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| 1 | The Qitai radio telescope显示文摘This study presents a general outline of the Qitai radio telescope(QTT)project.Qitai,the site of the telescope,is a county of Xinjiang Uygur Autonomous Region of China,located in the east Tianshan Mountains at an elevation of about 1800 m.The QTT is a fully steerable,Gregorian-type telescope with a standard parabolic main reflector of 110 m diameter.The QTT has adopted an umbrella support,homology-symmetric lightweight design.The main reflector is active so that the deformation caused by gravity can be corrected.The structural design aims to ultimately allow high-sensitivity observations from 150 MHz up to115 GHz.To satisfy the requirements for early scientific goals,the QTTwill be equipped with ultra-wideband receivers and large field-of-view multi-beam receivers.A multi-function signal-processing system based on RFSo C and GPU processor chips will be developed.These will enable the QTT to operate in pulsar,spectral line,continuum and Very Long Baseline Interferometer(VLBI)observing modes.Electromagnetic compatibility(EMC)and radio frequency interference(RFI)control techniques are adopted throughout the system design.The QTT will form a world-class observational platform for the detection of lowfrequency(nano Hertz)gravitational waves through pulsar timing array(PTA)techniques,pulsar surveys,the discovery of binary black-hole systems,and exploring dark matter and the origin of life in the universe.The QTT will also play an important role in improving the Chinese and international VLBI networks,allowing high-sensitivity and high-resolution observations of the nuclei of distant galaxies and gravitational lensing systems.Deep astrometric observations will also contribute to improving the accuracy of the celestial reference frame.Potentially,the QTT will be able to support future space activities such as planetary exploration in the solar system and to contribute to the search for extraterrestrial intelligence. | Na Wang Qian Xu Jun Ma Zhiyong Liu Qi Liu Hailong Zhang Xin Pei Maozheng Chen Richard N.Manchester Kejia Lee Xingwu Zheng Hans J.Kärcher Wulin Zhao Hongwei Li Dongwei Li Martin Süss Matthias Reichert Zhongyi Zhu Congsi Wang Mingshuai Li Rui Li Ning Li Guljaina Kazezkhan Wenming Yan Gang Wu Lang Cui Ming Zhang Haitao Li | 2023 | Science China(Physics,Mechanics & Astronomy)2023，66，8： | 14 |
| 2 | Degradation of bisphenol-A using ultrasonic irradiation assisted by low-concentration hydrogen peroxide显示文摘This study investigated the degradation of bisphenol-A (BPA) by ultrasonic irradiation in the presence of different additives (H2O2,air bubbles and humic acid) under various operating conditions,i.e.,ultrasonic frequency,power intensity and power density.The results demonstrated that the BPA degradation followed pseudo first-order kinetics under different experimental conditions.The optimum power intensities were 0.9,1.8,and 3.0W/cm 2 at the frequencies of 400,670,and 800 kHz,respectively.At the fixed frequency (800 kHz),the degradation rate of BPA was shown proportional to the increase of power density applied.With this manner,the BPA sonolysis could be facilitated at H2O2 dosage being lower than 0.1 mmol/L;while BPA degradation was hindered at H2O2 concentration in excess of 1 mmol/L.Additionally,BPA removal was shown to be inhibited by the presence of aeration and humic acid during ultrasonic irradiation.The present study suggested that the degradation rate of BPA assisted by ultrasonic irradiation was influenced by a variety of factors,and high BPA removal rate could be achieved under appropriate conditions. | Kejia Zhang Naiyun Gao Yang Deng Tsair Fuh Lin Yan Ma Lei Li Minghao Sui | 2011 | Journal of Environmental Sciences2011，23，1： | 9 |
| 3 | Characterization of typical taste and odor compounds formed by Microcystis aeruginosa显示文摘Production and characteristics of typical taste and odor (T&O) compounds by Microcystis aeruginosa were investigated. A few terpenoid chemicals, including 2-MIB, β-cyclocitral, and β-ionone, and a few sulfur compounds, such as dimethyl sulfide and dimethyl trisulfide, were detected. β-Cyclocitral and β-carotene concentrations were observed to be relevant to the growth phases of Microcystis. During the stable growth phase, 41-865 fg/cell of β-cyclocitral were found in the laboratory culture. β-Cyclocitral concentrations correlated closely with β-carotene concentrations, with the correlation coefficient R2 = 0.96, as it is formed from the cleavage reaction of β-carotene. For dead cell cases, a high concentration of dimethyl trisulfide was detected at 3.48-6.37 fg/cell. Four T&O compounds, including β-cyclocitral, β-ionone, heptanal and dimethyl trisulfide, were tested and found to be able to inhibit and damage Microcystis cells to varying degrees. Among these chemicals, β-cyclocitral has the strongest ability to quickly rupture cells. | Kejia Zhang Tsair Fuh Lin Tuqiao Zhang Cong Li Naiyun Gao | 2013 | Journal of Environmental Sciences2013，25，8： | 8 |
| 4 | Non-destructive detection of pigments in oil painting by using terahertz tomography显示文摘Dear Editors,Terahertz technology has been applied in many fields[1–3].The protection and restoration of historical relics and cultural heritage,which is a new application area of terahertz technology,have been attracting much attention recently[4,5]because of its social significance and market prospects.The most important premise is to obtain information of the cultural relics without damaging them again.Therefore the appropriate non-destructively testing methods are | ZHANG ZhenWei WANG KeJia LEI Yong ZHANG ZhuoYong ZHANG ZhenWei WANG KeJia LEI Yong ZHANG ZhuoYong ZHAO YuanMeng LI ChenYu GU An SHI NingChang ZHAO Kun ZHAN HongLei ZHANG CunLin | 2015 | Science China(Physics,Mechanics & Astronomy)2015，58，12： | 8 |
| 5 | Spatio-temporal variation in rock exhumation linked to large-scale shear zones in the southeastern Tibetan Plateau显示文摘Crustal-scale shear zones are believed to have played an important role in the tectonic and landscape evolution of orogens. However, the variation of long-term rock exhumation between the interior of shear zones and adjacent regions has not been documented in detail. In this study, we obtained new zircon U-Pb, biotite ^(40)Ar/^(39)Ar, zircon and apatite(U-Th)/He data, and conducted inverse thermal history modeling from two age-elevation profiles(the Pianma and Tu'er profiles) in the southeastern Tibetan Plateau. Our goal is to constrain the exhumation history of the Gaoligong and Chongshan shear zones and adjacent regions, so as to explore the effect of the shear zones on exhumation and their thermal effect on cooling that should not be ignored. Our results suggest that during the interval of 18–11 Ma the exhumation rates of rocks within the Gaoligong shear zone are anomalously high compared with those outside of. The rapid cooling during 18–11 Ma appears to be restricted to the shear zone, likely due to localized thermal effects of shearing and exhumation. After 11 Ma, both the areas within and outside of the shear zones experienced a similar two-stage exhumation history: slower cooling until the early Pliocene, and then a rapid increase in cooling rate since the early Pliocene. Our results indicate a synchronized exhumation but with spatially varied exhumation rates. Our study also highlights the important role of large-scale shear zones in exposing rocks, and thus the importance of the structural context when interpreting thermochronological data in the southeastern margin of the Tibetan Plateau. | Yukui GE Jing LIU-ZENG Jinyu ZHANG Wei WANG Yuntao TIAN Matthew FOX Lingsen ZENG Xiaoming SHEN Heng WANG Ze SU Kejia XIE | 2020 | Science China Earth Sciences2020，63，4： | 5 |
| 6 | SENP3 regulates the global protein turnover and the Spl level via antagonizing SUM02/ 3-targeted ubiquitination and degradation显示文摘 | Ming Wang Jing Sang Yanhua Ren Kejia Liu Xinyi Liu Jian Zhang Haolu Wang Jian Wang Amir Orian Jie Yang Jing Yi | 2016 | Protein & Cell2016，7，1： | 5 |
| 7 | Overexpression of miR-101 suppresses collagen synthesis by targeting EZH2 in hypertrophic scar fibroblasts显示文摘Background:MicroRNA-101(miR-101)is a tumor suppressor microRNA(miRNA)and its loss is associated with the occurrence and progression of various diseases.However,the biological function and target of miR-101 in the pathogenesis of hypertrophic scars(HS)remains unknown.Methods:We harvested HS and paired normal skin(NS)tissue samples from patients and cultured their fibroblasts(HSF and NSF,respectively).We used quantitative reverse transcriptase polymerase chain reaction(qRT-PCR),fluorescence in situ hybridization(FISH),enzyme-linked immunosorbent assays(ELISA)and Western blot analyses to measure mRNA levels and protein expression of miR-101,enhancer of zeste homolog 2(EZH2),collagen 1 and 3(Col1 and Col3)andα-smooth muscle actin(α-SMA)in different in vitro conditions.We also used RNA sequencing to evaluate the relevant signaling pathways and bioinformatics analysis and dual-luciferase reporter assays to predict miR-101 targets.We utilized a bleomycin-induced fibrosis mouse model in which we injected miR-101 mimics to evaluate collagen deposition in vivo.Results:We found low expression of miR-101 in HS and HSF compared to NS and NSF.Overexpressing miR-101 decreased Col1,Col3 andα-SMA expression in HSF.We detected high expression of EZH2 in HS and HSF.Knockdown of EZH2 decreased Col1,Col3 andα-SMA in HSF.Mechanistically,miR-101 targeted the 3-untranslated region(3UTR)of EZH2,as indicated by the decreased expression of EZH2.Overexpressing EZH2 rescued miR-101-induced collagen repression.MiR-101 mimics effectively suppressed collagen deposition in the bleomycin-induced fibrosis mouse model.Conclusions:Our data reveal that miR-101 targets EZH2 in HS collagen production,providing new insight into the pathological mechanisms underlying HS formation. | Jie Li Yan Li Yunchuan Wang Xiang He Jing Wang Weixia Cai Yanhui Jia Dan Xiao Jian Zhang Ming Zhao Kuo Shen Zichao Li Wenbin Jia Kejia Wang Yue Zhang Linlin Su Huayu Zhu Dahai Hu | 2021 | Burns & Trauma2021，9，1： | 3 |
| 8 | The Gravitational-wave physics Ⅱ: Progress显示文摘It has been a half-decade since the first direct detection of gravitational waves, which signifies the coming of the era of the gravitational-wave astronomy and gravitational-wave cosmology. The increasing number of the detected gravitational-wave events has revealed the promising capability of constraining various aspects of cosmology, astronomy, and gravity. Due to the limited space in this review article, we will briefly summarize the recent progress over the past five years, but with a special focus on some of our own work for the Key Project 'Physics associated with the gravitational waves' supported by the National Natural Science Foundation of China. In particular,(1) we have presented the mechanism of the gravitational-wave production during some physical processes of the early Universe, such as inflation, preheating and phase transition, and the cosmological implications of gravitational-wave measurements;(2) we have put constraints on the neutron star maximum mass according to GW170817 observations;(3) we have developed a numerical relativity algorithm based on the finite element method and a waveform model for the binary black hole coalescence along an eccentric orbit. | Ligong Bian Rong-Gen Cai Shuo Cao Zhoujian Cao He Gao Zong-Kuan Guo Kejia Lee Di Li Jing Liu Youjun Lu Shi Pi Jian-Min Wang Shao-Jiang Wang Yan Wang Tao Yang Xing-Yu Yang Shenghua Yu Xin Zhang | 2021 | Science China(Physics,Mechanics & Astronomy)2021，64，12： | 2 |
| 9 | Soft magnetic Co-Fe-B-P and Co-Fe-V-B-P amorphous alloy nano-particles prepared by aqueous chemical reduction显示文摘 | Wen M Zhong M F Kejia E Wu J D Li L J Oi H Q Cao S X Zhang T | 2006 | Journal of Alloys and Compounds2006，，： | 1 |
| 10 | Photocatalytic property of Zn O microrods modified by Cu2O nanocrystals显示文摘 | Liu Kejia Zhang Junying Gao Hong | 2013 | Journal of Alloys and Compounds2013，552，5： | 1 |
| 11 | Detecting Isolate Safe Areas in Wireless Sensor Monitoring Systems显示文摘Wireless sensors are deployed widely to monitor space, emergent events, and disasters. Collected realtime sensory data are precious for completing rescue missions quickly and efficiently. Detecting isolate safe areas is significant for various applications of event and disaster monitoring since valuable real-time information can be provided for the rescue crew to save persons who are trapped in isolate safe areas. We propose a centralized method to detect isolate safe areas via discovering holes in event areas. In order to shorten the detection delay, a distributed isolate safe area detection method is studied. The distributed method detects isolate safe areas during the process of event detection. Moreover, detecting isolate safe areas in a building is addressed particularly since the regular detecting method is not applicable. Our simulation results show that the distributed method can detect all isolate safe areas in an acceptable short delay. | Chunyu Ai Frank Haizhon Li Kejia Zhang | 2017 | Tsinghua Science and Technology2017，22，4： | 1 |
| 12 | Study on the Microscopic Network Model of PVA Hydrogel Based on the Tensile Behavior显示文摘Hydrogel is an emerging material widely used in the biological field.The tensile properties of hydrogel mainly depend on its polymer network,but due to the complex microstructure of the network,some properties of the hydrogel have yet to be qua nt itatively analyzed.In this article,we built a three-dimensional random fiber net work to characterize the micros tructure of a hydrogel.The fibers were simplified as elastic beams,and the cross-links were regarded as'hinges.'Combined with the macroscopic experimental results,the influence of the change of fiber length and the relationship between the polymer content and the cross-link density were studied.The model was verified by the quasi-static tensile test results of real PVA hydrogel materials with different fiber contents.The results show that the model can well match the tensile stress-strain curve and tensile strength of the PVA hydrogels with different fiber contents.The change in micros true ture of the fiber network induces nonlinear behaviors,and although the cross-link number increases with the increase in polymer content,the cross-link density(per unit PVA chain length)of the PVA hydrogel slightly decreases as the content increases. | Kejia Xu Liqun Tang Yongrou Zhang Rong Ding Xinyuan Wang Dafei Huang Jiansheng Lin | 2019 | Acta Mechanica Solida Sinica2019，32，5： | 1 |
| 13 | Simultaneous Denitrification and Carbon Removal in Microbial Fuel Cells显示文摘In this article,microbial fuel cell( MFC) was used for simultaneous denitrification and carbon removal to ascertain their electricity generation performance. The results showed that strengthening domestication and enrichment of electrogenic bacteria had the best start-up effect. An increase in volumetric loading reduced the rate of pollutant removal but promoted the output voltage. The changes of working conditions such as influent concentration,sludge concentration and temperature had a great influence on the electricity generation performance of MFC,and their optimum values were 500 mg/L,2 000 mg/L and 35℃,respectively. | Zhenbo SUN Yujin LI Kejia WEI Jiqiang ZHANG Haiying GUO Jing CAI | 2019 | Asian Agricultural Research2019，11，6： | 1 |
| 14 | Nanosecond pulsed electric fields prime mesenchymal stem cells to peptide ghrelin and enhance chondrogenesis and osteochondral defect repair in vivo显示文摘Mesenchymal stem cells(MSCs) are important cell sources in cartilage tissue development and homeostasis,and multiple strategies have been developed to improve MSCs chondrogenic differentiation with an aim of promoting cartilage regeneration.Here we report the effects of combining nanosecond pulsed electric fields(ns PEFs) followed by treatment with ghrelin(a hormone that stimulates release of growth hormone) to regulate chondrogenesis of MSCs.ns PEFs and ghrelin were observed to separately enhance the chondrogenesis of MSCs,and the effects were significantly enhanced when the bioelectric stimulation and hormone were combined,which in turn improved osteochondral tissue repair of these cells within Sprague Dawley rats.We further found that ns PEFs can prime MSCs to be more receptive to subsequent stimuli of differentiation by upregulated Oct4/Nanog and activated JNK signaling pathway.Ghrelin initiated chondrogenic differentiation by activation of ERK1/2 signaling pathway,and RNA-seq results indicated 243 genes were regulated,and JAK-STAT signaling pathway was involved.Interestingly,the sequential order of applying these two stimuli is critical,with ns PEFs pretreatment followed by ghrelin enhanced chondrogenesis of MSCs in vitro and subsequent cartilage regeneration in vivo,but not vice versa.This synergistic prochondrogenic effects provide us new insights and strategies for future cell-based therapies. | Kejia Li Litong Fan Jianjing Lin Boon Chin Heng Zhantao Deng Qiujian Zheng Jue Zhang Yangzi Jiang Zigang Ge | 2022 | Science China(Life Sciences)2022，65，5： | 1 |
| 15 | Granu-lar activated carbon (GAC) adsorption of two algalodorants, dimethyl trisulfide and /?-cyclocitral 显示文摘 | Zhang Kejia Gao Naiyun Deng Yang | 2011 | Desalination2011，266，13： | 1 |
| 16 | Aque-ous chlorination of algal odorants: reaction kineticsand formation of disinfection by-products显示文摘 | Zhang Kejia Gao Naiyun Deng Yang | 2012 | Sepa-ration and Purification Technology2012，92，： | 1 |
| 17 | Risk Factors for Gestational Diabetes Mellitus(GDM)in Subsequent Pregnancy Among Women Without GDM History in China:A Multicenter Retrospective Study显示文摘Objective:This study aimed to determine the likelihood of gestational diabetes mellitus(GDM)in subsequent pregnancy among women without GDM history and to identify risk factors for GDM in subsequent pregnancy.Methods:This retrospective cohort study involved participants who delivered twice in same hospital of 18 research centers when delivered the second baby from January 2018 to December 2018.Finally 6204 women were enrolled and 5180 women without GDM history were analyzed further.Women were categorized as non-GDM or GDM based on the blood glucose values of the subsequent pregnancy,and the characteristics and GDM risk of these groups were compared.A univariate analysis of potential risk factors was performed using the Chi-squared test and/ort-test for qualitative or quantitative variables,respectively.Associations withP values<0.1 were chosen to be included in the multivariate binary logistic regression model.Results:In primary analysis of 6204 women,the incidence of GDM in subsequent pregnancy is 48.9%(490/1002)in women with GDM history and 16.1%(835/5202)in women without GDM history.In a further analysis for 5180 women without GDM at index pregnancy,compared with the non-GDM group,the GDM group had a significantly higher age,prepregnancy body mass index,and blood glucose value at each oral glucose tolerance test(OGTT)timepoint(fasting,1 h and 2 h)during the index and subsequent pregnancies,as well as higher weight retention during the interval between the two pregnancies(P<0.001).Age above 35 years in subsequent pregnancy(odds ratio(OR)=1.540,95%confidence interval(CI)=1.257-1.886,P<0.001),macrosomia in index pregnancy(OR=1.749,95%CI=1.277-2.395,P=0.001),OGTT blood glucose values in index pregnancy(fasting,OR=2.487,95%CI=1.883-3.285,P<0.001;1 h,OR=1.142,95%CI=1.051-1.241,P=0.002;2 h,OR=1.290,95%CI=1.162-1.432,P<0.001)and weight retention(OR=1.052,95%CI=1.035-1.068,P<0.001)were independent risk factors for GDM in subsequent pregnancy.Conclusion:For women without GDM history,GDM risk factors including age,macrosomia history,OGTT value,and weight retention,these can be evaluated before a subsequent pregnancy.Early warning and interventions are needed for women at high risk. | Geng Song Yumei Wei Juan Juan Rina Su Jianying Yan Mei Xiao Xianlan Zhao Meihua Zhang Yuyan Ma Haiwei Liu Jingxia Sun Kejia Hu Huixia Yang | 2023 | Maternal-Fetal Medicine2023，5，1： | 1 |
| 18 | Three-dimensional temperature prediction in cylindrical turning with large-chamfer insert based on a modified slip-line field approach显示文摘Chamfered inserts have found broader applications in metal cutting process especially in high-performance machining of hard-to-cut materials for their excellent edge resistance and cutting toughness.However,excessive heat generation and resulting high cutting temperature eventually cause severe tool wear and poor surface integrity,which simultaneously limits the optimal selection of machining parameters.In the present study,an analytical thermal–mechanical model is proposed for the prediction of the three-dimensional(3-D)temperature field in cylindrical turning with chamfered round insert based on a modified slip-line field approach.First,an innovative discretization method is introduced in a general 3-D coordinate system to provide a comprehensive demonstration of the irregular cutting geometry and heat generation zones.Then,a plasticity-theory-based slip-line field model is developed and employed to determine the intensities and geometries of every elementary heat sources in Primary Deformation Zones(PDZ),Secondary Deformation Zones(SDZ)and Dead Metal Zones(DMZ).At last,a 3-D analytical model is suggested to calculate the temperature increases caused by the entire heat sources and associated images.The maximum cutting temperature region predicted is found existing upon the chip-tool contact area rather than the tool edge.Moreover,the rationalities of cutting parameters employed are analyzed along with theoretical material removal rates and ensuing maximum cutting temperatures.The results indicate that the cutting conditions with large depth of cut and high cutting speed are more desirable than those with high feed rates.The proposed models are respectively verified through a series of 3-D Finite Element(FE)simulations and dry cutting experiments of Inconel 718 with chamfered round insert.Satisfactory agreement has been reached between the predictions and simulations as well as the measurements,which confirms the correctness and effectiveness of the presented analytical model. | Cheng HU Kejia ZHUANG Yuanwei TANG Jian WENG Xiaoming ZHANG Han DING | 2021 | Chinese Journal of Aeronautics2021，34，10： | 1 |
| 19 | Prevalence and characteristics of macrosomia in the first and subsequent pregnancy: a multi-center retrospective study显示文摘To the Editor:Macrosomia is of growing prevalence and concern worldwide.In China,there has been a marked increase in the prevalence of macrosomia over the past few decades as a result of economic development and improvements in living standards. | Juan Juan Huixia Yang Yumei Wei Geng Song Rina Su Xu Chen Ruiqin Shan Jianying Yan Mei Xiao Ying Li Shihong Cui Xianlan Zhao Shangrong Fan Ling Feng Meihua Zhang Yuyan Ma Zishan You Haixia Mengn Haiwei Liu Jingxia Sun Yan Cai Kejia Hu | 2022 | Chinese Medical Journal2022，，12： | 1 |
| 20 | Channel Context and Dual-Domain Attention Based U-Net for Skin Lesion Attributes Segmentation显示文摘Skin melanoma is one of the most common malignant tumorsoriginating from melanocytes, and the incidence of the Chinese populationis showing a continuous increasing trend. Early and accurate diagnosisof melanoma has great significance for guiding clinical treatment.However, the symptoms of malignant melanoma are not obvious in theearly stage. It is difficult to be diagnosed with human observation. Meanwhile,it is easy to spread due to missed diagnosis. In order to accuratelydiagnose melanoma, end-to-end skin lesion attribute segmentation frameworkis presented in this paper. It is applied to facilitate the digitalizationprocess of attributes segmentation. The framework was improved on theU-Net construction that use the channel context feature fusion modulebetween the encoder and decoder to further merge context information. Adual-domain attention module is proposed to get more effective informationfrom the feature map. It shows that the proposed method effectivelysegments the lesion attributes and achieves good result in the ISIC2018task2 dataset. | XueLian Mu HaiWei Pan KeJia Zhang Teng Teng XiaoFei Bian ChunLing Chen | 2021 | 国际计算机前沿大会会议论文集2021，，1： | 0 |
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