|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | The Notch signaling pathway in retinal dysplasia and retina vascular homeostasis显示文摘The retina is one of the most essential elements of vision pathway in vertebrate. The dysplasia of retina cause congenital blindness or vision disability in individuals, and the misbalance in adult retinal vascular homeostasis leads to neovascularization-associated diseases in adults, such as diabetic retinopathy or age-related macular degeneration. Many developmental signaling pathways are involved in the process of retinal development and vascular homeostasis. Among them, Notch signaling pathway has long been studied, and Notch signaling-interfered mouse models show both neural retina dysplasia and vascular abnormality. In this review, we discuss the roles of Notch signaling in the maintenance of retinal progenitor cells, specification of retinal neurons and glial cells, and the sustaining of retina vascular homeostasis, especially from the aspects of conditional knockout mouse models. The potential of Notch signal manipulation may provide a powerful cell fate- and neovascularization-controlling tool that could have important applications in treatment of retinal diseases. | Minhua Zheng Zifeng Zhang Xingcheng Zhao Yuqiang Ding Hua Han | 2010 | Journal of Genetics and Genomics2010，37，9： | 13 |
| 2 | Optimization of a synthetic medium for ethanol production by xylose-fermenting Zymomonas mobilis using response surface methodology显示文摘A synthetic medium for ethanol production by recombinant xylose-fermenting Zymomonas mobilis was optimized using Plackett-Burman(PB) design and response surface methodology(RSM).The effects of 19 medium components were investigated by PB design.Eight of these components were determined to have significant effects on ethanol production.The statistical model was constructed via central composite design(CCD) using five selected variables,including xylose,trisodium citrate,choline chloride,pyridoxine,and thiamine.The validity of the developed model was verified.The ethanol concentration in the optimized medium was 6.7% higher than in the RM medium.The optimized medium was then simplified to give the final synthetic medium(S2),in which the ethanol concentration was 20.7% higher than in the RM medium.Xylose and trisodium citrate were the key medium components influencing ethanol production,while calcium pantothenate was the only growth factor required by recombinant Z.mobilis.Ethanol production and growth response were directly proportional to the logarithm of the concentration of trisodium citrate in the range of 0.1-1.6 g/L. | DONG HuiNa ZHAO XueMing MA YuanYuan ZHANG MinHua | 2012 | Chinese Science Bulletin2012，57，28： | 3 |
| 3 | Protein phosphatase PP4 is overexpressed in human breast and lung tumors显示文摘 | Bo Wang Ailian Zhao Lingling Sun Xueyan Zhong Jianing Zhong Haibo Wang Minhua Cai Jing Li Yi Xu Ji Liao Jianli Sang Dipanj an Chowdhury Gerd P Pfeifer Yun Yen Xingzhi Xu | 2008 | Cell Research2008，18，9： | 2 |
| 4 | Suboptimal distributed Kalman filtering fusion with feedback显示文摘In order to improve the accuracy of fusion algorithm, feedback is introduced into Kalman filtering fusion. Fusion center broadcasts its latest estimated states to the local sensors, which can improve the performance of local tracking error through reducing the covariance of each local error, and only needs calculating the trace of error variance matrices without calculating the inverse of error variance matrices. Simulation results show that it can reduce the computational complexity and the covariance of error, and it is convenient for engineering applications. | Zhao Minhua Zhu Zhuanmin Shi Meng Peng Qinke Huang Yongxuan | 2005 | Journal of Systems Engineering and Electronics2005，16，4： | 1 |
| 5 | Electrochemical impedance spectroscopy study of Ni/MH batteries 显示文摘 | Cheng Shaoan Zhang Jianqing Zhao Minhua | 1999 | Journal of Alloys and Compounds1999，293，295： | 1 |
| 6 | Electrochemical impedance spectroscopy study of MH/Ni batteries显示文摘 | Zhang Jianqing Zhao Minhua | 1999 | Journal of Alloys and Compounds1999，293，： | 1 |
| 7 | 显示文摘 | Gu Xiaohong Che Guodong Zhao Minhua | 2012 | Coat Technol Res2012，9，3： | 1 |
| 8 | Structure and mechanism of a group-I cobalt energy coupling factor transporter显示文摘联合精力的因素(ECF ) transporters 是最近在微生物识别的 ATP 有约束力的盒子 transporters 的一个大家庭。为从环境的微量元素举起负责, ECF transporters 是由膜底层绑定部件 EcfS 和由不可分的膜支架部件 EcfT 和二细胞质的 ATP 绑定 / 水解作用的部件 EcfA/A 组成的一个 ECF 模块组成的模块化的 transporters。ECF transporters 被分类进组我和 II。当前,组的分子的理解 -- 我 ECF transporters 很被限制,部分由于 transporter 的缺乏复杂结构的信息。这里,我们现在的结构和这个组的基于结构的分析 -- 我钴 ECF transporter CbiMNQO,谁的组成的子单元 CbiM/CbiN, CbiQ,和 CbiO 分别地对应于 group-II ECF transporters 的 EcfS, EcfT,和 EcfA 部件。通过不同 CbiMNQO 子单元的宪法和相关 ATPase 和 transporter 活动的决心,底层绑定子单元 CbiM 被发现刺激 CbiQOs 基础 ATPase 活动。CbiMQO 建筑群的结构在它的里面打开符合构造和 CbiO 的被决定在, -methyleneadenosine 第 5-triphosphate-bou 关上的符合构造。基于结构的分析揭示了在不同部件, CbiM 的 L1 循环的底层门函数,和 ATP 绑定和产品版本在 CbiMNQO transporter 建筑群以内导致的 CbiO 的 conformational 变化之间的相互作用。这些调查结果使我们能建议 CbiMNQO transporter,运输过程在要求旋转的一个工作模型或倒下 CbiQ 和 CbiM,和在联合 conformational 的 CbiN 力量功能在 CbiQ 和 CbiM 之间变化。 | Zhihao Bao Xiaofeng Qi Sen Hong Ke Xu Fangyuan He Minhua Zhang Jiugeng Chen Daiyin Chao Wei Zhao Dianfan Li Jiawei Wang Peng Zhang | 2017 | Cell Research2017，27，5： | 1 |
| 9 | Organic frameworks confined Cu single atoms and nanoclusters for tandem electrocatalytic CO_(2) reduction to methane显示文摘The electrochemical reduction reaction of carbon dioxide(CO_(2)RR)is considered to be an effective way to realize carbon neutrality.As a type of intensively studied materials,covalent organic frameworks(COFs)with a tunable pore structure and various functional groups are promising catalysts for CO_(2)RR.Herein,COF synthesized by 2,6‐diaminoanthraquinone and 2,4,6‐triformylphloroglucinol is employed to assist the synthesis of electrocatalysts from Cu single atoms(SAs)to nanoclusters by controlling the electrodeposition.A tandem catalyst for CO_(2)‐to‐CH4 conversion is thus achieved by the Cu nanoclusters dispersed among the isolated Cu SAs in the COF network.It is proposed that CO_(2) is first reduced to CO over the atomically isolated Cu SAs,followed by diffusion onto the neighboring Cu nanoclusters for further reduction into CH4.In addition,mechanistic analysis suggests that the coordinated K^(+)ions on the COF network promote the activation of CO_(2) and the adsorption of reaction intermediates,thus realizing the suppressed hydrogen evolution reaction and selective production of CH4.This study presents a new insight of COFs for the confined synthesis of a tunable SA to nanocluster electrocatalysts,disclosing the great potential of COFs in electrocatalysis. | Qinglan Zhao Yian Wang Meng Li Shangqian Zhu Tiehuai Li Jixiang Yang Ting Lin Ernest PDelmo Yinuo Wang Juhee Jang Meng Gu Minhua Shao | 2022 | SmartMat2022，3，1： | 1 |
| 10 | Electrochemical impedance spectroscopy study of Ni/MH batteries显示文摘 | ZHANG Jian-qing ZHAO Minhua | 1999 | J Alloys and Compounds1999，，3： | 1 |
| 11 | Generation of gene-target dogs using CRISPR/Cas9 system显示文摘Dear Editor,Dogs(Canis familiaris)serve as human companions and are raised to herd livestock,aid hunters,guard homes,perform police and rescue work,and guide the blind.Dogs exhibit close similarities to humans in terms of metabolic,physiological,and anatomical characteristics,and thus are ideal genetic and clinical models to study human diseases(Tsai et al.,2007).Gene target technology is a powerful tool to create new strains of animals with favorable traits.However,thus far,gene-target dogs have not been developed due to their unique species-specific reproductive characteristics,which limits the applications of dogs especially in the field of biomedical research.Recently,clustered regularly interspaced short palindromic repeats(CRISPRs)/CRISPR-associated(Cas)9 system was applied to edit specific genes with a high efficiency(Cong et al.,2013;Mali et al.,2013).Here we attempt to explore the feasibility of producing gene knockout(KO)dogs by using this technology.Beagle dog,the most widely used breed in biomedical research,was used as our animal model.Myostatin(MSTN)was chosen as the first gene of interest. | Qingjian Zou Xiaomin Wang Yunzhong Liu Zhen Ouyang Haibin Long Shu Wei Jige Xin Bentian Zhao Sisi Lai Jun Shen Qingchun Ni Huaqiang Yang Huilin Zhong Li Li Minhua Hu Quanjun Zhang Zhidong Zhou Jiaxin He Quanmei Yan Nana Fan Yu Zhao Zhaoming Liu Lin Guo Jiao Huang Guanguan Zhang Jun Ying Liangxue Lai Xiang Gao | 2015 | Journal of Molecular Cell Biology2015，7，6： | 1 |
| 12 | High expression level of TMPRSS4 predicts adverse outcomes of colorectal cancer patients显示文摘 | Ao Huang Houmin Zhou Hongchao Zhao Yingjun Quan Bo Feng Minhua Zheng | 2013 | Medical Oncology2013，，： | 1 |
| 13 | 显示文摘 | Cheng Shaoan Zhang Jianqing Zhao Minhua | 1999 | Journal of Alloys and Compounds1999，，： | 1 |
| 14 | Two-photon absorption and frequency-upconversion properties of a new organic dye HMASPS显示文摘Two-photon absorption (TPA) and frequency-upconversion properties of a new upconversion laser dye trans-4-[p-(N-hydroxyethyl-N-methyl-amino)styryl]-N-meth-ylpyridinium toluene-p-sulfonate (abbreviated to HMASPS) were reported in this note. The linear absorption, TPA, single-photon induced fluorescence, TPA induced fluorescence and TPA induced upconverted lasing spectra of HMASPS solution in dimethyl formamide (abbreviated to DMF) were measured at room temperature. The red shift for the central wavelength of TPA induced fluorescence peak, which was compared with that of the single-photon induced fluorescence peak, and the blue shift for that of TPA induced up-converted lasing compared with that of TPA induced fluorescence, were explained by using re-absorption effect. TPA peak was at 930 nm. There is an 11 nm blue shift for two-photon energy of TPA peak compared with the linear absorption peak. The molecular TPA cross-section σ’2 at1064 nm was measured to be 6.0×10-48 cm4 .s/photon by using the open | Guangyong Zhou Yan Ren Chun Wang Dong Wang Xian Zhao Qi Fang Zongshu Shao Minhua Jiang | 2001 | Chinese Science Bulletin2001，46，14： | 1 |
| 15 | Adaptive orbital navigation algorithm using magnetometers显示文摘 | Zhao Minhua Peng Qinke | 2004 | Intelligent Control and Automation2004，6，： | 1 |
| 16 | 前额叶皮质中兴奋性神经元集合编码短期记忆显示文摘文章简介短期记忆(STM)对于动物在一小段时间内保存信息来说至关重要。已经知道,持续性或复发性的神经活动和神经振荡在细胞水平上编码STM。然而,微回路级的编码机制仍然是一个谜。在本文中,我们对行为小鼠进行了双光子成像以监测神经元微回路的活动。 | Yonglu Tian Chaojuan Yang Yaxuan Cui Feng Su Yongjie Wang Yangzhen Wang Peijiang Yuan Shujiang Shang Hao Li Jizong Zhao Desheng Zhu Shiming Tang Peng Cao Yunbo Liu Xunli Wang Liecheng Wang Wenbo Zeng Haifei Jiang Fei Zhao Minhua Luo Wei Xiong 仇子龙 李相尧 张晨 | 2019 | 科学新闻2019，0，2： | 0 |
| 17 | Covalent interfacial coupling of vanadium nitride with nitrogen-rich carbon textile boosting its lithium storage performance as binder-free anode显示文摘Eliminating the usage of metal current collectors and binders in traditional battery electrode configuration is an effective strategy to significantly improve the capacities of lithium ion batteries (LIBs). Herein, we demonstrate the construction of porous vanadium nitride (VN) nanosheet network in situ grown on nitrogen-rich (N-rich) carbon textile (N-C@P-VN) as lightweight and binder-free anode for LIBs. The N-rich carbon textile is used both as the current collector and host to store Li^(+), thus improving the specific capacities of binder-free VN anode and meanwhile reducing the inert mass of the whole cell. Moreover, the open spaces in carbon textile and vertically aligned pores in VN nanosheet network can not only provide an expressway for Li+ and e− transport, but also afford more active sites. As a result, the binder-free N-C@P-VN anode maintains a specific capacity of 1,040 mAh·g^(−1) (or an areal capacity of 2.6 mAh·cm^(−2)) after 100 cycles at 0.1 mA·cm^(−2) in half cell. Moreover, in an assembled N-C@P-VN//LiFePO4 full cell, it exhibits an areal capacity of 1.7 mAh·cm^(−2) after 300 cycles at 0.1 C. The synergistic strategy of N-C substrate and porous VN network could be applied to guide rational design of similar N-C@nitride or sulfide hybrid systems with corresponding sulfur-doped carbon textile as the substrate. | Di Zhao Jinwen Qin Lirong Zheng Donglei Guo Jie Wang Minhua Cao | 2021 | Nano Research2021，14，11： | 0 |
| 18 | Change Features of GPS/MET Precipitable Water Vapor in Different Precipitation in Lianyungang显示文摘Based on the GPS/MET water vapor monitoring data and conventional meteorological data at Lianyungang station from April to July,2015,the relationship between precipitable water vapor and real precipitation was studied. According to different precipitation,change trends of precipitable water vapor in convective precipitation and steady precipitation were analyzed. Results showed that necessary condition of precipitation generation was high precipitable water vapor value in the air. Precipitable water vapor change presented wave-shape and phased characters. In convection precipitation,precipitable water vapor changed frequently and had larger change amplitude,while its change was slow in steady precipitation. The appearing time of the maximum values of rainfall intensity and precipitable water vapor was not necessarily consistent,but it was known that severe rainfall usually began at the high-value stage of precipitable water vapor,and high-value stage of precipitable water vapor often corresponded to higher precipitation probability. In addition,precipitable water vapor showed different characteristics in the above two different precipitation,and these results could provide a reference for precipitation forecast. | Hao Ling Zhao Liang Zhu Minhua Bai Xue Ma Chenchen | 2015 | Meteorological and Environmental Research2015，6，7： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员