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| 1 | Biodegradation of aniline by Candida tropicalis AN1 isolated from aerobic granular sludge显示文摘Aniline-degrading microbes were cultivated and acclimated with the initial activated sludge collected from a chemical wastewater treatment plant. During the acclimation processes, aerobic granular sludge being able to effectively degrade aniline was successfully formed, from which a preponderant bacterial strain was isolated and named as AN1. Effects of factors including pH, temperature, and second carbon/nitrogen source on the biodegradation of aniline were investigated. Results showed that the optimal conditions for the biodegradation of aniline by the strain AN1 were at pH 7.0 and 28-35°C. At the optimal pH and temperature, the biodegradation rate of aniline could reach as high as 17.8 mg/(L·hr) when the initial aniline concentration was 400 mg/L. Further studies revealed that the addition of 1 g/L glucose or ammonium chloride as a second carbon or nitrogen source could slightly enhance the biodegradation efficiency from 93.0% to 95.1%-98.5%. However, even more addition of glucose or ammonium could not further enhance the biodegradation process but delayed the biodegradation of aniline by the strain AN1. Based on morphological and physiological characteristics as well as the phylogenetic analysis of 26S rDNA sequences, the strain AN1 was identified as Candida tropicalis. | Dianzhan Wang Guanyu Zheng Shimei Wang Dewei Zhang Lixiang Zhou | 2011 | Journal of Environmental Sciences2011，23，12： | 10 |
| 2 | FREQUENCY RESPONSE ANALYSIS IN INTERNAL FLOWS显示文摘FREQUENCYRESPONSEANALYSISININTERNALFLOWS￥ZhangLi-xiang(YunnanPolytechnicUniversity,ElectricEngineering,Kunming650051,P.R.Chin... | Zhang, Lixiang Tijsseling, A.S. Vardy, A.E. | 1995 | Journal of Hydrodynamics1995，7，3： | 5 |
| 3 | Adipocyte-derived SFRP5 inhibits breast cancer cells migration and invasion through Wnt and epithelial-mesenchymal transition signaling pathways显示文摘Objective:Obesity is closely associated with metastasis in breast cancer patients.Secreted frizzled-related protein 5(SFRP5),one of the novel adipokines with anti-inflammatory properties,is associated with obesity.This study aims to study the role of SFRP5 in the crosstalk between obesity and breast cancer metastasis and identify the underlying mechanism.Methods:3T3-L1 pre-adipocytes were differentiated to mature adipocytes and a hypertrophic adipocyte model was induced with palmitic acid(PA).Cell motility was measured in MDA-MB-231 and MCF-7 breast cancer cells co-cultured with adipocytes conditioned medium(CM)with or without SFRP5 protein.Wnt and epithelialmesenchymal transition(EMT)signal pathways were investigated by western blot.Circulating SFRP5 level in 218 breast cancer patients and the association with clinicopathologic characteristics of breast cancer were further determined.Online databases ENCORI and PREDICT Plus were used to exam the link between SFRP5 and prognosis.Results:Reduced SFRP5 level was detected in the hypertrophic adipocyte model.Recombinant SFRP5 protein inhibited MDA-MB-231 and MCF-7 cells invasion and migration induced by PA-treated adipocyte CM,and SFRP5 inhibition by specific antibody reversed the effect of SFRP5.Furthermore,SFRP5 significantly inhibited Wnt and downstream EMT in breast cancer cells.Low circulating SFRP5 level correlated with body mass index(BMI),lymph node(LN)metastasis,TNM stage and high Ki67 expression in breast cancer patients.Increased SFRP5 level was associated with favorable predicted survival.Kaplan-Meier curves showed high SFRP5 level in tumor tissue was associated with better outcome of breast cancer patients.Conclusions:Our findings demonstrated SFRP5 is a vital adipokine that mediates the crosslink between obesity and the metastatic potential of breast cancer.Promotion of SFRP5 expression in the adipose microenvironment may represent a novel approach for preventing breast cancer metastasis. | Wenzhong Zhou Chunmiao Ye Liang Li Liyuan Liu Fei Wang Lixiang Yu Fei Zhou Yujuan Xiang Yongjiu Wang Gengshen Yin Zhongbing Ma Qinye Fu Qiang Zhang Dezong Gao Shuya Huang Zhigang Yu | 2020 | Chinese Journal of Cancer Research2020，32，3： | 5 |
| 4 | Abnormal Effective Connectivity of the Anterior Forebrain Regions in Disorders of Consciousness显示文摘A number of studies have indicated that disorders of consciousness result from multifocal injuries as well as from the impaired functional and anatomical connectivity between various anterior forebrain regions.However, the specific causal mechanism linking these regions remains unclear. In this study, we used spectral dynamic causal modeling to assess how the effective connections(ECs) between various regions differ between individuals. Next, we used connectome-based predictive modeling to evaluate the performance of the ECs in predicting the clinical scores of DOC patients. We found increased ECs from the striatum to the globus pallidus as well as from the globus pallidus to the posterior cingulate cortex, and decreased ECs from the globus pallidus to the thalamus and from the medial prefrontal cortex to the striatum in DOC patients as compared to healthy controls.Prediction of the patients' outcome was effective using the negative ECs as features. In summary, the present study highlights a key role of the thalamo-basal ganglia-cortical loop in DOCs and supports the anterior forebrain mesocircuit hypothesis. Furthermore, EC could be potentially used to assess the consciousness level. | Ping Chen Qiuyou Xie Xiaoyan Wu Huiyuan Huang Wei Lv Lixiang Chen Yequn Guo Shufei Zhang Huiqing Hu You Wang Yangang Nie Ronghao Yu Ruiwang Huang | 2018 | Neuroscience Bulletin2018，34，4： | 4 |
| 5 | Establishment of novel rat models for premalignant breast disease显示文摘 | Wang Feng Ma Zhongbing Wang Fei Fu Qinye Fang Yunzhi Zhang Qiang Gao Dezong Li Yuyang Li Liang Yu Lixiang Yu Zhigang | 2014 | Chinese Medical Journal2014，，11： | 4 |
| 6 | Adsorption of methyl orange from aqueous solution by composite magnetic microspheres of chitosan and quaternary ammonium chitosan derivative显示文摘Novel composite magnetic microspheres containing chitosan and quaternary ammonium chitosan derivative(CHMMs) were prepared by inverse suspension method,and used for the methyl orange(MO) removal from aqueous solutions.The CHMMs were characterized by a scanning electron microscope,a transmission electron microscope,and Fourier transform infrared spectroscopy,respectively.Compared with the chitosan beads,the incorporation of quaternary ammonium chitosan derivative significantly reduced the particle size.The MO adsorption by CHMMs was investigated by batch adsorption experiments.The adsorption kinetics was conformed to the pseudo second-order kinetics equation.The adsorption isotherm followed the Langmuir model better than the Freundlich model and the calculated maximum MO adsorption capacity was 266.6 mg·g^-1 at 293 K.Thermodynamic studies indicated that the MO adsorption was endothermic in nature with the enthalpy change(△H°) of 99.44 kJ·mol^-1.The CHMMs had a stable performance for MO adsorption in the pH range of 4-10,but high ionic strength deteriorated the MO removal due to the shielding of the ion exchange interaction.A 1 mol·L^-1 NaCl solution could be used to regenerate the exhausted CHMMs.The proposed CHMMs can be used as an effective adsorbent for dye removal or recovery from the dye wastewater. | Bin Zhao Xiaojing Sun Liang Wang Lixiang Zhao Zhaohui Zhang Junjing Li | 2019 | Chinese Journal of Chemical Engineering2019，27，8： | 3 |
| 7 | Single-cell transcriptomic landscape of human blood cells显示文摘High throughput single-cell RNA-seq has been successfully implemented to dissect the cellular and molecular features underlying hematopoiesis.However,an elaborate and comprehensive transcriptome reference of the whole blood system is lacking.Here,we profiled the transcriptomes of 7551 human blood cells representing 32 immunophenotypic cell types,including hematopoietic stem cells,progenitors and mature blood cells derived from 21 healthy donors.With high sequencing depth and coverage,we constructed a single-cell transcriptional atlas of blood cells(ABC) on the basis of both protein-coding genes and long noncoding RNAs(lncRNAs),and showed a high consistence between them.Notably,putative lncRNAs and transcription factors regulating hematopoietic cell differentiation were identified.While common transcription factor regulatory networks were activated in neutrophils and monocytes,lymphoid cells dramatically changed their regulatory networks during differentiation.Furthermore,we showed a subset of nucleated erythrocytes actively expressing immune signals,suggesting the existence of erythroid precursors with immune functions.Finally,a web portal offering transcriptome browsing and blood cell type prediction has been established.Thus,our work provides a transcriptional map of human blood cells at single-cell resolution,thereby offering a comprehensive reference for the exploration of physiological and pathological hematopoiesis. | Xiaowei Xie Mengyao Liu Yawen Zhang Bingrui Wang Caiying Zhu Chenchen Wang Qing Li Yingying Huo Jiaojiao Guo Changlu Xu Linping Hu Aiming Pang Shihui Ma Una Wang Wenbin Cao Shulian Chen Qiuling Li Sudong Zhang Xueying Zhao Wen Zhou Hongbo Luo Guoguang Zheng Erlie Jiang Sizhou Feng Lixiang Chen Lihong Shi Hui Cheng Sha Hao Ping Zhu Tao Cheng | 2021 | National Science Review2021，8，3： | 3 |
| 8 | Modes of genetic adaptations underlying functional innovations in the rumen显示文摘The rumen is the hallmark organ of ruminants and hosts a diverse ecosystem of microorganisms that facilitates efficient digestion of plant fibers.We analyzed 897 transcriptomes from three Cetartiodactyla lineages:ruminants,camels and cetaceans,as well as data from ruminant comparative genomics and functional assays to explore the genetic basis of rumen functional innovations.We identified genes with relatively high expression in the rumen,of which many appeared to be recruited from other tissues.These genes show functional enrichment in ketone body metabolism,regulation of microbial community,and epithelium absorption,which are the most prominent biological processes involved in rumen innovations.Several modes of genetic change underlying rumen functional innovations were uncovered,including coding mutations,genes newly evolved,and changes of regulatory elements.We validated that the key ketogenesis rate-limiting gene(HMGCS2)with five ruminant-specific mutations was under positive selection and exhibits higher synthesis activity than those of other mammals.Two newly evolved genes(LYZ1 and DEFB1)are resistant to Gram-positive bacteria and thereby may regulate microbial community equilibrium.Furthermore,we confirmed that the changes of regulatory elements accounted for the majority of rumen gene recruitment.These results greatly improve our understanding of rumen evolution and organ evo-devo in general. | Xiangyu Pan Yudong Cai Zongjun Li Xianqing Chen Rasmus Heller Nini Wang Yu Wang Chen Zhao Yong Wang Han Xu Songhai Li Ming Li Cunyuan Li Shengwei Hu Hui Li Kun Wang Lei Chen Bin Wei Zhuqing Zheng Weiwei Fu Yue Yang Tingting Zhang Zhuoting Hou Yueyang Yan Xiaoyang Lv Wei Sun Xinyu Li Shisheng Huang Lixiang Liu Shengyong Mao Wenqing Liu Jinlian Hua Zhipeng Li Guojie Zhang Yulin Chen Xihong Wang Qiang Qiu Brian PDalrymple Wen Wang Yu Jiang | 2021 | Science China(Life Sciences)2021，64，1： | 3 |
| 9 | Adsorption performance and mechanism of Schiff base functionalized polyamidoamine dendrimer/silica for aqueous Mn(Ⅱ) and Co(Ⅱ)显示文摘Schiff base functionalized polyamidoamine(PAMAM) dendrimer/silica were prepared for the adsorption of aqueous Mn(Ⅱ) and Co(Ⅱ).The effects that influence the adsorption were investigated systematically and the adsorption mechanism was illustrated by theoretical calculation.The optimum adsorption pH are 4 and 6 for Mn(II) and Co(Ⅱ).Adsorption kinetics follow pseudo-second-order model and the ratecontrolling step is film diffusion process.Adsorption isotherm shows that high initial metal ion concentration facilitates the uptake of metal ions.The adsorption capacity increases first and then decreases in the temperature range of 15-35℃.Density functional theory(DFT) calculation demonstrates that Schiff base functionalized PAMAM dendrimer tends to coordinate Mn(Ⅱ) and Co(Ⅱ) with the oxygen atoms of hydroxyl and carbonyl groups,nitrogen of tertiary amine and imino groups.The imino and tertiary amine groups mainly dominate the adsorption.The reproducibility of the adsorbents indicates they can be regenerated by 5% thiourea and 0.5 mol/L HNO_(3) solution efficiently. | Wenzhu Qiao Peixu Zhang Lixiang Sun Songmei Ma Wenlong Xu Shengguang Xu Yuzhong Niu | 2020 | Chinese Chemical Letters2020，31，10： | 2 |
| 10 | Organosilicon modified method to improve Li^+ storage capacity of graphene oxide (GO)显示文摘Organosilicon modified reduced graphene oxide(Mr GO) has been fabricated by direct organosilicon modification of graphene oxide(GO). Interestingly,it is observed that 3D rGO-like structures occurred after directly carrying out the organosilicon modification on the surface of GO. The obtained organosilicon Mr GO displays the more remarkable improvement of electrochemical performances than GO,which was verified by electrochemical measurements in detail. For instance,the organosilicon MrGO shows the cycling performances at 901 mA hg^-1 after 200 cycles at 0.1 Ag^-1 and 446 mA hg^-1 after 300 cycles at 2.0 Ag^-1,respectively. These results unveil that organic modification method is an effective way to improve the Li^+ storage capacity of general carbon materials. | WANG Kun JU DongYing XU GuiYing HAN BeiBei CHAI MaoRong WANG YingXin Li LiXiang ZHANG XueHu UCIDA Masaya ZHOU WeiMin | 2020 | Science China(Technological Sciences)2020，63，12： | 2 |
| 11 | Synthesis of an ordered porous carbon with the dual nitrogen-doped interfaces and its ORR catalysis performance显示文摘Both nitrogen-doping feature and pore structure are critical factors for developing nitrogen-doped carbons based catalysts with a high performance toward oxygen reduction reaction(ORR).Herein,a simple one-step CVD of acetylene and acetonitrile vapor method using silanized SBA-15 as a template has been developed to synthesize an ordered porous carbon(OPC) with dual nitrogen-doped interfaces.The optimized sample as prepared with the CVD of 4 h at 750℃ contains two types of ordered mesopores that one type is the ordered cylindrical pores inheriting from the pores of SBA-15 and has a pore width of4.0~5.0 nm,the other type is the ordered quasi-hexagonal pores with a width of 3.0~4.0 nm produced by etching the pore walls of SBA-15.These two types of pores whose pore walls are built by the nitrogen doped carbon layers resulted by the CVD and thus it actually makes the dual nitrogen-doped interfaced OPC(DN-OPC).Meanwhile,DN-OPC contains a few of micropores and a large SSA of 1430 m~2/g.This dualordered pores and dual nitrogen-doped interfaces cannot only facilitate mass transport but also utilize the active sites of DN-OPC for ORR.Therefore,as metal-free ORR catalyst,DN-OPC exhibits a good activity close to commercial Pt/C catalyst,and an excellent durability and methanol tolerance. | Hongwei Zhao Yanqiu Zhang Li Lixiang Xin Geng Haiming Yang Weimin Zhou Chengguo Sun Baigang An | 2021 | Chinese Chemical Letters2021，32，1： | 2 |
| 12 | Novel hole-transporting materials based on 1,4-bis(carbazoly)benzene for organic light-emitting devices显示文摘 | Zhang Qian Chen Jiangshan Wang Lixiang | 2004 | Journal of Materials Chemistry2004，14，： | 1 |
| 13 | High efficiency fluorescent white organic light-emitting diodes with red, green and blue separately monochromatic emission layers显示文摘 | Zhiqiang Zhang Qi Wang Yanfeng Dai Yipeng Liu Lixiang Wang Dongge Ma | 2009 | Organic Electronics2009，，3： | 1 |
| 14 | Analysis of Water Transport inside a Plant Xylem Vessel with Pitted Thickening显示文摘In this article,computational fluid dynamics(CFD)are used to explore the dynamics of water transport inside the pitted thickening of a plant xylem vessel.A pitted thickening model combined with the Bernoulli equation is used to analyze the influence of various factors(namely,the inner diameter,thickening width,thickening height,thickening spacing,number of laps and adjacent pit axial rotation).The pressure drop and the flow resistance coefficient are the variable parameters for our analysis.The results show that these two parameters are proportional to the thickening height and thickening width,and inversely proportional to the inner diameter,thickening spacing and number of laps.Three different wall thickening structures of the vessel are compared and the pitted thickening vessel is shown to provide the largest structural flow resistance,the annular thickening vessel has the second largest resistance and the helical thickening vessel corresponds to the smallest resistance of the three structures. | Tianyu Xu Lixiang Zhang | 2020 | Fluid Dynamics & Materials Processing2020，16，3： | 1 |
| 15 | A Comparative Study on Different Parallel Solvers for Nonlinear Analysis of Complex Structures显示文摘 | Lei Zhang Guoxin Zhang Lixiang Wang Zhaosong Ma Shihai Li Zhiqiang Hu | 2013 | Mathematical Problems in Engineering2013，，： | 1 |
| 16 | A GPU-Based Parallel Procedure for Nonlinear Analysis of Complex Structures Using a Coupled FEM/DEM Approach显示文摘 | Lixiang Wang Shihai Li Guoxin Zhang Zhaosong Ma Lei Zhang Zhiqiang Hu | 2013 | Mathematical Problems in Engineering2013，，： | 1 |
| 17 | Strongly coupled simulation of fluid-structure interaction in a Francis hydroturbine显示文摘 | Wang Wenquan He Xiaoqiao Zhang Lixiang | 2009 | International Journal for Numerical Methods in Fluids2009，60，5： | 1 |
| 18 | NORMAL MODES OF FLUID-STRUCTURE INTERACTION IN INTERNAL FLOWS显示文摘As an important cornerstone, the methodology of normal modal analysis plays a quite important role in dynamic analyses of linear vibrating systems, and makes much easy to access an understanding of frequency-domain characteristics of the systems. However, most reported work on fluid-structure interaction (FSI) in liquid-filled pipes has been directly carried out in the time domain. When needed, information in the frequency domain has been deduced by the discrete Fourier transforms. In this paper, an analysis is undertaken directly to get modal information of FSI in internal flows and has the advantage of enabling dispersive and dissipative terms to be included in a fully coupled manner.The development used herein highlights common features of the analysis in the frequency domain. The method is validated by comparison with an exact analytical solution, with the results obtained by the discrete Fourier transform from an analysis using the method of characteristics and by comparison with measured data | Zhang, Lixiang Huang, Wenhu Tijsseling, Arris S. Vardy, Alan E. | 1998 | Journal of Hydrodynamics1998，10，4： | 1 |
| 19 | Alkyl-chain branched effect on the aggregation and photophysical behavior of polydiarylfluorenes toward stable deep-blue electroluminescence and efficient amplified spontaneous emission显示文摘The control of the condensed superstructure of light-emitting conjugated polymers(LCPs)is a crucial factor to obtain high performance and stable organic optoelectronic devices.Side-chain engineering strategy is an effective platform to tune inter chain aggregation and photophysical behaviour of LCPs.Herein,we systematically investigated the alkyl-chain branched effecton the conformational transition and photophysical behaviour of polydiarylfluorenes toward efficient blue optoelectronic devices.The branched side chain will improve materials solubility to inhibit interchain aggregation in solution according to DLS and optical analysis,which is useful to obtain high quality film.Therefore,our branched PEODPF,POYDPF pristine film present high luminance efficiency of 36.1%and 39.6%,enhanced about 20%relative to that of PODPF.Compared to the liner-type sides'chain,these branched chains also suppress chain planarization and improve film morphological stability effectively.Interestingly,the branched polymer also had excellent stable amplified spontaneous emission(ASE)behaviour with low threshold(4.72μJ/cm2)and a center peak of 465 nm,even thermal annealing at 220℃in the air atmosphere.Therefore,side-chain branched strategy for LCPs is an effective means to control interchain aggregation,film morphology and photophysical property of LCPs. | Lili Sun Ning Sun Lubing Bai Xiang An Bin Liu Chen Sun Lixiang Fan Chuanxin Wei Yamin Han Mengna Yu Jinyi Lin Dan Lu Ning Wang Linghai Xie Kang Shen Xinwen Zhang Yanan Xu Juan Cabanillas-Gonzalez Wei Huang | 2019 | Chinese Chemical Letters2019，30，11： | 1 |
| 20 | Structural characterisation and antioxidant properties of polysaccharides from the fruiting bodies of Russula virescens显示文摘 | SUN Zhongwei ZHANG Lixiang ZHANG Bin | 2010 | Food Chemistry2010，118，3： | 1 |
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