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| 1 | Precise nanomedicine for intelligent therapy of cancer显示文摘Precise nanomedicine has been extensively explored for efficient cancer imaging and targeted cancer therapy, as evidenced by a few breakthroughs in their preclinical and clinical explorations. Here, we demonstrate the recent advances of intelligent cancer nanomedicine, and discuss the comprehensive understanding of their structure-function relationship for smart and efficient cancer nanomedicine including various imaging and therapeutic applications, as well as nanotoxicity. In particular, a few emerging strategies that have advanced cancer nanomedicine are also highlighted as the emerging focus such as tumor imprisonment, supramolecular chemotherapy, and DNA nanorobot. The challenge and outlook of some scientific and engineering issues are also discussed in future development. We wish to highlight these new progress of precise nanomedicine with the ultimate goal to inspire more successful explorations of intelligent nanoparticles for future clinical translations. | Huabing Chen Zhanjun Gu Hongwei An Chunying Chen Jie Chen Ran Cui Siqin Chen Weihai Chen Xuesi Chen Xiaoyuan Chen Zhuo Chen Baoquan Ding Qian Dong Qin Fan Ting Fu Dayong Hou Qiao Jiang Hengte Ke Xiqun Jiang Gang Liu Suping Li Tianyu Li Zhuang Liu Guangjun Nie Muhammad Ovais Daiwen Pang Nasha Qiu Youqing Shen Huayu Tian Chao Wang Hao Wang Ziqi Wang Huaping Xu Jiang-Fei Xu Xiangliang Yang Shuang Zhu Xianchuang Zheng Xianzheng Zhang Yanbing Zhao Weihong Tan Xi Zhang Yuliang Zhao | 2018 | Science China Chemistry2018，61，12： | 19 |
| 2 | An Improved Kalman Filter Positioning Method in NLOS Environment显示文摘In the precision positioning system, NLOS(Non Line of Sight) propagation and clock synchronization error caused by multiple base stations are the main reasons for reducing the reliability of communication and positioning accuracy. So, in the NLOS environment, it has an important role to eliminate the clock synchronization problem in the positioning system. In order to solve this problem, this paper proposes an improved Kalman filter localization method NLOS-K(Non Line of Sight-Kalman filter). First, the maximum likelihood estimation algorithm is used to iterate. Then, the Kalman filter algorithm is implemented and the Kalman gain matrix is redefined. The clock drift is compensated so that the clock between the master and slave base stations remains synchronized. The experimental results show that in the non-lineof-sight environment, compared with other algorithms, the positioning accuracy error of the improved algorithm is about 5 cm, and the accuracy compared with other algorithms is 97%. In addition, the influence of bandwidth and spectral density on the method is analyzed, and the accuracy and stability of positioning are improved as a whole. | Zhanjun Hao Beibei Li Xiaochao Dang | 2019 | China Communications2019，16，12： | 4 |
| 3 | Competition between the stimulated Raman and Brillouin scattering under the strong damping condition显示文摘 | Hao Liang Liu Zhanjun Hu Xiaoyan | 2013 | Laser and Particle Beams2013，31，2： | 1 |
| 4 | All-inorganic perovskite nanocrystal materials: new generation of scintillators for high quality X-ray imaging显示文摘Scintillating materials, which can convert high energy X-ray radiation into visible luminescence [1], are crucial parts of Xray imaging technology. Since the discovery of X-ray in 1895, scintillating materials have witnessed wild applications in various fields, including security inspection, space exploration, nondestructive detection, and medical diagnostics [2,3]- Conventional scintillators are generally large inorganic crystals and can only be grown at high temperature, which significantly increases the manufacturing difficulty and cost. The luminescence of current crystal scintillators is usually limited by lowefficiency or afterglow effects, and is difficult to be tuned cross the visible spectrum. As traditional scintillators have reached their performance limits, exploration of new scintillators has become a crucial topic considering the increased demands of X-ray imaging and detection technology [4-6]. | Kang Wang Hao Zhang Zhanjun Gu | 2019 | Science Bulletin2019，64，17： | 1 |
| 5 | Monitoring of Real-Time Complex Deformed Shapes of Thin-Walled Channel Beam Structures Subject to the Coupling Between Bi-Axial Bending and Warping Torsion显示文摘Structural health monitoring(SHM)is a research focus involving a large category of techniques performing in-situ identification of structural damage,stress,external loads,vibration signatures,etc.Among various SHM techniques,those able to monitoring structural deformed shapes are considered as an important category.A novel method of deformed shape reconstruction for thinwalled beam structures was recently proposed by Xu et al.[1],which is capable of decoupling complex beam deformations subject to the combination of different loading cases,including tension/compression,bending and warping torsion,and also able to reconstruct the full-field displacement distributions.However,this method was demonstrated only under a relatively simple loading coupling cases,involving uni-axial bending and warping torsion.The effectiveness of the method under more complex loading cases needs to be thoroughly investigated.In this study,more complex deformations under the coupling between bi-axial bending and warping torsion was decoupled using the method.The set of equations for deformation decoupling was established,and the reconstruction algorithm for bending and torsion deformation were utilized.The effectiveness and accuracy of the method was examined using a thin-walled channel beam,relying on analysis results of finite element analysis(FEA).In the analysis,the influence of the positions of the measurement of surface strain distributions on the reconstruction accuracy was discussed.Moreover,different levels of measurement noise were added to the axial strain values based on numerical method,and the noise resistance ability of the deformation reconstruction method was investigated systematically.According to the FEA results,the effectiveness and precision of the method in complex deformation decoupling and reconstruction were demonstrated.Moreover,the immunity of the method to measurement noise was proven to be considerably strong. | Rui Lu Zhanjun Wu Qi Zhou Hao Xu | 2019 | Structural Durability & Health Monitoring2019，13，3： | 1 |
| 6 | DNAzyme@CuSNPs dual mimic enzyme probe-amplified chemiluminescent imaging array immunosensor for multiple chicken cytokines detection显示文摘The detection of cytokines plays an important role in clinical diagnosis and immune mechanism research of chicken diseases.In this work,a novel and ultrasensitive chemiluminescent(CL)imaging array immunosensor was proposed to detect multiple chicken cytokines based on DNAzyme@CuS nanoparticles(DNAzyme@CuSNPs)dual mimic enzyme signal amplification strategy.DNAzyme@CuSNPs owns excellent peroxidase property,which was modified with second antibody(Ab_(2))to prepare DNAzyme@CusNPs detection probe,and demonstrated high catalysis CL imaging signal due to synergistic catalysis.Chicken interleukin-4(ChIL-4)and chicken interferon-y(ChIFN-y)were used as model analysis samples,the DNAzyme@CusSNPs-based CL imaging immunosensor achieved simultaneous and high-throughput detection of ChIL-4 and ChIFN-y with wide linear range of 10^(-3)-10^(2) ng/mL,and the detection limits are 0.41 pg/mL and 0.36 pg/mL,respectively.The multiplex chicken cytokines CL imaging array immunosensor shows a high sensitivity,wide linear range,excellent specificity and acceptable stability.This research opens dual mimic enzyme signal-amplified strategy to develop sensitive CL imaging immunoassay for chicken diseases detection application. | Jingyi Zhan Feng Shi Juan Li Hao Zeng Ming Chen Xiaoya Hu Zhanjun Yang | 2023 | Chinese Chemical Letters2023，34，12： | 0 |
| 7 | A Method of Improving the Tracking Method of CSI Personnel显示文摘 | Zhanjun Hao Beibei Li Xiaochao Dang | 2018 | 国际计算机前沿大会会议论文集2018，，2： | 0 |
| 8 | Recent research progress of laser plasma interactions in Shenguang laser facilities显示文摘Wereport experimental research on laser plasma interaction(LPI)conducted in Shenguang laser facilities during the past ten years.The research generally consists of three phases:(1)developing platforms for LPI research in mm-scale plasma with limited drive energy,where both gasbag and gas-filled hohlraum targets are tested;(2)studying the effects of beam-smoothing techniques,such as continuous phase plate and polarization smoothing,on the suppression of LPI;and(3)exploring the factors affecting LPI in integrated implosion experiments,which include the laser intensity,gas-fill pressure,size of the laser-entrance hole,and interplay between different beam cones.Results obtained in each phase will be presented and discussed in detail. | Tao Gong Liang Hao Zhichao Li Dong Yang Sanwei Li Xin Li Liang Guo Shiyang Zou Yaoyuan Liu Xiaohua Jiang Xiaoshi Peng Tao Xu Xiangming Liu Yulong Li Chunyang Zheng Hongbo Cai Zhanjun Liu Jian Zheng Zhebin Wang Qi Li Ping Li Rui Zhang Ying Zhang Fang Wang Deen Wang Feng Wang Shenye Liu Jiamin Yang Shaoen Jiang Baohan Zhang Yongkun Ding | 2019 | Matter and Radiation at Extremes2019，4，5： | 0 |
| 9 | An Algorithm for Hybrid Nodes Barrier Coverage Based on Voronoi in Wireless Sensor Networks显示文摘In order to make up for the deficiencies and insufficiencies that In order to make up for the deficiencies and insufficiencies that wireless sensor network is constituted absolutely by static or dynamic sensor nodes. So a deployment mechanism for hybrid nodes barrier coverage (HNBC)is proposed in wireless sensor network, which collaboratively consists of static and dynamic sensor nodes. We introduced the Voronoi diagram to divide the whole deployment area. According to the principle of least square method, and the static nodes are used to construct the reference barrier line (RBL). And we implemented effectively barrier coverage by monitoring whether there is a coverage hole in the deployment area, and then to determine whether dynamic nodes need limited mobility to redeploy the monitoring area. The simulation results show that the proposed algorithm improved the coverage quality, and completed the barrier coverage with less node moving distance and lower energy consumption, and achieved the expected coverage requirements | Xiaochao Dang Rucang Ma Zhanjun Hao Meixiu Ma | 2017 | 国际计算机前沿大会会议论文集2017，，2： | 0 |
| 10 | A Modified Principal Component Analysis Method for Honeycomb Sandwich Panel Debonding Recognition Based on Distributed Optical Fiber Sensing Signals显示文摘The safety and integrity requirements of aerospace composite structures necessitate real-time health monitoring throughout their service life.To this end,distributed optical fiber sensors utilizing back Rayleigh scattering have been extensively deployed in structural health monitoring due to their advantages,such as lightweight and ease of embedding.However,identifying the precise location of damage from the optical fiber signals remains a critical challenge.In this paper,a novel approach which namely Modified Sliding Window Principal Component Analysis(MSWPCA)was proposed to facilitate automatic damage identification and localization via distributed optical fiber sensors.The proposed method is able to extract signal characteristics interfered by measurement noise to improve the accuracy of damage detection.Specifically,we applied the MSWPCA method to monitor and analyze the debonding propagation process in honeycomb sandwich panel structures.Our findings demonstrate that the training model exhibits high precision in detecting the location and size of honeycomb debonding,thereby facilitating reliable and efficient online assessment of the structural health state. | Shuai Chen Yinwei Ma Zhongshu Wang Zongmei Xu Song Zhang Jianle Li Hao Xu Zhanjun Wu | 2024 | Structural Durability & Health Monitoring2024，18，2： | 0 |
| 11 | Shape Sensing of Thin Shell Structure Based on Inverse Finite Element Method显示文摘Shape sensing as a crucial component of structural health monitoring plays a vital role in real-time actuation and control of smart structures,and monitoring of structural integrity.As a model-based method,the inverse finite element method(iFEM)has been proved to be a valuable shape sensing tool that is suitable for complex structures.In this paper,we propose a novel approach for the shape sensing of thin shell structures with iFEM.Considering the structural form and stress characteristics of thin-walled structure,the error function consists of membrane and bending section strains only which is consistent with the Kirchhoff–Love shell theory.For numerical implementation,a new four-node quadrilateral inverse-shell element,iDKQ4,is developed by utilizing the kinematics of the classical shell theory.This new element includes hierarchical drilling rotation degrees-of-freedom(DOF)which enhance applicability to complex structures.Firstly,the reconstruction performance is examined numerically using a cantilever plate model.Following the validation cases,the applicability of the iDKQ4 element to more complex structures is demonstrated by the analysis of a thin wallpanel.Finally,the deformation of a typical aerospace thin-wall structure(the composite tank)is reconstructed with sparse strain data with the help of iDKQ4 element. | Zhanjun Wu Tengteng Li Jiachen Zhang Yifan Wu Jianle Li Lei Yang Hao Xu | 2022 | Structural Durability & Health Monitoring2022，16，1： | 0 |
| 12 | The effects of incident light wavelength difference on the collective stimulated Brillouin scattering in plasmas显示文摘The first laser–plasma interaction experiment using lasers of eight beams grouped into one octad has been conducted on the Shenguang Octopus facility.Although each beam intensity is below its individual threshold for stimulated Brillouin backscattering(SBS),collective behaviors are excited to enhance the octad SBS.In particular,when two-color/cone lasers with wavelength separation 0.3 nm are used,the backward SBS reflectivities show novel behavior in which beams of longer wavelength achieve higher SBS gain.This property of SBS can be attributed to the rotation of the wave vectors of common ion acoustic waves due to the competition of detunings between geometrical angle and wavelength separation.This mechanism is confirmed using massively parallel supercomputer simulations with the three-dimensional laser–plasma interaction code LAP3D. | Qiang Wang Zhichao Li Zhanjun Liu Tao Gong Wenshuai Zhang Tao Xu Bin Li Ping Li Xin Li Chunyang Zheng Lihua Cao Xincheng Liu Kaiqiang Pan Hang Zhao Yonggang Liu Bo Deng Lifei Hou Yingjie Li Xiangming Liu Yulong Li Xiaoshi Peng Zanyang Guan Qiangqiang Wang Xingsen Che Sanwei Li Qiang Yin Wei Zhang Liqiong Xia Peng Wang Xiaohua Jiang Liang Guo Qi Li Minqing He Liang Hao Hongbo Cai Wudi Zheng Shiyang Zou Dong Yang Feng Wang Jiamin Yang Baohan Zhang Yongkun Ding Xiantu He | 2023 | Matter and Radiation at Extremes2023，8，5： | 0 |
| 13 | Inverse Load Identification in Stiffened Plate Structure Based on in situ Strain Measurement显示文摘For practical engineering structures,it is usually difficult to measure external load distribution in a direct manner,which makes inverse load identification important.Specifically,load identification is a typical inverse problem,for which the models(e.g.,response matrix)are often ill-posed,resulting in degraded accuracy and impaired noise immunity of load identification.This study aims at identifying external loads in a stiffened plate structure,through comparing the effectiveness of different methods for parameter selection in regulation problems,including the Generalized Cross Validation(GCV)method,the Ordinary Cross Validation method and the truncated singular value decomposition method.With demonstrated high accuracy,the GCV method is used to identify concentrated loads in three different directions(e.g.,vertical,lateral and longitudinal)exerted on a stiffened plate.The results show that the GCV method is able to effectively identify multi-source static loads,with relative errors less than 5%.Moreover,under the situation of swept frequency excitation,when the excitation frequency is near the natural frequency of the structure,the GCV method can achieve much higher accuracy compared with direct inversion.At other excitation frequencies,the average recognition error of the GCV method load identification less than 10%. | Yihua Wang Zhenhuan Zhou Hao Xu Shuai Li Zhanjun Wu | 2021 | Structural Durability & Health Monitoring2021，15，2： | 0 |
| 14 | Efficient multinucleotide deletions using deaminase-Cas9 fusions in human cells显示文摘CRISPR/Cas9 system is a robust genome editing platform in biotechnology and medicine.However,it generally produces small insertions/deletions(indels,typically 1-3 bp)but rarely induces larger deletions in specific target sites.Here,we report a cytidine deaminase-Cas9 fusion-induced deletion system(C-DEL)and an adenine deaminase-Cas9 fusion-induced deletion system(A-DEL)by combining Cas9 with rat APOBEC1(r A1)and Tad A 8e,respectively.Both C-DEL and A-DEL improve the efficiency of deletions compared with the conventional Cas9 system in human cells.In addition,the C-DEL system generates a considerable fraction of predictable multinucleotide deletions from 5’-deaminated C bases to the Cas9-cleavage site and increases the proportion of larger deletions at the target loci.Taken together,the CDEL and A-DEL systems provide a practical strategy for producing efficient multinucleotide deletions,expanding the CRISPR/Cas9 toolsets for gene modifications in human cells. | Siyu Chen Zhiquan Liu Hao Yu Liangxue Lai Zhanjun Li | 2022 | Journal of Genetics and Genomics2022，49，10： | 0 |
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