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| 1 | Photo-controlled degradation of PLGA/Ti3C2 hybrid coating on Mg-Sr alloy using near infrared light显示文摘A PLGA/Ti_(3)C_(2) hybrid coating was successfully deposited on the surface of magnesium-strontium(Mg-Sr)alloys.Compared with the corrosion current density(icorr)of the Mg-Sr alloy(7.13×10^−5 A/cm^2),the modified samples(Mg/PLGA/Ti_(3)C_(2))was lower by approximately four orders of magnitude(7.65×10^−9 A/cm^2).After near infrared 808 nm laser irradiation,the icorr of the modified samples increased to 3.48×10^−7 A/cm^2.The mechanism is that the local hyperthermia induced the free volume expansion of PLGA,and the increase in intermolecular gap enhanced the penetration of electrolytes.Meanwhile,the cytotoxicity study showed that the hybrid coating endowed the Mg-Sr alloy with enhanced biocompatibility. | Li Liu Bo Huang Xiangmei Liu Wei Yuan Yufeng Zheng Zhaoyang Li Kelvin Wai Kwok Yeung Shengli Zhu Yanqin Liang Zhenduo Cui Shuilin Wu | 2021 | Bioactive Materials2021，6，2： | 4 |
| 2 | Hierarchical Ni_(3)S_(4)@MoS_(2)nanocomposites as efficient electrocatalysts for hydrogen evolution reaction显示文摘Hydrogen evolution reaction(HER)through water splitting is a promising way to solve the energy shortage.Noble-metal-free HER electrocatalysts with high efficiency is very important for practical applications.Herein,we prepare the Ni_(3)S_(4)@MoS_(2)electrocatalyst on carbon cloth(CC)through a two-step hydrothermal process.The Ni_(3)S_(4)nanorods are uniformly integrated with the MoS_(2)nanosheets,forming a hierarchical structure and heterogeneous interfaces.The fast electron transfer on the interface enhances the kinetics of catalytic reaction.The hierarchical structure provides more exposed active sites.The Ni_(3)S_(4)@MoS_(2)/CC exhibits good catalytic activity and long-term stability for HER.This work provided a practicable strategy to develop efficient electrocatalysts for HER in alkaline media. | Yuxi Ren Shengli Zhu Yanqin Liang Zhaoyang Li Shuilin Wu Chuntao Chang Shuiyuan Luo Zhenduo Cui | 2021 | Journal of Materials Science & Technology2021，，36： | 3 |
| 3 | The enhanced photocatalytic sterilization of MOF-Based nanohybrid for rapid and portable therapy of bacteria-infected open wounds显示文摘Open wounds are prone to infection and difficult to heal,which even threatens the life of patients because bacterial infections can induce other lethal complications without prompt treatment.The commonly used antibiotics treatment for bacterial infections has been reported to cause globally bacterial resistance and even the occurrence of superbacteria.The highly effective and antibiotic-independent therapeutic strategies are urgently needed for treating various kinds of bacteria-infected diseases.In this work,we synthesized an eco-friendly nanohybrid material(ZnDMZ)consisting of a kind of biodegradable metal organic framework(MOF,ZIF-8)combined with Zn-doped MoS_(2)(Zn-MoS_(2))nanosheets,which exhibited great ability to kill bacteria and promote the healing of bacteria-infected wounds under 660 nm light irradiation.The underlying mechanism is that besides the local hyperthermia,the nanohybrid material exhibits enhanced photocatalytic performance than single component in it,i.e.,it can also be excited by 660 nm light to produce more oxygen radical species(ROS)due to the following factors.On one hand,the Zn doping can reduce the work function and the band gap of MoS_(2),which promotes the movement of photoexcited electrons to the surface of the material.On the other hand,the combination between Zn-MoS_(2) and MOF induces the formation of a built-in electric field due to their work function difference,thus accelerating the separation of photoexcited electron-hole pairs.Because of the synergy of photocatalytic effect,photothermal effect and the released Zn ions,the synthesized ZnDMZ possessed a highly effective antibacterial efficacy of 99.9%against Staphylococcus aureus under 660 nm light irradiation for 20 min without cytotoxicity.In vivo tests showed that this nanohybrid material promoted the wound healing due to the released Zn ions.This nanohybrid will be promising for rapid and portable treatment of bacteria-infected open wounds in pathogenic bacteria contaminated environments. | Chaofeng Wang Yue Luo Xiangmei Liu Zhenduo Cui Yufeng Zheng Yanqin Liang Zhaoyang Li Shengli Zhu Jie Lei Xiaobo Feng Shuilin Wu | 2022 | Bioactive Materials2022，7，7： | 3 |
| 4 | A Z-scheme heterojunction of ZnO/CDots/C_(3)N^(4) for strengthened photoresponsive bacteria-killing and acceleration of wound healing显示文摘The abuse of antibiotics is leading to the emergence of resistant bacteria.In this work,a drug-free composite of ZnO/CDots/g-C3N4 with Z-scheme heterojunction was developed,which was employed to kill bacteria effectively within a very short time under the irradiation of visible light due to the enhanced photocatalytic and photothermal effects.In this system,the CDots acted as a bridge between g-C3N4 and ZnO,effectively inhibiting the recombination of photo-generated electrons with holes and consequently enhancing the photocatalytic properties.In addition,CDots endowed the system with excellent photothermal effects.As a result,the antibacterial efficacy of ZnO/CDots/g-C3N4 composite against S.aureus and E.coli reached up to 99.97%and 99.99%respectively,after 15 min of visible light irradiation,due to the synergistic action of photo-inspired radical oxygen species and hyperthermia.The Zn ions released from the composite promoted the growth of fibroblasts,which accelerated the wound healing process. | Yiming Xiang Qilin Zhou Zhaoyang Li Zhenduo Cui Xiangmei Liu Yanqin Liang Shengli Zhu Yufeng Zheng Kelvin Wai Kwok Yeung Shuilin Wu | 2020 | Journal of Materials Science & Technology2020，54，22： | 2 |
| 5 | Simultaneously enhancing the photocatalytic and photothermal effect of NH_(2)-MIL-125-GO-Pt ternary heterojunction for rapid therapy of bacteria-infected wounds显示文摘Infections caused by bacteria threaten human health,so how to effectively kill bacteria is an urgent problem.We therefore synthesized a NH_(2)-MIL-125-GO-Pt ternary composite heterojunction with graphene oxide(GO)and platinum(Pt)nanoparticles co-doped with metal-organic framework(NH_(2)-MIL-125)for use in photocatalytic and photothermal synergistic disinfection under white light irradiation.Due to the good conductivity of GO and the Schottky junction between Pt and MOF,the doping of GO and Pt will effectively separate and transfer the photogenerated electron-hole pairs generated by NH_(2)-MIL-125,thereby effectively improving the photocatalytic efficiency of NH_(2)-MIL-125.Meanwhile,NH_(2)-MIL-125-GO-Pt has good photothermal effect under white light irradiation.Therefore,the NH_(2)-MIL-125-GO-Pt composite can be used for effective sterilization.The antibacterial efficiency of NH_(2)-MIL-125-GO-Pt against Staphylococcus aureus and Escherichia coli were as high as 99.94%and 99.12%,respectively,within 20 min of white light irradiation.In vivo experiments showed that NH_(2)-MIL-125-GO-Pt could effectively kill bacteria and promote wound healing.This work brings new insights into the use of NH_(2)-MIL-125-based photocatalyst materials for rapid disinfection of environments with pathogenic microorganisms. | Yue Luo Bo Li Xiangmei Liu Yufeng Zheng Erjing Wang Zhaoyang Li Zhenduo Cui Yanqin Liang Shengli Zhu Shuilin Wu | 2022 | Bioactive Materials2022，7，12： | 2 |
| 6 | Ag_(3)PO_(4) decorated black urchin-like defective TiO_(2) for rapid and long-term bacteria-killing under visible light显示文摘Both phototherapy via photocatalysts and physical puncture by artificial nanostructures are promising substitutes for antibiotics when treating drug-resistant bacterial infectious diseases.However,the photodynamic therapeutic efficacy of photocatalysts is seriously restricted by the rapid recombination of photogenerated electron-hole pairs.Meanwhile,the nanostructures of physical puncture are limited to two-dimensional(2D)platforms,and they cannot be fully used yet.Thus,this research developed a synergistic system of Ag_(3)PO_(4) nanoparticles(NPs),decorated with black urchin-like defective TiO_(2)(BU-TiO_(2-X)/Ag_(3)PO_(4)).These NPs had a decreased bandgap compared to BU-TiO_(2-X),and BU-TiO_(2)-X/Ag_(3)PO_(4)(3:1)exhibited the lowest bandgap and the highest separation efficiency for photogenerated electron-hole pairs.After combination with BU-TiO_(2-X),the photostability of Ag_(3)PO_(4) improved because the oxygen vacancy of BU-TiO_(2-X) retards the reduction of Ag^(+) in Ag_(3)PO_(4) into Ag^(0),thus reducing its toxicity.In addition,the nanospikes on the surface of BU-TiO_(2-X) can,from all directions,physically puncture bacterial cells,thus assisting the hybrid’s photodynamic therapeutic effects,alongside the small amount of Ag^(+) released from Ag_(3)PO_(4).This achieves synergy,endowing the hybrid with high antibacterial efficacy of 99.76±0.15%and 99.85±0.09%against Escherichia coli and Staphylococcus aureus,respectively,after light irradiation for 20 min followed by darkness for 12 h.It is anticipated that these findings may bring new insight for developing synergistic treatment strategies against bacterial infectious diseases or pathogenic bacterial polluted environments. | Yingde Xu Xiangmei Liu Yufeng Zheng Changyi Li Kelvin Wai Kwok Yeung Zhenduo Cui Yanqin Liang Zhaoyang Li Shengli Zhu Shuilin Wu | 2021 | Bioactive Materials2021，6，6： | 2 |
| 7 | Using tea nanoclusters asβ-lactamase inhibitors to cure multidrug-resistant bacterial pneumonia:A promising therapeutic strategy by Chinese materioherbology显示文摘β-lactamase,a kind of hydrolase in multi-drug resistant pathogens,can hydrolyzeβ-lactam antibiotics and make these kinds of antibiotics invalid.Small-molecular inhibitors about the enzyme and their mechanism are widely investigated but they may result in unavoidable adverse reactions and drug-resistance.Herein,we propose a new therapeutic strategy of Chinese materioherbology,in which herbal medicine or traditional Chinese medicinal herbs can be employed as biological functional materials or refreshed/excited by means of materialogy.Nat-ural tea nanoclusters(TNCs)were extracted from tea to inhibitβ-lactamase.Different from the mechanism of small-molecular inhibitors inhibiting enzymes by binding to the corresponding active sites,the TNCs as a cap cover the protein pocket and create a spatial barrier between the active sites and antibiotics,which was named“capping-pocket”effect.TNCs were combined with amoxicillin sodium(Amo)to treat the methicillin-resistant Staphylococcus aureus(MRSA)pneumonia in mice.This combinatorial therapy remarkably outperforms antibiotic monotherapy in reducing MRSA infections and the associated inflammation in mice.The therapeutic strategy exhibited excellent biosafety,without any side effects,even in piglets.Hence,TNCs have great clinical value in potentiatingβ-lactam antibiotic activity for combatting multi-drug resistant pathogen infections and the'pocket capping'effect can guide the design of new enzyme inhibitors in near future. | Ziao Zhou Jun Li Lei Tan Xiangmei Liu Yufeng Zheng Zhenduo Cui Changyi Li Kelvin Wai Kwok Yeung Zhaoyang Li Yanqin Liang Shengli Zhu Shuilin Wu | 2022 | Fundamental Research2022，2，3： | 1 |
| 8 | Understanding the macroscopical flexibility/fragility of nanoporous Ag:Depending on network connectivity and micro-defects显示文摘The effective engineering applications of nanoporous metals(NPMs)in flexible energy storage and wearable healthcare biosensor monitoring require its uniform ligaments network,specifically crack-free and flexible monolithic bodies.However,the macroscopic fragility of NPMs restricts their applications in wearable electronics fields.Here we focus on the synthetization of highly flexible NPMs.The effects of structural factors,e.g.ligament-network connectivity and micro-cracks on the mechanical properties of nanoporous Ag(np Ag)are investigated.The well-interconnected np Ag metal exhibits higher tensile strength,nanohardness and Vickers hardness than those for the ill-interconnected np Ag metal.The quality of the network connectivity dominates the strength and hardness of the np Ag.The flexibility/fragility is determined by the micro-crack in np Ag.The crack-free np Ag exhibits good flexible behavior.When micro-cracks are introduced,the np Ag becomes fragile.The control of soft volume shrinkage rate(Vsr)and slow surface diffusivity(Ds)effectively suppresses the crack initiation and propagation of as-formed np Ag.These results provide useful insights to synthesize more flexible and crack-free NPM materials for effective use in public wearable electronics and diverse flexible engineering applications in the future. | Chaoyang Wang Shengli Zhu Yanqin Liang Zhenduo Cui Shuilin Wu Chunling Qin Shuiyuan Luo Akihisa Inoue | 2020 | Journal of Materials Science & Technology2020，52，18： | 1 |
| 9 | Multiscale structures of Zr-based binary metallic glasses and the correlation with glass forming ability显示文摘Thermal behaviors and structures of three Zr-based binary glass formers, Zr_(50)Cu_(50), Zr_(64)Cu_(36) and Zr_(64)Ni_(36), were investigated and compared using differential scanning calorimetry(DSC), transmission electron microscopy(TEM), high energy X-ray diffraction(XRD) and small angle X-ray scattering(SAXS). The high energy XRD results show that the bulk glass former Zr_(50)Cu_(50) has a denser atomic packing efficiency and reduced mediumrange order than those of marginal glass formers Zr_(64)Cu_(36) and Zr_(64)Ni_(36). Based on TEM observations for the samples after heat treatment at 10 K above their crystallization onset temperatures, the number density of crystals for Zr_(50)Cu_(50) was estimated to be 10^(23)-10^(24) m^(-3), which was four-orders higher than that in Zr_(64)Cu_(36)and Zr_(64)Ni_(36) metallic glasses. SAXS results indicate that Zr_(50)Cu_(50) has higher degree of nanoscale inhomogeneities than those in Zr_(64)Cu_(36) and Zr_(64)Ni_(36) at as-cast state. The observed multiscale structures are discussed in terms of the phase stability and glass-forming ability of Zr-based binary glass formers. | Xuelian Wu Si Lan Zhenduo Wu Xiaoya Wei Yang Ren Ho Yin Tsang Xunli Wang | 2017 | Progress in Natural Science:Materials International2017，27，4： | 1 |
| 10 | Photothermy-strengthened photocatalytic activity of polydopamine-modified metal-organic frameworks for rapid therapy of bacteria-infected wounds显示文摘Herein,a metal-organic framework(MOF)was modified using polydopamine(PDA)to develop the MOFPDA as a photoresponsive bacteria-killing agent under 660 nm light irradiation.The modification using PDA led to the production of not only more heat,but also much more~1O_(2).This is because the PDA could interact with the porphyrin ring of the MOF throughπ-πinteraction and the charge transfer between PDA and the MOFs decreases the ene rgy of the band of hybrid nanoparticles.In addition,greater levels of hyperthermia induced by PDA modification accelerated the charge trans fe r,which significantly strengthened the photocatalytic perfo rmance of MO F-PDA.Furthermore,after modification,the light abso rbance and water dispersibility of nanoparticles were both enhanced;both are important for the improvement of photocatalytic and photothermal properties.Consequently,MOF-PDA exhibited the highly effective antibacterial efficacy of 99.62%and 99.97%against Staphylococcus aureus and Escherichia coli,respectively,under 20 min 660 nm light irradiation. | Donglin Han Yuan Li Xiangmei Liu Kelvin Wai Kwok Yeung Yufeng Zheng Zhenduo Cui Yanqin Liang Zhaoyang Li Shengli Zhu Xianbao Wang Shuilin Wu | 2021 | Journal of Materials Science & Technology2021，，3： | 1 |
| 11 | Rapid and highly effective bacteria-killing by polydopamine/IR780@MnO_2–Ti using near-infrared light显示文摘Bacterial infections are becoming a serious public health challenge because the abuse of antibiotics worldwide has caused bacterial resistance and the occurrence of superbugs. In this work, a new near-infrared(NIR) photoresponsive coating was constructed on Ti implant material, which was composed of MnO_2, IR780 photosensitizer and polydopamine(PDA). Under the irradiation of 808 nm NIR light, the component of MnO_2 in the coating exhibited high photothermal performance, and IR780 could be stimulated to generate ROS as a photosensitizer. The addition of PDA not only improved the cytocompatibility of the composite coating but also strengthened the light absorption ability of the system. Under the irradiation of 808 nm NIR light for 15 min, the composite coating killed 99.94% Staphylococcus aureus and 99.89% Escherichia coli on Ti plates. This rapid and highly effective bactericidal rate was ascribed to the synergistic effects of photothermal performance and photodynamic effect of the coatings excited by NIR light. Cell culture tests showed that PDA/IR780@MnO_2–Ti had good cytocompatibility due to the excellent biocompatibility of PDA and nanostructured surface. Therefore,this surface system will be a very promising plateform to safely and effectively kill bacteria on biomedical devices and implants in a short time. | Xingfu Teng Xiangmei Liu Zhenduo Cui Yufeng Zheng Da-fu Chen Zhaoyang Li Yanqin Liang Shengli Zhu Shuilin Wu | 2020 | Progress in Natural Science:Materials International2020，30，5： | 1 |
| 12 | Surface photodynamic ion sterilization of ITO-Cu_(2)O/ZnO preventing touch infection显示文摘Pathogenic microbial infections are threatening the people’s health and even life.The most common channel of infections can be caused by skin contact,especially hand touching facilities such as touching screen.In this work,Cu_(2)O covered with ZnO nanofilm was prepared on the surface of indium tin oxide conductive glass by electrodeposition and the followed atomic layer deposition process.This composite coating had a light transmittance of 71.5%,which met the light transmission needs of touch screen device.Electron spin resonance spectra showed that composite materials can generate more reactive oxygen species(ROS)than a single component under solar light irradiation.This was because a p-n junction with a built-in electric field was formed at the interface after Cu_(2)O contacting with ZnO.In the process of photocatalysis,photogenerated electrons and holes migrated at the interface driven by the built-in electric field,which promoted the separation of carriers.The antibacterial rate against Staphylococcus aureus reached 92.5%after 3 min of light irradiation with simulated sunlight due to the synergy of ROS and Cu ions,Zn ions.Therefore,this work may provide a potential method for antibacterial application of preventing hand touch infections. | Zexin Liu Xiangmei Liu Zhenduo Cui Yufeng Zheng Zhaoyang Li Yanqin Liang Xubo Yuan Shengli Zhu Shuilin Wu | 2022 | Journal of Materials Science & Technology2022，，27： | 1 |
| 13 | Self-supporting amorphous nanoporous NiFeCoP electrocatalyst for efficient overall water splitting显示文摘The design of cost-effective and earth-abundant bifunctional electrocatalysts for highly efficient oxygen evolution reaction(OER)and hydrogen evolution reaction(HER)is important for water splitting as an advanced renewable energy transformation system.In this work,the self-supporting amorphous Ni Fe Co P catalyst with nanoporous structure via a facile electrochemical dealloying method is reported.Benefiting from the bicontinuous nanostructure,disordered atomic arrangement,abundant active sites and synergic effect of various transition metals,the as-prepared nanoporous NiFeCoP(np-NiFeCoP)catalyst exhibits good electrocatalytic activity,which achieves the current densities of 10 mA cm^(-2) at low overpotentials of 244 mV and 105 mV for OER and HER in 1.0 M KOH,respectively.In addition,the bifunctional electrocatalyst also shows outstanding and durable electrocatalytic activity in water splitting with a small voltage of 1.62 V to drive a current density of 10 mA cm^(-2) in a two-electrode electrolyzer system.The present work would provide a feasible strategy to explore the efficient and low-cost bifunctional electrocatalysts toward overall water splitting. | Yao Pang Wence Xu Shengli Zhu Zhenduo Cui Yanqin Liang Zhaoyang Li Shuilin Wu Chuntao Chang Shuiyuan Luo | 2021 | Journal of Materials Science & Technology2021，，23： | 1 |
| 14 | Eco-friendly and degradable red phosphorus nanoparticles for rapid microbial sterilization under visible light显示文摘Pathogens pose a serious challenge to environmental sanitation and a threat to public health.The frequent use of chemicals for sterilization in recent years has not only caused secondary damage to the environment but also increased pathogen resistance to drugs,which further threatens public health.To address this issue,the use of non-chemical antibacterial means has become a new trend for environmental disinfection.In this study,we developed red phosphorus nanoparticles(RPNPs),a safe and degradable photosensitive material with good photocatalytic and photothermal properties.The red phosphorus nanoparticles were prepared using a template method and ultrasonication.Under the irradiation of simulated sunlight for 20 min,the RPNPs exhibited an efficiency of 99.98%in killing Staphylococcus aureus due to their excellent photocatalytic and photothermal abilities.Transmission electron microscopy and ultraviolet–visible spectroscopy revealed that the RPNPs exhibited degradability within eight weeks.Both the RPNPs and their degradation products were nontoxic to fibroblast cells.Therefore,such RPNPs are expected to be used as a new type of low-cost,efficient,degradable,biocompatible,and eco-friendly photosensitive material for environmental disinfection. | Qian Wu Xiangmei Liu Bo Li Lei Tan Yong Han Zhaoyang Li Yanqin Liang Zhenduo Cui Shengli Zhu Shuilin Wu Yufeng Zheng | 2021 | Journal of Materials Science & Technology2021，，8： | 1 |
| 15 | Probiotic-based nanoparticles for targeted microbiota modulation and immune restoration in bacterial pneumonia显示文摘While conventional bacterial pneumonia mainly centralizes avoidance of bacterial colonization,it remains unclear how to restore the host immunity for hyperactive immunocompetent primary and immunocompromised secondary bacterial pneumonia.Here,probiotic-based nanoparticles of OASCLR were formed by coating chitosan,hyaluronic acid and ononin on living Lactobacillus rhamnosus.OASCLR nanoparticles could effectively kill various clinic common pathogens and antibacterial efficiency was>99.97%.Importantly,OASCLR could modulate lung microbiota,increasing the overall richness and diversity of microbiota by decreasing pathogens and increasing probiotic and commensal bacteria.Additionally,OASCLR could target inflammatory macrophages by the interaction of OASCLR with the macrophage binding site of CD 44 and alleviate overactive immune responses for hyperactive immunocompetent pneumonia.Surprisingly,OASCLR could break the state of the macrophage’s poor phagocytic ability by upregulating the expression of the extracellular matrix assembly,immune activation and fibroblast activation in immunocompromised pneumonia.The macrophage’s phagocytic ability was increased from 2.61% to 12.3%.Our work provides a potential strategy for hyperactive immunocompetent primary and immunocompromised secondary bacterial pneumonia. | Jieni Fu Xiangmei Liu Zhenduo Cui Yufeng Zheng Hui Jiang Yu Zhang Zhaoyang Li Yanqin Liang Shengli Zhu Paul K Chu Kelvin Wai Kwok Yeung Shuilin Wu | 2023 | National Science Review2023，10，2： | 0 |
| 16 | Rapid Ferroelectric‑Photoexcited Bacteria‑Killing of Bi_(4)Ti_(3)O_(12)/Ti_(3)C_(2)T_(x) Nanofiber Membranes显示文摘In this study,an antibacterial nanofiber membrane[polyvinylidene fluoride/Bi_(4)Ti_(3)O_(12)/Ti_(3)C_(2)T_(x)(PVDF/BTO/Ti_(3)C_(2)T_(x))]is fabricated using an electrostatic spinning process,in which the self-assembled BTO/Ti_(3)C_(2)T_(x) heterojunction is incorporated into the PVDF matrix.Benefiting from the internal electric field induced by the spontaneously ferroelectric polarization of BTO,the photoexcited electrons and holes are driven to move in the opposite direction inside BTO,and the electrons are transferred to Ti_(3)C_(2)T_(x) across the Schottky interface.Thus,directed charge separation and transfer are realized through the cooperation of the two components.The recombination of electron–hole pairs is maximumly inhibited,which notably improves the yield of reactive oxygen species by enhancing photocatalytic activity.Furthermore,the nanofiber membrane with an optimal doping ratio exhibits outstanding visible light absorption and photothermal conversion performance.Ulti-mately,photothermal effect and ferroelectric polarization enhanced photocatalysis endow the nanofiber membrane with the ability to kill 99.61%±0.28%Staphylococcus aureus and 99.71%±0.16%Escherichia coli under 20 min of light irradiation.This study brings new insights into the design of intelligent antibacterial textiles through a ferroelectric polarization strategy. | Zhiying Wang Jianfang Li Yuqian Qiao Xiangmei Liu Yufeng Zheng Zhaoyang Li Jie Shen Yu Zhang Shengli Zhu Hui Jiang Yanqin Liang Zhenduo Cui Paul KChu Shuilin Wu | 2023 | Advanced Fiber Materials2023，5，2： | 0 |
| 17 | Inflammation and Microbiota Regulation Potentiate Pneumonia Therapy by Biomimetic Bacteria and Macrophage Membrane Nanosystem显示文摘While conventional nanosystems can target infected lung tissue,they cannot achieve precise cellular targeting and enhanced therapy by modulating inflammation and microbiota for effective therapy.Here,we designed a nucleus-targeted nanosystem with adenosine triphosphate(ATP)and reactive oxygen species stimuli-response to treat pneumonia coinfected with bacteria and virus that is enhanced through inflammation and microbiota regulation.The nucleus-targeted biomimetic nanosystem was prepared through the combined bacteria-macrophage membrane and loaded hypericin and ATP-responsive dibenzyl oxalate(MMHP)subsequently.The MMHP despoiled the Mg^(2+)of intracellular cytoplasm in bacteria to achieve an effective bactericidal performance.Meanwhile,MMHP can target the cell nucleus and inhibit the H1N1 virus duplication by inhibiting the activity of nucleoprotein.MMHP possessed an immunomodulatory ability to reduce the inflammatory response and activate CD8^(+)T cells for assisted infection elimination.During the mice model,the MMHP effectively treated pneumonia coinfected with Staphylococcus aureus and H1N1 virus.Meanwhile,MMHP mediated the composition of gut microbiota to enhance the pneumonia therapy.Therefore,the dual stimuli-responsive MMHP possessed promising clinical translational potential to therapy infectious pneumonia. | Yuan Li Xiangmei Liu Zhenduo Cui Yufeng Zheng Hui Jiang Yu Zhang Zhaoyang Li Shengli Zhu Paul K Chu Shuilin Wu | 2023 | Research2023，，4： | 0 |
| 18 | Continuous chemical redistribution following amorphous-to-crystalline structural ordering in a Zr-Cu-Al bulk metallic glass显示文摘Bulk metallic glasses(BMGs)are thermodynamically metastable.As such,crystallization occurs when a BMG is thermally annealed at a temperature above the glass transition temperature.While extensive studies have been performed on the crystallization kinetics of BMGs,most of them have focused on the amorphous-to-crystalline structural ordering,and little attention has been paid to chemical distribution and its relationship with the structural ordering during the crystallization process.In this paper,a new approach,with simultaneous differential scanning calorimetry(DSC)and small angle neutron scatter-ing(SANS)measurements,was applied to study in situ the crystallization of a Zr_(45.5)Cu_(45.5)Al_(9)BMG upon isothermal annealing at a temperature in the supercooled liquid region.Quantitative analysis of the DSC and SANS data showed that the structural evolution during isothermal annealing could be classified into three stages:(Ⅰ)incubation;(Ⅱ)amorphous-to-crystalline structural ordering;(Ⅲ)continuous chemical redistribution.This finding was validated by composition analysis with atom probe tomography(APT),which further identified a transition region formed by expelling Al into the matrix.The transition re-gion,with a composition of(Cu,Al)_(50)Zr_(50),served as an intermediate step facilitating the formation of a thermodynamically stable crystalline phase with a composition of(Cu,Al)_(10)Zr_(7). | Xuelian Wu Si Lan Xiyang Li Ming Yang Zhenduo Wu Xiaoya Wei Haiyan He Muhammad Naeem Jie Zhou Zhaoping Lu Elliot Paul Gilbert Dong Ma Xun-Li Wang | 2022 | Journal of Materials Science & Technology2022，，6： | 0 |
| 19 | In situ study on medium-range order evolution during the polyamorphous phase transition in a Pd-Ni-P nanostructured glass显示文摘Engineering multiscale structural hierarchies in glassy alloys enable a broad spectrum of potential applications.Metallic glasses were born in hierarchical structures from atomic-to-nanometer scales.However,the frozen-in structures in traditional metallic glasses prepared by rapid quenching techniques are challenging to tailor.Here,we show that a PdNiPbulk nanostructured glass of polyamorphous interfacial structures was prepared by inert-gas condensation with a laser evaporation source,and its multiscale structures could be engineered.In-situ scattering experiment results reveal polyamorphous phase transitions occurred in the interfacial regions,which are accompanied by the evolution of medium-range order and the nanoscale heterogeneous structures during the condensation process of glassy nanoparticles under high pressure and the following heating process.Moreover,changes in the cluster connectivity resulting from repacking of the local ordering induced by pressure and temperature could be observed.The thermophysical and mechanical properties,including boson peaks,hardness,and elasticity modulus,could be changed as a function of heat-treatment parameters.Our findings would shed light on the synthesis of bulk nanostructured glassy alloys with tailorable thermodynamic and dynamical behavior as well as mechanical properties based on the understanding of metastability for polyamorphous interfacial phases. | Shu Fu Sinan Liu Jiacheng Ge Junjie Wang Huiqiang Ying Shangshu Wu Mengyang Yan Li Zhu Yubin Ke Junhua Luan Yang Ren Xiaobing Zuo Zhenduo Wu Zhen Peng Chain-Tsuan Liu Xun-Li Wang Tao Feng Si Lan | 2022 | Journal of Materials Science & Technology2022，，30： | 0 |
| 20 | Medium-range order endows a bulk metallic glass with enhanced tensile ductility显示文摘Developing ductile bulk metallic glasses(BMGs)can benefit from an in-depth understanding of the structure-property relation during plastic deformation.However,endowing BMGs with tensile ductility in BMGs needs to reveal the response of critical structure units during deformation.Here,we report the experimental results of an in-situ synchrotron high-energy X-ray study of a Zr-based BMG under uniaxial tension after preprocessing by canning compression of the three-dimensional compressive stress state.It is revealed that the canning-compressed BMG(CC-BMG)sample has better tensile ductility and higher ultimate strength than the as-cast sample,which possesses heterogeneous and loosely packed local struc-tures on medium-range scales.The experimental results revealed two stages of plastic deformation in the CC-BMGs compared with one stage of plastic deformation in the as-cast BMG.Moreover,the shift in the first sharp diffraction peak along the tension direction for the canning-compressed sample is substan-tially more pronounced than that of the as-cast sample.Furthermore,the real-space analysis illustrates a competition mechanism between the 2-atom and 3-atom connection modes on medium-range order during the plastic deformation of the CC-BMG.Additionally,the ordering on the medium-range scale de-creases in the first plastic deformation stage but increases in the second plastic deformation stage.There-fore,a structural crossover phenomenon occurs in the CC-BMG during plastic deformation.Our results demonstrate a structure-property correlation for the CC-BMGs of heterogeneous medium-range ordered structures,which may be beneficial for endowing BMGs with ductility based on medium-range order engineering techniques. | Sinan Liu Weixia Dong Zhiqiang Ren Jiacheng Ge Shu Fu Zhenduo Wu Jing Wu Yu Lou Wentao Zhang Huaican Chen Wen Yin Yang Ren Joerg Neuefeind Zesheng You Ying Liu Xun-Li Wang Si Lan | 2023 | Journal of Materials Science & Technology2023，，28： | 0 |
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