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| 1 | Detection of serum IgM and IgG for COVID-19 diagnosis显示文摘Dear Editor,Infection with the novel coronavirus(SARS-CoV-2,which is the virus responsible for the coronavirus disease 2019(COVID-19))was first reported in Wuhan,China on December 31,2019.The outbreak of COVID-19 remains ongoing and was linked to more than 80,000 infected patients and more than 3,000 deaths in China as of March 7,2020(Holshue et al.,2020). | Ling Zhong Junlan Chuan Bo Gong Ping Shuai Yu Zhou Yi Zhang Zhilin Jiang Dingding Zhang Xiaoqi Liu Shi Ma Yi Huang He Lin Qingwei Wang Lulin Huang Dan Jiang Fang Hao Juan Tang Chunqi Zheng Hua Yu Zhibin Wang Qi Jiang Tao Zeng Mei Luo Fanwei Zeng Fanxin Zeng Jianghai Liu Junxi Tian Yu Xu Tengxiang Long Kaiju Xu Xingxiang Yang Yuping Liu Yi Shi Li Jiang Zhenglin Yang | 2020 | Science China(Life Sciences)2020，63，5： | 8 |
| 2 | OSBPL2-disrupted pigs recapitulate dual features of human hearing loss and hypercholesterolaemia显示文摘Oxysterol binding protein like 2(OSBPL2), an important regulator in cellular lipid metabolism and transport, was identified as a novel deafness-causal gene in our previous work. To resemble the phenotypic features of OSBPL2 mutation in animal models and elucidate the potential genotypephenotype associations, the OSBPL2-disrupted Bama miniature(BM) pig model was constructed using CRISPR/Cas9-mediated gene editing, somatic cell nuclear transfer(SCNT) and embryo transplantation approaches, and then subjected to phenotypic characterization of auditory function and serum lipid profiles. The OSBPL2-disrupted pigs displayed progressive hearing loss(HL) with degeneration/apoptosis of cochlea hair cells(HCs) and morphological abnormalities in HC stereocilia, as well as hypercholesterolaemia. High-fat diet(HFD) feeding aggravated the development of HL and led to more severe hypercholesterolaemia. The dual phenotypes of progressive HL and hypercholesterolaemia resembled in OSBPL2-disrupted pigs confirmed the implication of OSBPL2 mutation in nonsydromic hearing loss(NSHL) and contributed to the potential linkage between auditory dysfunction and dyslipidaemia/hypercholesterolaemia. | Jun Yao Huasha Zeng Min Zhang Qinjun Wei Ying Wang Haiyuan Yang Yajie Lu Rongfeng Li Qiang Xiong Lining Zhang Zhibin Chen Guangqian Xing Xin Cao Yifan Dai | 2019 | Journal of Genetics and Genomics2019，46，8： | 7 |
| 3 | Genetic variants of miRNA sequences and non-small cell lung cancer survival显示文摘 | Hu Zhibin Chen Jiaping Tian Tian Zhou Xiaoyi Gu Haiyong Xu Lin Zeng Yi Miao Ruifen Jin Guangfu Ma Hongxia Chen Yijiang Shen Hongbing | 2008 | Journal of Clinical Investigation2008，，7： | 1 |
| 4 | Partner selection with a due date constraint in virtual enterprises显示文摘 | ZENG Zhibin LI Yan ZHU Wenxing | 2006 | Applied Mathematics and Computation2006，175，2： | 1 |
| 5 | Comprehensive study of crystalline AlN/sapphire templates after high-temperature annealing with various sputtering conditions显示文摘High-quality AlN/sapphire templates were fabricated by the combination of sputtering and high-temperature(HT)annealing.The influence of sputtering parameters including nitrogen flux,radio frequency power,and substrate temperature on the crystalline quality and surface morphology of annealed AlN films were investigated.With lower substrate temperature,lower power,and lower N2 flux,the full width at half maximum of the X-ray rocking curve for AlN(0002)and(102)were improved to 97.2 and 259.2 arcsec after high-temperature annealing.This happens because the increased vacancy concentration of sputtered AlN films can facilitate the annihilation of dislocations by increasing the recovery rate during HT annealing.Step and step-bunching morphologies were clearly observed with optimized sputtering conditions. | Wen Gu Zhibin Liu Yanan Guo Xiaodong Wang Xiaolong Jia Xingfang Liu Yiping Zeng Junxi Wang Jinmin Li Jianchang Yan | 2020 | Journal of Semiconductors2020，41，12： | 1 |
| 6 | Risk prediction of esophageal squamous-cell carcinoma with common genetic variants and lifestyle factors in Chinese population显示文摘 | Jiang Chang Ying Huang Lixuan Wei Baoshan Ma Xiaoping Miao Yun Li Zhibin Hu Dianke Yu Weihua Jia Yu Liu Wen Tan Zhonghu He Yang Ke Tangchun Wu Hongbing Shen Yixin Zeng Chen Wu Dongxin Lin | 2013 | Carcinogenesis2013，，8： | 1 |
| 7 | Design of a wideband common-mode filter using approximate closed-loop pattern of compact C-shaped defected ground structure显示文摘A compact common-mode filter is proposed to suppress common-mode noise for application of high-speed differential signal traces. The filter adopts one big C-shaped defected ground structure(DGS) cell in the left of ground plane and two small C-shaped DGS cells with opposite direction in the right of ground plane. Because these DGS cells have different dimensions, the filter has three adjacent equivalent resonant points, which can suppress wideband common-mode noise effectively. The left C-shaped DGS and its adjacent C-shaped DGS cell form an approximate closed structure, which can efficiently reduce the influence of the mutual capacitance. The filter provides a common-mode suppression from 3.6 GHz to 14.4 GHz over 15 dB while it has a small size of 10 mm × 10 mm. The fractional bandwidth of the filter is 120%, and the differential signals still keep good signal integrity. The experimental results are in good agreement with the simulated results. | Yao Yindi Zeng Zhibin | 2017 | The Journal of China Universities of Posts and Telecommunications2017，24，3： | 1 |
| 8 | Genetic vari- ants of mlRNA sequences and non - small cell lung cancer survival显示文摘 | Zhibin Hu Jiaping Chen Tian Tian Zhou X Gu H Xu L Zeng Y Miao R Jin G Ma H Chen Y Shen H | 2008 | J CAin Invest2008，118，7： | 1 |
| 9 | Partner selection with a due date eonstraint in virtual enterprises显示文摘 | ZENG Zhibin LI Yan ZHU Wenxing | 2006 | Applied Mathematies and Computation2006，175，2： | 1 |
| 10 | Identification of A-to-I RNA editing profiles and their clinical relevance in lung adenocarcinoma显示文摘Adenosine-to-inosine(A-to-I)RNA editing is a widespread posttranscriptional modification that has been shown to play an important role in tumorigenesis.Here,we evaluated a total of 19,316 RNA editing sites in the tissues of 80 lung adenocarcinoma(LUAD)patients from our Nanjing Lung Cancer Cohort(NJLCC)and 486 LUAD patients from the TCGA database.The global RNA editing level was significantly increased in tumor tissues and was highly heterogeneous across patients.The high RNA editing level in tumors was attributed to both RNA(ADAR1 expression)and DNA alterations(mutation load).Consensus clustering on RNA editing sites revealed a new molecular subtype(EC3)that was associated with the poorest prognosis of LUAD patients.Importantly,the new classification was independent of classic molecular subtypes based on gene expression or DNA methylation.We further proposed a simplified model including eight RNA editing sites to accurately distinguish the EC3 subtype in our patients.The model was further validated in the TCGA dataset and had an area under the curve(AUC)of the receiver operating characteristic curve of 0.93(95%CI:0.91-0.95).In addition,we found that LUAD cell lines with the EC3 subtype were sensitive to four chemotherapy drugs.These findings highlighted the importance of RNA editing events in the tumorigenesis of LUAD and provided insight into the application of RNA editing in the molecular subtyping and clinical treatment of cancer. | Cheng Wang Mingtao Huang Congcong Chen Yuancheng Li Na Qin Zijian Ma Jingyi Fan Linnan Gong Hui Zeng Liu Yang Xianfeng Xu Jun Zhou Juncheng Dai Guangfu Jin Zhibin Hu Hongxia Ma Fengwei Tan Hongbing Shen | 2022 | Science China(Life Sciences)2022，65，1： | 1 |
| 11 | Genetic variants of miRNA sequences and non-small cell lung cancer survival显示文摘 | Hu Zhibin Chen Jiaping Tian Tian Zhou Xiaoyi Gu Haiyong Xu Lin Zeng Yi Miao Ruifen Jin Guangfu Ma Hongxia Chen Yijiang Shen Hongbing | 2008 | Journal of Clinical Investigation2008，，7： | 1 |
| 12 | Detection of platelet microRNA expression in patients with diabetes mellitus with and without ischemic stroke显示文摘 | Xiaomei Duan Qiong Zhan Bingxin Song Sian Zeng Juan Zhou Yuming Long Jinfeng Lu Zhibin Li Mei Yuan Xiaoping Chen Qidong Yang Jian Xia | 2014 | Journal of Diabetes and Its Complications2014，，： | 1 |
| 13 | SARS-CoV-2 Surveillance Through China Influenza Surveillance Information System—China,December 1,2022 to February 12,2023显示文摘Introduction:The World Health Organization(WHO)proposed using influenza surveillance systems to carry out coronavirus disease 2019(COVID-19)surveillance due to the similarity between the two diseases in some respiratory symptoms.To assess the prevalence of COVID-19,we analyzed the influenzalike illness(ILI)and positive rate of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)detections in ILI patients reported to the influenza Surveillance Information System(CNISIS)since late 2022.Methods:Data related to ILI were reported by national surveillance sentinel hospitals.Positive testing for SARS-CoV-2 and influenza viruses was conducted using real-time reverse transcription polymerase chain reaction(rRT-PCR)detection by the national influenza surveillance network laboratories.Surveillance data were reported to CNISIS.Results:Beginning on December 12,2022(Week 50),the ILI percentage increased dramatically,peaking in Week 51 at 12.1%.Subsequently,the ILI percentage began to decline rapidly from Week 52,2022,and by Week 6,2023(February 6-12),the ILI and ILI percentage had returned to the levels observed at the beginning of December 2022.From December 1,2022 to February 12,2023,115,844 specimens were tested for both SARS-CoV-2 and influenza virus.Of these,30,381(26.2%)were positive for SARSCoV-2 and 1,763(1.5%)were positive for influenza virus.The positive rate of SARS-CoV-2 tests peaked at 74.1%around December 23 and 25.Conclusions:Sentinel-based surveillance,previously established for influenza,is an effective way to track the circulation trend of SARS-CoV-2 during community-level epidemics.There was no coprevalence of SARS-CoV-2 and influenza virus during the outbreak of SARS-CoV-2,even during the winter influenza season.However,it is important to remain vigilant for the potential rise of influenza activities following the COVID-19 epidemic. | Xiaoxu Zeng Yiran Xie Xiaokun Yang Zhibin Peng Jing Tang Lei Yang Shuxia Lin Jun Han Yanping Zhang Dayan Wang | 2023 | China CDC weekly2023，5，7： | 1 |
| 14 | Renin--angiotensin system inhibitor is associated with the reduced risk of all-cause mortality in COVID-19 among patients with/without hypertension显示文摘Consecutively hospitalized patients with confirmed coronavirus disease 2019(COVID-19)in Wuhan,China were retrospectively enrolled from January 2020 to March 2020 to investigate the association between the use of renin–angiotensin system inhibitor(RAS-I)and the outcome of this disease.Associations between the use of RAS-I(angiotensin-converting enzyme inhibitor(ACEI)or angiotensin receptor blocker(ARB)),ACEI,and ARB and in-hospital mortality were analyzed using multivariate Cox proportional hazards regression models in overall and subgroup of hypertension status.A total of 2771 patients with COVID-19 were included,with moderate and severe cases accounting for 45.0%and 36.5%,respectively.A total of 195(7.0%)patients died.RAS-I(hazard ratio(HR)=0.499,95%confidence interval(CI)0.325–0.767)and ARB(HR=0.410,95%CI 0.240–0.700)use was associated with a reduced risk of all-cause mortality among patients with COVID-19.For patients with hypertension,RAS-I and ARB applications were also associated with a reduced risk of mortality with HR of 0.352(95%CI 0.162–0.764)and 0.279(95%CI 0.115–0.677),respectively.RAS-I exhibited protective effects on the survival outcome of COVID-19.ARB use was associated with a reduced risk of all-cause mortality among patients with COVID-19. | Huai-yu Wang Suyuan Peng Zhanghui Ye Pengfei Li Qing Li Xuanyu Shi Rui Zeng Ying Yao Fan He Junhua Li Liu Liu Shuwang Ge Xianjun Ke Zhibin Zhou Gang Xu Ming-hui Zhao Haibo Wang Luxia Zhang Erdan Dong | 2022 | Frontiers of Medicine2022，16，1： | 0 |
| 15 | Optimal decomposition level selection approach in wavelet threshold denoising algorithm for ECG signal显示文摘The effect of electrocardiogram(ECG)signal wavelet denoising depends on the optimal configuration of its control parameters and the selection of the optimal decomposition level.Nevertheless,the existing optimal decomposition level selection scheme has some problems,such as lack of reliable theoretical guidance and insufficient accuracy,which need to be solved urgently.To solve this problem,this paper proposes an optimal decomposition level selection method based on multi-index fusion,which is used to select the optimal decomposition level for wavelet threshold denoising of ECG signal.In the stage of index selection,in order to overcome the limitation of a single evaluation index,the optimal multi-evaluation index is selected through the joint analysis of the geometric and physical significance of traditional evaluation indexes.In the stage of index fusion,based on the method of weighting the selected multiple indexes by the information entropy weight method and the coefficient of variation method,an optimal decomposition level selection method based on the evaluation index Z is proposed to improve the accuracy of the optimal decomposition level selection.Finally,extensive experiments are carried out on the real ECG signal from the Massachusetts Institute of Technology-Beth Israel Hospital(MIT-BIH)arrhythmia database and simulated signal to test the performance of the proposed method.The experimental results show that the accuracy of this method is superior to other related methods,and it can achieve better denoising effect of ECG signal. | Yao Yindi Yi Jun Zeng Zhibin Li Xiong Wang Chen Li Yuhang | 2023 | The Journal of China Universities of Posts and Telecommunications2023，30，4： | 0 |
| 16 | Wideband bandstop defected ground structure filter with enhanced common-mode suppression using split ring显示文摘An effective method to broaden the rejection bandwidth of dump-shaped defected ground structure(DGS) filter design is proposed in the paper. One traditional dumbbell-shaped DGS is split by using one split ring, and reconstructed into two different compact DGSs. The distance between both of the DGSs is so close that there exists mutual inductance, which can be utilized to broaden the rejection bandwidth effectively. The effect of different parameters of the split ring on the rejection bandwidth and depth of the filter is analyzed. Simulated results demonstrate that, with the same area of 5.5mm by 10 mm, rejection bandwidth of the proposed filter is from 4.4 GHz to 10.5 GHz for the common-mode noise(CM) while that of the traditional dumbbell-shaped DGS is from 5.3 GHz to 7.3 GHz. Compared to other schematics adopting multiple DGS to broaden bandwidth, it can broaden the bandwidth by dividing the existed DGS into multiple parts and reconstructing a new filter. The experimental results show good agreement with simulated results. | Yao Yindi Zeng Zhibin | 2015 | The Journal of China Universities of Posts and Telecommunications2015，22，5： | 0 |
| 17 | Dynamic single-cell mapping unveils Epstein-Barr virusimprinted T-cell exhaustion and on-treatment response显示文摘Epstein-Barr virus(EBV)-associated gastric cancer(GC)manifests an intriguing immunotherapy response.However,the cellular basis for EBV-imprinted tumour immunity and on-treatment response remains undefined.This study aimed to finely characterize the dynamic tumour immune contexture of human EBV(+)GC treated with immunochemotherapy by longitudinal scRNA-seg and paired scTCR/BCR-seq.EBV(+)GC exhibits an inflamed-immune phenotype with increased T-cell and B-cell infiltration. | Miao-Zhen Qiu Chaye Wang Zhiying Wu Qi Zhao Zhibin Zhao Chun-Yu Huang Wenwei Wu Li-Qiong Yang Zhi-Wei Zhou Yu Zheng Hong-Ming Pan Zexian Liu Zhao-Lei Zeng Hui-Yan Luo Feng Wang Feng-Hua Wang Si-Yu Yang Meng-Xing Huang Zhexiaon Lian Haiyan Zhang Rui-Hua Xu | 2023 | Signal Transduction and Targeted Therapy2023，8，10： | 0 |
| 18 | Propofol inhibits cells migration and invasion via HOTAIR/miR-93/HIF-1α-mediated lactate secretion in colon cancer显示文摘Propofol,a common intravenous anesthetic used in clinical,has been shown to regulate cells proliferation,inflammation,angiogenesis and metastasis as well as exerting anti-cancer effect in several different types of cancer.However,the functions and mechanisms of propofol in lactate secretion and invasion of cancer cells remain unknown.The primary aim of this study was to investigate the role of propofol in cells migration and invasion of colon cancer(CRC).Scratches assay,Transwell assay were used to detect colon cells migration and invasion.Realtime Quantitative Polymerase Chain Reaction(RT-qPCR),Western blotting were utilized to detect the expression of related molecules.Dual-luciferase assay was performed to identify transcriptional activity of target genes,RNA pulldown assay was used to confirm the interactions of RNAs.Results indicated that propofol inhibited cell migration and invasion through suppressing lactic acid production in CRC.Moreover,propofol reduced lactic acid production by down-regulating the expression of hypoxia inducible factor-1α(HIF-1α)and monocarboxylate transporter 4(MCT4).In addition,propofol inhibited the expression of HIF-1αand cells migration/invasion via suppressing the interaction of HOX transcript antisense RNA(HOTAIR)with miR-93.The present study indicated that propofol inhibited colon cancer cell migration and invasion by reducing lactic acid production and the expression of HIF-1αand MCT4 via HOTAIR/miR-93 axis.These data may provide potential metabolic targets for CRC treatment. | RUONAN GU WENJING GUO WENYANG WANG GUIHUAN LI XIAOJU LAI ZHIBIN HUANG WANLU ZHAO ZHICONGWU HUA CHEN WENYANG LUO FANGYIN ZENG FAN DENG | 2021 | BIOCELL2021，45，6： | 0 |
| 19 | Chromatin architectural alterations due to null mutation of a major CG methylase in rice显示文摘Associations between 3D chromatin architectures and epigenetic modifications have been characterized in animals.However,any impact of DNA methylation on chromatin architecture in plants is understudied,which is confined to Arabidopsis thaliana.Because plant species differ in genome size,composition,and overall chromatin packing,it is unclear to what extent findings from A.thaliana hold in other species.Moreover,the incomplete chromatin architectural profiles and the low-resolution high-throughput chromosome conformation capture(Hi-C)data from A.thaliana have hampered characterizing its subtle chromatin structures and their associations with DNA methylation.We constructed a high-resolution Hi-C interaction map for the null OsMET1-2(the major CG methyltransferase in rice)mutant(osmet1-2)and isogenic wild-type rice(WT).Chromatin structural changes occurred in osmetl-2,including intra-/inter-chromosomal interactions,compartment transition,and topologically associated domains(TAD)variations.Our findings provide novel insights into the potential function of DNA methylation in TAD formation in rice and confirmed DNA methylation plays similar essential roles in chromatin packing in A,thaliana and rice. | Jinbin Wang Xiaochong Li Qianli Dong Changping Li Juzuo Li Ning Li Baoxu Ding Xiaofei Wang Yanan Yu Tianya Wang Zhibin Zhang Yiyang Yu Man Lang Zixian Zeng Bao Liu Lei Gong | 2022 | Journal of Integrative Plant Biology2022，64，12： | 0 |
| 20 | Effects of the Fermentation of Lophatherum gracile Brongn on Its Active Ingredients of Total Flavonoids and Total Polysaccharide显示文摘[Objectives] In order to explore the effect of fermentation on Lophatherum gracile Brongn. [Methods] The single factor experiment was applied to screen the fermentation conditions of L. gracile Brongn,and the effect of fermentation on the contents of total flavonoids and total polysaccharides was explored. [Results] The experiment defined the best fermentation conditions as: keeping natural state of p H,temperature 35℃,inoculation amount 6%,rotation speed 210 r/min,fermentation time 36 h. The results showed that the content increase of total flavonoids in the fermentation group was 5. 59% higher than the that in the non-fermentation group. [Conclusions]The selected fermentation method could improve the contents of total flavonoids and total polysaccharides. | Liqin PAN Zhibin LI Xiaomin ZENG Shixin XIAO Xiaodan LI Xue BAI Panwei LI Min YANG Juan LIU | 2018 | Medicinal Plant2018，9，4： | 0 |
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