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| 1 | The altered PD-1/PD-L1 pathway delivers the ‘one-two punch’ effects to promote the Treg/Th17 imbalance in pre-eclampsia显示文摘The programmed cell death-1(PD-1)/PD-ligand 1(PD-L1)pathway is critical for normal pregnancy by promoting regulatory T(Treg)cell development and inhibiting the Th17 response.However,the relationship between the PD-1/PD-L1 pathway and the Treg/Th17 imbalance in pre-eclampsia(PE)is an enigma.In this study,decreased PD-1 and PD-L1 expression and a Treg/Th17 imbalance were observed at the maternal-fetal interface in PE.The regulatory effects of the PD-1/PD-L1 pathway on the Treg and Th17 cell quantities were determined in vitro by targeting T-cell proliferation,differentiation and transdifferentiation.First,decreased PD-1 expression might contribute to a higher Th17 cell frequency by promoting proliferation in PE.Second,the percentages of Treg but not Th17 cells differentiated from peripheral naive CD4+T cells were increased by PD-L1 Fc administration.This effect was accompanied by decreased PI3K/AKT/m-TOR and increased PTEN mRNA expression and was completely reversed by PD-1 blockade.Finally,the percentage of IL-17-producing Treg cells increased and was positively associated with the Th17 cell frequency in PE.Increased RORγt and IL-17 but not Foxp3 and IL-10 mRNA expression by Treg cells was observed with PD-1 blockade.Similar findings occurred when Treg cells were exposed to IL-6/IL-23/IL-1βand were reversed by PD-L1 Fc.Taken together,our findings indicate that the PD-1/PD-L1 pathway contributes to the Treg/Th17 imbalance via‘one-two punch’approaches:(i)promoting Th17 cell proliferation,(ii)inhibiting Treg cell differentiation and(iii)enhancing Treg cell plasticity into Th17 cells in PE.The therapeutic value of PD-L1 Fc for PE treatment will be explored in the future. | Yonghong Zhang Zhaozhao Liu Mei Tian Xiaohui Hu Liling Wang Jinlu Ji Aihua Liao | 2018 | Cellular & Molecular Immunology2018，15，7： | 21 |
| 2 | Mathematical prototypes for collocating geostationary satellites显示文摘Collocating geostationary satellites sharing the same position is much demanded for satellite operation recently,the separation strategies are adopted to safeguard the satellites collocated of leaving the relative distance beyond collision with different sets of orbit parameters.This paper presents the mathematical prototypes which establish the allowable relative distance with uncertainty of orbital determination(OD),as well as the orbital element offset for each pair of collocated satellites,and puts forward algorithms to build such relationship to face the challenge of putting three satellites sharing the same position,the algorithms to allocate the longitude,eccentricity and inclination for each satellite are also given to ascertain that the mathematical prototypes are the guide specification to design collocation strategy for geostationary satellites. | LI HengNian GAO ZhaoZhao LI JiSheng LI QuanJun XUE Dan LI DongLin | 2013 | Science China(Technological Sciences)2013，56，5： | 6 |
| 3 | Injectable silk/hydroxyapatite nanocomposite hydrogels with vascularization capacity for bone regeneration显示文摘Localized and sustained osteogenic-angiogenic stimulation to bone defects is critical for effective bone repair.Here,desferrioxamine(DFO)was loaded on silk fibroin nanofibers and blended with hydroxyapatite nanorods(HA),forming injectable DFO-loaded silk fibroin-HA nanocomposite hydrogels.The composite hydrogels remained homogeneous distribution of HA with high ratio(60%)and also higher stiffness than that of pure silk fibroin nanofiber hydrogels,which provided stable osteogenic stimulation niches for tissue regeneration.Without the scarify of injectability,the hydrogels achieved slow delivery of DFO for above 60 days,resulting in suitable angiogenesis in vitro and in vivo and better osteogenesis than DFO-free systems.Compared to previous injectable silk fibroin-HA hydrogels,the introduction of vascularization capacity further stimulated the osteogenic differentiation of stem cells and accelerated new bone formation.Quicker and better bone healing were detected at defect sites after the injection of DFO-loaded nanocomposite hydrogels,indicating the effective synergistic effect of osteogenic and angiogenic cues.This work provides a simple and effective strategy of introducing angiogenic cues to bone matrices.We believe that the injectable nanocomposite hydrogels are suitable for the regeneration of bone tissues. | Keke Wang Weinan Cheng Zhaozhao Ding Gang Xu Xin Zheng Meirong Li Guozhong Lu Qiang Lu | 2021 | Journal of Materials Science & Technology2021，，4： | 2 |
| 4 | Performance evaluation of deep learning-based post-processing and diagnostic reporting system for coronary CT angiography: a clinical comparative study显示文摘To the Editor:Coronary computed tomography angiography(CCTA)has been increasingly,widely performed for diagnosing coronary artery,disease,lAnatomical diagnosis,that is,stenosis grading,is stillthe main diagnostic index provided'by most CCTA tests.Post-processing and interpretation of stenosis are 2 essential'steps that need to be performed bycardiovascular imaging professionals from scan completion to diagnosis conclusion,which is repetitive and time-consuming,taking an average of 30 minutes each case in China and becoming the bottleneck and gradually creating an imbalance between supply and demand.In ine with the rapid development of artificial intelligence(Al)technology in recent years,it has been expected to solve these specific problems.We developed an AI system for automating post-processing and diagnostic reporting of CCTA data using deep learning algorithms to establishanew1-clickworkflowforeverydayuse,namely,CCTA-AI(Figure 1).To further assess its capabilities,this study intends to answer 2 following questions:To what extent can it improve the efficiency of post-processing?To what extent can CCTA-AI detect and calculate coronary artery stenosis due to each atherosclerotic plaque? | Nan Luo Yi He Jitao Fan Ning Guo Guang Yang Yuanyuan Kong Jianyong Wei Tao Bi Jie Zhou Jiaxin Cao Xianjun Han Fang Li Shiyu Zhang Rujing Sun Zhaozhao Wang Tian Ma Lixue Xu Hui Chen Hongwei Li Zhenchang Wang Zhenghan Yang | 2022 | Chinese Medical Journal2022，135，19： | 2 |
| 5 | Application of fluorescence in situ hybridization in the detection of bladder transitional-cell carcinoma: A multi-center clinical study based on Chinese population显示文摘Objective:To evaluate the diagnostic value of fluorescence in situ hybridization(FISH)in bladder cancer.Methods:We enrolled healthy volunteers and patients who were clinically suspected to have bladder cancer and conducted FISH tests and cytology examinations from August 2007 to December 2008.Receiver operating characteristic(ROC)curve analysis was performed and the area under curve(AUC)values were calculated for both the FISH and urine cytology tests.Results:A cohort of 988 healthy volunteers was enrolled to establish a reference range for the normal population.A total of 4807 patients with hematuria were prospectively,randomly enrolled for the simultaneous analysis of urine cytology,FISH testing,and a final diagnosis as determined by the pathologic findings of a biopsy or a surgically-excised specimen.Overall,the sensitivity of FISH in detecting transitional-cell carcinoma was 82.7%,while that of cytology was 33.4%(p<0.001).The sensitivity values of FISH for non-muscle invasive and muscle invasive bladder transitional-cell carcinoma were 81.7%and 89.6%,respectively(p=0.004).The sensitivity values of FISH for low and high grade bladder cancer were 82.6%and 90.1%,respectively(p=0.002).Conclusion:FISH is significantly more sensitive than voided urine cytology for detecting bladder cancer in patients evaluated for gross hematuria at all cancer grades and stages.Higher sensitivity using FISH was obtained in high grade and muscle invasive tumors. | Liqun Zhou Kaiwei Yang Xuesong Li Yi Ding Dawei Mu Hanzhong Li Yong Yan Jinyi Li Dongwen Wang Wei Li Yulong Cong Jiangping Gao Kewei Ma Yajun Xiao Sheng Zhang Hongyi Jiang Weilie Hu Qiang Wei Xunbo Jin Zhichen Guan Qingyong Liu Danfeng Xu Xin Gao Yongguang Jiang Weimin Gan Guang Sun Qing Wang Yanhui Liu Jianquan Hou Liping Xie Xishuang Song Fengshuo Jin Jiafu Feng Ming Cai Zhaozhao Liang Jie Zhang Dingwei Ye Lin Qi Lulin Ma Jianzhong Shou Yuping Dai Jianyong Shao Ye Tian Shizhe Hong Tao Xu Chuize Kong Zefeng Kang Yuexin Liu Xun Qu Benkang Shi Shaobin Zheng Yi Lin Shujie Xia Dong Wei Jianbo Wu Weiling Fu Zhiping Wang Jianbo Liang | 2019 | Asian Journal of Urology2019，6，1： | 2 |
| 6 | Dynamic Elastic Modulus and Damping Ratio of Lignin-Modified Loess显示文摘To effectively improve the poor engineering properties of loess and enhance its seismic performance,the industrial by-product lignin is used as a modified material.Based on lots of dynamic triaxial tests,the dynamic elastic modulus and damping ratio of lignin-modified loess were tested.The effects of lignin content on the dynamic elastic modulus and damping ratio of lignin-modified loess were analyzed.Combined with scanning electron microscopy(SEM)and X-ray diffraction(XRD),the microscopic mechanism of lignin to improve the dynamic properties of loess was studied.The results show that lignin can effectively modify the dynamic deformation of loess under dynamic load.Under the same dynamic stress condition,the dynamic strain of lignin-modified loess is smaller than compacted loess.The dynamic elastic modulus of modified loess with different lignin content are quite different,but both decrease with the increase of dynamic strain.And the dynamic elastic modulus of modified loess is greater than compacted loess.The maximum dynamic elastic modulus of modified loess with a lignin content of 1%are significantly greater than others.Under the same dynamic strain condition,the damping ratio of lignin-modified loess is smaller than compacted loess.Lignin can effectively fill loess pores and cement loess particles.Compared with compacted loess,no new mineral components are generated in the lignin-modified loess.The optimum lignin content of dynamics characteristic of modified loess is present,and the optimum lignin content is 1%. | Qian Wang Zhaozhao Liu Xiumei Zhong Zhongnan Gao Fuqiang Liu | 2021 | Journal of Renewable Materials2021，9，3： | 1 |
| 7 | Green‑Solvent Processed Blade‑Coating Organic Solar Cells with an Efficiency Approaching 19%Enabled by Alkyl‑Tailored Acceptors显示文摘Power-conversion-efficiencies(PCEs)of organic solar cells(OSCs)in laboratory,normally processed by spin-coating technology with toxic halogenated solvents,have reached over 19%.However,there is usually a marked PCE drop when the bladecoating and/or green-solvents toward large-scale printing are used instead,which hampers the practical development of OSCs.Here,a new series of N-alkyl-tailored small molecule acceptors named YR-SeNF with a same molecular main backbone are developed by combining selenium-fused central-core and naphthalene-fused endgroup.Thanks to the N-alkyl engineering,NIR-absorbing YR-SeNF series show different crystallinity,packing patterns,and miscibility with polymeric donor.The studies exhibit that the molecular packing,crystallinity,and vertical distribution of active layer morphologies are well optimized by introducing newly designed guest acceptor associated with tailored N-alkyl chains,providing the improved charge transfer dynamics and stability for the PM6:L8-BO:YRSeNF-based OSCs.As a result,a record-high PCE approaching 19%is achieved in the blade-coating OSCs fabricated from a greensolvent o-xylene with high-boiling point.Notably,ternary OSCs offer robust operating stability under maximum-power-point tracking and well-keep>80%of the initial PCEs for even over 400 h.Our alkyl-tailored guest acceptor strategy provides a unique approach to develop green-solvent and blade-coating processed high-efficiency and operating stable OSCs,which paves a way for industrial development. | Hairui Bai Ruijie Ma Wenyan Su Top Archie Dela Pea Tengfei Li Lingxiao Tang Jie Yang Bin Hu Yilin Wang Zhaozhao Bi Yueling Su Qi Wei Qiang Wu Yuwei Duan Yuxiang Li Jiaying Wu Zicheng Ding Xunfan Liao Yinjuan Huang Chao Gao Guanghao Lu Mingjie Li Weiguo Zhu Gang Li Qunping Fan Wei Ma | 2023 | Nano-Micro Letters2023，15，12： | 1 |
| 8 | Robust ultrathin and transparent AZO/Ag-SnOx/AZO on polyimide substrate for flexible thin film heater with temperature over 400℃显示文摘We developed flexible and transparent thin film heaters(TFHs)with a structure of AZO/AgSnOx/AZO/polyimide(PI)which exhibited superior stability under operational conditions.Ultrathin and robust doped silver(Ag)films were produced by introducing a small amount of SnOx during the sputtering process.The AZO/Ag-SnOx/AZO stacks showed the best figure of merit value of 139.9,which was higher than that of ITO counterpart(25.5)with the same thickness.In addition,it exhibited excellent durability,which showed unaffected optical and electrical properties under the heat treatment of 500℃for 30 min in air,highly-accelerated tempe ratu re and humidity stress test(HAST)at 121℃and 97%RH for 36 h,10,000 times of scratching and 1500 times of inner and outer bending test.Furthermore,the TFHs based on AZO/Ag-SnOx/AZO/PI achieved a high temperature of 438.8℃with response time in several seconds,which outperformed most previous studies.The robust high-temperature TFHs in this research hold promising commercial applications in flexible and high temperature occasions. | Zhaozhao Wang Jia Li Junjun Xu Jinhua Huang Ye Yang Ruiqin Tan Guofei Chen Xingzhong Fang Yue Zhao Weijie Song | 2020 | Journal of Materials Science & Technology2020，47，13： | 1 |
| 9 | The AIM2 inflammasome is essential for host-defense against cytosolic bacteria and DNA viruses 显示文摘 | VijayAK Rathinam Zhaozhao Jiang | 2010 | Nat Immunol2010，11，5： | 1 |
| 10 | The Role of miRNAs in the Differentiation of Adipose-Derived Stem Cells显示文摘 | Jing Chen Shuwen Deng Shu Zhang Zhaozhao Chen Songtao Wu Xiaoxiao Cai Xingmei Yang Bin Guo Qiang Peng | 2014 | Current Stem Cell Research & Therapy2014，，3： | 1 |
| 11 | Metal-Free Synthesis of 3,3-Disubstituted Oxindoles via 1,2-Alkylarylation of Activated Alkenes with Alcohols显示文摘 | ZHOU Zhaozhao HUA Huiliang LUO Jianyi | 2013 | Tetrahedron2013，69，10： | 1 |
| 12 | A modified quantitative EMSA and its application in the study of RNA protein interactions显示文摘 | Yue Li Zhaozhao Jiang Haixu Chen | 2004 | Journal of Biochemical and Biophysical Methods2004，60，2： | 1 |
| 13 | Effect of fracture parameters on desorption properties of shales 显示文摘 | Fan Kunkun Sun Runyuan Ma Zichao Zhang Yunfei Wei Yan Zhang Zhaozhao | 2013 | Applied Mechanics and Materials2013，，： | 1 |
| 14 | Molecular cytogenetic analyses of two new wheat-rye 6RL translocation lines with resistance to wheat powdery mildew显示文摘Rye(Secale cereale)is a valuable gene donor for wheat improvement,especially for its resistance to diseases.Developing rye-derived resistance sources is important for wheat breeding.In the present study,two wheat-rye derivatives,designated JS016 and JS110,were produced by crossing common wheat cultivar Yangmai 23 with Pakistani rye accession W2A.Using sequential genomic in situ hybridization(GISH)and multicolor fluorescence in situ hybridization(mc-FISH),JS016 and JS110 were identified as a T6BS.6RL translocation line and a T6BS.6BL6RL translocation line,respectively.Ten newly 6RL chromosome arm-specific markers were developed and used to confirm the 6RL translocation.The wheat 55K single-nucleotide polymorphism(SNP)array further verified the molecular cytogenetic identification results above and clarified their breakpoints at 430.9 and 523.0 Mb of chromosome 6B in JS016 and JS110,respectively.Resistance spectrum and allelism test demonstrated that JS016 and JS110 possessed novel powdery mildew resistance gene(s)that was derived from the 6RL translocation but differed from Pm20.Moreover,JS016 and JS110 had better agronomic traits than the previously reported 6RL translocation line carrying Pm20.To efficiently transfer and detect the 6RL translocation from JS016 and JS110,one 6RL-specific Kompetitive allele specific PCR(KASP)marker was developed and validated in high throughput marker-assisted selection(MAS). | Shanying Zhu Haonan Du Fuyu Su Jin Wang Qingfeng Meng Tianlei Liu Rui Guo Zhaozhao Chen Huanhuan Li Wenxuan Liu Pengtao Ma Huagang He | 2023 | The Crop Journal2023，11，2： | 1 |
| 15 | Vitapex can promote the expression of BMP-2 during the bone regeneration of periapical lesions in rats显示文摘 | Xianyin Xia Zhaozhao Man Hui Jin Ruirui Du Wenjing Sun Xiumei Wang | 2013 | Journal of Indian Society of Pedodontics and Preventive Dentistry2013，，： | 1 |
| 16 | First high-frequency pulse tube cryocooler down to 2.5 K and its promising application in China’s deep space exploration显示文摘From the Moon,Mars,to the central body of the solar system,the Sun,and even exoplanets,deep space exploration[1]has promoted research on the formation and evolution of the solar system and the universe,especially,in terms of tracing life’s origins.The inherent characteristic of high energy flux density determines that space detectors cannot fully dissipate heat through radiative cooling under the cosmic microwave background radiation temperature of 2.7 K. | YANG Biao GAO ZhaoZhao CHEN LiuBiao LIU SiXue ZHOU Qiang GUO Jia CUI Chen ZHU WenXiu JIN Hai ZHOU Yuan WANG JunJie | 2023 | Science China(Technological Sciences)2023，66，8： | 0 |
| 17 | Ultrasmall NiS_(2)Nanocrystals Embedded in Ordered Macroporous Graphenic Carbon Matrix for Efficiently Pseudocapacitive Sodium Storage显示文摘Sodium-ion hybrid capacitor(SIHC)is one of the most promising alternatives for large-scale energy storage due to its high energy and power densities,natural abundance,and low cost.However,overcoming the imbalance between slow Na^(+)reaction kinetics of battery-type anodes and rapid ion adsorption/desorption of capacitive cathodes is a significant challenge.Here,we propose the high-rate-performance NiS_(2)@OMGC anode material composed of monodispersed NiS_(2) nanocrystals(8.8±1.7 nm in size)and N,S-co-doped graphenic carbon(GC).The NiS_(2)@OMGC material has a three-dimensionally ordered macroporous(3DOM)morphology,and numerous NiS_(2) nanocrystals are uniformly embedded in GC,forming a core-shell structure in the local area.Ultrafine NiS_(2) nanocrystals and their nano-microstructure demonstrate high pseudocapacitive Na-storage capability and thus excellent rate performance(355.7 mAh/g at 20.0 A/g).A SIHC device fabricated using NiS_(2)@OMGC and commercial activated carbon(AC)cathode exhibits ultrahigh energy densities(197.4 Wh/kg at 398.8 W/kg)and power densities(43.9 kW/kg at 41.3 Wh/kg),together with a long life span.This outcome exemplifies the rational architecture and composition design of this type of anode material.This strategy can be extended to the design and synthesis of a wide range of high-performance electrode materials for energy storage applications. | Zhaozhao Liu Jiang Wang Ran Bi Pinyi Zhao Mengqian Wu Xinyu Liu Likun Yin Chengyang Wang Mingming Chen Kemeng Ji | 2023 | Transactions of Tianjin University2023，29，2： | 0 |
| 18 | Orthologous genesPm12andPm21from twowild relatives of wheat show evolutionary conservation but divergent powdery mildew resistance显示文摘Wheat powdery mildew,caused by Blumeria graminis f.sp.tritici(Bgt),is a devastating disease that threatens wheat production worldwide.Pm12,which originated from Aegilops speltoides,a wild relative of wheat,confers strong resistance to powdery mildew and therefore has potential use in wheat breeding.Using susceptible mutants induced by gamma irradiation,we physically mapped and isolated Pm12 and showed it to be orthologous to Pm21 from Dasypyrum villosum,also a wild relative of wheat.The resistance function of Pm12 was validated via ethyl methanesulfonatemutagenesis,virus-induced gene silencing,and stable genetic transformation.Evolutionary analysis indicates that the Pm12/Pm21 loci in wheat species are relatively conserved but dynamic.Here,we demonstrated that the two orthologous genes,Pm12 and Pm21,possess differential resistance against the same set of Bgt isolates.Overexpression of the coiledcoil domains of both PM12 and PM21 induces cell death in Nicotiana benthamiana leaves.However,their full-length forms display different cell death-inducing activities caused by their distinct intramolecular interactions.Cloning of Pm12 will facilitate its application in wheat breeding programs.This study also gives new insight into two orthologous resistance genes,Pm12 and Pm21,which show different race specificities and intramolecular interaction patterns. | Shanying Zhu Cheng Liu Shuangjun Gong Zhaozhao Chen Rong Chen Tianlei Liu Renkang Liu Haonan Du Rui Guo Genying Li Miaomiao Li Renchun Fan Zhiyong Liu Qian-Hua Shen Anli Gao Pengtao Ma Huagang He | 2023 | Plant Communications2023，4，2： | 0 |
| 19 | Design,preparation,application of advanced array structured materials and their action mechanism analyses for high performance lithium-sulfur batteries显示文摘Lithium-sulfur battery(LSB)has brought much attention and concern because of high theoretical specific capacity and energy density as one of main competitors for next-generation energy storage systems.The widely commercial application and development of LSB is mainly hindered by serious“shuttle effect”of lithium polysulfides(Li PSs),slow reaction kinetics,notorious lithium dendrites,etc.In various structures of LSB materials,array structured materials,possessing the composition of ordered micro units with the same or similar characteristics of each unit,present excellent application potential for various secondary cells due to some merits such as immobilization of active substances,high specific surface area,appropriate pore sizes,easy modification of functional material surface,accommodated huge volume change,enough facilitated transportation for electrons/lithium ions,and special functional groups strongly adsorbing Li PSs.Thus many novel array structured materials are applied to battery for tackling thorny problems mentioned above.In this review,recent progresses and developments on array structured materials applied in LSBs including preparation ways,collaborative structural designs based on array structures,and action mechanism analyses in improving electrochemical performance and safety are summarized.Meanwhile,we also have detailed discussion for array structured materials in LSBs and constructed the structure-function relationships between array structured materials and battery performances.Lastly,some directions and prospects about preparation ways,functional modifications,and practical applications of array structured materials in LSBs are generalized.We hope the review can attract more researchers'attention and bring more studying on array structured materials for other secondary batteries including LSB. | Nanping Deng Xiaofan Feng Yongbing Jin Zhaozhao Peng Yang Feng Ying Tian Yong Liu Lu Gao Weimin Kang Bowen Cheng | 2024 | Journal of Energy Chemistry2024，89，2： | 0 |
| 20 | Manipulating active layer morphology of molecular donor/polymer acceptor based organic solar cells through ternary blends显示文摘The development of molecular donor/polymer acceptor blend(MD/PA)-type organic solar cells(OSCs) lags far behind other type OSCs. It is due to the large-size phase separation morphology of MD/PAblend, which results from the high crystallinity of molecular donors. In this article, to suppress the crystallinity of molecular donors, we use ternary blends to develop OSCs based on one polymer acceptor(P-BNBP-f BT) and two molecular donors(DR3 TBDTT and BTR) with similar chemical structures.The ternary OSC exhibits a power conversion efficiency(PCE) of 4.85%, which is higher than those of the binary OSCs(PCE=3.60% or 3.86%). To our best knowledge, it is the first report of ternary MD/PA-type OSCs and this PCE is among the highest for MD/PA-type OSCs reported so far. Compared with the binary blends, the ternary blend exhibits decreased crystalline size and improved face-on orientation of the donors. As a result, the ternary blend exhibits improved and balanced charge mobilities, suppressed charge recombination and increased donor/acceptor interfacial areas, which leads to the higher shortcircuit current density. These results suggest that using ternary blend is an effective strategy to manipulate active layer morphology and enhance photovoltaic performance of MD/PA-type OSCs. | Zijian Zhang Zicheng Ding David J.Jones Wallace W.H.Wong Bin Kan Zhaozhao Bi Xiangjian Wan Wei Ma Yongsheng Chen Xiaojing Long ChuANDong Dou Jun Liu Lixiang Wang | 2018 | Science China Chemistry2018，61，8： | 0 |
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