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| 1 | Endoscopic characteristics in predicting prognosis of biopsy-diagnosed gastric low-grade intraepithelial neoplasia显示文摘Background: Endoscopic biopsy can underestimate gastric malignancies as low-grade intraepithelial neoplasia (LGIN). Definitively diagnosed LGIN would progress. This study aimed to evaluate predictive factors to identify malignancies misdiagnosed as LGIN by biopsy and LGIN at high risk of progression.Methods: The clinical records of patients diagnosed with gastric LGIN by endoscopic biopsy who underwent at least two endoscopies during the first year of follow-up between 2007 and 2017 were retrospectively collected. Three endoscopists reviewed photographs of the initial endoscopy, described lesion characteristics, and made endoscopic diagnoses. Logistic regression was used to analyze predictors to identify malignancies underestimated as LGIN. A receiver operating characteristic curve was used to evaluate the diagnostic accuracy of these predictors. Patient clinical outcomes of follow-up >1 year were collected. Kaplan-Meier estimates with log-rank tests and Cox proportional hazards regression were used to analyze predictors of progression.Results: Overall, 48 of 182 (26.4%) patients were proven to have malignancies. A single lesion, a large lesion size, and marked intestinal metaplasia (IM) were independent predictors of initially misdiagnosed malignancies. The area under the curve of these predictors was 0.871, with a sensitivity of 68.7% and specificity of 92.5%. Twelve of 98 patients (12.2%) progressed during the 33-month median follow-up period. A whitish appearance, irregular margins, marked IM, and histological diagnosis of LGIN more than twice within the first year were predictors for progression.Conclusions: Lesions diagnosed as LGIN by biopsy with marked IM and other predictors above should be prudently treated for high potential to be malignancies or progress. Endoscopic follow-up with repeated biopsies within the first year is recommended. | Long Zou Qingwei Jiang Tao Guo Xi Wu Qiang Wang Yunlu Feng Shengyu Zhang Weigang Fang Weixun Zhou Aiming Yang | 2022 | Chinese Medical Journal2022，，1： | 3 |
| 2 | Single-cell transcriptomic landscape of human blood cells显示文摘High throughput single-cell RNA-seq has been successfully implemented to dissect the cellular and molecular features underlying hematopoiesis.However,an elaborate and comprehensive transcriptome reference of the whole blood system is lacking.Here,we profiled the transcriptomes of 7551 human blood cells representing 32 immunophenotypic cell types,including hematopoietic stem cells,progenitors and mature blood cells derived from 21 healthy donors.With high sequencing depth and coverage,we constructed a single-cell transcriptional atlas of blood cells(ABC) on the basis of both protein-coding genes and long noncoding RNAs(lncRNAs),and showed a high consistence between them.Notably,putative lncRNAs and transcription factors regulating hematopoietic cell differentiation were identified.While common transcription factor regulatory networks were activated in neutrophils and monocytes,lymphoid cells dramatically changed their regulatory networks during differentiation.Furthermore,we showed a subset of nucleated erythrocytes actively expressing immune signals,suggesting the existence of erythroid precursors with immune functions.Finally,a web portal offering transcriptome browsing and blood cell type prediction has been established.Thus,our work provides a transcriptional map of human blood cells at single-cell resolution,thereby offering a comprehensive reference for the exploration of physiological and pathological hematopoiesis. | Xiaowei Xie Mengyao Liu Yawen Zhang Bingrui Wang Caiying Zhu Chenchen Wang Qing Li Yingying Huo Jiaojiao Guo Changlu Xu Linping Hu Aiming Pang Shihui Ma Una Wang Wenbin Cao Shulian Chen Qiuling Li Sudong Zhang Xueying Zhao Wen Zhou Hongbo Luo Guoguang Zheng Erlie Jiang Sizhou Feng Lixiang Chen Lihong Shi Hui Cheng Sha Hao Ping Zhu Tao Cheng | 2021 | National Science Review2021，8，3： | 3 |
| 3 | SUMOylation-modified Pelota-Hbs1 RNA surveillance complex restricts the infection of potyvirids in plants显示文摘RNA quality control nonsense-mediated decay is involved in viral restriction in both plants and animals.However,it is not known whether two other RNA quality control pathways,nonstop decay and no-go decay,are capable of restricting viruses in plants.Here,we show that the evolutionarily conserved Pelota–Hbs1 complex negatively regulates infection of plant viruses in the family Potyviridae(termed potyvirids),the largest group of plant RNA viruses that accounts for more than half of the viral crop damage worldwide.Pelota enables the recognition of the functional G1-2A6-7 motif in the P3 cistron,which is conserved in almost all potyvirids.This allows Pelota to target the virus and act as a viral restriction factor.Furthermore,Pelota interacts with the SUMO E2-conjugating enzyme SCE1 and is SUMOylated in planta.Blocking Pelota SUMOylation disrupts the ability to recruit Hbs1 and inhibits viral RNA degradation.These findings reveal the functional importance of Pelota SUMOylation during the infection of potyvirids in plants. | Linhao Ge Buwei Cao Rui Qiao Hongguang Cui Shaofang Li Hongying Shan Pan Gong Mingzhen Zhang Hao Li Aiming Wang Xueping Zhou Fangfang Li | 2023 | Molecular Plant2023，16，3： | 2 |
| 4 | Synthesis of Ti3AIC2 Powders using Sn as an additive 显示文摘 | AIM X ZHAI H X ZHOU Y | 2006 | Journal of American Ceramic Society2006，89，3： | 1 |
| 5 | PREVALENCE OF SOLENOPSIS INVICTA (HYMENOPTERA: FORMICIDAE) VENOM ALLERGIC REACTIONS IN MAINLAND CHINA显示文摘 | Xu Yijuan Huang Jun Zhou Aiming Zeng Ling | 2012 | The Florida Entomologist2012，，4： | 1 |
| 6 | Costbenefit analysis on IRP/DSM application--a case study in Shanghai显示文摘 | LIU Deshun WANG Youhong ZHOU Aiming | | Energy Policy0，25，10： | 1 |
| 7 | Recent advances in RNA structurome显示文摘RNA structures are essential to support RNA functions and regulation in various biological processes. Recently, a range of novel technologies have been developed to decode genome-wide RNA structures and novel modes of functionality across a wide range of species. In this review, we summarize key strategies for probing the RNA structurome and discuss the pros and cons of representative technologies. In particular, these new technologies have been applied to dissect the structural landscape of the SARS-CoV-2 RNA genome. We also summarize the functionalities of RNA structures discovered in different regulatory layers-including RNA processing, transport, localization, and mRNA translation-across viruses, bacteria, animals, and plants. We review many versatile RNA structural elements in the context of different physiological and pathological processes(e.g., cell differentiation, stress response, and viral replication). Finally, we discuss future prospects for RNA structural studies to map the RNA structurome at higher resolution and at the single-molecule and single-cell level, and to decipher novel modes of RNA structures and functions for innovative applications. | Bingbing Xu Yanda Zhu Changchang Cao Hao Chen Qiongli Jin Guangnan Li Junfeng Ma Siwy Ling Yang Jieyu Zhao Jianghui Zhu Yiliang Ding Xianyang Fang Yongfeng Jin Chun Kit Kwok Aiming Ren Yue Wan Zhiye Wang Yuanchao Xue Huakun Zhang Qiangfeng Cliff Zhang Yu Zhou | 2022 | Science China(Life Sciences)2022，65，7： | 1 |
| 8 | FungalTraits:a user-friendly traits database of fungi and fungus-like stramenopiles显示文摘The cryptic lifestyle of most fungi necessitates molecular identification of the guild in environmental studies.Over the past decades,rapid development and affordability of molecular tools have tremendously improved insights of the fungal diversity in all ecosystems and habitats.Yet,in spite of the progress of molecular methods,knowledge about functional properties of the fungal taxa is vague and interpretation of environmental studies in an ecologically meaningful manner remains challenging.In order to facilitate functional assignments and ecological interpretation of environmental studies we introduce a user friendly traits and character database FungalTraits operating at genus and species hypothesis levels.Combining the information from previous efforts such as FUNGuild and FunFun together with involvement of expert knowledge,we reannotated 10,210 and 151 fungal and Stramenopila genera,respectively.This resulted in a stand-alone spreadsheet dataset covering 17 lifestyle related traits of fungal and Stramenopila genera,designed for rapid functional assignments of environmental stud-ies.In order to assign the trait states to fungal species hypotheses,the scientific community of experts manually categorised and assigned available trait information to 697,413 fungal ITS sequences.On the basis of those sequences we were able to summarise trait and host information into 92,623 fungal species hypotheses at 1%dissimilarity threshold. | Sergei Põlme Kessy Abarenkov RHenrik Nilsson Björn D.Lindahl Karina Engelbrecht Clemmensen Havard Kauserud Nhu Nguyen Rasmus Kjøller Scott T.Bates Petr Baldrian Tobias Guldberg Frøslev Kristjan Adojaan Alfredo Vizzini Ave Suija Donald Pfister Hans-Otto Baral Helle Järv Hugo Madrid Jenni Nordén Jian-Kui Liu Julia Pawlowska Kadri Põldmaa Kadri Pärtel Kadri Runnel Karen Hansen Karl-Henrik Larsson Kevin David Hyde Marcelo Sandoval-Denis Matthew E.Smith Merje Toome-Heller Nalin N.Wijayawardene Nelson Menolli Jr Nicole K.Reynolds Rein Drenkhan Sajeewa S.N.Maharachchikumbura Tatiana B.Gibertoni Thomas Læssøe William Davis Yuri Tokarev Adriana Corrales Adriene Mayra Soares Ahto Agan Alexandre Reis Machado Andrés Argüelles-Moyao Andrew Detheridge Angelina de Meiras-Ottoni Annemieke Verbeken Arun Kumar Dutta Bao-Kai Cui C.K.Pradeep César Marín Daniel Stanton Daniyal Gohar Dhanushka N.Wanasinghe Eveli Otsing Farzad Aslani Gareth W.Griffith Thorsten H.Lumbsch Hans-Peter Grossart Hossein Masigol Ina Timling Inga Hiiesalu Jane Oja John Y.Kupagme József Geml Julieta Alvarez-Manjarrez Kai Ilves Kaire Loit Kalev Adamson Kazuhide Nara Kati Küngas Keilor Rojas-Jimenez Krišs Bitenieks Laszlo Irinyi LászlóGNagy Liina Soonvald Li-Wei Zhou Lysett Wagner M.Catherine Aime MaarjaÖpik María Isabel Mujica Martin Metsoja Martin Ryberg Martti Vasar Masao Murata Matthew PNelsen Michelle Cleary Milan C.Samarakoon Mingkwan Doilom Mohammad Bahram Niloufar Hagh-Doust Olesya Dulya Peter Johnston Petr Kohout Qian Chen Qing Tian Rajasree Nandi Rasekh Amiri Rekhani Hansika Perera Renata dos Santos Chikowski Renato L.Mendes-Alvarenga Roberto Garibay-Orijel Robin Gielen Rungtiwa Phookamsak Ruvishika S.Jayawardena Saleh Rahimlou Samantha C.Karunarathna Saowaluck Tibpromma Shawn P.Brown Siim-Kaarel Sepp Sunil Mundra Zhu-Hua Luo Tanay Bose Tanel Vahter Tarquin Netherway Teng Yang Tom May Torda Varga Wei Li Victor Rafael Matos Coimbra Virton Rodrigo Targino de Oliveira Vitor Xavier de Lima Vladimir S.Mikryukov Yongzhong Lu Yosuke Matsuda Yumiko Miyamoto Urmas Kõljalg Leho Tedersoo | 2020 | Fungal Diversity2020，，6： | 1 |
| 9 | Molecular chain movements and transitions of SEBS above room temperature studied by moving- window two- dimensional correlation infrared spectroscopy显示文摘 | Tao Zhou Aiming Zhang Changsheng Zhao | 2007 | Macromolecules2007，11，： | 1 |
| 10 | Plant and animal positive-sense single-stranded RNA viruses encode small proteins important for viral infection in their negative-sense strand显示文摘Positive-sense single-stranded RNA(+ssRNA)viruses,the most abundant viruses of eukaryotes in nature,require the synthesis of negative-sense RNA(-RNA)using their genomic(positive-sense)RNA(+RNA)as a template for replication.Based on current evidence,viral proteins are translated via viral+RNAs,whereas-RNA is considered to be a viral replication intermediate without coding capacity.Here,we report that plant and animal+ssRNA viruses contain small open reading frames(ORFs)in their-RNA(reverse ORFs[rORFs]).Using turnip mosaic virus(TuMV)as a model for plant+ssRNA viruses,we demonstrate that small proteins encoded by rORFs display specific subcellularlocalizations,and confirm the presence of rORF2 in infected cells through mass spectrometry analysis.The protein encoded by TuMV rORF2 forms punctuate granules that are localized in the perinuclear region and co-localized with viral replication complexes.The rORF2 protein can directly interact with the viral RNA-dependent RNA polymerase,and mutation of rORF2 completely abolishes virus infection,whereas ectopic expression of rORF2 rescues the mutant virus.Furthermore,we show that several rORFs in the-RNA of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)have the ability to suppress type l interferon production and facilitate the infection of ve-sicular stomatitis virus.In addition,we provide evidence that TuMV might utilize internal ribosome entry sites to translate these small rORFs.Taken together,these findings indicate that the-RNA of+ssRNA vi-ruses can also have the coding capacity and that small proteins encoded therein play critical roles in viral infection,revealing a viral proteome larger than previously thought. | Pan Gong Qingtang Shen Mingzhen Zhang Rui Qiao Jing Jiang Lili Su Siwen Zhao Shuai Fu Yu Ma Linhao Ge Yaqin Wang Rosa Lozano-Durán Aiming Wang Fangfang Li Xueping Zhou | 2023 | Molecular Plant2023，16，11： | 0 |
| 11 | The Authentic Record of the Livelihood of Tibetans Living on the Snowy Plateau-The documentary“A Year in Tibet”Attracts Worldwide Attention显示文摘'This year,I have seemingly become a famous movie star as my name is well-known amongst many overseas tourists traveling to Gyantse.It is incredible to me that this documentary series had such a great influence after being broadcasted all over the world.I remember the time when Sun Shuyun(the director of the documentary) came to invite me to be the main character of the documentary and be | Zhou Aiming | 2009 | China's Tibet2009，20，5： | 0 |
| 12 | Parathyroid carcinoma-related severe acute pancreatitis during pregnancy:a case report and literature review显示文摘Introduction Primary hyperparathyroidism(PHPT)is caused by hyperfunctioning parathyroid adenoma,hyperplasia,or carcinoma.Parathyroid carcinoma is a rare disease affecting<1%of PHPT patients and is associated with complications such as acute pancreatitis(AP),which can be complicated by pregnancy[1].Currently,pregnant patients with AP or PHPT can only be treated empirically as there is no consensus approach.Here,we report a rare case of parathyroid carcinoma with adenomarelated AP during pregnancy.The detailed diagnosis and treatment process are described,and clinical features of similar cases are summarized.We hope to improve the diagnosis and treatment of PHPT-related pancreatitis during pregnancy. | Yaxuan Zhou Qiang Wang Long Zou XiWu Aiming Yang | 2023 | Gastroenterology Report2023，11，1： | 0 |
| 13 | Risk factors for CMV infection within 100 days posttransplantation in patients with acute leukemia显示文摘Objective:To investigate the risk factors for cytomegalovirus(CMV)infection within 100 days and the relationship between early CMV infection and 1-year relapse for patients with acute leukemia following allogeneic hematopoietic stem cell transplantation(allo-HSCT).Methods:Three hundred fifty-nine patients with acute leukemia who received allo-HSCT at our center between January 2015 and January 2020 were retrospectively reviewed.Results:Of 359 patients,48.19%(173)patients experienced CMV infection within 100 days posttransplantation.In univariate and multivariate logistic analysis,haploidentical-related donor(HRD)(P<0.001;odds ratio[OR],5.542;95%confidence interval[CI],3.186–9.639),and ratio of CD3^(+)CD8^(+)cells in lymphocytes<14.825%(P<0.001;OR,3.005;95%CI,1.712–5.275)were identified as 2 independent risk factors.One-year relapse rate(RR)between the CMV infection group and the non-CMV infection group was not statistically significant(18.5%vs 19.9%,P=0.688).When we divided the total cohort into AML,ALL,and MAL subgroups,there were no significant differences as well(P=0.138;P=0.588;P=0.117;respectively).Conclusion:In conclusion,donor type(HRD)and the insufficient recovery of CD3^(+)CD8^(+)cells were independent risk factors for CMV infection within 100 days posttransplantation in patients with acute leukemia.CMV infection within 100 days did not influence the incidence of relapse in 1 year for patients with acute leukemia. | Juan Chen Aiming Pang Yuanqi Zhao Li Liu Runzhi Ma Jialin Wei Xin Chen Yi He Donglin Yang Rongli Zhang Weihua Zhai Qiaoling Ma Erlie Jiang Mingzhe Han Jiaxi Zhou Sizhou Feng | 2022 | Blood Science2022，4，3： | 0 |
| 14 | TO SUPPORT AND EXTEND THE INDUSTRIL CHAIN ON THE QINGHAI-TIBET PLATEAU BY DEVELOPING AND ADVANCING TECHNIQUE显示文摘At 9am,May 17th,2013,we set out through heavy snow from the County of Hongyuan for the Xiaman Goat Husbandry Farm in Western Ruoergai.Along the way,we saw few humans but there were groups of yaks grazing with a quiet,masterful air on the snow-covered prairie.The road was uneven | Zhou Aiming | 2013 | China's Tibet2013，24，5： | 0 |
| 15 | The Ticking Clock Counting Down to the Demise of Feudalism and the Serfdom System——An Interview with Gyaltsen Norbu,the Former Chairman of the Government of TAR显示文摘Gyaltsen Norbu is a Tibetan,born in Bathang of Sichuan Province.In June of 1950,he joined the People’s Liberation Army and served in the vanguard of the 18th Military Force.He undertook such posts as cadre of Tibetan language in the 3rd Division of the 18th Military Force,information advisor for Chamdo Garrison Corp of Xichang Military Force, information advisor of Detection | Zhou Aiming | 2009 | China's Tibet2009，20，2： | 0 |
| 16 | MY WITNESS TO AND PARTICIPATION IN THE MARCH TO TIBET IN 1950S——ZHENGYING,THE MINISTER WHO BEGAN HIS CAREER AS A LITTLE“TONGSI”显示文摘In 1983 the book entitled Tibet Transformation,written by Israel Epstein,illustrated the author’s three interviews in Tibet.He concluded that there were three generations of Tibetan cadres:red- army soldier in the long march,cadres from 1950 to 1951 and cadres thereafter.Mr.Zheng Ying is categorized as the second generation.The author of this book gave readers a unique description of Zheng Ying by writing:'He is tall with a dark countenance and behaves discreetly.''When he was 17, in 1950,he joined the People’s Liberation Army(PLA)and later followed the march by the military force into Tibet.In 1953,he transferred from the military to the Working Committee of the Communist | Zhou Aiming | 2010 | China's Tibet2010，21，5： | 0 |
| 17 | Comfortable Housing-the Essence of a People’s Livelihood-An Interview with Jampa Phuntsok,the Chairman of the Government of TAR显示文摘In the 1^(st) Session of the 9^(th) People's Congress of e Tibet Autonomous Region (TAR),held on nuary 22,2008,Mr.Jampa Phuntsok was again ted Chairman of the Tibetan Government.There is no doubt that the election outcome demonstrates once more that the population of over 2.8 million Tibetans ac- knowledges the achievements of the preceding leadership. Not surprisingly,in this five-year administrative | Zhou Aiming | 2008 | China's Tibet2008，19，3： | 0 |
| 18 | THE PEACEFUL LIBERATION OF TIBET IS A SPLENDID CHAPTER IN THE UNIFICATION OF THE CHINESE NATION——An Interview with Mr.Zhu Weiqun,the Vice Minister of the United Front Work Department of the Central Government of China显示文摘On the occasion to celebrate the signing of the'Seventeen Articles Agreement'and the 60th anniversary of the peaceful liberation of Tibet,at the request of the reporter from the journal China’s Tibet,Mr.Zhu Weiqun,the vice minister of the United Front Work Department of the Central Government of China,gave this interview. | Zhou Aiming | 2011 | China's Tibet2011，22，3： | 0 |
| 19 | MY MUCH-BELOVED SOUTHWEST UNIVERSITY FOR NATIONALITIES——An Interview with Lozang Gyaltsen,the Party Secretary of the Southwest University for Nationalities显示文摘The Southwest College for Nationalities was founded in July 1950 and was formally established on June 1st,1951.The college was renamed the Southwest University for Nationalities with the approval of the China Ministry of Education on April 16th,2003. On June 1st,2011,the university is going to celebrate its 60th anniversary.Having completed 60 years of hard work and won success through strenuous efforts and a creative approach with generations of students,the university has realized its dreams and glories one after another.Taking this opportunity for celebration,the journal cooperates with Southwest University for Nationalities to edit a'Special column to celebrate the 60th Anniversary of the founding of the Southwest University for Nationalities.' | Zhou Aiming | 2011 | China's Tibet2011，22，3： | 0 |
| 20 | KING GESAR FLOWS ENDLESSLY FROM STONES——Miraculous Stories of the Female Balladeer Ngodring Droma显示文摘(Continued the Last Issue) AN AUSPICIOUS DAY Two days later,we returned to the house of Ngodring Droma.A small blue Auto brand car was parked in the yard but we could not see the owner.Director Sonam called her name and then Ngodring Droma slowly walked out.'Today is my meditation day.Nevertheless,now you are already here,please come in!'Once again walldng into her small living room,Professor Yang suddenly cried out.'Aiyaya...What auspidousness! It is definitely an auspidous day.You see,the buttered flowers are blooming. On a small table,two butter lamps on a colorful plate were blooming with 'butter flowers'.Often,when a butter flower bursts naturally from butter lamp it is recognized as | Zhou Aiming Yang Jiaming and Quzha | 2011 | China's Tibet2011，22，3： | 0 |
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