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| 1 | STABILITY OF ALPINE MEADOW ECOSYSTEM ON THE QINGHAI-TIBETAN PLATEAU显示文摘The meadow ecosystem on the Qing- hai-Tibetan Plateau is considered to be sensitive to climate change. An understanding of the alpine meadow ecosystem is therefore important for pre- dicting the response of ecosystems to climate change. In this study, we use the coefficients of variation (Cv) and stability (E) obtained from the Haibei Alpine Meadow Ecosystem Research Station to characterize the ecosystem stability. The results suggest that the net primary production of the alpine meadow eco- system was more stable (Cv = 13.18%) than annual precipitation (Cv = 16.55%) and annual mean air temperature (Cv = 28.82%). The net primary produc- tion was insensitive to either the precipitation (E = 0.0782) or air temperature (E = 0.1113). In summary, the alpine meadow ecosystem on the Qinghai- Tibetan Plateau is much stable. Comparison of alpine meadow ecosystem stability with other five natural grassland ecosystems in Israel and southern African indicates that the alpine meadow ecosystem on the Qinghai-Tibetan Plateau is the most stable ecosys- tem. The alpine meadow ecosystem with relatively simple structure has high stability, which indicates that community stability is not only correlated with biodiversity and community complicity but also with environmental stability. An average oscillation cycles of 3―4 years existed in annual precipitation, annual mean air temperature, net primary production and the population size of consumers at the Haibei natural ecosystem. The high stability of the alpine meadow ecosystem may be resulting also from the adaptation of the ecosystem to the alpine environment. | ZHOU Huakun ZHOU Li ZHAO Xinquan LIU Wei LI Yingnian GU Song ZHOU Xinmin | 2006 | Chinese Science Bulletin2006，51，3： | 21 |
| 2 | Using balance of seasonal herbage supply and demand to inform sustainable grassland management on the Qinghai–Tibetan Plateau显示文摘To mitigate the impacts of grassland degradation on the Qinghai–Tibetan Plateau(QTP), in recent decades China has been implementing large-scale conservation programs and has invested about 42 billion CNY(7 billion USD). However, these programs are faced with major challenges involving trade-offs between ecological function, livestock production and income of pastoralists.Scientific assessments, as well as technical and policy issues, have not fully captured the complex ecological,social and economic dynamics of the challenges facing grassland management on the QTP. Pastoral livestock production on the QTP is characterized by imbalance in both quality and quantity between livestock seasonal nutrient requirements and herbage production, which forces pastoralists to keep larger numbers of livestock for longer periods, leading to overgrazing. To solve these problems, an integrated crop-livestock system is promoted to improve the efficiency of livestock production and conserve natural grassland as well for a sustainable system for the QTP. | Xinquan ZHAO Liang ZHAO Qi LI Huai CHEN Huakun ZHOU Shixiao XU Quanmin DONG Gaolin WU Yixin HE | 2018 | Frontiers of Agricultural Science and Engineering2018，5，1： | 11 |
| 3 | Reversible and irreversible heat generation of NCA/Si–C pouch cell during electrochemical energy-storage process显示文摘To meet the requirements of electronic vehicles(EVs) and hybrid electric vehicles(HEVs),the high energy density Li Ni_(0.8) Co_(0.15) Al_(0.05) O_2(NCA) cathode and Si–C anode have attracted more attention.Here we report the thermal behaviors of NCA/Si–C pouch cell during the charge/discharge processes at different current densities.The total heat generations are derived from the surface temperature change during electrochemical Li+insertion/extraction in adiabatic surrounding.The reversible heat is determined by the entropic coefficients,which are related with open-circuit voltage at different temperatures; while the irreversible heat is determined by the internal resistance,which can be obtained via V–I characteristic,electrochemical impedance spectroscopy and hybrid pulse power characterization(HPPC).During the electrochemical process,the reversible heat contributes less than 10% to total heat generation; and the heat generated in charge process is less than that in discharge process.The results of thermal behaviors analyses are conducive to understanding the safety management and paving the way for building a reliable thermal model of high energy density lithium ion battery. | Ying Bai Limin Li Yu Li Guanghai Chen Huichun Zhao Zhaohua Wang Chuan Wu Hongyun Ma Xinquan Wang Hongyue Cui Jiang Zhou | 2019 | Journal of Energy Chemistry2019，28，2： | 7 |
| 4 | Marginal sealing around integral bilayer scaffolds for repairing osteochondral defects based on photocurable silk hydrogels显示文摘Osteochondral repair remains a major challenge in current clinical practice despite significant advances in tissue engineering.In particular,the lateral integration of neocartilage into surrounding native cartilage is a difficult and inadequately addressed problem that determines the success of tissue repair.Here,a novel design of an integral bilayer scaffold combined with a photocurable silk sealant for osteochondral repair is reported.First,we fabricated a bilayer silk scaffold with a cartilage layer resembling native cartilage in surface morphology and mechanical strength and a BMP-2-loaded porous subchondral bone layer that facilitated the osteogenic differentiation of BMSCs.Second,a TGF-β3-loaded methacrylated silk fibroin sealant(Sil-MA)exhibiting biocompatibility and good adhesive properties was developed and confirmed to promote chondrocyte migration and differentiation.Importantly,this TGF-β3-loaded Sil-MA hydrogel provided a bridge between the cartilage layer of the scaffold and the surrounding cartilage and then guided new cartilage to grow towards and replace the degraded cartilage layer from the surrounding native cartilage in the early stage of knee repair.Thus,osteochondral regeneration and superior lateral integration were achieved in vivo by using this composite.These results demonstrate that the new approach of marginal sealing around the cartilage layer of bilayer scaffolds with Sil-MA hydrogel has tremendous potential for clinical use in osteochondral regeneration. | Xiaolin Wu Mingliang Zhou Fei Jiang Shi Yin Sihan Lin Guangzheng Yang Yuezhi Lu Wenjie Zhang Xinquan Jiang | 2021 | Bioactive Materials2021，6，11： | 7 |
| 5 | Structural basis for bivalent binding and inhibition of SARS-CoV-2 infection by human potent neutralizing antibodies显示文摘Neutralizing monoclonal antibodies(nAbs)to severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)represent promising candidates for clinical intervention against coronavirus disease 2019(COVID-19).We isolated a large number of nAbs from SARS-CoV-2-infected individuals capable of disrupting proper interaction between the receptor binding domain(RBD)of the viral spike(S)protein and the receptor angiotensin converting enzyme 2(ACE2).However,the structural basis for their potent neutralizing activity remains unclear.Here,we report cryo-EM structures of the ten most potent nAbs in their native full-length IgG-form or in both IgG-form and Fab-form bound to the trimeric S protein of SARS-CoV-2.The bivalent binding of the full-length IgG is found to associate with more RBDs in the“up”conformation than the monovalent binding of Fab,perhaps contributing to the enhanced neutralizing activity of IgG and triggering more shedding of the S1 subunit from the S protein.Comparison of a large number of nAbs identified common and unique structural features associated with their potent neutralizing activities.This work provides a structural basis for further understanding the mechanism of nAbs,especially through revealing the bivalent binding and its correlation with more potent neutralization and the shedding of S1 subunit. | Renhong Yan Ruoke Wang Bin Ju Jinfang Yu Yuanyuan Zhang Nan Liu Jia Wang Qi Zhang Peng Chen Bing Zhou Yaning Li Yaping Shen Shuyuan Zhang Long Tian Yingying Guo Lu Xia Xinyue Zhong Lin Cheng Xiangyang Ge Juanjuan Zhao Hong-Wei Wang Xinquan Wang Zheng Zhang Linqi Zhang Qiang Zhou | 2021 | Cell Research2021，31，5： | 4 |
| 6 | Redefinition and Formation Age of the Tanjianshan Group in Xitieshan Region, Qinghai显示文摘The Tanjianshan Group, which was previously divided into a, b, c and d formations, has been controversial for a long time. It mainly distributes in the northern margin of Qaidam Basin and is an important early Paleozoic greenschist facies metamorphic volcanic sedimentary rock formation. Detailed field investigation and zircon LA-ICPMS U-Pb dating of the key strata suggest that the original lower part of a Formation(a-1) versus the original middle upper of d Formation(d-3 and d-4), the original upper part of a Formation(a-2) and b Formation versus the original lower part of d Formation(d-1 and d-2) of Tanjianshan Group are contemporaneous heterotopic facies volcanicclasolite deposit, respectively. The former formations formed during the middle-late Ordovician(463–458 Ma), while the latter ones formed in the late Ordovician(about 445 Ma). The original c formation of Tanjianshan Group, which formed after 430 Ma, is similar to the Maoniushan Formation of Kunlun Mountains and north Qaidam Basin. According to the rules of stratigraphic division and naming, new stratum formations of Tanjianshan Group are re-built and divided into Duancenggou(O1-2td), Zhongjiangou(O2-3tz) and Xitieshan(O3tx) formations. The original c Formation is separated from Tanjianshan Group and is renamed as the Wuminggou Formation(S3-D1w), which shows a discordant contact with underlying Tanjianshan Group and overlying Amunike Formation(D3a). The zircon U-Pb age frequency spectrogram of Tanjianshan Group indicates three prominent peaks of 430 Ma, 460 Ma and 908 Ma, which is consistent with the metamorphic and magmatic crystallization ages obtained from para- and orthogneisses in north Qaidam HP-UHP metamorphic belt, implying that strong Caledonian and Jinningian tectonic and magmatic events have ever happened in North Qaidam. | LIANG Xinquan FU Jiangang WANG Ce JIANG Ying ZHOU Yun YANG Yongqiang WANG Zeli PAN Chuanchu | 2014 | Acta Geologica Sinica(English Edition)2014，88，2： | 3 |
| 7 | Dinosaur eggs and dinosaur egg-bearing deposits(Upper Cretaceous) of Henan Province,China:Occurrences,palaeoenvironments,taphonomy and preservation显示文摘The Upper Cretaceous dinosaur egg-bearing deposits in Henan Province,central China are divided into three formations in ascending order:Gaogou,Majiacun and Sigou.The Gaogou Formation belongs to alluvial fan deposits containing the fossil dinosaur egg assemblage of Faveoloolithus,Dendroolithus,Dictyoolithus,Paraspheroolithus and Longiteresoolithus.The Majiacun Formation is interpreted as braided stream to meandering stream deposits with assemblage of Ovaloolithus,Paraspheroolithus,Placoolithus,Dendroolithus,Prismatoolithus, rare Youngoolithus and Nanhiungoolithus.The Sigou Formation is shallow lacustrine/palustrine to low-sinuosity river sedimentary rocks with assemblage of Macroolithus,Elongatoolithus,Ovaloolithus and Paraspheroolithus. To date,37 oospecies,13 oogenera and 8 oofamilies of dinosaur eggs have been distinguished.Autochthonous dinosaur eggs are preserved in the floodplain deposits,whereas allochthonous and parautochthonous dinosaur eggs are preserved in the alluvial fans.This suggests that river floodplains are the best environments for the preservation of numerous autochthonous dinosaur eggs.The preservation of most dinosaur eggs in brown to red calcic palaeosoils,muddy siltstones or mudstones suggests that the paleoclimate of the nesting area was semiarid.The presence of gray and green mudstone and coal layers,however,indicates that there existed an ephemeral subhumid climate during the middle and Late Cretaceous.It is suggested that such a climate was favorable for the development of meandering streams in a vegetated environment. | Xinquan Liang Shunv Wen Dongsheng Yang Shiquan Zhou Shichong Wu | 2009 | Progress in Natural Science:Materials International2009，19，11： | 3 |
| 8 | Orchestration of energy metabolism and osteogenesis by Mg^(2+)facilitates low-dose BMP-2-driven regeneration显示文摘The clinical application of bone morphogenetic protein-2(BMP-2)is limited by several factors,including ineffectiveness at low doses and severe adverse effects at high doses.To address these efficacy and safety limitations,we explored whether orchestration of energy metabolism and osteogenesis by magnesium ion(Mg^(2+))could reduce the dose and thereby improve the safety of BMP-2.Our results demonstrated that rapid metabolic activation triggered by BMP-2 was indispensable for subsequent osteogenesis.Moreover,inadequate metabolic stimulation was shown to be responsible for the ineffectiveness of low-dose BMP-2.Next,we identified that Mg^(2+),as an'energy propellant',substantially increased cellular bioenergetic levels to support the osteogenesis via the Akt-glycolysis-Mrs2-mitochondrial axis,and consequently enhanced the osteoinductivity of BMP-2.Based on the mechanistic discovery,microgel composite hydrogels were fabricated as low-dose BMP-2/Mg^(2+)codelivery system through microfluidic and 3D printing technologies.An in vivo study further confirmed that rapid and robust bone regeneration was induced by the codelivery system.Collectively,these results suggest that this bioenergetic-driven,cost-effective,low-dose BMP-2-based strategy has substantial potential for bone repair. | Sihan Lin Shi Yin Junfeng Shi Guangzheng Yang Xutao Wen Wenjie Zhang Mingliang Zhou Xinquan Jiang | 2022 | Bioactive Materials2022，7，12： | 2 |
| 9 | Nitric oxide, g-aminobutyric acid, and mannose pretreatment influence metabolic profiles in white clover under water stress显示文摘Nitric oxide(NO),γ-aminobutyric acid(GABA),and mannose(MAS)could be important regulators of plant growth and adaptation to water stress.The application of sodium nitroprusside(SNP,a NO donor),GABA,and MAS improved plant growth under watersufficient conditions and effectively mitigated water stress damage to white clover.The metabonomic analysis showed that both SNP and GABA application resulted in a significant increase in myo-inositol content;the accumulation of mannose was commonly regulated by SNP and MAS;GABA and MAS induced the accumulation of aspartic acid,quinic acid,trehalose,and glycerol under water deficit.In addition,citric acid was uniquely up-regulated by SNP associated with tricarboxylic acid(TCA)cycle under water stress.GABAspecially induced the accumulation of GABA,glycine,methionine,and aconitic acid related to GABA shunt,amino acids metabolism,and TCA cycle in response to water stress.MAS uniquely enhanced the accumulation of asparagine,galactose,and D-pinitol in association with amino acids and sugars metabolism under water stress.SNP-,GABA-,and MAS-induced changes of metabolic profiles and associated metabolic pathways could contribute to enhanced stress tolerance via involvement in the TCA cycle for energy supply,osmotic adjustment,antioxidant defense,and signal transduction for stress defense in white clover. | Zhou Li Bin Yong Bizhen Cheng Xing Wu Yan Zhang Xinquan Zhang Yan Peng | 2019 | Journal of Integrative Plant Biology2019，61，12： | 2 |
| 10 | Experimental and numerical analysis of secondary disasters induced by oxygen rich combustion within a tunnel显示文摘Various physical parameters, including gas concentrations (O2, CO, CH4, and H2) and temperatures at dif- ferent air velocities, were determined for full scale wood fires in the Chongqing Coal Research Institute fire test tunnel. Both experimental measurements and numerical simulations are discussed. The numer- ical analysis was performed with the computational fluid dynamics software package ''FLUENT''. The results show that the experimental data agree with the simulation results. The results verify that Roberts' theory of burning is correct. They also prove that the air velocity is the key factor that determines the type of combustion. Also, it is shown that secondary disasters are unlikely for oxygen rich combustion with a limited fire load. | Cheng Caixia Sun Fuchun Zhou Xinquan Niu Huiyong Liang De | 2011 | Mining Science and Technology2011，21，6： | 2 |
| 11 | Detrital Zircon Provenance of Pliocene Yinggehai Formation in the Ledong Gas Field of the Yinggehai-Song Hong Basin显示文摘1 Introduction Over the past decades,a number of hydrocarbon reservoirs have been discovered in the deepwater area of the Yinggehai-Song Hong Basin,South China Sea.The NW-oriented Yinggehai-Song Hong Basin,located on the continental shelf at water depths of 50-200 m in the northwestern South China Sea,is one of the | WANG Ce LIANG Xinquan FU Jiangang ZHOU Yun JIANG Ying DONG Chaoge | 2015 | Acta Geologica Sinica(English Edition)2015，89，A01： | 2 |
| 12 | Coal Seam Methane Distribution and Its Significance in Pingdingshan Mining Area 显示文摘 | GUO Deyong ZHOU Xinquan SHEN Shaochuan | 2002 | Journal of Coal Science & Engineering2002，8，2： | 1 |
| 13 | The role of herbivores in the grassland carbon budget for Three-Rivers Headwaters region,Qinghai-Tibetan Plateau,China显示文摘Background:An accurate assessment of the carbon budget is a crucial part of projecting future climate change and its impact on ecosystems.Grasslands foster multiple ecological functions including support for wild animals and livestocks.Herbivores intake forage biomass carbon,then digest and metabolize,and finally retain some carbon.The carbon processes have not been well quantified,resulting in uncertainties in the estimation of regional carbon budgets for grassland ecosystems.Methods:An animal metabolic carbon flux model was developed for herbivores in the Three-Rivers Headwaters region of China.The forage intake and metabolic carbon rates were estimated through metabolic body weight and daily digested measures for the main herbivore species.Results:The carbon intake was 5.52 Tg C year−1(45%)from partial aboveground biomass(12.2 Tg C year−1),in which 39.31%was released into the atmosphere by respiration CO_(2),43.77%was returned to the ecosystem as feces and urine,and 16.96%was retained in herbivores for population regeneration or for human well-being.Conclusions:This study,as the first research on this topic,quantified the carbon flux of herbivores and found livestock accounts for a major part of consumed carbon on grasslands,which is important for understanding regional carbon budgets to mitigate and adapt to climate change over grasslands worldwide. | Junbang Wang Xinquan Zhao Xihuang Ouyang Liang Zhao Wenying Wang Chan Zuo Zhenhua Zhang Huakun Zhou Alan Watson Yingnian Li | 2022 | Grassland Research2022，1，3： | 1 |
| 14 | Ecological basis of alpine mead-ow ecosystem management in Tibet:Haibei alpine meadow e-cosystem research station显示文摘 | Zhao Xinquan Zhou Xingmin | 1999 | A Journal of the Human Envi-ronment1999，28，8： | 1 |
| 15 | Alpine grassland degradation and its control in the source regions of Yangtze and Yellow Rivers,China显示文摘 | Zhou Huakun Zhao Xinquan Tang Yanhong Zhou Li | 2005 | Grassland Science2005，51，： | 1 |
| 16 | 显示文摘 | Zhou Yiming Xin Xinquan | 1999 | Chinese J Inorg Chem1999，15，3： | 1 |
| 17 | Biomineralization inspired 3D printed bioactive glass nanocomposite scaffolds orchestrate diabetic bone regeneration by remodeling micromilieu显示文摘TypeⅡdiabetes mellitus(TIIDM)remains a challenging clinical issue for both dentists and orthopedists.By virtue of persistent hyperglycemia and altered host metabolism,the pathologic diabetic micromilieu with chronic inflammation,advanced glycation end products accumulation,and attenuated biomineralization severely impairs bone regeneration efficiency.Aiming to“remodel”the pathologic diabetic micromilieu,we 3D-printed bioscaffolds composed of Sr-containing mesoporous bioactive glass nanoparticles(Sr-MBGNs)and gelatin methacrylate(GelMA).Sr-MBGNs act as a biomineralization precursor embedded in the GelMA-simulated extracellular matrix and release Sr,Ca,and Si ions enhancing osteogenic,angiogenic,and immunomodulatory properties.In addition to angiogenic and anti-inflammatory outcomes,this innovative design reveals that the nanocomposites can modulate extracellular matrix reconstruction and simulate biomineralization by activating lysyl oxidase to form healthy enzymatic crosslinked collagen,promoting cell focal adhesion,modulating osteoblast differentiation,and boosting the release of OCN,the noncollagenous proteins(intrafibrillar mineralization dependent),and thus orchestrating osteogenesis through the Kindlin-2/PTH1R/OCN axis.This 3D-printed bioscaffold provides a multifunctional biomineralization-inspired system that remodels the“barren”diabetic microenvironment and sheds light on the new bone regeneration approaches for TIIDM. | Zeqian Xu Xuanyu Qi Minyue Bao Tian Zhou Junfeng Shi Zhiyan Xu Mingliang Zhou Aldo R.Boccaccini Kai Zheng Xinquan Jiang | 2023 | Bioactive Materials2023，，7： | 1 |
| 18 | One Fire Detection Method Using Neural Networks * * Supported by the Key Technologies Research and Development Program of the Eleventh Five-Year Plan of China (No. 2007BAK22B04) and 2008 Independent Task (No. SKLCRSM08B12)显示文摘 | Caixia Cheng Fuchun Sun Xinquan Zhou | 2011 | Tsinghua Science & Technology2011，，1： | 1 |
| 19 | A rapidly magnetically assembled stem cell microtissue with“hamburger”architecture and enhanced vascularization capacity显示文摘With the development of magnetic manipulation technology based on magnetic nanoparticles(MNPs),scaffold-free microtissues can be constructed utilizing the magnetic attraction of MNP-labeled cells.The rapid in vitro construction and in vivo vascularization of microtissues with complex hierarchical architectures are of great importance to the viability and function of stem cell microtissues.Endothelial cells are indispensable for the formation of blood vessels and can be used in the prevascularization of engineered tissue constructs.Herein,safe and rapid magnetic labeling of cells was achieved by incubation with MNPs for 1 h,and ultrathick scaffold-free microtissues with different sophisticated architectures were rapidly assembled,layer by layer,in 5 min intervals.The in vivo transplantation results showed that in a stem cell microtissue with trisection architecture,the two separated human umbilical vein endothelial cell(HUVEC)layers would spontaneously extend to the stem cell layers and connect with each other to form a spatial network of functional blood vessels,which anastomosed with the host vasculature.The“hamburger”architecture of stem cell microtissues with separated HUVEC layers could promote vascularization and stem cell survival.This study will contribute to the construction and application of structural and functional tissues or organs in the future. | Yuezhi Lu Chun-Hua Yu Guangzheng Yang Ningjia Sun Fei Jiang Mingliang Zhou Xiaolin Wu Jiaxin Luo Cui Huang Wenjie Zhang Xinquan Jiang | 2021 | Bioactive Materials2021，6，11： | 1 |
| 20 | Coal forming environments and their relationship to tectonic activity in the Cevennes Stephanian coal basin显示文摘 | Guo Deyong Zhou Xinquan Shen Shaochuan | 2002 | Journal of coal Science & Engineering ( China )2002，8，： | 1 |
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