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| 1 | Monomeric type I and type III transforming growth factor-β receptors and their dimerization revealed by single-molecule imaging显示文摘转变生长因素 -- 尾(TGF- 尾) 与二 transmembrane serine/threonine kinase 受体,类型 II (T 尾 R II ) 和类型绑我受体(T 尾 R 我) ,并且一附件受体,类型 III 受体(T 尾 R III ) ,到越过房间膜的 transduce 信号。以前的生物化学的研究建议了那 T 尾 R 我和 T 尾 R III 被先存在 homo-dimers。用到图象绿色的单个分子的显微镜学荧光灯标记蛋白质的膜蛋白质,第一次,我们表明了那 T 尾 R 我和 T 尾 R III 能在低表达式水平作为单体存在。在 TGF-尾 1 刺激之上,我跟随的 T 尾 R 为激活的一般导致 ligand 的受体 dimerization 模型,而是这个过程是 T 尾 R II 依赖。non-kinase 受体 T 尾 R III 的 monomeric 地位面对 TGF-尾 1 是未改变的。随受体表示的增加,两 T 尾 R 我和 T 尾 R III 能在房间表面上被装配进 dimers。 | Wei Zhang Jinghe Yuan Yong Yang Li Xu Qiang Wang Wei Zuo Xiaohong Fang Ye-Guang Chen | 2010 | Cell Research2010，20，11： | 10 |
| 2 | Nanoscale imaging with an integrated system combining stimulated emission depletion microscope and atomic force microscope显示文摘We have built an integrated imaging system by combining stimulated emission depletion(STED)microscope and atomic force microscope(AFM).The STED microscope was constructed based on the supercontinuum fiber laser and a super lateral resolution of42 nm was achieved.With this integrated imaging system,morphological features,mechanical parameters and fluorescence super resolution imaging were obtained simultaneously for both nanobeads and fixed cell samples.This new integrated imaging system is expected to obtain comprehensive information at the nanoscale for studies in nanobiology and nanomedicine. | YU JianQiang YUAN JingHe ZHANG XueJie LIU JianLi FANG XiaoHong | 2013 | Chinese Science Bulletin2013，58，33： | 9 |
| 3 | Time Sensitive Networking Technology Overview and Performance Analysis显示文摘Time sensitive networking(TSN)is a set of standards developed on the basis of audio video bridging(AVB).It has a promising future in the Industrial Internet of Things and vehicle-mounted multimedia,with such advantages as high bandwidth,interoperability and low cost.In this paper,the TSN protocol stack is described and key technologies of network operation are summarized,including time synchronization,scheduling and flow shaping,flow management and fault tolerant mechanism.The TSN network model is then established.Its performance is illustrated to show how the frame priority works and also show the influence of IEEE802.1Qbv time-aware shaper and IEEE802.1Qbu frame preemption on network and time-sensitive data.Finally,we briefly discuss the challenges faced by TSN and the focus of future research. | FU Shousai ZHANG Hesheng CHEN Jinghe | 2018 | ZTE Communications2018，16，4： | 5 |
| 4 | Economic evaluation of cervical cancer screening strategies in urban China显示文摘Objective:This study evaluated the feasibility of different cervical cancer screening strategies in urban China.Methods:A Markov model was constructed to simulate a hypothetical cohort of 100,000 females aged 30-59 years in a 20-year period.Screening strategies included liquid-based cytology(LBC)every three years,human papillomavirus(HPV)DNA testing every three and five years,respectively,and a combination of HPV DNA testing and LBC(HPV+LBC)every three and five years,respectively.Model outcomes included cumulative incidence over 20 years,cumulative risk of cervical cancer,costs,life year saved(LYS),quality-adjusted life years(QALYs)and benefits.The cost-effectiveness ratios(CERs),incremental cost-effectiveness ratios(ICERs),costutility ratios(CURs),and benefit-cost ratios(BCRs)were used as outcomes in the health economic evaluation analysis.Univariate sensitivity analyses were performed to examine the stability of the results.Results:The cumulative incidence of the five screening strategies ranged from 833.02 to 1,158.07 cases per100,000 females.HPV DNA testing was most effective in reducing the cumulative risk of cervical cancer,saving life years and QALYs and gaining benefits.The CERs of HPV DNA testing every three and five years,and LBC every three years were considered to be very cost-effective if they were below China's GDP per capita.The CERs of HPV+LBC were considered to be cost-effective if they were below three times GDP per capita.The incremental cost-effectiveness analysis showed that HPV DNA testing every three and five years,LBC every three years and HPV+LBC every five years were dominant strategies.Conclusions:The findings of this study indicated that HPV DNA testing every five years or LBC every three years should be recommended in urban China. | Li Ma Yuying Wang Xiaohong Gao Yi Dai Yu Zhang Zhaojing Wang Xiaoxia Wang Limin Wang Jing Jiang Xinhua Jing Chunxia Yang Fanghui Zhao Jinghe Lang Youlin Qiao | 2019 | Chinese Journal of Cancer Research2019，31，6： | 4 |
| 5 | Super-resolution imaging and tracking of TGF-β receptor II on living cells显示文摘Single-particle tracking photoactivated localization microscopy(spt PALM) has recently emerged as a powerful tool for high-density imaging and tracking of individual molecules in living cells. In this work, we have monitored and compared the diffusion dynamics of TGF-b type II receptor(Tb RII) at high expression level using both traditional single-particle tracking(SPT) and spt PALM.The ligand-induced aggregation of Tb RII oligomers was further indicated by spt PALM. Due to the capacity of distinguishing and tracking single molecules within diffraction limit, spt PALM outperforms traditional SPT by providing more accurate biophysical information. | Zi Ye Nan Li Libo Zhao Yahong Sun Hefei Ruan Mingliang Zhang Jinghe Yuan Xiaohong Fang | 2016 | Science Bulletin2016，61，8： | 3 |
| 6 | Evaluation of triage strategies for high-risk human papillomavirus-positive women in cervical cancer screening:A multicenter randomized controlled trial in different resource settings in China显示文摘Objective:We aimed to evaluate the effectiveness of different triage strategies for high-risk human papillomavirus(hrHPV)-positive women in primary healthcare settings in China.Methods:This study was undertaken in 11 rural and 9 urban sites.Women aged 35-64 years old were enrolled.HrHPV-positive women were randomly allocated to liquid-based cytology(LBC),visual inspection with acetic acid and Lugol’s iodine(VIA/VILI)(rural only)triage,or directly referred to colposcopy(direct COLP).At 24 months,hrHPV testing,LBC and VIA/VILI were conducted for combined screening.Results:In rural sites,1,949 hrHPV-positive women were analyzed.A total of 852,218 and 480 women were randomly assigned to direct COLP,LBC and VIA/VILI.At baseline,colposcopy referral rates of LBC or VIA/VILI triage could be reduced by 70%-80%.LBC(n=3 and n=7)or VIA/VILI(n=8 and n=26)could significantly decrease the number of colposcopies needed to detect one cervical intraepithelial neoplasia(CIN)2 or worse and CIN3+compared with direct COLP(n=14 and n=23).For the 24-month cumulative detection rate of CIN2+,VIA/VILI triage was 0.50-fold compared with LBC triage and 0.46-fold with the direct COLP.When stratified by age,baseline LBC triage+performed best(P<0.001),peaking among women aged 35-44 years(Ptrend=0.002).In urban sites,1,728 women were hrHPV genotyping test positive.A total of 408,571 and 568women were randomly assigned to direct COLP for HPV16/18+,direct COLP for other hrHPV subtypes+,and LBC triage for other hrHPV subtypes+.LBC(n=12 and n=31)significantly decreased the number of colposcopies needed to detect one CIN2+and CIN3+compared with direct COLP(n=14 and n=44).HPV16/18+increased the 24-month cumulative detection rate of CIN2+(17.89%,P<0.001).Conclusions:LBC triage for hrHPV-positive women in rural settings and direct COLP for HPV16/18+women and LBC triage for other hrHPV subtype+women in urban settings might be feasible strategies. | Le Dang Linghua Kong Yuqian Zhao Yi Dai Li Ma Lihui Wei Shulan Zhang Jihong Liu Mingrong Xi Long Chen Xianzhi Duan Qing Xiao Guzhalinuer Abulizi Guonan Zhang Ying Hong Qi Zhou Xing Xie Li Li Mayinuer Niyazi Zhifen Zhang Jiyu Tuo Yiling Ding Youlin Qiao Jinghe Lang | 2022 | Chinese Journal of Cancer Research2022，34，5： | 2 |
| 7 | Reliability evaluation on sense-switch p-channel flash显示文摘In this paper,the reliability of sense-switch p-channel flash is evaluated extensively.The endurance result indicates that the p-channel flash could be programmed and erased for more than 10000 cycles;the room temperature read stress shows negligible influence on the p-channel flash cell;high temperature data retention at 150℃ is extrapolated to be about 5 years and 53 years corresponding to 30% and 40% degradation in the drive current,respectively.Moreover,the electrical parameters of the p-channel flash at different operation temperature are found to be less affected.All the results above indicate that the sense-switch p-channel flash is suitable to be used as the configuration cell in flash-based FPGA. | Side Song Guozhu Liu Hailiang Zhang Lichao Chao Jinghe Wei Wei Zhao Genshen Hong Qi He | 2021 | Journal of Semiconductors2021，42，8： | 2 |
| 8 | Seismogenic Structures of the 2006 ML4.0 Dangan Island Earthquake Offshore Hong Kong显示文摘The northern margin of the South China Sea, as a typical extensional continental margin, has relatively strong intraplate seismicity. Compared with the active zones of Nanao Island, Yangjiang, and Heyuan, seismicity in the Pearl River Estuary is relatively low. However, a ML4.0 earthquake in 2006 occurred near Dangan Island(DI) offshore Hong Kong, and this site was adjacent to the source of the historical M5.8 earthquake in 1874. To reveal the seismogenic mechanism of intraplate earthquakes in DI, we systematically analyzed the structural characteristics in the source area of the 2006 DI earthquake using integrated 24-channel seismic profiles, onshore–offshore wide-angle seismic tomography, and natural earthquake parameters. We ascertained the locations of NW-and NE-trending faults in the DI sea and found that the NE-trending DI fault mainly dipped southeast at a high angle and cut through the crust with an obvious low-velocity anomaly. The NW-trending fault dipped southwest with a similar high angle. The 2006 DI earthquake was adjacent to the intersection of the NE-and NW-trending faults, which suggested that the intersection of the two faults with different strikes could provide a favorable condition for the generation and triggering of intraplate earthquakes. Crustal velocity model showed that the high-velocity anomaly was imaged in the west of DI, but a distinct entity with low-velocity anomaly in the upper crust and high-velocity anomaly in the lower crust was found in the south of DI. Both the 1874 and 2006 DI earthquakes occurred along the edge of the distinct entity. Two vertical cross-sections nearly perpendicular to the strikes of the intersecting faults revealed good spatial correlations between the 2006 DI earthquake and the low to high speed transition in the distinct entity. This result indicated that the transitional zone might be a weakly structural body that can store strain energy and release it as a brittle failure, resulting in an earthquake-prone area. | XIA Shaohong CAO Jinghe SUN Jinlong LV Jinshui XU Huilong ZHANG Xiang WAN Kuiyuan FAN Chaoyan ZHOU Pengxiang | 2018 | Journal of Ocean University of China2018，17，1： | 2 |
| 9 | A 12-bit 250-MS/s Charge-Domain Pipelined Analog-to-Digital Converter with Feed-Forward Common-Mode Charge Control显示文摘A feed-forward Common-Mode(CM) charge control circuit for a high-speed Charge-Domain(CD)pipelined Analog-to-Digital Converter(ADC) is presented herein.This study aims at solving the problem whereby the precision of CD pipelined ADCs is restricted by the variation in input CM charge,which can compensate for CM charge errors caused by a variation in CM charge input in real time.Based on the feed-forward CM charge control circuit,a 12-bit 250-MS/s CD pipelined ADC is designed and realized using a 1 P6 M 0.18-μm CMOS process.The ADC achieved a Spurious Free Dynamic Range(SFDR) of 78.1 d B and a Signal-to-Noise-and-Distortion Ratio(SNDR) of 64.6 d B for a 20.1-MHz input:a SFDR of 74.9 d B and SNDR of 62.0 d B were achieved for a 239.9-MHz input at full sampling rate.The variation in signal-to-noise ratio was less than 3 d B over a 0–1.2 V input CM voltage range.The power consumption of the prototype ADC is only 85 m W at 1.8 V supply,and it occupies an active die area of 2.24 mm^2. | Zongguang Yu Xiaobo Su Zhenhai Chen Jiaxuan Zou Jinghe Wei Hong Zhang Yan Xue | 2018 | Tsinghua Science and Technology2018，23，1： | 2 |
| 10 | Fluorimetric determination of epinephrine with o - phenylenediamine 显示文摘 | Yang Jinghe Zhang Guiling Wu Xia | 1998 | Analytica Chimica Acta1998，363，1： | 1 |
| 11 | Pyroptotic macrophages stimulate the SARS-CoV-2-associated cytokine storm显示文摘Coronavirus disease 2019(COVID-19)is an unprecedented pandemic caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).As of 22 February 2021,the worldwide pandemic has resulted in more than 110 million cases and 2.4 million deaths.1 Clinical investigation of COVID-19 patients has shown that a systemic cytokine storm can occur,especially in severe cases.2 Treatment of the SARS-CoV-2-associated cytokine storm with tocilizumab3 or anakinra4 has been shown to immediately improve the clinical outcome in most severe and critical COVID-19 patients.These data highlight the systemic cytokine storm as an important exacerbating event in severe COVID-19;however,our understanding of the molecular mechanisms involved in the initiation of the SARS-CoV-2-associated cytokine storm is limited.In the present study,we uncovered a reasonable explanation for cytokine storm initiation through the analysis of 13 autopsy samples from severe COVID-19 patients. | Jinghe Zhang Haibo Wu XiaoHong Yao Dingyu Zhang Yonggang Zhou Binqing Fu Wei Wang Heng Li Zhe Wang Ziming Hu Yong Ren Rui Sun Zhigang Tian Xiuwu Bian Haiming Wei | 2021 | Cellular & Molecular Immunology2021，18，5： | 1 |
| 12 | Single-molecule imaging reveals the stoichiometry change of epidermal growth factor receptor during transactivation by β_2-adrenergic receptor显示文摘Stimulation of G protein-coupled receptors(GPCRs) can lead to the transactivation of the epidermal growth factor receptors(EGFR). The cross-communication between the two signaling pathways regulates several important physiological or pathological processes. However, the molecule mechanism underlying EGFR transactivation remains poorly understood. Here, we aim to study the GPCR-mediated EGFR transactivation process using the single-molecule fluorescence imaging and tracking approach.We found that although EGFR existed as monomers at the plasma membrane of resting cells, they became dimers and thus diffused slower following the activation of β2-adrenergic receptor(β2-AR) by isoproterenol(ISO). We further proved thatβ2-AR-mediated changes of EGFR in stoichiometry and dynamics were mediated by Src kinase. Thus, the observations obtained via the single-molecule imaging and tracking methods shed new insights into the molecular mechanism of EGFR transactivation at single molecule level. | Mingliang Zhang Kangmin He Jimin Wu Nan Li Jinghe Yuan Wei Zhou Zi Ye Zijian Li Han Xiao Zhizhen Lv Youyi Zhang Xiaohong Fang | 2017 | Science China Chemistry2017，60，10： | 1 |
| 13 | Synthesis and characterization of silica-alumina co-doped polyimide film 显示文摘 | ZHONG Jinghe ZHANG Mingyan JIANG Qibin | 2006 | Materials Letters2006，60，： | 1 |
| 14 | Seismotectonics of the Taiwan Shoal Region in the Northeastern South China Sea:Insights from the Crustal Structure显示文摘A cluster of earthquakes occurred in the Taiwan Shoal region on the outer rise of the Manila Trench. Although most were of small to medium magnitudes, one strong earthquake occurred on September 16, 1994. Several previous studies have provided important information to progress our understanding of this single earthquake. However, little is currently known about the earthquake cluster, and it is necessary to investigate the deep crustal structure of the Taiwan Shoal region to understand the mechanisms involved in controlling and generating it. This study presents a two-dimensional seismic tomographic image of the crustal structure along the OBS2012 profile based on ocean-bottom seismograph(OBS) data, which exhibits a high-velocity anomaly flanked by low-velocity anomalies in the upper crust beneath the Taiwan Shoal. In this study, 765 earthquakes(Richter magnitude ML > 1.5) occurring between 1991 and 2015 were studied and analyses of earthquake epicenters, regional faults, and the crustal structure provides an improved understanding of the nature of active tectonics in this region. Results of analyses indicate firstly that the high-velocity area represents major asperities that correspond to the location of the earthquake cluster and where stress is concentrated. It is also depicted that the earthquake cluster was influenced by fault interactions. However, the September 1994 earthquake occurred independently of these seismic activities and was associated with reactivation of a preexisting fault. It is also determined that slab pull is resisted by the exposed precollision accretionary prism, and the resistive force is causing accumulation of inplane compressive-stress. This may trigger a future damaging earthquake in the Taiwan Shoal region. | WAN Kuiyuan SUN Jinlong XU Huilong XIE Xiaoling XIA Shaohong ZHANG Xiang CAO Jinghe ZHAO Fang FAN Chaoyan | 2018 | Journal of Ocean University of China2018，17，1： | 1 |
| 15 | Fluorimetric determination of nucleic acids with terbium and lutetium显示文摘 | Lin Cunguo Zhang Guiling Yang Jinghe | 2002 | Microchemical Journal2002，71，： | 1 |
| 16 | , Synthesis and characterization of silica - alumina co doped polyimide film 显示文摘 | Zhong Jinghe Zhang Mingyan Jiang Qibin | 2006 | Materials Letters2006，60，： | 1 |
| 17 | Fluorimetric determination of epinephrine with o-phenylenediamine显示文摘 | Yang Jinghe Zhang Guiling Wu Xia | 1998 | Anal Chim Acta1998，363，： | 1 |
| 18 | Calculation of the intracellular elastic modulus based on an atomic force microscope micro-cutting system显示文摘Better understanding of variations in the mechanical properties of cancer cells could help to provide novel solutions for the diagnosis,prevention,and treatment of cancers.We therefore developed a calculation model of the intracellular elastic modulus based on the contact pressure between the silicon tip of an atomic force microscope and the target cells,and cutting depth.Ovarian cells(UACC-1598) and colon cancer cells(NCI-H716) were cut into sequential layers using an atomic force microscope silicon tip.The cutting area on the cells was 8μm×8μm,and the loading force acting on the cells was increased from 17.523 to 32.126μN.The elastic modulus distribution was measured after each cutting process.There were significant differences in contact pressure and cutting depth between different cells under the same loading force,which could be attributed to differences in their intrinsic structures and mechanical properties.The differences between the average elastic modulus and surface elastic modulus for UACC-1598 and NCI-H716 cells were 0.288±0.08 kPa and 0.376±0.16 kPa,respectively.These results demonstrate that this micro-cutting method can be used to measure intracellular mechanical properties,which could in turn provide a more accurate experimental basis for the development of novel methods for the diagnosis and treatment of various diseases. | YU Miao WANG JingHe WANG HongXiang LIU Li YAN YongDa ZHANG JunJie LIANG YingChun DONG Shen | 2012 | Chinese Science Bulletin2012，57，15： | 1 |
| 19 | A chromosome-scale reference genome of Aquilegia oxysepala var.kansuensis显示文摘The genus Aquilegia(Ranunculaceae)has been cultivated as ornamental and medicinal plants for centuries.With petal spurs of strikingly diverse size and shape,Aquilegia has also been recognized as an excellent system for evolutionary studies.Pollinator‐mediated selection for longer spurs is believed to have shaped the evolution of this genus,especially the North American taxa.Recently,however,an opposite evolutionary trend was reported in an Asian lineage,where multiple origins of mini-or even nonspurred morphs have occurred.Interesting as it is,the lack of genomic resources has limited our ability to decipher the molecular and evolutionary mechanisms underlying spur reduction in this special lineage.Using long-read sequencing(PacBio Sequel),in combination with optical maps(BioNano DLS)and Hi–C,we assembled a high-quality reference genome of A.oxysepala var.kansuensis,a sister species to the nonspurred taxon.The final assembly is approximately 293.2 Mb,94.6%(277.4 Mb)of which has been anchored to 7 pseudochromosomes.A total of 25,571 protein-coding genes were predicted,with 97.2%being functionally annotated.When comparing this genome with that of A.coerulea,we detected a large rearrangement between Chr1 and Chr4,which might have caused the Chr4 of A.oxysepala var.kansuensis to partly deviate from the“decaying”path that was taken before the split of Aquilegia and Semiaquilegia.This high-quality reference genome is fundamental to further investigations on the development and evolution of petal spurs and provides a strong foundation for the breeding of new horticultural Aquilegia cultivars. | Jinghe Xie Haifeng Zhao Kunpeng Li Rui Zhang Yongchao Jiang Meimei Wang Xuelian Guo Ben Yu Hongzhi Kong Yuannian Jiao Guixia Xu | 2020 | Horticulture Research2020，7，1： | 1 |
| 20 | LAMC1, LAMA2 and LAMA3 gene polymorphisms and the risk for severe pelvic organ prolapse显示文摘Pelvic organ prolapse (POP) is the descent of the pelvic organs,including bladder, uterus, vagina and rectum, resulting in pelvic discomfort, urinary and fecal incontinence and sexual dysfunction(1)The prevalence of symptomatic POP in China is 9.56%according to a cross-sectional study involving 54,000 adult women in six provinces in the mainland of China (unpublished data). The etiology of this disorder is multifactorial, including race, age, body mass index(BMI), parity and menopause (1)The loss of the integrity of vaginal connective tissue has been demonstrated to weaken the pelvic floor support and promote the development of POP. | Lei Li Jia Kang Ye Zhang Meng Mao Yuxiang Yang Jinghe Lang Zhijing Sun Juan Chen Lan Zhu | 2019 | Science Bulletin2019，64，7： | 1 |
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