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| 1 | Effects of maize root exudates and organic acids on the desorption of phenanthrene from soils显示文摘The eects of maize root exudates and low-molecular-weight-organic anions (LMWOAs) on the desorption of phenanthrene from eight artificially contaminated soils were evaluated. A significant negative correlation was observed between the amounts of phenanthrene desorbed and the soil organic carbon (SOC) contents (P < 0.01), and the inuences of soil pH and clay content on phenanthrene desorption were insignificant (P > 0.1). Neither maize root exudates nor oxalate and citrate anions inuenced desorption of phenanthrene with the addition of NaN3. A faster phenanthrene desorption occurred without the addition of NaN3 in the presence of maize root exudates than oxalate or citrate due to the enhanced degradation by root exudates. Without the addition of NaN3, oxalate or citrate at dierent concentrations could inhibit phenanthrene desorption to dierent extents and the inhibiting eect by citrate was more significant than by oxalate. This study leads to the conclusion that maize root exudates can not enhance the desorption under abiotic condition with the addition of NaN3 and can promote the desorption of phenanthrene in soils without the addition of NaN3. | ZHU Yanhong, ZHANG Shuzhen, HUANG Honglin, WEN Bei State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China. | 2009 | Journal of Environmental Sciences2009，21，7： | 14 |
| 2 | Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2显示文摘Emerging and re-emerging RNA viruses occasionally cause epidemics and pandemics worldwide,such as the on-going outbreak of the novel coronavirus SARS-CoV-2.Herein,we identified two potent inhibitors of human DHODH,S312 and S416,with favorable drug-likeness and pharmacokinetic profiles,which all showed broad-spectrum antiviral effects against various RNA viruses,including influenza A virus,Zika virus,Ebola virus,and particularly against SARS-CoV-2.Notably,S416 is reported to be the most potent inhibitor so far with an EC5o of 17 nmol/L and an SI value of 10,505.88 in infec-ted cells.Our results are the first to validate that DHODH is an attractive host target through high antiviral efficacy in vivo and low virus replication in DHODH knock-out cells.This work demonstrates that both S312/S416 and old drugs(Leflunomide/Teriflunomide)with dual actions of antiviral and immuno-regulation may have clinical potentials to cure SARS-CoV-2 or other RNA viruses circulating worldwide,no matter such viruses are mutated or not. | Rui Xiong Leike Zhang Shiliang Li Yuan Sun Minyi Ding Yong Wang Yongliang Zhao Yan Wu Weijuan Shang Xiaming Jiang Jiwei Shan Zihao Shen Yi Tong Liuxin Xu Yu Chen Yingle Liu Gang Zou Dimitri Lavillete Zhenjiang Zhao Rui Wang Lili Zhu Gengfu Xiao Ke Lan Honglin Li Ke Xu | 2020 | Protein & Cell2020，11，10： | 14 |
| 3 | Spatio-temporal variation of photosynthetically active radiation in China in recent 50 years显示文摘在中国上基于 weather/ecological 车站的长期的测量数据,计算并且生产每年平均、平均 seasonally 的光合地活跃的放射(同等) 的这份报纸从 1961 ~ 2007 的空间数据,用 climatological 计算和 spatialization 技术。在中国在上的每年平均、平均 seasonally 的同等空间数据的时间空间的变化特征最近 50 年与 Mann-Kendall 趋势分析方法和 GIS 被分析空间分析技术。结果显示出那:(1 ) 总体上,同等的空间分发越过中国复杂、不同类,与在中国的东方、南部的部分的更低的同等和在西方的部分的更高的同等。在中国上的吝啬的年度同等从 17.7 摩尔 m ? 2 d ? 1 ~ 39.5 摩尔 m ? 2 d ? 1。(2 ) 在中国上的每个象素的每年平均、平均 seasonally 的同等总体上被平均,平均数与变动进程显然珍视衰落,并且每年平均的同等的变化的率是 ? 0.138 摩尔 m ? 2 d ? 1/10a。在四个季节之中的变化振幅是不同的,与在里面的最大的落下夏天,和同等的下降速度在 1990 年代,速度在以后慢下来前是更快的。(3 ) 由每个象素的分析证明那同等显著地衰退(=0.05 ) 在中国的大多数部分。夏天和冬季在同等的 interannual 可变性起更重要的作用。诺思中国总是是在四个季节的一个减少的地区,当 Qinghai 西藏高原的西北转弯是在四个季节的一个增加的地区时。(4 ) 同等的 interannual 可变性的空间分布在不同时期之中变化。在某个区域的同等的 interannual 可变性不仅在四个季节之中,而且在不同时期之中是不同的。 | ZHU Xudong HE Honglin LIU Min YU Guirui SUN Xiaomin GAO Yanhua | 2010 | Journal of Geographical Sciences2010，20，6： | 12 |
| 4 | A Transgenic Study on Affecting Potato Tuber Yield by Expressing the Rice Sucrose Transporter Genes OsSUT5Z and OsSUT2M显示文摘在许多植物,蔗糖 transporters 为从来源和进口的两个蔗糖出口是必要的进水池,显示功能在吸收划分。为了调查蔗糖 transporters 是否能改进淀粉的收益,种,土豆植物(茄属 tuberosum L。cv。 | Aijun Sun Yan Dai Xinsheng Zhang Chunmin Li Kun Meng Honglin Xu Xiaoli Wei Guifang Xiao Pieter B.F, Ouwerkerk Mei Wang Zhen Zhu | 2011 | Journal of Integrative Plant Biology2011，53，7： | 9 |
| 5 | Autoantigen Microarray for High-throughput Autoantibody Profiling in Systemic Lupus Erythematosus显示文摘Systemic lupus erythematosus(SLE) is a complex autoimmune disease characterized by the production of autoantibodies to a broad range of self-antigens. Profiling the autoantibody repertoire using array-based technology has emerged as a powerful tool for the identification of biomarkers in SLE and other autoimmune diseases. Proteomic microarray has the capacity to hold large number of self-antigens on a solid surface and serve as a high-throughput screening method for the determination of autoantibody specificities. The autoantigen arrays carrying a wide variety of self-antigens, such as cell nuclear components(nucleic acids and associated proteins), cytoplasmic proteins, phospholipid proteins, cell matrix proteins, mucosal/secreted proteins, glomeruli, and other tissue-specific proteins, have been used for screening of autoantibody specificities associated with different manifestations of SLE. Arrays containing synthetic peptides and molecular modified proteins are also being utilized for identification of autoantibodies targeting to special antigenic epitopes. Different isotypes of autoantibodies, including Ig G, Ig M, Ig A, and Ig E, as well as other Ig subtypes, can be detected simultaneously with multi-color labeled secondary antibodies. Serum and plasma are the most common biologic materials for autoantibody detection, but other body fluids such as cerebrospinal fluid, synovial fluid, and saliva can also be a source of autoantibody detection.Proteomic microarray as a multiplexed high-throughput screening platform is playing an increasingly-important role in autoantibody diagnostics.In this article,we highlight the use of autoantigen microarrays for autoantibody exploration in SLE. | Honglin Zhu Hui Luo Mei Yan Xiaoxia Zuo Quan-Zhen Li | 2015 | Genomics, Proteomics & Bioinformatics2015，13，4： | 6 |
| 6 | Orthogonal nonnegative matrix factorization based local hidden Markov model for multimode process monitoring显示文摘Traditional data driven fault detection methods assume that the process operates in a single mode so that they cannot perform well in processes with multiple operating modes. To monitor multimode processes effectively,this paper proposes a novel process monitoring scheme based on orthogonal nonnegative matrix factorization(ONMF) and hidden Markov model(HMM). The new clustering technique ONMF is employed to separate data from different process modes. The multiple HMMs for various operating modes lead to higher modeling accuracy.The proposed approach does not presume the distribution of data in each mode because the process uncertainty and dynamics can be well interpreted through the hidden Markov estimation. The HMM-based monitoring indication named negative log likelihood probability is utilized for fault detection. In order to assess the proposed monitoring strategy, a numerical example and the Tennessee Eastman process are used. The results demonstrate that this method provides efficient fault detection performance. | Fan Wang Honglin Zhu Shuai Tan Hongbo Shi | 2016 | Chinese Journal of Chemical Engineering2016，24，7： | 3 |
| 7 | Gender associates with both susceptibility to infection and pathogenesis of SARS-CoV-2 in Syrian hamster显示文摘Epidemiological studies of the COVID-19 patients have suggested the male bias in outcomes of lung illness.To experimentally demonstrate the epidemiological results,we performed animal studies to infect male and female Syrian hamsters with SARS-CoV-2.Remarkably,high viral titer in nasal washings was detectable in male hamsters who presented symptoms of weight loss,weakness,piloerection,hunched back and abdominal respiration,as well as severe pneumonia,pulmonary edema,consolidation,and fibrosis.In contrast with the males,the female hamsters showed much lower shedding viral titers,moderate symptoms,and relatively mild lung pathogenesis.The obvious differences in the susceptibility to SARS-CoV-2 and severity of lung pathogenesis between male and female hamsters provided experimental evidence that SARS-CoV-2 infection and the severity of COVID-19 are associated with gender. | Lunzhi Yuan Huachen Zhu Ming Zhou Jian Ma Rirong Chen Yao Chen Liqiang Chen Kun Wu Minping Cai Junping Hong Lifeng Li Che Liu Huan Yu Yali Zhang Jia Wang Tianying Zhang Shengxiang Ge Jun Zhang Quan Yuan Yixin Chen Qiyi Tang Honglin Chen Tong Cheng Yi Guan Ningshao Xia | 2021 | Signal Transduction and Targeted Therapy2021，6，4： | 3 |
| 8 | Research on fabric characteristics and borehole instability mechanisms of fractured igneous rocks显示文摘There are favorable exploration prospects in igneous rock reservoirs.However,problems of borehole instability occur frequently during drilling igneous formations,which is a serious impediment to oil and gas exploration and production.The lack of systematic understanding of the inherent instability mechanisms is an important problem.A series of experiments were conducted on several igneous rock samples taken from the sloughing formations in the Tuha area in an attempt to reveal the inherent mechanisms of wellbore instability when drilling in fractured igneous rocks.Research methods involved slurry chemistry,analysis of micro-geological features(Micro-CT imaging,SEM),and rock mechanics testing.The experimental results indicated that clay minerals were widely distributed in the intergranular space of the diagenetic minerals,crystal defects,and microcracks.Drilling fluid filtrate would invade the rock along the microcracks.The invasion amount gradually increased over time,which constantly intensified the hydration and swelling of clay minerals,leading to changes in the microscopic structure of igneous rocks.Primary and secondary microcracks can propagate and merge into single cracks and thus reducing rock cohesion and the binding force along cleavage planes.Based on this result the authors propose that a key towards solving wellbore instability in igneous formations is that specific micro-geological characteristics of the igneous rocks should be taken into consideration in the design of antisloughing drilling muds. | Liu Xiangjun Zhu Honglin Liang Lixi | 2013 | Petroleum Science2013，10，2： | 2 |
| 9 | Designing a dual-functional material with barrier anti-corrosion and photocatalytic antifouling properties using g-C_(3)N_(4) nanosheet with ZnO nanoring显示文摘As a semiconductor material with a 2 D-laminate structure, g-C_(3)N_(4)(bandwidth 2.7 e V) has a similar structure and excellent performance to graphene. However, high surface energy and photogenerated e–h recombination of g-C_(3)N_(4)seriously hinder its application in the field of marine anticorrosion and antifouling.To solve these problems, we synthesized the g-C_(3)N_(4)nanosheets decorated with Zn O nanoring via chemical etching technology. Whether the NR Zn O-CNNs have surface protection performance among the pure EP on the corrosion protection for metal substrate were investigated. The antifouling properties NR Zn OCNNs hybrid were also estimated through photocatalytic bacterial and algae resistance tests. Combined with the electrochemical results, it was found that the impedance modulus of NR Zn O-CNNs/EP within 45 days showed two orders of magnitude higher than that of pure EP in the 3.5 wt% Na Cl solution. Besides, Local electrochemical impedance spectroscopy(LEIS) further explored the anticorrosion behavior of NR Zn O-CNNs/EP coating, which indicated that the NR Zn O-CNNs/EP coating with a scratch maintained an excellent corrosion resistance between 0–24 h. Under the visible light conditions, the lifetime of photogenerated e–h was prolonged due to the formation of NR Zn O-CNNs heterojunction structure, it was observed that the antibacterial rate against Bacillus subtilis reached 100% within 8 h. An Antialgae test was performed on chlorella seawater solution, which indicated that 5 mg/m L of NR Zn O-CNNs hybrid could make chlorella sharply reduce within 4 days. Simultaneously, the corrosion protection and photocatalytic antifouling mechanisms of NR Zn O-CNNs were proposed, thus it provided a broader platform for the design of versatile marine protection materials. | Yiqian Lv Yueqing Zheng Honglin Zhu Yinghao Wu | 2022 | Journal of Materials Science & Technology2022，，11： | 2 |
| 10 | Human umbilical cord mesenchymal stem cells for psoriasis:a phase 1/2a,single-arm study显示文摘Psoriasis is a common,chronic immune-mediated systemic disease that had no effective and durable treatment.Mesenchymal stem cells(MSCs)have immunomodulatory properties.Therefore,we performed a phase 1/2a,single-arm clinical trial to evaluate the safety and efficacy of human umbilical cord-derived MSCs(UMSCs)in the treatment of psoriasis and to preliminarily explore the possible mechanisms.Seventeen patients with psoriasis were enrolled and received UMsC infusions.Adverse events,laboratory parameters,PASl,and PGA were analyzed.We did not observe obvious side effects during the treatment and 6-month follow-up.A total of 47.1%(8/17)of the psoriasis patients had at least 40%improvement in the PASl score,and 17.6%(3/17)had no sign of disease or minimal disease based on the PGA score.And the efficiency was 25%(2/8)for males and 66.7%(6/9)for females.After UMSC transplantation(UMSCT),the frequencies of Tregs and CD4^(+)memory T cells were significantly increased,and the frequencies of T helper(Th)17 and CD4^(+)naive T cells were significantly decreased in peripheral blood(PB)of psoriasis patients.And all responders showed significant increases in Tregs and CD4^(+)memory T cells,and significant decreases in Th17 cells and serum IL-17 level after UMsCT.And baseline level of Tregs in responders were significantly lower than those in nonresponders.In conclusion,allogeneic UMSCT is safe and partially effective in psoriasis patients,and level of Tregs may be used as a potent biomarker to predict the clinical efficacy of UMSCT.Trial registration Clinical Trials NCT03765957. | Lamei Cheng Siqi Wang Cong Peng Xiao Zou Chao Yang Hua Mei Chuang Li Xian Su Na Xiao Qi Ouyang Mi Zhang Qiaolin Wang Yan Luo Minxue Shen Qun Qin Honglin Wang Wu Zhu Guangxiu Lu Ge Lin Yehong Kuang Xiang Chen | 2022 | Signal Transduction and Targeted Therapy2022，7，9： | 2 |
| 11 | Coat protein promoter from cotton leaf curl virus is not a tissue-specifically expressed promoter显示文摘Geminivirus is a kind of single-stranded DNA virus. Experimental results from tomato golden mosaic virus (TGMV) showed that expression pattern of coat protein gene (cp) promoter was phloem specifically expressed. In this note, the studies on cp promoter of cotton leaf curl virus (CLCuV) which is found and identified recently suggest that the promoter is not phloem specifically expressed. The expressing activity of gus gene driven by the promoter exists not only in phloem but also in mesophyll tissues and root tip meristem. Transient expression suggests that cp promoter transactivated by AC2 shows expressing activity in mesophyll and vascular tissue of leaf vein. | XIE Yingqiu ZHU Zhen LIU Yule WU Qian XU Honglin | 2000 | Chinese Science Bulletin2000，45，20： | 2 |
| 12 | Cleavage of BID by Caspase 8 Mediates the Mitochondrial Damage in the Fas Pathway of Apoptosis显示文摘 | Honglin Li Hong Zhu Chi-jie Xu Junying Yuan | 1998 | Cell1998，，4： | 2 |
| 13 | Cloning and Functional Analysis of the Bifunctional Agglutinin/Trypsin Inhibitor from Helianthus tuberosus L.显示文摘以便发现新抗虫性基因,四相应 cDNAs, hta -- 一,有一些 775, 718, 784 和 752 bp 的 hta-b, hta-c 和 hta-d,分别地(GenBank 就职数字 AF477031-AF477034 ) ,从 Helianthustuberosus L 的一个 tuber cDNA 表示图书馆被孤立。顺序分析表明所有四 cDNAs 包含 444 bp 的一个开的读物框架,编码 147 氨基酸残余的多肽,并且 cDNAs 的序列很类似于 jacalin 相关的家庭的甘露糖绑定凝集素基因的那些。Inhemagglutination 反应和幸运十抑制试金,从表示 GST-HTA 的导致的 Escherichia 关口 i BL21 (DE3 ) 的净化亲密关系的 HTA (向日葵 tuberosusagglutinin ) 比另外的测试的糖为甘露糖显示出红血球凝聚能力和一个更高的糖类绑定能力。Trypsininhibitory 活动在导致的 E 的粗略的摘录被检测。表示 HTA 的关口 i BL21 (DE3 ) ,并且被胰岛素进一步验证禁止的活动在本国的聚丙烯酰胺上染色胶化。在 HTA 和胰岛素之间的相互作用的 Themechanism 被分子的建模学习。我们发现很多的氢契约和静电的相互作用能在 HTA-b 的建议有约束力的地点和胰岛素的活跃地点之间被形成,并且稳定的 HTA/trypsin 建筑群能被形成。上面的结果暗示 HTA 可能是一个双性人有糖类绑定活动和胰岛素的功能的蛋白质禁止的活动。而且,北弄污分析证明 hta 主要在 H 的澡盆 ers 被表示。tuberosus,很微弱地在茎表示了,然而并非根本在另外的纸巾表示了。南部的弄污分析显示那 hta 被编码由一 multi-genefamily。抗虫性特点在另一份报纸被描述了。 | Tuanjie Chang Hongli Zhai Songbiao Chen Guisheng Song Honglin Xu Xiaoli Wei Zhen Zhu | 2006 | Journal of Integrative Plant Biology2006，48，8： | 2 |
| 14 | Interfacial polymerized polyaniline/graphite oxide nanocomposites toward electrochemical energy storage显示文摘 | Jiahua Zhu Minjiao Chen Honglin Qu Xi Zhang Huige Wei Zhiping Luo Henry A. Colorado Suying Wei Zhanhu Guo | 2012 | Polymer2012，，25： | 1 |
| 15 | Dynamic changes in O-GlcNAcylation regulate osteoclast differentiation and bone loss via nucleoporin 153显示文摘Bone mass is maintained by the balance between osteoclast-induced bone resorption and osteoblast-triggered bone formation.In inflammatory arthritis such as rheumatoid arthritis(RA),however,increased osteoclast differentiation and activity skew this balance resulting in progressive bone loss.O-GlcNAcylation is a posttranslational modification with attachment of a single O-linkedβ-D-N-acetylglucosamine(O-GlcNAc)residue to serine or threonine residues of target proteins.Although O-GlcNAcylation is one of the most common protein modifications,its role in bone homeostasis has not been systematically investigated.We demonstrate that dynamic changes in O-GlcNAcylation are required for osteoclastogenesis.Increased O-GlcNAcylation promotes osteoclast differentiation during the early stages,whereas its downregulation is required for osteoclast maturation.At the molecular level,O-GlcNAcylation affects several pathways including oxidative phosphorylation and cell-cell fusion.TNFαfosters the dynamic regulation of O-GlcNAcylation to promote osteoclastogenesis in inflammatory arthritis.Targeted pharmaceutical or genetic inhibition of O-GlcNAc transferase(OGT)or O-GlcNAcase(OGA)arrests osteoclast differentiation during early stages of differentiation and during later maturation,respectively,and ameliorates bone loss in experimental arthritis.Knockdown of NUP153,an O-GlcNAcylation target,has similar effects as OGT inhibition and inhibits osteoclastogenesis.These findings highlight an important role of O-GlcNAcylation in osteoclastogenesis and may offer the potential to therapeutically interfere with pathologic bone resorption. | Yi-Nan Li Chih-Wei Chen Thuong Trinh-Minh Honglin Zhu Alexandru-Emil Matei Andrea-Hermina Györfi Frederic Kuwert Philipp Hubel Xiao Ding Cuong Tran Manh Xiaohan Xu Christoph Liebel Vladyslav Fedorchenko Ruifang Liang Kaiyue Huang Jens Pfannstiel Min-Chuan Huang Neng-Yu Lin Andreas Ramming Georg Schett Jörg H.W.Distler | 2022 | Bone Research2022，10，4： | 1 |
| 16 | 显示文摘 | Zhu Honglin Luiz A | 2004 | Applied Surface Science2004，236，： | 1 |
| 17 | Chemical mechanical polishing (CMP) anisotropy in sapphire 显示文摘 | Zhu Honglin | 2004 | Applied Surface Science2004，，236： | 1 |
| 18 | Chemical mechanical polishing (CMP) anisotropy in sapphire 显示文摘 | Zhu Honglin | 2004 | Applied Surface Science2004，，236： | 1 |
| 19 | Artificial Intelligence in Pharmaceutical Sciences显示文摘Drug discovery and development affects various aspects of human health and dramatically impacts the pharmaceutical market.However,investments in a new drug often go unrewarded due to the long and complex process of drug research and development(R&D).With the advancement of experimental technology and computer hardware,artificial intelligence(AI)has recently emerged as a leading tool in analyzing abundant and high-dimensional data.Explosive growth in the size of biomedical data provides advantages in applying AI in all stages of drug R&D.Driven by big data in biomedicine,AI has led to a revolution in drug R&D,due to its ability to discover new drugs more efficiently and at lower cost.This review begins with a brief overview of common AI models in the field of drug discovery;then,it summarizes and discusses in depth their specific applications in various stages of drug R&D,such as target discovery,drug discovery and design,preclinical research,automated drug synthesis,and influences in the pharmaceutical market.Finally,the major limitations of AI in drug R&D are fully discussed and possible solutions are proposed. | Mingkun Lu Jiayi Yin Qi Zhu Gaole Lin Minjie Mou Fuyao Liu Ziqi Pan Nanxin You Xichen Lian Fengcheng Li Hongning Zhang Lingyan Zheng Wei Zhang Hanyu Zhang Zihao Shen Zhen Gu Honglin Li Feng Zhu | 2023 | Engineering2023，，8： | 1 |
| 20 | A metallothionein-like gene htMT2 strongly expressed in internodes and nodes of Helianthus tuberosus and effects of metal ion treatment on its expression显示文摘 | Tuanjie Chang Xiang Liu Honglin Xu Kun Meng Songbiao Chen Zhen Zhu | 2004 | Planta2004，，3： | 1 |
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