxygen fugacity,which may explain the formation of three types of distinct granites.Variations of Rb,Sr and Ba concentrations in different type granites were controlled by fractional crystallization of biotite and feldspar.Fractional crystallization of monazite,allanite and apatite resulted in LREE changes in granite,and formation of garnet mainly caused HREE changes.Granites from the Xihuashan mining area have relatively high εNd(t) values(-9.77 to -11.46),indicating that they were probably generated by partial melting of underlying Proterozoic metasedimentary rocks with minor addition of juvenile crust or mantle-derived magmas. | YANG Jiehua PENG Jiantang ZHAO Junhong FU Yazhou YANG Chen HONG Yinglong | 2012 | Acta Geologica Sinica(English Edition)2012，86，1： | 17 |
| 4 | Optimization of air quantity regulation in mine ventilation networks using the improved differential evolution algorithm and critical path method显示文摘In mine ventilation networks, the reasonable airflow distribution is very important for the production safety and economy. Three basic problems of the natural, full-controlled and semi-controlled splitting were reviewed in the paper. Aiming at the high difficulty semi-controlled splitting problem, the general nonlinear multi-objectives optimization mathematical model with constraints was established based on the theory of mine ventilation networks. A new algorithm, which combined the improved differential evaluation and the critical path method(CPM) based on the multivariable separate solution strategy,was put forward to search for the global optimal solution more efficiently. In each step of evolution,the feasible solutions of air quantity distribution are firstly produced by the improved differential evolution algorithm, and then the optimal solutions of regulator pressure drop are obtained by the CPM.Through finite steps iterations, the optimal solution can be given. In this new algorithm, the population of feasible solutions were sorted and grouped for enhancing the global search ability and the individuals in general group were randomly initialized for keeping diversity. Meanwhile, the individual neighborhood in the fine group which may be closely to the optimal solutions were searched locally and slightly for achieving a balance between global searching and local searching, thus improving the convergence rate. The computer program was developed based on this method. Finally, the two ventilation networks with single-fan and multi-fans were solved. The results show that this algorithm has advantages of high effectiveness, fast convergence, good robustness and flexibility. This computer program could be used to solve large-scale generalized ventilation networks optimization problem in the future. | Chen Kaiyan Si Junhong Zhou Fubao Zhang Renwei Shao He Zhao Hongmei | 2015 | International Journal of Mining Science and Technology2015，25，1： | 15 |
| 5 | Toll-like receptor 3(TLR3)regulation mechanisms and roles in antiviral innate immune responses显示文摘Toll-like receptor 3(TLR3)is a member of the TLR family,mediating the transcriptional induction of type I interferons(IFNs),proinflammatory cytokines,and chemokines,thereby collectively establishing an antiviral host response.Studies have shown that unlike other TLR family members,TLR3 is the only RNA sensor that is utterly dependent on the Tollinterleukin-1 receptor(TIR)-domain-containing adaptor-inducing IFN-β(TRIF).However,the details of how the TLR3-TRIF signaling pathway works in an antiviral response and how it is regulated are unclear.In this review,we focus on recent advances in understanding the antiviral mechanism of the TRIF pathway and describe the essential characteristics of TLR3 and its antiviral effects.Advancing our understanding of TLR3 may contribute to disease diagnosis and could foster the development of novel treatments for viral diseases. | Yujuan CHEN Junhong LIN Yao ZHAO Xianping MA Huashan YI | 2021 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2021，22，8： | 11 |
| 6 | Jurassic Intra-plate Basaltic Magmatism in Southeast China:Evidence from Geological and Geochemical Characteristics of the Chebu Gabbroite in Southern Jiangxi Province显示文摘Geochemical and isotopic investigations have been carried out on the Chebu gabbroite in southern Jiangxi Province, southeast China and these results are compared with gabbro bodies along the coast of Fujian Province in order to understand their magma sources and tectonic implications. The Chebu intrusion formed at the beginning of the Middle Jurassic (172±4.3 Ma). These rocks are Ti-rich and Al-poor in major elements, characterized by strong enrichment in large-ion lithophile elements (LILE) and moderate enrichment in high field strength elements (HFSE) and light rare-earth elements (LREE), without pronounced Nb or Ta anomalies. Age-correlated Sr-Nd isotope ratios show moderately high ranges of (87Sr/86Sr)i from 0.7065 to 0.7086 and 0.5124 to 0.5125 of (143Nd/144Nd)i. The geochemical characteristics of the Chebu gabbroite suggest that it is notably different from island-arc basalt and similar to intra-plate basaltic rocks. By combining interpretations of its geological and geochemical characteristics and the regional geological development history, the Chebu gabbroitic intrusion is thought to be the product of asthenosphere upwelling and rapid lithosphere extension during a transition of tectonic systems in southeast China. The tectonic environment and source characteristics of the intrusion are different from Cretaceous gabbro bodies along the coast of Fujian Province, The former formed in a tectonic environment of rapid intra-plate lithospheric extension and the source characteristics were of a weakly enriched primitive mantle, whereas the latter originated mainly in a volcanic-magmatic arc extensional tectonic environment and the nature of the source was an enriched mantle with more subduct subducted components. | XIE Guiqing MAO Jingwen HU Ruizhong LI Ruiling JIANG Guohao CAO Jinjian ZHAO Junhong | 2005 | Acta Geologica Sinica(English Edition)2005，79，5： | 10 |
| 7 | Zircon U/Pb dating and Hf-O isotopes of the Zhouan ultramafic intrusion in the northern margin of the Yangtze Block,SW China:Constraints on the nature of mantle source and timing of the supercontinent Rodinia breakup显示文摘The Zhouan ultramafic intrusion in the northern margin of the Yangtze Block is mainly composed of lherzolite.Zircon grains selected from lherzolite are irregular in shape with distinct oscillatory and sector zoning and have Th/U ratios ranging from 0.8 to 10.6,indicating a magmatic origin.The weighted average 206 Pb/238 U age is 637±4 Ma (2σ,n=15),which can be considered as the crystallization age of the Zhouan intrusion.Zircon grains have δ18O values ranging from 5.2‰ to 7.0‰,with an averaged value of 5.8±0.4‰ (1σ,n=33),similar to the mantle δ18O value of zircon.Their 176Hf/177Hf(t) ratios range from 0.282410 to 0.282594 with εHf(t) values ranging from 1.3 to 7.6,lower than the corresponding value of the depleted mantle (~15),indicating an enriched mantle source.The enriched mantle source may have generated from a metasomatized lithospheric mantle with subducted slab.A number of ~635 Ma mafic-ultramafic intrusions in the Suizao basin are associated with coeval bimodal volcanics of the Yaolinghe Formation,indicating a continental rift setting.The ~635 Ma magmatic event in this region may represent the product of the last breakup of the Rodinia supercontinent in the northern margin of the Yangtze Block at Neoproterozoic. | WANG MengXi WANG ChristinaYan ZHAO JunHong | 2013 | Science China(Technological Sciences)2013，56，3： | 10 |
| 8 | Soil Organic Carbon Contents and Stocks in Coastal Salt Marshes with Spartina alterniflora Following an Invasion Chronosequence in the Yellow River Delta,China显示文摘Plant invasion alters the fundamental structure and function of native ecosystems by affecting the biogeochemical pools and fluxes of materials and energy. Native(Suaeda salsa) and invasive(Spartina alterniflora) salt marshes were selected to study the effects of Spartina alterniflora invasion on soil organic carbon(SOC) contents and stocks in the Yellow River Delta. Results showed that the SOC contents(g/kg) and stocks(kg/m^2) were significantly increased(P < 0.05) after Spartina alterniflora invasion of seven years, especially for the surface soil layer(0–20 cm). The SOC contents exhibited an even distribution along the soil profiles in native salt marshes, while the SOC contents were gradually decreased with depth after Spartina alterniflora invasion of seven years. The natural ln response ratios(Ln RR) were applied to identify the effects of short-term Spartina alterniflora invasion on the SOC stocks. We also found that Spartina alterniflora invasion might cause soil organic carbon losses in a short-term phase(2–4 years in this study) due to the negative Ln RR values, especially for 20–60 cm depth. And the SOCD in surface layer(0–20 cm) do not increase linearly with the invasive age. Spearman correlation analysis revealed that silt + clay content was exponentially related with SOC in surface layer(Adjusted R^2 = 0.43, P < 0.001), suggesting that soil texture could play a key role in SOC sequestration of coastal salt marshes. | ZHANG Guangliang BAI Junhong JIA Jia WANG Xin WANG Wei ZHAO Qingqing ZHANG Shuai | 2018 | Chinese Geographical Science2018，28，3： | 8 |
| 9 | Changes of Biogenic Elements in Phragmites australis and Suaeda salsa from Salt Marshes in Yellow River Delta,China显示文摘Little information is available on biogenic elements(carbon, nitrogen, phosphorus and sulfur) and the ecological stoichiometric characteristics of plants in coastal wetlands. To investigate the contents of carbon, nitrogen, phosphorus and sulfur of plants, and their ecological stoichiometric characteristics in the Yellow(Huanghe) River Delta, plant samples were collected from two typical salt marshes(Suaeda salsa and Phragmites australis wetlands) during the period of from August to October in 2007, and the ratios of C/N, C/P, N/P, C/N/P and C/N/P/S were calculated. Results showed that during the studying period, plant C, N and P were lower than the global average values, and plant N and P were lower than the China's average values. Leaf C and S in Suaeda salsa were significantly lower than those in Phragmites australis(P < 0.05), and leaf N and P in Suaeda salsa and Phragmites australis showed no significant differences(P > 0.05). Average C/N ratios were 23.75 in leaf, 73.36 in stem, 65.67 in root of Suaeda salsa, and 33.77 in leaf, 121.68 in stem, 97.13 in root of Phragmites australis. Average C/N ratios of Suaeda salsa and Phragmites australis were all great than 25, indicating the salt marsh in the Yellow River Delta is an N limitation system. Average C/P ratios were 276.78 in leaf, 709.28 in stem and 1031.32 in root of Suaeda salsa, and 536.94 in leaf, 768.13 in stem and 875.22 in root of Phragmites australis. The average N/P ratios of Suaeda salsa were 12.92 in leaf, 10.77 in stem and 10.91 in root, and the average N/P ratios of Phragmites australis were 16.40 in leaf, 7.40 in stem and 6.92 in root, indicating the Suaeda salsa wetlands were N limited and Phragmites australis wetlands were N limited in August and P limited in October in 2007. The average C/N, C/P and C/N/P ratios in Suaeda salsa and Pragmites australis were higher than the global average values, indicating the lower quality of organic matter provided by wetland plants in the Yellow River delta. | JIA Jia BAI Junhong WANG Wei ZHANG Guangliang WANG Xin ZHAO Qingqing ZHANG Shuai | 2018 | Chinese Geographical Science2018，28，3： | 7 |
| 10 | Surface effects on a mode-III reinforced nano-elliptical hole embedded in one-dimensional hexagonal piezoelectric quasicrystals显示文摘To effectively reduce the field concentration around a hole or crack,an anti-plane shear problem of a nano-elliptical hole or a nano-crack pasting a reinforcement layer in a one-dimensional(1D)hexagonal piezoelectric quasicrystal(PQC)is investigated subject to remotely mechanical and electrical loadings.The surface effect and dielectric characteristics inside the hole are considered for actuality.By utilizing the technique of conformal mapping and the complex variable method,the phonon stresses,phason stresses,and electric displacements in the matrix and reinforcement layer are exactly derived under both electrically permeable and impermeable boundary conditions.Three size-dependent field intensity factors near the nano-crack tip are further obtained when the nano-elliptical hole is reduced to the nano-crack.Numerical examples are illustrated to show the effects of material properties of the surface layer and reinforced layer,the aspect ratio of the hole,and the thickness of the reinforcing layer on the field concentration of the nano-elliptical hole and the field intensity factors near the nano-crack tip.The results indicate that the properties of the surface layer and reinforcement layer and the electrical boundary conditions have great effects on the field concentration of the nano-hole and nano-crack,which are useful for optimizing and designing the microdevices by PQC nanocomposites in engineering practice. | Zhina ZHAO Junhong GUO | 2021 | Applied Mathematics and Mechanics(English Edition)2021，42，5： | 6 |
| 11 | Effect of manual acupuncture on bowel motility in normal kunming mouse显示文摘OBJECTIVE:To observe the effects of acupuncture on motility of jejunum and distal colon at different acupoints on normal Kunming mice.METHODS:The jejunal and colorectal motor activity of forty Kunming mice were recorded by the intra-intestinal capsule.The capsules contained with distilled water were placed into the cavities of jejunum and distal colon.The changes of bowel were compared with the background activity recorded before any stimulation.The chosen acupoints were as follows:Zusanli(ST 36) on the lower legs,Tianshu(ST 25) on the mid-lower abdomen.RESULTS:Manual acupuncture(MA) at Zusanli(ST36) significantly promoted the motility of jejunum and distal colon(manifested as increased change rate of average amplitude and increased change rate of mean area under the contractile curve) of normal Kunming mice(P < 0.01).MA atTianshu(ST25) significantly inhibited the motility of jejunum(manifested as decreased change rate of average amplitude,decreased change rate of mean area under the contractile curve,and the reduced frequency) of normal Kunming mice(P < 0.01),while significantly increased the distal colonic motility(manifested as increased amplitude and increased mean area under the contractile curve) of normal Kunming mice(P < 0.01).CONCLUSION:MA at specific acupoints[Zusanli(ST 36),Tianshu(ST 25)]has different effects on the motility of jejunum and distal colon,which might involve the segmental innervations of the related nerve. | Zhao Yuxue Cui Changxiang Qin Qingguang Ben Hui Gao Junhong Yu Xiaochun Zhu Bing | 2015 | Journal of Traditional Chinese Medicine2015，35，2： | 5 |
| 12 | Mining,characterization,and exploitation of EST-derived microsatellites in Gossypium barbadense显示文摘Simple sequence repeats(SSRs) have been widely applied as molecular markers in genetic studies.However,the number of expressed sequence tags(ESTs) and SSR markers from Gossypium barbadense is fewer than those from other cotton species.In this study,EST-SSR distribution from G.barbadense was characterized and new G.barbadense-derived EST-SSR markers were determined on the basis of the ESTs obtained by randomly sequencing 2 cDNA libraries associated with fiber development in G.barbadense.By mining 9697 non-redundant ESTs,a total of 638 SSR loci derived from 595 ESTs were observed.In G.barbadense,the frequency of ESTs containing SSRs was 6.13%,with an average of 1 SSR in every 10.4 kb of EST sequence.Furthermore,trinucleotide was found to be the most abundant repeat type among 2-6-nucleotide repeat types.It accounted for 26.6% of the total,followed by the hexanucleotide(26.0%) and pentanucleotide repeats(25.9%).Among all the repeat motifs,(AAG)n accounted for the highest proportion.EST-SSR primer pairs were developed using the Primer3 program,and the redundant primers were removed using the virtual PCR approach.As a result,380 non-redundant EST-SSR primer pairs were developed and used to detect polymorphisms between the mapping parents G.hirsutum 'TM-1' and G.barbadense 'Hai7124' for constructing linkage groups in cultivated allotetraploid cotton.Out of these,98(25.8%) primer pairs detected polymorphisms.Finally,95 polymorphic loci from 82 primer pairs were integrated into the backbone genetic map;of these,42 were mapped into the A subgenome and 53 into the D subgenome.The present work provided the foundation for constructing saturated genetic maps and conducting comparative genomic studies on different cotton species. | LU YuanDa CAI CaiPing WANG Lei LIN ShaoYan ZHAO Liang TIAN LiangLiang LU JunHong ZHANG TianZhen GUO WangZhen | 2010 | Chinese Science Bulletin2010，55，18： | 5 |
| 13 | Effects of three needling manipulations of the right-side Zusanli(ST 36) on brain using functional magnetic resonance imaging显示文摘OBJECTIVE: To investigate the effects on the brain using three needling manipulations(twirling, lifting-thrusting, and twirling plus lifting-thrusting)when the right-side Zusanli(ST 36) acupoint was stimulated with needles.METHODS: Seventeen healthy subjects accepted three needling manipulations stimulating the right Zusanli(ST 36) over separate days. Functional magnetic resonance imaging was used to detect changes in the brain during the manipulations, and then the needling sensations were recorded using the MGH acupuncture sensation scale(MASS) after each scan. f MRI data were processed using Statistical Parametric Mapping 8 to analyze the positiveand negative activation in the brain induced by different acupuncture manipulations.RESULTS: The individual needling sensations showed no statistically significant differences among the three manipulations. However, the MASS index showed that lifting-thrusting > twirling plus lifting-thrusting > twirling. Lifting-thrusting activated left premotor cortex, left postcentral,right middle frontal gyrus, left inferior frontal gyrus,right lingual gyrus, left insula, right putamen, bilateral cingulate gyrus and right cerebellum; and deactivated bilateral hippocampus and left caudate.Twirling activated bilateral orbital middle frontal gyrus, left opercular and triangular inferior frontal gyrus, and right middle occipital gyrus; and deactivated bilateral precuneus, right amygdala, left anterior cingulate gyrus, right inferior temporal gyrus,right middle frontal gyrus, right supplementary motor gyrus, and left postcentral. Twirling plus lifting-thrusting activated bilateral postcentral, left inferior occipital gyrus, left insula, left thalamus, left cingulate gyrus, and right putamen; and deactivated right superior frontal gyrus, right superior parietal gyrus, right temporal gyrus, right middle occipital gyrus, right insula, and left lingual gyrus. Pairwise comparisons of the three manipulations showed that signals induced by lifting-thrusting were the strongest, especially in the limbic system,followed by twirling plus lifting-thrusting; twirling alone was the weakest.CONCLUSION: Three methods of needling manipulations similarly activated areas associated with the somatosensory system, vision, cognition, and emotional regulation. This may have significant implications for acupuncture in clinical practice. | Lu Fengyan Gao Junhong Wang Yuanyuan Dai Qiufu Bao Yan Hong Yang Zhang Guolei Xin Juanjuan Zhao Yuxue Wu Shuyang Chen Yuanyuan Li Xiaojiao Fang Jiliang Yu Xiaochun | 2017 | Journal of Traditional Chinese Medicine2017，37，3： | 5 |
| 14 | Bevacizumab biosimilar LY01008 compared with bevacizumab(Avastin)as first-line treatment for Chinese patients with unresectable,metastatic,or recurrent non-squamous non-small-cell lung cancer:A multicenter,randomized,double-blinded,phase Ⅲ trial显示文摘Background:Previous studies have demonstrated the preclinical pharmacological and toxicological consistency,and clinical pharmacokinetic equivalence of bevacizumab biosimilar LY01008 with reference bevacizumab(Avastin).This randomized controlled trial aimed to compare the efficacy and safety of LY01008 with Avastin in first-line treatment of Chinese patients with advanced or recurrent non-squamous non-small cell lung cancer(NSCLC).Methods:StageⅢB-ⅣNSCLC patients with evaluable lesions,good physical status,and adequate organ functions from 67 centers across China were randomized in a ratio of 1:1 to receive LY01008 or Avastin 15 mg/kg intravenously in combination with paclitaxel/carboplatin(combined treatment)for 4-6 cycles,followed by maintenance monotherapy with LY01008 until disease progression,intolerable toxicity,or death.The primary endpoint was objective response rate(ORR)in accordance with Response Evaluation Criteria in Solid Tumors(RECIST)version 1.1 confirmed by independent radiological review committees(IRRC).Secondary endpoints included disease control rate(DCR),duration of response(DoR),progression-free survival(PFS),overall survival(OS),and safety.This study was registered in Clinical Trials.gov(NCT03533127).Results:Between December 15^(th),2017,and May 15^(th),2019,a total of 649 patients were randomized to the LY01008(n=324)or Avastin(n=325)group.As of September 25th,2019 for primary endpoint analysis,589 patients received ORR evaluation,with a median number of combined treatment cycles of 5(range 1-6)andmedian duration of treatment of 3.0(range 0.0-5.1)months.ORRof responseevaluable patients in the LY01008 and Avastin groups were 48.5% and 53.0%,respectively.The stratified ORR ratio was 0.91(90%CI 0.80-1.04,within the prespecified equivalence margin of 0.75-1.33).Up to May 15^(th),2020,with a median follow-up of 13.6(range 0.8-28.4)months,no notable differences in DCR,median DoR,median PFS,median OS,and 1-year OS rate were observed between the LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,or recurrent non-squamous NSCLC patients in the first-line setting. | Yuankai Shi Kaijian Lei Yuming Jia Bingqiang Ni Zhiyong He Minghong Bi Xicheng Wang Jianhua Shi Ming Zhou Qian Sun Guolei Wang Dongji Chen Yongqian Shu Lianke Liu Zhongliang Guo Yong Liu Junquan Yang Ke Wang Ke Xiao LinWu Tienan Yi Debin Sun Mafei Kang Tianjiang Ma Yimin Mao Jinsheng Shi Tiegang Tang Yan Wang Puyuan Xing Dongqing Lv Wangjun Liao Zhiguo Luo Bin Wang Xiaohong Wu Xiaoli Zhu Shuhua Han Qisen Guo Rongyu Liu Zhiwei Lu Jianyong Zhang Jian Fang Changlu Hu Yinghua Ji Guolong Liu Hong Lu Dedong Wu Junhong Zhang Shuyang Zhu Zheng Liu Wensheng Qiu Feng Ye Yan Yu Yanqiu Zhao Qinhong Zheng Jun Chen Zhanyu Pan Yiping Zhang Wenjuan Lian Bo Jiang Bo Qiu Guojun Zhang Hua Zhang Yanju Chen Yuan Chen Hongbing Duan Manxiang Li Shengming Liu Lijun Ma Hongming Pan Xia Yuan Xueli Yuan Yulong Zheng Emei Gao Li Zhao Shumin Wang Can Wu | 2021 | Cancer Communications2021，41，9： | 5 |
| 15 | Preparation and characterization of PVDF-PFSA flat sheet ultrafiltration membranes显示文摘高效 polyvinylidene 氟化物( PVDF )公寓表 ultrafiltration ( UF )膜被一个沉浸 降水阶段倒置方法作为一个毛孔前者并且作为膜和聚乙烯乙二醇的一个吸水的部件用 perfluorosulfonic 酸( PFSA )准备了( M w = 400 )( PEG400 )作为一毛孔形成代理人。木钉的存在和扔的答案的阶段分离上并且在包括他们的孔的 UF 膜的形态学和表演上的 PFSA 的集中的效果,水流动,牛的浆液白朊(BSA ) 的拒绝蛋白质,和犯规反的性质被调查。在浇蒸汽的暴露之上的阶段图,粘性和阶段分离证明 PEG400 和 PFSA 支持了扔的答案的 demixing。扫描电子显微镜学大小证明 PVDF-PFSA 混合膜比本国的 PVDF 膜有更多的 macropores 和指状的结构。PVDF-PFSA 膜(5 wt-%PEG400 + 5 wt-% PFSA ) 有 141.7 L/m2 (25 %) 的纯水流动一?? | Jiquan MA Junhong ZHAO Zhongbin REN Lei LI | 2012 | Frontiers of Chemical Science and Engineering2012，6，3： | 3 |
| 16 | AVP(4-8) Improves Cognitive Behaviors and Hippocampal Synaptic Plasticity in the APP/PS1 Mouse Model of Alzheimer’s Disease显示文摘Memory deficits with aging are related to the neurodegeneration in the brain, including a reduction in arginine vasopressin(AVP) in the brain of patients with Alzheimer’s disease(AD). AVP(4-8), different from its precursor AVP, plays memory enhancement roles in the CNS without peripheral side-effects. However, it is not clear whether AVP(4-8) can improve cognitive behaviors and synaptic plasticity in the APP/PS1 mouse model of AD. Here, we investigated for the first time the neuroprotective effects of AVP(4-8) on memory behaviors and in vivo long-term potentiation(LTP) in APP/PS1-AD mice.The results showed that:(1) APP/PS1-AD mice had lower spontaneous alternation in the Y-maze than wild-type(WT) mice, and this was significantly reversed by AVP(4-8);(2) the prolonged escape latency of APP/PS1-AD mice in the Morris water maze was significantly decreased by AVP(4-8), and the decreased swimming time in target quadrant recovered significantly after AVP(4-8) treatment;(3) in vivo hippocampal LTP induced by high-frequency stimulation had a significant deficit in the AD mice, and this was partly rescued by AVP(4-8);(4) AVP(4-8)significantly up-regulated the expression levels of postsynaptic density 95(PSD95) and nerve growth factor(NGF)in the hippocampus of AD mice. These results reveal the beneficial effects of AVP(4-8) in APP/PS1-AD mice,showing that the intranasal administration of AVP(4-8)effectively improved the working memory and long-term spatial memory of APP/PS1-AD mice, which may be associated with the elevation of PSD95 and NGF levels in the brain and the maintenance of hippocampal synaptic plasticity. | Xiumin Zhang Fang Zhao Chenfang Wang Jun Zhang Yu Bai Fang Zhou Zhaojun Wang Meina Wu Wei Yang Junhong Guo Jinshun Qi | 2020 | Neuroscience Bulletin2020，36，3： | 3 |
| 17 | SARS-CoV-2 spike protein interacts with and activates TLR41显示文摘Dear Editor,Accumulating clinical data suggest the main causes of death by COVID-19 include respiratory failure and the onset of sepsis.1 Importantly,sepsis has been observed in nearly all deceased patients.2,3,4,5 It remains elusive how SARS-CoV-2 infection results in viral sepsis in humans.Toll-like receptor 4(TLR4)mediates anti-gram-negative bacterial immune responses by recognizing lipopolysaccharide(LPS)from bacteria.6 We recently found that SARS-CoV-2 infection provoked an anti-bacterial like response at the very early stage of infection via TLR4.However,the identity of the original trigger initiating these abnormal immune responses during SARS-CoV-2 infection is unknown. | Yingchi Zhao Ming Kuang Junhong Li Ling Zhu Zijing Jia Xuefei Guo Yaling Hu Jun Kong Hang Yin Xiangxi Wang Fuping You | 2021 | Cell Research2021，31，7： | 3 |
| 18 | Tumor Suppressor Functions of miR-133a in Colorectal Cancer显示文摘 | Yujuan Dong Junhong Zhao Chung-Wah Wu Lijing Zhang Xiaodong Liu Wei Kang Wing-Wah Leung Ning Zhang Francis K.L. Chan Joseph J.Y. Sung Simon S.M. Ng Jun Yu | 2013 | Molecular Cancer Research2013，，9： | 3 |
| 19 | Significance of vulnerability assessment in establishment of Hainan provincal disaster medical system显示文摘Hainan is an island province in south China with a high frequency of unconventional emergencies due to its special geographic location and national military defense role.Given the limited transportation route from Hainan to the outside world,self-rescue is more important to Hainan Province than other provinces in China and it is therefore imperative to establish an independent, scientific as well as efficient provincal disaster medical system in Hainan.The regulatory role for vulnerability analysis/assessment has been demonstrated in establisment of disaster medical system in varoius countries and or regions.In this paper,we attempt to describe/propose how to adopt vulnerability assessment through mathematical modeling of major biophysical social vulnerability factors to establish an independent,scientific,effieicnt and comprehensive provincial disaster medical system in Hainan. | Min Li Chuanzhu Lu Wei Son Junhong Miao Yipeng Ding Longhe Li Leilei Zhang Nin Zhao Bijiang Hu Yunjun Zhang | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，8： | 2 |
| 20 | Large-scale achromatic flat lens by light frequency-domain coherence optimization显示文摘Flat lenses,including metalens and diffractive lens,have attracted increasing attention due to their ability to miniaturize the imaging devices.However,realizing a large scale achromatic flat lens with high performance still remains a big challenge.Here,we developed a new framework in designing achromatic multi-level diffractive lenses by light coherence optimization,which enables the implementation of large-scale flat lenses under non-ideal conditions.As results,a series achromatic polymer lenses with diameter from 1 to 10mm are successfully designed and fabricated.The subsequent optical characterizations substantially validate our theoretical framework and show relatively good performance of the centimeter-scale achromatic multi-level diffractive lenses with a super broad bandwidth in optical wavelengths(400-1100 nm).After comparing with conventional refractive lens,this achromatic lens shows significant advantages in white-light imaging performance,implying a new strategy in developing practical planar optical devices. | Xingjian Xiao Yunwei Zhao Xin Ye Chen Chen Xinmou Lu Yansen Rong Junhong Deng Guixin Li Shining Zhu Tao Li | 2022 | Light(Science & Applications)2022，11，12： | 2 |
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