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| 1 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 2 | Changes of Hemoglobin and Hematocrit in Elderly Patients Receiving Lower Joint Arthroplasty without AIIogeneic Blood Transfusion显示文摘 | Qi Zhou Yiqin Zhou Haishan Wu Yuli Wu Qirong Qian Hui Zhao Yunli Zhu Peiliang Fu | 2015 | Chinese Medical Journal2015，，1： | 14 |
| 3 | FGF1^(△HBS) prevents diabetic cardiomyopathy by maintaining mitochondrial homeostasis and reducing oxidative stress via AMPK/Nur77 suppression显示文摘As a classically known mitogen,fibroblast growth factor 1(FGF1)has been found to exert other pleiotropic functions such as metabolic regulation and myocardial protection.Here,we show that serum levels of FGF1 were decreased and positively correlated with fraction shortening in diabetic cardiomyopathy(DCM)patients,indicating that FGF1 is a potential therapeutic target for DCM.We found that treatment with a FGF1 variant(FGF1^(△HBS))with reduced proliferative potency prevented diabetes-induced cardiac injury and remodeling and restored cardiac function.RNA-Seq results obtained from the cardiac tissues of db/db mice showed significant increase in the expression levels of anti-oxidative genes and decrease of Nur77 by FGF1AHBS treatment.Both in vivo and in vitro studies indicate that FGF1^(△HBS) exerted these beneficial effects by markedly reducing mitochondrial fragmentation,reactive oxygen species(ROS)generation and cytochrome c leakage and enhancing mitochondrial respiration rate and β-oxidation in a 5;AMP-activated protein kinase(AMPK)/Nur77-dependent manner,all of which were not observed in the AMPK null mice.The favorable metabolic activity and reduced proliferative properties of FGF1^(△HBS) testify to its promising potential for use in the treatment of DCM and other metabolic disorders. | Dezhong Wang Yuan Yin Shuyi Wang Tianyang Zhao Fanghua Gong Yushuo Zhao Beibei Wang Yuli Huang Zizhao Cheng Guanghui Zhu Zengshou Wang Yang Wang Jun Ren Guang Liang Xiaokun Li Zhifeng Huang | 2021 | Signal Transduction and Targeted Therapy2021，6，4： | 6 |
| 4 | Effect and safety of acupotomy in treatment of knee osteoarthritis:a systematic review and Meta-analysis显示文摘OBJECTIVE: To evaluate the clinical efficacy and safety of acupotomy in treatment of knee osteoarthritis(OA).METHODS: Extensive literature searches were carried out in PubMed, EMBASE, Cochrane Library(Issue 5, 2017), Chinese Biomedical Literature Database, China National Knowledge Infrastructure Database, China Science and Technology Journal Database and Wanfang Database. All databases were retrieved from their inception until May 31, 2017.Randomized controlled trials incorporating acupotomy versus intra-articular sodium hyaluronate for knee osteoarthritis were included. According to Cochrane Reviews’ Handbook(5.2), two reviewers screened each article and extracted data independently and were blinded to the findings of each reviewer. Meta-analysis was performed by the Cochrane Collaboration’s RevMan 5.3 software.RESULTS: We identified 12 studies involving 1150 patients aged between 40 and 78 years old. The pooled analysis indicated that acupotomy showed a significant improvement for short-term effect[cure rate: odds ratio(OR) = 2.04, 95% confidence interval(CI)(1.46, 2.85), P < 0.01;total effective rate:OR = 2.25, 95% CI(1.55, 3.28), P < 0.01;pain score:standard mean difference(SMD) =-1.02;95% CI(-1.72,-0.31);P = 0.005;Western Ontario and McMaster Universities Questionnaire(WOMAC) score:SMD =-0.74;95% CI(-1.11,-0.37);P < 0.01];and also for long-term effect [total effective rate:OR = 2.99, 95%CI(1.88, 4.76), Z = 4.64, P < 0.01;pain score: SMD =-1.68;95% CI(-2.14,-1.22);P <0.001;WOMAC score: SMD =-0.91;95% CI(-1.40,-0.41);P < 0.001]. In addition, there was no obvious difference between acupotomy group and control group in adverse events [OR = 2.13, 95% CI(0.14, 32.28), P = 0.58].CONCLUSION: Acupotomy is a safe and effective treatment for KOA. However, due to the methodological deficiency of the included studies, well-designed randomized controlled trials are required to further confirm the findings. | Fang Ting Li Qi Zhou Fanyuan Liu Fushui Liu Zhongyong Zhao Meimei Chen Mei You Jianyu Jin Yuli Xie Jinmei | 2020 | Journal of Traditional Chinese Medicine2020，40，3： | 6 |
| 5 | NOMA-Based UAV-Aided Networks for Emergency Communications显示文摘High spectrum efficiency(SE)requirement and massive connections are the main challenges for the fifth generation(5G)and beyond 5G(B5G)wireless networks,especially for the case when Internet of Things(IoT)devices are located in a disaster area.Non-orthogonal multiple access(NOMA)-based unmanned aerial vehicle(UAV)-aided network is emerging as a promising technique to overcome the above challenges.In this paper,an emergency communications framework of NOMA-based UAV-aided networks is established,where the disasters scenarios can be divided into three broad categories that have named emergency areas,wide areas and dense areas.First,a UAV-enabled uplink NOMA system is established to gather information from IoT devices in emergency areas.Then,a joint UAV deployment and resource allocation scheme for a multi-UAV enabled NOMA system is developed to extend the UAV coverage for IoT devices in wide areas.Furthermore,a UAV equipped with an antenna array has been considered to provide wireless service for multiple devices that are densely distributed in disaster areas.Simulation results are provided to validate the effectiveness of the above three schemes.Finally,potential research directions and challenges are also highlighted and discussed. | Wanmei Feng Jie Tang Nan Zhao Yuli Fu Xiuyin Zhang Kanapathippillai Cumanan Kai-Kit Wong | 2020 | China Communications2020，17，11： | 5 |
| 6 | Application of immune checkpoint targets in the anti-tumor novel drugs and traditional Chinese medicine development显示文摘Immune checkpoints are the crucial regulators of immune system and play essential roles in maintaining self-tolerance,preventing autoimmune responses,and minimizing tissue damage by regulating the duration and intensity of the immune response.Furthermore,immune checkpoints are usually overexpressed in cancer cells or noninvasive cells in tumor tissues and are capable of suppressing the antitumor response.Based on substantial physiological analyses as well as preclinical and clinical studies,checkpoint molecules have been evaluated as potential therapeutic targets for the treatment of multiple types of cancers.In the last few years,extensive evidence has supported the immunoregulatory effects of traditional Chinese medicines(TCMs).The main advantage of TCMs and natural medicine is that they usually contain multiple active components,which can act on multiple targets at the same time,resulting in additive or synergistic effects.The strong immune regulation function of traditional Chinese medicine on immune checkpoints has also been of great interest.For example,Astragalus membranaceus polysaccharides can induce anti-PD-1 antibody responses in animals,and these antibodies can overcome the exhaustion of immune cells under tumor immune evasion.Furthermore,many other TCM molecules could also be novel and effective drug candidates for the treatment of cancers.Therefore,it is essential to assess the application of immune checkpoints in the development of new drugs and TCMs.In this review,we focus on research progress in the field of immune checkpoints based on three topics:(1)immune checkpoint targets and pathways,(2)development of novel immune checkpoint-based drugs,and(3)application of immune checkpoints in the development of TCMs. | Yuli Wang Xingyan Zhang Yuyan Wang Wenjing Zhao Huling Li Lixing Zhang Xinping Li Tiejun Zhang Hongbing Zhang He Huang Changxiao Liu | 2021 | Acta Pharmaceutica Sinica B2021，11，10： | 3 |
| 7 | Neoadjuvant chemotherapy with FOLFOX: Improved outcomes in Chinese patients with locally advanced gastric cancer显示文摘 | Zi‐YuLi Cherry E.Koh Zhao‐DeBu Ai‐WenWu Lian‐HaiZhang Xiao‐JiangWu QiWu Xiang‐LongZong HuiRen LeiTang Xiao‐PengZhang Ji‐YouLi YingHu LinShen Jia‐FuJi | 2012 | J Surg Oncol2012，，8： | 2 |
| 8 | 3-Oxodapagliflozin as a Potent and Highly Selective SGLT2 Inhibitor for the Treatment of Type 2 Diabetes显示文摘 | ZHANG Shuo WANG Yuli LIU Wei XIE Yafei LIU Yuqiang XU Weiren TANG Lida WANG Jianwua ZHAO Guilong | 2014 | Chemical Research in Chinese Universities2014，30，5： | 2 |
| 9 | gem-Dimethyl-bearing C-Glucosides as Sodium-glucose Co-transporter 2 (SGLT2) Inhibitors显示文摘三新奇 gem-dimethyl C 配糖物作为钠葡萄糖 co 搬运被设计 2 (SGLT2 ) 禁止者,和他们的综合体从 D 葡萄糖开始了,三 2-substituted-5-bromobenzoic 酸经由一个灵巧的 8 步协议被完成,与是无水的关键步铝第三级的白酒和苯乙醚的催化氯化物的 Friedel 手艺完化。这三个 SGLT2 禁止者在 vivo 被评估与一鼠标口头的葡萄糖忍耐测试(OGTT ) ,和所有这三混合物的 anti-hyperglycemic 活动与积极控制 Dapagliflozin 的是可比较的。 | Shi, Yongheng Zhao, Guilong Lou, Yuanyuan Wang, Yuli Shao, Hua Liu, Wei Xu, Weiren Tang, Lida | 2011 | Chinese Journal of Chemistry2011，29，6： | 2 |
| 10 | Photosensitive damage of lysozyme caused by pazufloxacin and the protective effect of ferulic acid显示文摘Laser flash photolysis and sodium dodecyl sulfate-polyacrylamide gel electrophoresis(SDS-PAGE) experiments were carried out to study the photosensitive damage induced by pazufloxacin(PAX) and the protection of lysozyme(Lyso) by ferulic acid(FCA), an active antioxidant. Transient absorption spectra revealed electron transfer from Lyso and FCA to 3PAX*, with respective bimolecular reaction rate constants of 6.3×107 and 1.4×1010 dm3/(mol s). A pulse radiolysis study was also performed to investigate the formation of Lyso radical cations. Results showed that FCA effectively inhibited the cross-linking of protein induced by fluoroquinolones. Finally, a mechanism of the protective effect of FCA on Lyso was proposed. | Yulie Xu Yancheng Liu Haixia Li Peng Zhang Jianfeng Zhao Wenfeng Wang | 2015 | Science China Chemistry2015，58，3： | 2 |
| 11 | A new topology discovery protocol for multi-ring interconnected resilient packet ring 显示文摘 | ZHOU Yuli ZENG Qingji ZHAO Zhengfu | 2003 | Proceeding of SPIE2003，5282，： | 1 |
| 12 | Modeling persis- tent organic pollutant partitioning between tree bark and air and its application to spatial monitoring of atmospheric POPs in mainland China显示文摘 | Zhao Yuli Yang Limin Wang Qiuquan | 2008 | Environ Sci Technol2008，42，： | 1 |
| 13 | Study of Semileptonic Decays Bs- → Ds2 (2 536 ) lv^- and Bs- → Dsz ( 2 536 ) lv^- in the CQM Model 显示文摘 | ZHAO Shumin ZHANG Yinjie YAN Yuli | 2008 | Chin Phys C2008，32，8： | 1 |
| 14 | Effect of clearance on wrin kling of thin-walled rectangular tube in rota(y draw bending process 显示文摘 | Zhao Gangyao Liu Yuli Yang He | 2010 | The International Journal of Advanced Manufacturing Tech nology2010，50，4： | 1 |
| 15 | Combus- tion Synthesis of Mg-Based Hydrogen Storage Alloy Mg17AI12显示文摘 | Yuli Zhou Zelun Zhao Lingjun Wei | 2013 | Advanced Powder Technology2013，24，3： | 1 |
| 16 | Molecular identification and expression analysis of foxl2 and sox9b in Oryzias celebensis显示文摘Oryzias celebensis is determined by an XX-XY system,however,its sex-related genes have not been confirmed.The genes foxl2 and sox9b are important for gonadal development in vertebrates.In the present study,the foxl2 and sox9b cDNAs were cloned and their expression patterns were analyzed.The cDNA sequence of foxl2 and sox9b were obtained by rapid amplification of cDNA ends(RACEs).Reverse transcription polymerase chain reaction(RT-PCR)showed that O.celebensis foxl2(Ocfoxl2)transcript was predominately expressed in the ovary while O.celebensis sox9b(Ocsox9b)transcript was mainly expressed in the testis.In embryos,Ocfoxl2 transcript was first detected in gastrula.In contrast,Ocsox9b transcript was of maternal origin as expression was detected at the two cell stage.By chromogenic and fluorescent in situ hybridization(ISH),Ocfoxl2 mRNA in the ovary was highly expressed in early oocytes and weakly expressed in the granulosa cells and thecal cells in the later oocytes.In contrast,Ocsox9b mRNA was mainly found in Sertoli cells surrounding spermatogonia and in spermatids and sperm in the testis.In summary,Ocfoxl2 identified somatic cells and differentiating oocytes in the ovary,indicating it is involved in ovarian development.Ocsox9b is identified in Sertoli cells and late developing male germ cells indicating it is involved in testicular development. | Yuli Zhao Yu Zhang Ying Zhong Jing Guo Mengyue Lu Lang Gui Mingyou Li | 2021 | Aquaculture and Fisheries2021，6，5： | 1 |
| 17 | Protective effect of Sheng-Nao-Kang decoction on focal cerebral ischemia-reperfusion injury in rats显示文摘 | Lin Chen Ye Zhao Tianlong Zhang Xuan Dang Renming Xie Zhenzhi Li Yang Li Yuli Li Wenna Zhao Hongru Song | 2014 | Journal of Ethnopharmacology2014，，： | 1 |
| 18 | Deep learning quantified mucus-tumor ratio predicting survival of patients with colorectal cancer using whole-slide images显示文摘Background:In colorectal cancer(CRC),mucinous adenocarcinoma differs from other adenocarcinomas in gene-phenotype,morphology,and prognosis.However,mucinous components are present in a large number of adenocarcinomas,and the prognostic value of mucus proportion has not been investigated.Artificial intelligence provides a way to quantify mucus proportion on whole-slide images(WSIs)accurately.We aimed to quantify mucus proportion by deep learning and further investigate its prognostic value in two CRC patient cohorts.Methods:Deep learning was used to segment WSIs stained with hematoxylin and eosin.Mucus-tumor ratio(MTR)was defined as the proportion of mucinous component in the tumor area.A training cohort(N=419)and a validation cohort(N=315)were used to evaluate the prognostic value of MTR.Survival analysis was performed using the Cox proportional hazard model.Result:Patients were stratified tomucus-low andmucus-high groups,with 24.1%as the threshold.In the training cohort,patients with mucus-high had unfavorable outcomes(hazard ratio for high vs.low 1.88,95%confidence interval 1.18–2.99,P=0.008),with 5-year overall survival rates of 54.8%and 73.7%in mucus-high and mucus-lowgroups,respectively.The resultswere confirmed in the validation cohort(2.09,1.21–3.60,0.008;62.8%vs.79.8%).The prognostic value of MTR was maintained in multivariate analysis for both cohorts.Conclusion:The deep learning quantified MTR was an independent prognostic factor in CRC.With the advantages of advanced efficiency and high consistency,our method is suitable for clinical application and promotes precision medicine development. | Ke Zhao Lin Wu Yanqi Huang Su Yao Zeyan Xu Huan Lin Huihui Wang Yanting Liang Yao Xu Xin Chen Minning Zhao Jiaming Peng Yuli Huang Changhong Liang Zhenhui Li Yong Li Zaiyi Liu | 2021 | Precision Clinical Medicine2021，4，1： | 0 |
| 19 | Characterization and expression analysis of gonad specific igf3 in the medaka ovary显示文摘The gonad specific expression of insulin-like growth factor 3(igf3)has suggested an important role of igf3 in fish reproduction.In this study,medaka igf3 was isolated and its expression patterns were compared with igf1,and germ cell gene vasa in adult medaka ovary.Molecular cloning and sequencing showed that the open reading frame(ORF)of medaka igf3 was comprised of 501 nucleotides and encoded 166 amino acid residues.Reverse transcription polymerase chain reaction(RT-PCR)analysis showed that igf3 RNA was specifically expressed in developing embryos and adult gonads of both sexes.Real time quantitative PCR(q-PCR)indicated that igf3 expression was gradually increased during oogenesis,and reached its highest level at stage V.Using Chromogenic and fluorescent in situ hybridization,igf3 was shown to be present in the germ cells of oogonia and in oocytes at stages I-III,as well as abundant in granulosa cells and theca cells of oocytes at stages IV-V.In addition,igf3 and igf1 were expressed mutually in the outer theca cells of stage V oocytes in ovary.Collectively,we demonstrated that gonad specific igf3 could mark medaka ovarian somatic cells and germ cells.These findings highlight the importance of igf3 during ovarian development. | Jiale Xie Ying Zhong Yuli Zhao Wenjie Xie Jing Guo Lang Gui Mingyou Li | 2022 | Aquaculture and Fisheries2022，7，3： | 0 |
| 20 | Preliminary Study on Biological Control of Mycotoxin Contamination in Agricultural Products and Its Mechanism显示文摘Aflatoxin is the most powerful carcinogen and highly toxic mycotoxin known in nature. It can cause serious toxin pollution to agricultural products, foods and fodders, and is extremely harmful to human and animal health. For aflatoxin pollution, the emphasis is on the control of source, and biological control is favored by scientists because of its advantages of environmental protection and ecological safety. According to the morphology, color and appearance of microbial colonies isolated from maize kernels, 300 bacterial strains were obtained from main maize-producing areas including Tangshan City, Handan City, Shijiazhuang City and Cangzhou City. Two biocontrol bacterial strains(B120 and B65) having a strong control effect on aflatoxins were screened. After identification by molecular biology and physical and chemical properties, the two biocontrol bacterial strains were identified as Bacillus amyloliquefaciens. Their effects on spore germination, mycelial growth and toxin degradation of Aspergillus flavus were investigated. The results showed that strains B120 and B65 could significantly inhibit the spore germination and mycelial growth of A. flavus and reduce aflatoxin production. This study provides a new way to prevent and control the pollution control of aflatoxins in agricultural products. | Shoumin JIA Suyan GAO Sining TANG Litian ZHANG Haitao ZHAO Yuli WANG Aili XIANG Zhaoju WU Lixue DONG | 2019 | Agricultural Biotechnology2019，8，2： | 0 |
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