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| 1 | 2019新型冠状病毒基因组特征和流行病学:病毒起源和受体结合的意义显示文摘研究者对来自9例新型冠状病毒肺炎住院患者的支气管肺泡灌洗液样本和培养的分离株进行了下一代测序。从这些个体中获得了严重急性呼吸综合征-冠状病毒2(severe acute respiratory syndrome-coronavirus 2,SARS-CoV-2)的完整和部分基因组序列。利用Sanger测序连接病毒重叠群以获得全长基因组,cDNA末端快速扩增确定终端区。对这些SARSCoV-2基因组和其他冠状病毒基因组进行了系统进化分析,以确定该病毒的进化史并有助于推断其可能的起源。 | 刘青(译) 刘莉(审校) Lu R Zhao X Li J Niu P Yang B Wu H Wang W Song H Huang B Zhu N Bi Y Ma X Zhan F Wang L Hu T Zhou H Hu Z Zhou W Zhao L Chen J Meng Y Wang J Lin Y Yuan J Xie Z Ma J Liu WJ Wang D Xu W Holmes EC Gao GF Wu G Chen W Shi W Tan W | 2020 | 中华高血压杂志2020，28，3： | 516 |
| 2 | Abnormal activation of the synuclein-gamma gene in hepatocellular carcinomas by epigenetic alteration.显示文摘 | Zhao W Liu H Liu W Wu Y Chen W Jiang B Zhou Y Xue R Luo C Wang L Jiang JD Liu J | 2006 | 中国生物学文摘2006，20，4： | 31 |
| 3 | 体内腺相关病毒-常间回文重复序列丛集及其相关蛋白9介导的基因编辑可改善家族性高胆固醇血症的动脉粥样硬化显示文摘低密度脂蛋白受体(low-density lipoprotein receptor,Ldlr)基因突变是家族性高胆固醇血症的主要原因之一,可导致动脉粥样硬化,并具有很高的终生心血管病风险。常间回文重复序列丛集(clustered regularly interspaced short palindromic repeats,CRISPR)/CRISPR相关蛋白9(CRISPR-related protein 9,Cas9)系统是基因编辑纠正基因突变从而改善疾病的有效工具。该研究的目的是通过腺相关病毒(adeno-associated virus,AAV)携带的CRISPR/Cas9系统进行体内体细胞基因编辑,以确定其能否在小鼠模型中治疗由Ldlr突变体引起的家族性高胆固醇血症。 | 刘青(译) 叶鹏(审校) Zhao H Li Y He L Pu W Yu W Li Y Wu YT Xu C Wei Y Ding Q Song BL Huang H Zhou B | 2020 | 中华高血压杂志2020，28，3： | 22 |
| 4 | Association of farnesyl diphosphate synthase polymorphisms and response to alendronate treatment in Chinese postmenopausal women with osteoporosis显示文摘 | Liu Y Li M Zhou PR Xing XP Xia WB Xu L Liu H J Zhang ZL LiaoEY Chen DC Liu J Tao TZ Wu W | 2014 | Chinese Medical Journal2014，，4： | 16 |
| 5 | Polymorphisms of MTHFD,plasma homocysteine levels, and risk of gastric cancer in ahigh-risk Chinese population显示文摘Purpose:Accumulative evidence suggests that folate has a protective effect on gastric cancer. The methylenetetrahyd-rofolate dlehydrogenase(MTHFD) plays an important role in folate and homocysteine metabolisms, and polymorphisms of MTHFD may result in disturbance of the folate-mediated homocysteine pathway. The aim of this study is to test the hypothesis that genetic variants of MTHFD and plasma homocysteine levels are associated with risk of gastric cancer and modulated by genotypes of methylenetetrahydrofolate reductase(MTHFR). Experimental Design: We genotyped G1958A and T401C in MTHFD and C677T in MTHFR and detected total plasma homocysteine(tHcy) levels in a case-control study of 589 gastric cancer cases and 635 cancer-free controls in a high-risk Chinese population. Results:The variant genotypes of MTHFD 1958AA and 401CC were associated with a significantly increased risk of gastric canceradjusted odds ratio(OR), 2.05; 95% confidence interval(95% CI),1.34-3.13 for 1958AA; adjusted OR,1.43; 95% CI,1.14-1.80 for 401CC compared with 1958GG/GA and 401TT/TC genotypes, respectively. Both of the effects were more evident in the subjects carrying MTHFR 677CT/TT genotypes. The average tHcy level was significantly higher in gastric cancer cases than in controls(P < 0.01), and the upper quartile of tHcy (> 13.6 mu mol/L) was associated with an 82% significantly increased risk of gastric cancer, compared with the lowest quartile of tHcy(<= 8.0 pmol/L;adjusted OR,1.82; 95% CI,1.20-2.75). Conclusions:The strong associations between MTHFD variants and the plasma tHcy levels and gastric cancer risk suggest, for the first time, a possible gene-environment interaction between genetic variants of folate-metabolizing genes and high tHcy levels in gastric carcinogenesis. | Wang, L. N Ke, Q Chen, W. S Wang, J. M Tan, Y. F Zhou, Y Hua, Z. L Ding, W. L Niu, J. Y Shen, J Zhang, Z. F Wang, X. R Xu, Y. H Shen, H. B Yi Xing | 2007 | 南京医科大学学报(自然科学版)2007，27，7： | 10 |
| 6 | Mutation analysis of autosomal dominant polycystic kidney disease genes in Han Chinese显示文摘 | Zhang S Mei C Zhang D Dai B Tang B Sun T Zhao H Zhou Y Li L Wu Y Wang W Shen X Song J | 2005 | 第二军医大学学报2005，26，8： | 6 |
| 7 | 中国成年女性初潮年龄与高血压风险的关系:大型国家代表性群体研究结果显示文摘本研究纳入中国高血压调查中年龄≥18岁的女性234867例,旨在探索中国成年女性初潮年龄与高血压风险的相关性。参与者被要求完成标准问卷,血压测量和体格检查由经过培训的医务人员完成。采用Spearman相关性分析探索初潮年龄和其他个体特征的相关性。采用logistic回归根据初潮年龄计算高血压发生的OR。结果显示,中国女性平均初潮年龄为14.8岁。 | 袁源(摘译) 郑武洪(审校) Chen L Zhang L Chen Z Wang X Zheng C Kang Y Zhou H Wang Z Gao R | 2021 | 中华高血压杂志2021，29，10： | 3 |
| 8 | Molecular dynamics study on ionic hydration 显示文摘 | ZHOU J LUX H WANG Y R | 2002 | Fluid Phase Equilibria2002，，： | 2 |
| 9 | Genetic transformation of wheat mediated by Agrobacterium tumefaciens显示文摘 | Cheng M Fry J E Pang S Zhou H Hironaka C M Duncan D R Conner T W Wan Y | 1997 | Plant Physiol1997，，： | 2 |
| 10 | 透析前后血压水平与全因死亡风险的关系:一项剂量-效应关系的荟萃分析显示文摘血液透析人群的血压管理是一个巨大挑战。该研究旨在通过剂量-效应关系的荟萃分析,评估血液透析人群中透析前后血压水平与全因死亡风险之间关联的定量特征和潜在阈值。研究人员搜索了2017年3月18日之前发表的、关于透析前后血压水平与全因死亡率风险关联的所有前瞻性队列研究资料,共纳入来自8项研究的229688例普通血液透析患者。 | 刘莉 叶鹏 Han YC Tu Y Zhou LT Pan MM Wang B Liu H Tang RN Liu BC | 2018 | 中华高血压杂志2018，26，11： | 2 |
| 11 | , An alternative method for simulating IPSF in two-photon laser scanning microscopy显示文摘 | ZHOU Y J CHEN D Q HUANG W H | 2002 | SPIE2002，4927，： | 2 |
| 12 | Effect of closure of live poultry markets on poultry-to-person transmission of avian influenza A H7N9 virus: an ecological study显示文摘 | Hongjie Yu Joseph T Wu Benjamin J Cowling Qiaohong Liao Vicky J Fang Sheng Zhou Peng Wu Hang Zhou Eric H Y Lau Danhuai Guo Michael Y Ni Zhibin Peng Luzhao Feng Hui Jiang Huiming Luo Qun Li Zijian Feng Yu Wang Weizhong Yang Gabriel M Leung | 2013 | The Lancet2013，，： | 2 |
| 13 | Sensor alignment with earth centered earth fixed (ECEF) coordinate system显示文摘 | Zhou Y Leung H | 1999 | IEEE Trans on AES1999，35，2： | 1 |
| 14 | Shrub facilitation of desert land restoration in the Horqin Sand Land of Inner Mongolia显示文摘 | ZHAO H L ZHOU R L SU Y Z | 2007 | Ecological Engineering2007，31，： | 1 |
| 15 | Inhibition of glycolysis in cancer cells:a novel strategy to overcome drug resistance associated with mitochondrial respiratory defect and hypoxia显示文摘 | Xu RH Pelicano H Zhou Y | 2005 | Cancer Res2005，65，2： | 1 |
| 16 | Intracellular co-localization of SPLUNC1 protein with nanobacteria in nasopharyngeal carcinoma epithelia HNE1 cells depended on the bactericidal permeability increasing protein domain显示文摘 | Zhou H D Li G Y Yang Y X | 2006 | Mol Immunol2006，43，11： | 1 |
| 17 | Effects of Au plating on smallscale resistance spot welding of thin-sheet nickel显示文摘 | Tan W Zhou Y Kerr H W | 2002 | Metall Mater Trans A2002，33，8： | 1 |
| 18 | A novel ultraviolet irradiation photoreduetion technique for the preparation of single-crystal Ag nanorods and Ag dendrites 显示文摘 | Zhou Y Yu S H Wang C Y | 1999 | Advanced Materials1999，11，10： | 1 |
| 19 | A DNA vaccine targeting survivin combines apoptosis with suppression of angiogenesis in lung tumor eradication显示文摘 | Xiang R Mizutani N Luo Y Chiodoni C Zhou H Mizutani M | 2005 | Cancer Res2005，65，： | 1 |
| 20 | Proteomic analysis of hepatitis B virus-associated hepatocellular carcinoma:Identification of potential tumor markers显示文摘 | TAN Y X ZHOU H | 2005 | Proteomics2005，5，4： | 1 |
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