|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Data Analysis of Chang'E-1 Gamma-Ray Spectrometer and Global Distribution of U,K,and Th Elemental Abundances显示文摘Gamma 光线分光计(GRS ) 是 Chang'E-1 (CE-1 ) 上的主要收费载重之一月亮的探查,主要试图在月亮的表面上检测元素的丰富和分布。在 03:58 在 2007 年 11 月 28 日,它执行了月亮的 gamma 光线的第一观察。2008 年 10 月 24 日,有效 gamma 光线系列的 2105 h 被 CE-1 GRS 获得了,它盖住月亮的整个表面。这份报纸主要描述处理由使用导出元素的丰富的过程和 CE-1 GRS 时间系列改正了系列的方法的数据:首先,到进为印射的象素的箱数据;然后,执行累积系列的背景扣除并且获得元素的一个山峰区域;并且最后,当模特儿使用元素的丰富倒置生产元素的丰富。在这些上基于比 EPR 在 5s 处理方法, U 的全球丰富地图, K,和 Th。在在 near-EPR 海底山下面的岩浆结晶化压力和融化的条件之间的关联暗示来源吗? | ZOU Yongliao ZHANG Liyan LIU Jianzhong MU Lingli REN Xin ZHANG Guangliang CHANG Jin YAN Jun ZHANG Nan ZHANG Hongbo LU Chang LIU Jianjun ZUO Wei SU Yan WEN Weibin BIAN Wei WANG Min XU Chun LI Chunlai OUYANG Ziyuan | 2011 | Acta Geologica Sinica(English Edition)2011，85，6： | 6 |
| 2 | Biosynthesis of antibiotic chuangxinmycin from Actinoplanes tsinanensis显示文摘Chuangxinmycin is an antibiotic isolated from Actinoplanes tsinanensis CPCC 200056 in the1970 s with a novel indole-dihydrothiopyran heterocyclic skeleton. Chuangxinmycin showed in vitro antibacterial activity and in vivo efficacy in mouse infection models as well as preliminary clinical trials.But the biosynthetic pathway of chuangxinmycin has been obscure since its discovery. Herein, we report the identification of a stretch of DNA from the genome of A. tsinanensis CPCC 200056 that encodes genes for biosynthesis of chuangxinmycin by bioinformatics analysis. The designated cxn cluster was then confirmed to be responsible for chuangxinmycin biosynthesis by direct cloning and heterologous expressing in Streptomyces coelicolor M1146. The cytochrome P450 CxnD was verified to be involved in the dihydrothiopyran ring closure reaction by the identification of seco-chuangxinmycin in S. coelicolor M1146 harboring the cxn gene cluster with an inactivated cxn D. Based on these results, a plausible biosynthetic pathway for chuangxinmycin biosynthesis was proposed, by hijacking the primary sulfur transfer system for sulfur incorporation. The identification of the biosynthetic gene cluster of chuangxinmycin paves the way for elucidating the detail biochemical machinery for chuangxinmycin biosynthesis, and provides the basis for the generation of novel chuangxinmycin derivatives by means of combinatorial biosynthesis and synthetic biology. | Yuanyuan Shi Zhibo Jiang Xingxing Li Lijie Zuo Xuan Lei Liyan Yu Linzhuan Wu Jiandong Jiang Bin Hong | 2018 | Acta Pharmaceutica Sinica B2018，8，2： | 2 |
| 3 | Geochemistry of Ore-bearing Lamprophyre from the Cu-Ni Deposit in Dhi Samir,Yemen显示文摘Magmatic Cu-Ni 硫化物存款通常与 mafic-ultramafic 岩石被联系,煌斑岩是 Cu-Ni 硫化物存款的包围岩石之一,这没被报导。然而,在也门的 Dhi Samir 存款是在煌斑岩堤被招待的 Cu-Ni 存款的一个稀罕例子。在这篇论文,全面研究在 Dhi Samir 区域为 Cu-Ni-bearing 岩石在岩石学,石油化学和同位素地球化学上被做,结果证明与 Cu-Ni orebodies 有关的黑暗岩石是钠弱的钾并且属于计算碱的系列煌斑岩,特别 camptonite,由充实的碱,铁和钛描绘了。当高地力量元素稍微弄空时,在这些岩石 large-ion-lithophile,元素显然被集中,显示出清楚的否定异例 Ta 和 Nb,和 Ti 的弱缺乏。REE 是很,高度(225.67290.05 ppm ) 和 REE 分区弯扁平、使权利倾向,与低否定 Eu 异例展示一个充实 LREE 的模式。magmatic 来源区域的学习显示岩石有低(87Sr/86Sr ) 并且高 Nd (t) ,和岩浆可能从充实的披风被导出我(EM-I ) 结束成员。在锆石 U-Pb 同位素标明日期上基于 LA-ICPMS,在 Dhi Samir 采矿区域的煌斑岩有 602 precipi 的年龄吗?? | ZUO Liyan PEI Rongfu SHUAI Kaiye YANG Fengqi ZHU Riwei ZHANG Liemeng | 2011 | Acta Geologica Sinica(English Edition)2011，85，1： | 2 |
| 4 | Chinese consensus guidelines for therapeutic drug monitoring of polymyxin B,endorsed by the Infection and Chemotherapy Committee of the Shanghai Medical Association and the Therapeutic Drug Monitoring Committee of the Chinese Pharmacological Society显示文摘Polymyxin B,which is a last-line antibiotic for extensively drug-resistant Gram-negative bacterial infections,became available in China in Dec.2017.As dose adjustments are based solely on clinical experience of risk toxicity,treatment failure,and emergence of resistance,there is an urgent clinical need to perform therapeutic drug monitoring(TDM)to optimize the use of polymyxin B.It is thus necessary to standardize operating procedures to ensure the accuracy of TDM and provide evidence for their rational use.We report a consensus on TDM guidelines for polymyxin B,as endorsed by the Infection and Chemotherapy Committee of the Shanghai Medical Association and the Therapeutic Drug Monitoring Committee of the Chinese Pharmacological Society.The consensus panel was composed of clinicians,pharmacists,and microbiologists from different provinces in China and Australia who made recommendations regarding target concentrations,sample collection,reporting,and explanation of TDM results.The guidelines provide the first-ever consensus on conducting TDM of polymyxin B,and are intended to guide optimal clinical use. | XIAOFEN LIU CHENRONG HUANG PHILLIP JBERGEN JIAN LI JINGJING ZHANG YIJIAN CHEN YONGCHUAN CHEN BEINING GUO FUPIN HU JINFANG HU LINLIN HU XIN LI HONGQIANG QIU HUA SHAO TONGWEN SUN YU WANG PING XU JING YANG YONG YANG ZHENWEI YU BIKUI ZHANG HUAIJUN ZHU XIAOCONG ZUO YI ZHANG LIYAN MIAO JING ZHANG | 2023 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2023，24，2： | 1 |
| 5 | Chinese Fetal Growth:A Multicenter Cohort Study Based on Fetal Ultrasound Measurements显示文摘Objective:To build a reference fetal growth chart for the Chinese population based on fetal ultrasound measurements.Methods:This was a multicenter,population-based retrospective cohort study.Longitudinal ultrasound measurement data were collected from 24 hospitals in 18 provinces of China from 1st September through 31st October of 2019.The estimated fetal weight(EFW)was calculated based on head circumference,abdominal circumference,and femur length using Hadlock formula 3.Fetal growth curves were estimated using a two-level linear regression model with cubic splines.All participants were divided into two groups:the northern group(n=5829)and the southern group(n=3246)based on the geographical division of China and male fetus group(n=4775)and female fetus group(n=4300)based on fetal gender.The EFW was compared by fetal gender and geographical group.All statistical models were adjusted for maternal sociodemographic characteristics.Results:A total of 9075 participants with 31,700 ultrasound measurement records were included in this study.Male fetuses demonstrated significantly larger EFW compared to female ones starting at 16 weeks of gestation and extending to delivery(global testP<0.01).The overall geographic difference in EFW was significant(global testP=0.03),and week-specific comparisons showed that the northern group had a greater EFW starting at 15 weeks of gestation and extending to 29 weeks of gestation,although this difference did not extend to the time of delivery.TheZ-score of EFW confirmed that our Chinese fetal growth charts differed from previously published standards.Conclusion:This study provides EFW and ultrasound biometric reference measurements for Chinese fetuses and reveals differences from other fetal growth charts.The chart is worth promoting in more regions of China but should be tested prudently before use. | Xiaoli Gong Tianchen Wu Xiaoli Wang Lizhen Zhang Yiping You Hongwei Wei Xifang Zuo Ying Zhou Xinli Xing Zhaoyan Meng Qi Lyu Zhaodong Liu Jian Zhang Liyan Hu Junnan Li Li Li Chulin Chen Chunyan Liu Guoqiang Sun Aiju Liu Jingsi Chen Yuan Lyu Yuan Wei Yangyu Zhao | 2023 | Maternal-Fetal Medicine2023，5，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员