|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | A Chromosome-Level Genome Assembly of Garlic (Allium sativum) Provides Insights into Genome Evolution and Allicin Biosynthesis显示文摘Garlic,an economically important vegetable,spice,and medicinal crop,produces highly enlarged bulbs and unique organosulfur compounds.Here,we report a chromosome-level genome assembly for garlic,with a total size of approximately 16.24 Gb,as well as the annotation of 57561 predicted protein-coding genes,making garlic the first Allium species with a sequenced genome.Analysis of this garlic genome assembly reveals a recent burst of transposable elements,explaining the substantial expansion of the garlic genome.We examined the evolution of certain genes associated with the biosynthesis of allicin and inulin neoseries-type fructans,and provided new insights into the biosynthesis of these two compounds.Furthermore,a large-scale transcriptome was produced to characterize the expression patterns of garlic genes in different tissues and at various growth stages of enlarged bulbs.The reference genome and large-scale transcriptome data generated in this study provide valuable new resources for research on garlic biology and breeding. | Xiudong Sun Siyuan Zhu Ningyang Li Yi Cheng Jing Zhao Xuguang Qiao Li Lu Shiqi Liu Yanzhou Wang Chan Liu Benping Li Wu Guo Shuang Gao Zemao Yang Fu Li Zheng Zeng Qing Tang Yupeng Pan Mengjiao Guan Jian Zhao Xiaomi ng Lu Huanwe n Meng Zhenlin Han Chun she ng Gao Wenkai Jiang Xing Zhao Shilin Tian Jianguang Su Zhihui Cheng Touming Liu | 2020 | Molecular Plant2020，13，9： | 14 |
| 2 | Integrated photonic RF self-interference cancellation on a silicon platform for full-duplex communication显示文摘In-band full-duplex(IBFD) technology can double the spectrum utilization efficiency for wireless communications,and increase the data transmission rate of B5G and 6G networks and satellite communications. RF self-interference is the major challenge for the application of IBFD technology, which must be resolved. Compared with the conventional electronic method, the photonic self-interference cancellation(PSIC) technique has the advantages of wide bandwidth, high amplitude and time delay tuning precision, and immunity to electromagnetic interference.Integrating the PSIC system on chip can effectively reduce the size, weight, and power consumption and meet the application requirement, especially for mobile terminals and small satellite payloads. In this paper, the silicon integrated PSIC chip is presented first and demonstrated for IBFD communication. The integrated PSIC chip comprises function units including phase modulation, time delay and amplitude tuning, sideband filtering, and photodetection, which complete the matching conditions for RF self-interference cancellation. Over the wide frequency range of C, X, Ku, and K bands, from 5 GHz to 25 GHz, a cancellation depth of more than 20 dB is achieved with the narrowest bandwidth of 140 MHz. A maximum bandwidth of 630 MHz is obtained at a center frequency of10 GHz. The full-duplex communication experiment at Ku-band by using the PSIC chip is carried out. Cancellation depths of 24.9 dB and 26.6 dB are measured for a bandwidth of 100 MHz at central frequencies of 12.4 GHz and14.2 GHz, respectively, and the signal of interest(SOI) with 16-quadrature amplitude modulation is recovered successfully. The factors affecting the cancellation depth and maximum interference to the SOI ratio are investigated in detail. The performances of the integrated PSIC system including link gain, noise figure, receiving sensitivity, and spurious free dynamic range are characterized. | XIUYOU HAN XINXIN SU MENG CHAO XINDI YANG WEIHENG WANG SHUANGLING FU YICHENG DU ZHENLIN WU MINGSHAN ZHAO | 2023 | Photonics Research2023，11，10： | 1 |
| 3 | Inference for general parametric functions in Box-cox-type transformation models显示文摘 | Zhenlin Yang Eden Ka-Ho Wu Anthony F | | 0，，02： | 1 |
| 4 | Isotoosendanin exerts inhibition on triple-negative breast cancer through abrogating TGF-β-induced epithelial—mesenchymal transition via directly targeting TGFβR1显示文摘As the most aggressive breast cancer,triple-negative breast cancer(TNBC) is still incurable and very prone to metastasis.The transform growth factor β(TGF-β)-induced epithelial—mesenchymal transition(EMT) is crucially involved in the growth and metastasis of TNBC.This study reported that a natural compound isotoosendanin(ITSN) reduced TNBC metastasis by inhibiting TGF-β-induced EMT and the formation of invadopodia.ITSN can directly interact with TGF-β receptor type-1(TGFβR1) and abrogated the kinase activity of TGFβR1,thereby blocking the TGF-β-initiated downstream signaling pathway.Moreover,the ITSN-provided inhibition on metastasis obviously disappeared in TGFβR1-overexpressed TNBC cells in vitro as well as in mice bearing TNBC cells overexpressed TGFβR1.Furthermore,Lys232 and Asp351 residues in the kinase domain of TGFβR1 were found to be crucial for the interaction of ITSN with TGFβR1.Additionally,ITSN also improved the inhibitory efficacy of programmed cell death 1 ligand 1(PD-L1) antibody for TNBC in vivo via inhibiting the TGF-β-mediated EMT in the tumor microenvironment.Our findings not only highlight the key role of TGFβR1 in TNBC metastasis,but also provide a leading compound targeting TGFβR1 for the treatment of TNBC metastasis.Moreover,this study also points out a potential strategy for TNBC treatment by using the combined application of anti-PD-L1 with a TGFβR1 inhibitor. | Jingnan Zhang Ze Zhang Zhenlin Huang Manlin Li Fan Yang Zeqi Wu Qian Guo Xiyu Mei Bin Lu Changhong Wang Zhengtao Wang Lili Ji | 2023 | Acta Pharmaceutica Sinica B2023，13，7： | 1 |
| 5 | A case-control study for the association between Change in weight,Family history and hypertension at different ages显示文摘 | Wu Guanglin Yang Huimin Qi Xiuying Jia Zhenlin | 2001 | Asia-Pacific Houranl of Public health2001，13，2： | 1 |
| 6 | Visualization of flow behavior during bioleaching of waste rock dumps under saturated and unsaturated conditions显示文摘 | Shenghua Yin Aixiang Wu Kaijian Hu Yiming Wang Zhenlin Xue | 2013 | Hydrometallurgy2013，，： | 1 |
| 7 | Adjuvant Therapy With Capecitabine Postpones Recurrence of Hepatocellular Carcinoma After Curative Resection: A Randomized Controlled Trial显示文摘 | Yong Xia MD Yinghe Qiu MD Jun Li MD Lehua Shi MD Kui Wang MD Tao Xi MD Feng Shen MD Zhenlin Yan MD Mengchao Wu MD | 2010 | Annals of Surgical Oncology2010，，12： | 1 |
| 8 | A non-ACE2 competing human single-domain antibody confers broad neutralization against SARS-CoV-2 and circulating variants显示文摘The current COVID-19 pandemic has heavily burdened the global public health system and may keep simmering for years.The frequent emergence of immune escape variants have spurred the search for prophylactic vaccines and therapeutic antibodies that confer broad protection against SARS-CoV-2 variants.Here we show that the bivalency of an affinity maturated fully human singledomain antibody(n3113.1-Fc)exhibits exquisite neutralizing potency against SARS-CoV-2 pseudovirus,and confers effective prophylactic and therapeutic protection against authentic SARS-CoV-2 in the host cell receptor angiotensin-converting enzyme 2(ACE2)humanized mice.The crystal structure of n3113 in complex with the receptor-binding domain(RBD)of SARS-CoV-2,combined with the cryo-EM structures of n3113 and spike ecto-domain,reveals that n3113 binds to the side surface of up-state RBD with no competition with ACE2.The binding of n3113 to this novel epitope stabilizes spike in up-state conformations but inhibits SARS-CoV-2 S mediated membrane fusion,expanding our recognition of neutralization by antibodies against SARS-CoV-2.Binding assay and pseudovirus neutralization assay show no evasion of recently prevalent SARS-CoV-2 lineages,including Alpha(B.1.1.7),Beta(B.1.351),Gamma(P.1),and Delta(B.1.617.2)for n3113.1-Fc with Y58L mutation,demonstrating the potential of n3113.1-Fc(Y58L)as a promising candidate for clinical development to treat COVID-19. | Zhenlin Yang Yulu Wang Yujia Jin Yuanfei Zhu Yanling Wu Cheng Li Yu Kong Wenping Song Xiaolong Tian Wuqiang Zhan Ailing Huang Shanshan Zhou Shuai Xia Xiaoxu Tian Chao Peng Cuicui Chen Yibing Shi Gaowei Hu Shujuan Du Yuyan Wang Youhua Xie Shibo Jiang Lu Lu Lei Sun Yuanlin Song Tianlei Ying | 2021 | Signal Transduction and Targeted Therapy2021，6，12： | 1 |
| 9 | Adaptive absorbing boundary conditions for Schrodinger-type equations: Application to nonlinear and multi-dimensional problems显示文摘 | Xu Zhenlin Han Houde Wu Xiaonan | 2007 | J Comput Phys2007，225，： | 1 |
| 10 | A perspective on regression and Bayesian approaches for system identification of pattern formation dynamics显示文摘We present two approaches to system identification, i.e. the identification of partial differentialequations (PDEs) from measurement data. The first is a regression-based variational systemidentification procedure that is advantageous in not requiring repeated forward model solves andhas good scalability to large number of differential operators. However it has strict data typerequirements needing the ability to directly represent the operators through the available data.The second is a Bayesian inference framework highly valuable for providing uncertaintyquantification, and flexible for accommodating sparse and noisy data that may also be indirectquantities of interest. However, it also requires repeated forward solutions of the PDE modelswhich is expensive and hinders scalability. We provide illustrations of results on a model problemfor pattern formation dynamics, and discuss merits of the presented methods. | Zhenlin Wang Bowei Wu Krishna Garikipati Xun Huan | 2020 | Theoretical & Applied Mechanics Letters2020，10，3： | 1 |
| 11 | Adjuvant Therapy With Capecitabine Postpones Recurrence of Hepatocellular Carcinoma After Curative Resection: A Randomized Controlled Trial显示文摘 | Yong Xia Yinghe Qiu Jun Li Lehua Shi Kui Wang Tao Xi Feng Shen Zhenlin Yan Mengchao Wu | 2010 | Annals of Surgical Oncology2010，，12： | 1 |
| 12 | Background progenitor activation is associated with recurrence after hepatectomy of combined hepatocellular‐cholangiocarcinoma显示文摘 | Xiong Cai Jian Zhai David E. Kaplan Yijun Zhang Lining Zhou Xutao Chen Guangyang Qian Qiudong Zhao Yonghai Li Lu Gao Wenming Cong Minghua Zhu Zhenlin Yan Lehua Shi Dong Wu Lixin Wei Feng Shen Mengchao Wu | 2012 | Hepatology2012，，5： | 1 |
| 13 | The influence of rs139416141 in neighbor of Brcal gene(NBR1)on bone mineral density in postmenopausal Chinese women显示文摘Bone mineral density(BMD)is used to assess bone mass at present and〜70%of the variance is determined by genetic factors[1].BMD in a lifetime is in a dynamic change from peak values obtained during growth to a gradual decrease during postmenopause and aging.Bone micro-architecture deterioration in postmenopausal women is a result of in creased bone remodeling and liable to&acture of the hip,wrist and spine[2].This bone remodeling imbalance due to estrogen deficiency causes skeletal tissues in the state of enhancement of osteoclastogenesis and impairment of osteogenesis. | Yang Zhang Zhenlin Zhang Zinan Zhang Lijie Zhao Ying Xue Haojie Wu Jianming Hou | 2020 | Acta Biochimica et Biophysica Sinica2020，52，9： | 0 |
| 14 | Optimal Design of 850nm 2 × 2 Multimode Interference Polymer Waveguide Coupler by Imprint Technique显示文摘2 | Yuchen SHAO Xiuyou HAN Xiaonan HAN Zhili LU Zhenlin WU Jie TENG Jinyan WANG Geert MORTHIER Mingshan ZHAO | 2016 | Photonic Sensors2016，6，3： | 0 |
| 15 | Polymer Integrated Waveguide Optical Biosensor by Using Spectral Splitting Effect显示文摘 | Xiaonan HAN Xiuyou HAN Yuchen SHAO Zhenlin WU Yuxin LIANG Jie TENG Shuhui BO Geert MORTHIER Mingshan ZHAO | 2017 | Photonic Sensors2017，7，2： | 0 |
| 16 | Inhalable antibodies for the treatment of COVID-19显示文摘By the end of July 2022,the SARS-CoV-2 pandemic had caused more than 6 million deaths worldwide.This viral infection results in a series of atypical respiratory diseases termed COVID-19,from asymptomatic infection to severe symptoms such as acute respiratory distress syndrome and pulmonary fibrosis.Development of vaccines and therapeutic measures that mitigate the sufferings caused by the pandemic has been achieved in a short period of time.Only 1 year after the emergence of the pandemic,COVID-19 vaccines have been approved in several countries. | Zhenlin Yang Cheng Li Yuanlin Song Tianlei Ying Yanling Wu | 2022 | The Innovation2022，3，6： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员