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| 1 | Identification of Regulatory DNA Elements Using Genome-wide Mapping of DNase I Hypersensitive Sites during Tomato Fruit Development显示文摘开发并且西红柿水果成熟被 transcriptional 规定精确控制,它取决于规章的蛋白质的安排可接近性到倡导者和另外的 cis 规章的 DNA 元素。基因表示上的这可接近性和它的效果在定义发展进程起一个主要作用。为了理解规章的机制和词法、解剖的功能的元素 modulating,在水果开发期间变化,我们产生了 DNase 的染色体宽的高分辨率的地图我从西红柿栽培变种 “Moneymaker” 的水果纸巾的过分敏感的地点(DHS )在 20 点,天张贴开花期以及裂缝舞台。由越过水果发展阶段探索 DHS 的变化,我们指出了与发展特定的基因有关的最可能的过分敏感的地点。由在维生素酸 biosynthetic 小径在这些发展特定的基因或基因的 DHS 上检测有约束力的主题,我们揭示了贡献协调植物成熟的基因抄写的普通规章的元素并且专业化新陈代谢的小径。我们的结果贡献一更好涉及西红柿水果开发的基因的规章的动力学理解并且成熟。 | Zhengkun Qiu Ren Li Shuaibin Zhang Ketao Wang Meng Xu Jiayang Li Yongchen Du Hong YU Xia Cui | 2016 | Molecular Plant2016，9，8： | 6 |
| 2 | Analysis of Vitamin P Content and Inheritance Models in Eggplant显示文摘The eggplant(Solanum melongena L.)is rich in vitamin P(also known as rutin),which is beneficial for humans.In this study,the vitamin P contents of 53 eggplant lines were measured via UV spectrophotometry.The results showed that the vitamin P content differed significantly among the eggplant lines and the actual contents of vitamin P in fresh fruit pulp and fresh peel were 0.18–0.82mg·g^−1 and 0.42–2.32mg·g^−1,respectively.Furthermore,themixed major gene and polygene inheritance modelmethod was used for the inheritance analysis of the vitamin P content in F2 populations of three hybridization combinations.Inheritance analysis demonstrated that the vitamin P content of these eggplant lines was a quantitative trait.One or two major genes were the contributor,and the genetic effect was an additive-dominance effect.The high vitamin P content trait was regulated by the main gene and followed an additive effect.The heritability of the major genes controlling the high vitamin P content was low,while the heritability of the major gene that controls the low vitamin P content trait was high.These results provide a theoretical basis for the breeding of eggplants with high vitamin P content. | Riyue Dong Bingwei Yu Shuangshuang Yan Zhengkun Qiu Jianjun Lei Changming Chen Ye Li Bihao Cao | 2020 | Horticultural Plant Journal2020，6，4： | 3 |
| 3 | Hydrogenation of nitroaromatics by polymer-anchored bimetallic palladium-ruthenium andpalladium-platium catalysts under mild conditions显示文摘 | Yu Zhengkun Liao Shijian Xu Yun | 1997 | J Mol Catal A:Chem1997，120，13： | 1 |
| 4 | Metal and phosgene-free synthesis of 1 H-quinazolin-2,4-diones by selenium-catalyzed carbon- ylation of o-nitrobenzamides显示文摘 | Wu Xiaowei Yu Zhengkun | 2010 | Tetrahedron Lett2010，51，11： | 1 |
| 5 | Synthesis and Structural Characterization of (CH2)n-Bridged Indenyl-Pyrazoles and Their Cyclopentadienyl Nickel (II) Complexes显示文摘 | Tan Weiqiang Yu Zhengkun Liu Bing | 2009 | J Organomet Chem2009，694，： | 1 |
| 6 | Antiviral Treatment Alters the Frequency of Activating and Inhibitory Receptor-Expressing Natural Killer Cells in Chronic Hepatitis B Virus Infected Patients显示文摘 | Juan Lv Qinglong Jin Haibo Sun Xiumei Chi Xiaoli Hu Hongqing Yan Yu Pan Weihua Xiao Zhigang Tian Jinlin Hou Damo Xu Zhengkun Tu Junqi Niu Alex Kleinjan | 2012 | Mediators of Inflammation2012，，： | 1 |
| 7 | Spin-orbit coupled degenerate fermi gases显示文摘 | Wang Pengjun Yu Zengqiang Fu Zhengkun | | 0，，： | 1 |
| 8 | Spin-orbit coupled degenerate Fermi gases 显示文摘 | Wang Pengjun Yu Zengqiang Fu Zhengkun | 2012 | Physical Review Letters2012，109，09： | 1 |
| 9 | Spinorbit coupled degenerate Fermi gases显示文摘 | Wang Pengjun Yu Zengqiang Fu Zhengkun | 2012 | Physical Review Letters2012，109，9： | 1 |
| 10 | Hydrogenation of nitroaromatics by polymer-anchored bimetallic palladium- ruthenium and Palladium-Platium catalysts under mild conditions显示文摘 | Liao Shijian Xu Yun | 1997 | Journal of Molecular Catalysis A:Chemical1997，120，： | 1 |
| 11 | Efficient synthesis of cyclic carbonates under atmospheric CO_(2) by DMAP-based ionic liquids: the difference of inert hydrogen atom and active hydrogen atom in cation显示文摘The coupling reaction of carbon dioxide(CO_(2)) and epoxides is one of the most efficient pathways to achieve the carbon balance.However,to accomplish it under the mild conditions,especially under the atmospheric pressure,is still a perplexing problem.Three novel ionic liquids(ILs),[DMAPBrPC][TMGH],[DMAPBrPC][DBUH],and[DMAPBrPC][BTMA],are designed and synthesized.All of them display the excellent catalytic activity for the title reaction achieving the yield over 96.6% under the atmospheric CO_(2) pressure at 60℃.Interestingly,[DMAPBrPC][BTMA]with the inert hydrogen atom in cation exhibits the superior catalytic activity as compared to other two ILs with the protic hydrogen atom in cation along with the same anion.The active hydrogen atom in[DMAPBrPC][TMGH]and[DMAPBrPC][DBUH]would impede the–COO^(-)group to absorb CO 2,which is an unfavorable item for the reaction.Moreover,the strong hydrogen bond in[DMAPBrPC][TMGH]and[DMAPBrPC][DBUH]would lessen the nucleophilic ability of Br^(-) anion resulting in the inferior catalytic performance,which is further confirmed by the density functional theory(DFT)calculations.The cation without the active hydrogen atom could also be employed to design the ILs with the excellent catalytic feature when it is combined with the suitable anion. | Zhengkun Zhang Jinya Li Guanyao Yu Chao Zeng Menglong Wang Susu Huang Li Wang Jinglai Zhang | 2023 | Green Chemical Engineering2023，4，3： | 0 |
| 12 | Integrated optoelectronics with two-dimensional materials显示文摘As we enter the post-Moore era,heterogeneous optoelectronic integrated circuits(OEICs)are attracting significant attention as an alternative approach to scaling to smaller-sized transistors.Two-dimensional(2D)materials,offering a range of intriguing optoelectronic properties as semiconductors,semimetals,and insulators,provide great potential for developing nextgeneration heterogeneous OEICs.For instance,Fermi levels of 2D materials can be tuned by applying electrical voltages,while their atomically thin geometries are inherently suited for the fabrication of planar devices without suffering from lattice mismatch.Since the first graphene-on-silicon OEICs were demonstrated in 2011,2D-material heterogeneous OEICs have significantly progressed.To date,researchers have a better understanding of the importance of interface states on the optical properties of chip-integrated 2D materials.Moreover,there has been impressive progress towards the use of 2D materials for waveguide-integrated lasers,modulators,and photodetectors.In this review,we summarize the history,status,and trend of integrated optoelectronics with 2D materials. | Zhenzhou Cheng Rongxiang Guo Jiaqi Wang Yi Wang Zhengkun Xing Lei Ma Wei Wei Yu Yu Hon Ki Tsang Tiegen Liu | 2022 | National Science Open2022，1，3： | 0 |
| 13 | A bHLH transcription factor,CsSPT,regulates high-temperature resistance in cucumber显示文摘High-temperature stress threatens the growth and yield of crops. Basic helix-loop-helix(bHLH) transcription factors(TFs) have been shown to play important roles in regulating high-temperature resistance in plants. However, the bHLH TFs responsible for high-temperature tolerance in cucumbers have not been identified. We used transcriptome profiling to screen the high temperature-responsive candidate bHLH TFs in cucumber. Here, we found that the expression of 75 CsbHLH genes was altered under high-temperature stress. The expression of the CsSPT gene was induced by high temperatures in TT(Thermotolerant) cucumber plants. However, the Csspt mutant plants obtained by the CRISPR-Cas9 system showed severe thermosensitive symptoms, including wilted leaves with brown margins and reduced root density and cell activity.The Csspt mutant plants also exhibited elevated H_(2)O_(2) levels and down-regulated photosystem-related genes under normal conditions.Furthermore, there were high relative electrolytic leakage(REC), malondialdehyde(MDA), glutathione(GSH), and superoxide radical(O_(2)^(·-)) levels in the Csspt mutant plants, with decreased Proline content after the high-temperature treatment. Transcriptome analysis showed that the photosystem and chloroplast activities in Csspt mutant plants were extremely disrupted by the high-temperature stress compared with wildtype(WT) plants. Moreover, the plant hormone signal transduction, as well as MAPK and calcium signaling pathways were activated in Csspt mutant plants under high-temperature stress. The HSF and HSP family genes shared the same upregulated expression patterns in Csspt and WT plants under high-temperature conditions. However, most bHLH, NAC, and bZIP family genes were significantly down-regulated by heat in Csspt mutant plants. Thus, these results demonstrated that CsSPT regulated the high-temperature response by recruiting photosynthesis components, signaling pathway molecules, and transcription factors. Our results provide important insights into the heat response mechanism of CsSPT in cucumber and its potential as a target for breeding heat-resistant crops. | Yonggui Liang Chenyu Yang Fangyan Ming Bingwei Yu Zhihua Cheng Yixi Wang Zhengkun Qiu Xiaolan Zhang Bihao Cao Shuangshuang Yan | 2024 | Horticultural Plant Journal2024，10，2： | 0 |
| 14 | Photoelectrochemical Biosensor for 5-Formylcytosine Based on WS_(2)/Bi/Bi_(2)O_(2)CO_(3) Nanocomposite and Rolling Circle Amplification显示文摘As a key epigenetic modification,5-formylcytosine(5fC)controls many important cell functions,such as gene expression and cell differentiation.However,5fC exists in mammalian tissues and cells with low content,and its structure is highly similar to 5-methylcytosine(5mC),5-hydroxymethylcytosine(5hmC)and 5-carboxycytosine(5caC), which requires the detection method for detecti ng 5fC with high sensitivity and specificity.In this experiment,WS_(2)/Bi/Bi_(2)O_(2)CO_(3) was used as the photoactive material,5fC antibody was used as the target molecule recog nition reage nt,and rolling amplification(RCA)was employed as the signal amplification strategy to con struct a no vel photoelectrochemical biose nsor for detecti ng 5-formylcytosi ne deox ynu cleotide(SfdCTP). | Qian Wang Huanshun Yin Yunlei Zhou Lulu Cao Zhengkun Yu Yamin Xu Shiyun Ai | 2022 | Chinese Journal of Chemistry2022，40，2： | 0 |
| 15 | Genetic Architecture of Childhood Kidney and Urological Diseases in China显示文摘Kidney disease is manifested in a wide variety of phenotypes,many of which have an important hereditary component.To delineate the genotypic and phenotypic spectrum of pediatric nephropathy,a multicenter registration system is being imple-mented based on the Chinese Children Genetic Kidney Disease Database(CCGKDD).In this study,all the patients with kidney and urological diseases were recruited from 2014 to 2020.Genetic analysis was conducted using exome sequencing for families with multiple affected individuals with nephropathy or clinical suspicion of a genetic kidney disease owing to early-onset or extrarenal features.The genetic diagnosis was confirmed in 883 of 2256(39.1%)patients from 23 provinces in China.Phenotypic profiles showed that the primary diagnosis included steroid-resistant nephrotic syndrome(SRNS,23.5%),glomerulonephritis(GN,32.2%),congenital anomalies of the kidney and urinary tract(CAKUT,21.2%),cystic renal disease(3.9%),renal calcinosis/stone(3.6%),tubulopathy(9.7%),and chronic kidney disease of unknown etiology(CKDu,5.8%).The pathogenic variants of 105 monogenetic disorders were identified.Ten distinct genomic disorders were identified as pathogenic copy number variants(CNVs)in 11 patients.The diagnostic yield differed by subgroups,and was highest in those with cystic renal disease(66.3%),followed by tubulopathy(58.4%),GN(57.7%),CKDu(43.5%),SRNS(29.2%),renal calcinosis/stone(29.3%)and CAKUT(8.6%).Reverse phenotyping permitted correct identification in 40 cases with clinical reassessment and unexpected genetic conditions.We present the results of the largest cohort of children with kidney disease in China where diagnostic exome sequencing was performed.Our data demonstrate the utility of family-based exome sequencing,and indicate that the combined analysis of genotype and phenotype based on the national patient registry is pivotal to the genetic diagnosis of kidney disease. | Ye Fang Hua Shi Tianchao Xiang Jiaojiao Liu Jialu Liu Xiaoshan Tang Xiaoyan Fang Jing Chen Yihui Zhai Qian Shen Guomin Li Li Sun Yunli Bi Xiang Wang Yanyan Qian Bingbing Wu Huijun Wang Wenhao Zhou Duan Ma Jianhua Mao Xiaoyun Jiang Shuzhen Sun Ying Shen Xiaorong Liu Aihua Zhang Xiaowen Wang Wenyan Huang Qiu Li Mo Wang Xiaojie Gao Yubin Wu Fang Deng Ruifeng Zhang Cuihua Liu Li Yu Jieqiu Zhuang Qing Sun Xiqiang Dang Haitao Bai Ying Zhu Siguang Lu Bili Zhang Xiaoshan Shao Xuemei Liu Mei Han Lijun Zhao Yuling Liu Jian Gao Ying Bao Dongfeng Zhang Qingshan Ma Liping Zhao Zhengkun Xia Biao Lu Yulong Wang Mengzhun Zhao Jianjiang Zhang Shan Jian Guohua He Huifeng Zhang Bo Zhao Xiaohua LI Feiyan Wang Yufeng Li Hongtao Zhu Xinhui Luo Jinghai Li Jia Rao Hong Xu | 2021 | Phenomics2021，1，3： | 0 |
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