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199篇 您的检索式:作者名="Zhigang SUN"
    题名 作者 年代 出处 被引量
1NK cell-based immunotherapy for malignant diseases显示文摘生来的杀手(NK ) 房间对癌症在主人免疫起关键作用。在反应,癌症开发机制逃离 NK 房间攻击或导致有缺点的 NK 房间。当前的 NK 基于房间的癌症免疫疗法试图用几条途径克服 NK 房间麻痹。一条途径使用扩展 allogeneic NK 房间,它没被象自体同源的 NK 房间一样的自我 histocompatibility 抗原禁止,为采纳细胞的免疫疗法。另一条采纳转移途径使用稳定的 allogeneic NK 房间线,它为质量控制和大规模生产是更实际的。第三条途径是新鲜 NK 房间或 NK 房间线的基因修正高度表示 cytokines, Fc 受体或妄想的肿瘤抗原受体。治疗学的 NK 细胞能从各种各样的来源被导出,包括细胞,干细胞或甚至导致的 pluripotent 干细胞( iPSCs ),和许多激发器能被用于的外设或绳索血在实验室或好生产实践( GMP )的大规模生产设备包括可溶的生长因素,使不能调动的分子或抗体,和另外的细胞的使活跃之物。到在临床的试用的癌症的对待几类型的 NK 房间治疗的一张表这里被考察。基于 NK 的免疫疗法的几条不同途径例如织物特定的 NK 房间,漂亮面向受体的 NK 房间和化学上对待的 NK 房间,被讨论。一些新技术或策略到由非侵略的成像的监视器 NK 房间治疗,预定 NK 房间治疗由的效率在 vivo 实验并且在临床的试用评估 NK 房间治疗途径也被介绍。Min Cheng Yongyan Chen Weihua Xiao Rui Sun Zhigang Tian 2013Cellular & Molecular Immunology2013,10,3:61
2NK cell receptor imbalance and NK cell dysfunction in HBV nfection and hepatocellular carcinoma显示文摘Hepatocellular 癌(HCC ) 当前由于手术后的复发和转移是癌症死亡和普通差预后的恶意的第三个领先的原因。在长期的肝炎 B 之间有重要关联病毒(HBV ) 感染和 hepatocarcinogenesis。作为对病毒的感染和肿瘤的宿主防卫的第一根线,生来的杀手( NK )细胞表示很多有免疫力的识别受体( NK 受体( NKR ))在 hepatocytes ,肝正弦曲线 endothelial 细胞,星形的细胞和 Kupffer 细胞上认出 ligands ,它维持在有免疫力的反应和 NK 细胞的有免疫力的忍耐之间的平衡。不幸地,百分比和肝 NK 房间的绝对数字在 HCC 的发展和前进期间显著地减少。NK 房间受体和肝 NK 房间的机能障碍的反常表示贡献长期的 HBV 感染和 HCC 的前进并且显著地为肝癌症与差的预后被联系。在这评论,我们在 HCC 在反肿瘤免疫者回答集中于 NK 房间受体的角色,特别地 HBV 相关的 HCC。我们明确地讨论肿瘤房间怎么从 NK 房间躲避攻击并且 NKR 的新兴的理解怎么可以为 HCC 帮助新奇治疗的发展。小说单音 -- 并且指向 NK 房间 receptor-ligand 系统的治疗学的策略可以潜在地导致的联合在 HCC 的成功、有效的免疫疗法。Cheng Sun Haoyu Sun Cai Zhang Zhigang Tian 2015Cellular & Molecular Immunology2015,12,3:55
3Pathogenic T-cells and inflammatory monocytes incite inflammatory storms in severe COVID-19 patients显示文摘Pathogenic human coronavirus infections,such as severe acute respiratory syndrome CoV(SARS-CoV)and Middle East respiratory syndrome CoV(MERS-CoV),cause high morbidity and mortality[1,2].Recently,a severe pneumonia-associated respiratory syndrome caused by a new coronavirus(SARS-CoV-2)was reported in December 2019 in the city of Wuhan,Hubei province,China[3-5],which was also named as pneumonia-associated respiratory syndrome(PARS)[6]and can cause coronavirus disease 2019(COVID-19)to seriously endanger human health.Yonggang Zhou Binqing Fu Xiaohu Zheng Dongsheng Wang Changcheng Zhao Yingjie Qi Rui Sun Zhigang Tian Xiaoling Xu Haiming Wei 2020National Science Review2020,7,6:54
4Functional exhaustion of antiviral lymphocytes in COVID-19 patients显示文摘In December 2019,a novel coronavirus was first reported in Wuhan,China.1 It was named by the World Health Organization as severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)and is responsible for coronavirus disease 2019(COVID-19).Up to 28 February 2020,79,394 cases have been confirmed according to China’s National Health Commission.Outside China,the virus has spread rapidly to over 36 countries and territories.Yuanhong Xuand Zhigang Tian Meijuan Zheng Yong Gao Gang Wang Guobin Song Siyu Liu Dandan Sun Yuanhong Xu Zhigang Tian 2020Cellular & Molecular Immunology2020,17,5:54
5Renewable Energy Transmission by HVDC Across the Continent:System Challenges and Opportunities显示文摘Rapid development of renewable energy in China is driving a major shift in the characteristics and control requirements of the electricity grid.Since the best renewable energy resources are far away from load centers in the east and southeast,transmission over long distances is required.Over 20 high-voltage DC(HVDC)transmission lines,with a combined capacity exceeding 150 GW,are in operation or are currently under construction.This rapid expansion of new generation and transmission capacities based on power electronics starts to change the characteristics of the grid,especially in areas where they concentrate,creating new stability problems and operational challenges.New system theories and technologies are required to support the development and operation of a future grid that relies more and more on power electronics.This paper highlights the characteristics of power electronics as used in renewable energy generation and HVDC transmission systems,discusses the impacts of these power-electronics-based assets on grid stability and operational requirements,and identifies opportunities for the development of both new system theories and system technologies to support a national energy policy that emphasizes the use of clean energy.Jian Sun Mingjie Li Zhigang Zhang Tao Xu Jingbo He Haijiao Wang Guanghui Li 2017CSEE Journal of Power and Energy Systems2017,3,4:43
6Development of a Haploid-Inducer Mediated Genome Editing System for Accelerating Maize Breeding显示文摘Crop breeding aims to generate pure in bred lines with multiple desired traits. Doubled haploid (DH) and genome editing using CRISPR/Cas9 are two powerful game-changing technologies in crop breeding. However, both of them still fall short for rapid generation of pure elite lines with integrated favorable traits. Here, we report the development of a Haploid-Inducer Mediated Genome Editing (IMGE) approach, which utilizes a maize haploid inducer line carrying a CRISPR/Cas9 cassette targeting for a desired agronomic trait to pollinate an elite maize in bred line and to generate genome-edited haploids in the elite maize background. Homozygous pure DH lines with the desired trait improvement could be generated within two generations, thus bypassing the lengthy procedure of repeated crossing and backcrossing used in conventional breeding for integrating a desirable trait into elite commercial backgrounds.Baobao Wang Lei Zhu Binbin Zhao Yongping Zhao Yurong Xie Zhigang Zheng Yaoyao Li Juan Sun Haiyang Wang 2019Molecular Plant2019,12,4:32
7The Chrysanthemum nankingense Genome Provides Insights into the Evolution and Diversification of Chrysanthemum Flowers and Medicinal Traits显示文摘The Asteraceae (Compositae),a large plant family of approximately 24 000-35 000 species,accounts for^10% of all angiosperm species and contributes a lot to plant diversity.The most representative members of the Asteraceae are the economically important chrysanthemums (Chrysanthemum L.)that diversified through reticulate evolution.Biodiversity is typically created by multiple evolutionary mechanisms such as wholegenome duplication 0NGD)or polyploidization and locally repetitive genome expansion.However,the lack of genomic data from chrysanthemum species has prevented an in-depth analysis of the evolutionary mechanisms involved in their diversification.Here,we used Oxford Nanopore long-read technologyto sequence the diploid Chrysanthemum nankingense genome,which represents one of the progenitor genomes of domesticated chrysanthemums.Our analysis revealed that the evolution of the C.nankingense genome was driven by bursts of repetitive element expansion and WGD events including a recentWGD that distinguishes chrysanthemum from sunflower,which diverged from chrysanthemum approximately 38.8 million years ago.Variations of ornamental and medicinal traits in chrysanthemums are linked to the expansion of candidate gene families by duplication events including paralogous gene duplication.Collectively,our study of the assembled reference genome offers new knowledge and resources to dissect the history and pattern of evolution and diversification of chrysanthemum plants,and also to accelerate their breeding and improvement.Chi Song Yifei Liu Aiping Song Gangqiang Dong Hongbo Zhao Wei Sun Shyam Ramakrishnan Ying Wang Shuaibin Wang Tingzhao Li Yan Niu Jiafu Jiang Bin Dong Ye Xia Sumei Chen Zhigang Hu Fadi Chen Shilin Chen 2018Molecular Plant2018,11,12:24
8Effect of Reclamation Time and Land Use on Soil Properties in Changjiang River Estuary,China显示文摘The objective of this study is to analyze soil physical and chemical properties,soil comprehensive functions and impact factors after different years of reclamation.Based on the survey data taken from 216 soil sampling points in the Fengxian Reclamation Area of the Changjiang (Yangtze) River Estuary,China in April 2009 and remotely sensed TM data in 2006,while by virtue of multivariate analysis of variance (MANOVA),geo-statistical analysis (GA),prin-cipal component analysis (PCA) and canonical correspondence analysis (CCA),it was concluded that:1) With the in-crease in reclamation time,soil moisture,soil salinity,soil electric conductivity and soil particle size tended to decline,yet soil organic matter tended to increase.Soil available phosphorous tended to increase in the early reclamation period,yet it tended to decline after about 49 years of reclamation.Soil nitrate nitrogen,soil ammonia nitrogen and pH changed slightly in different reclamation years.Soil physical and chemical properties reached a steady state after about 30 years of reclamation.2) According to the results of PCA analysis,the weighted value (0.97 in total) that represents soil nutrient factors (soil nitrate nitrogen,soil organic matter,soil available phosphorous,soil ammonia nitrogen,pH and soil particle size) were higher than the weighted value (0.48 in total) of soil limiting factors (soil salinity,soil elec-tric conductivity and soil moisture).The higher the F value is,the better the soil quality is.3) Different land use types play different roles in the soil function maturity process,with farmlands providing the best contribution.4) Soil physi-cal and chemical properties in the reclamation area were mainly influenced by reclamation time,and then by land use types.The correlation (0.1905) of the composite index of soil function (F) with reclamation time was greater than that with land use types (-0.1161).SUN Yongguang LI Xiuzhen ülo MANDER HE Yanlong JIA Yue MA Zhigang GUO Wenyong XIN Zaijun 2011Chinese Geographical Science2011,21,4:17
9NK cells in immunotolerant organs显示文摘象肝,子宫和肺那样的机关拥有特点 immunotolerant 特征,为支撑自我动态平衡使这些机关重要。这些机关包含一相对大量否定规章的有免疫力的房间,它被相信参加有免疫力的回答的规定。因为自然漂亮细胞在这些器官组成所有淋巴细胞的一个大比例,增加的注意被给了这些细胞在维持 immunotolerance 起的作用。这里,我们在这些 immunotolerant 机关考察分发,区别, phenotypic 特征和自然漂亮房间的功能的特征,除了这些房间上的本地微型环境的影响并且这些因素怎么贡献器官特定的疾病。Haoyu Sun Cheng Sun Zhigang Tian Weihua Xiao 2013Cellular & Molecular Immunology2013,10,3:13
10Tailoring color emissions from N-doped graphene quantum dots for bioimaging applications显示文摘Unlike inorganic quantum dots,fluorescent graphene quantum dots(GQDs)display excitation-dependent multiple color emission.In this study,we report N-doped GQDs(N-GQDs)with tailored single color emission by tuning p-conjugation degree,which is comparable to the inorganic quantum dot.Starting from citric acid and diethylenetriamine,as prepared N-GQDs display blue,green,and yellow light emission by changing the reaction solvent from water,dimethylformamide(DMF),and solvent free.The X-ray photoelectron spectroscopy,ultraviolet-visible spectra results clearly show the N-GQDs with blue emission(N-GQDs-B)have relatively short effective conjugation length and more carboxyl group because H_(2)O is a polar protic solvent,which tends to donate proton to the reagent to depress the H_(2)O elimination reaction.On the other hand,the polar aprotic solvent(DMF)cannot donate hydrogen,the elimination of H_(2)O is promoted and more nitrogen units enter GQD framework.With the increase of effective p-conjugation length and N content,the emission band of N-GQDS red-shifts to green and yellow.We also demonstrate that N-GQDs could be a potential great biomarker for fluorescent bioimaging.Dan Qu Min Zheng Jing Li Zhigang Xie Zaicheng Sun 2015Light(Science & Applications)2015,4,1:13
11Isolation and genetic charac-terization of a fragile plant mutant in rice (Oryza sativa L.)显示文摘The fragile rice mutant was isolated from an M2 population of indica variety Shuang Ke Zao (SKZ) treated with γ-rays, and designated as fp1 {fragile plant 1) because of its fragile leaves and culms. To map FP1 locus, an F2 mapping population was derived from a cross between the fp1 and C-bao, a polymorphic japonic variety. The primary mapping result places the FP1 locus in an interval between two molecular markers, microsatellite marker RM16 (3.1 cM proximal to FP1) and STS marker G144a (9.1 cM distal to FP1) in the centromere region of chromosome 3. A CAPS marker C524a was further developed between RM16 and G144a, with 0.4 cM genetic distances to the FP1 locus, providing a practical starting point for constructing a BAC con-tig spanning the FP1 locus and cloning the fp1 gene. Allelism test demonstrated that fpl is allelic to be 1, a fragile rice mutant reported previously.QIAN Qian LI Yunhai ZENG Dali TENG Sheng WANG Zhengke LI Xueyong DONG Zhigang DAI Ning SUN Lei LI Jiayang 2001Chinese Science Bulletin2001,46,24:12
12Natural killer cells in liver diseases显示文摘Meijuan Zheng Haoyu Sun Zhigang Tian 2018Frontiers of Medicine2018,12,3:11
13Improved activity of Ni/MgAl_2O_4 for CO_2 methanation by the plasma decomposition显示文摘CO2 methanation has been a hot topic because of its important application in the spacecraft and potential utilization of carbon dioxide. Nickel catalyst is active for this reaction. However, its activity still needs to be improved. Dielectric barrier discharge(DBD) plasma, initiated at ambient condition and operated at ~150 °C,has been employed in this work for decomposition of nickel precursor to prepare Ni/Mg Al2O4. The plasma decomposition results in high dispersion, unique structure, enhanced reducibility of Ni particles and promoted catalyst-support interaction. An improved activity of CO2 methanation with a higher yield of methane has been achieved over the plasma decomposed catalyst, compared to the catalyst prepared thermally. For example, the methane yield of the plasma prepared catalyst is 71.8% at 300 °C but it is 62.9% over the thermal prepared catalyst. The catalyst characterization confirmed that CO2 methanation over the DBD plasma prepared catalyst follows pathway of CO methanation.Zhigang Fan Kaihang Sun Ning Rui Binran Zhao Chang-jun Liu 2015Journal of Energy Chemistry2015,24,5:9
14Status and development of high-power laser facilities at the NLHPLP显示文摘In this paper, we review the status of the multifunctional experimental platform at the National Laboratory of High Power Laser and Physics(NLHPLP). The platform, including the SG-II laser facility, SG-II 9th beam, SG-II upgrade(SG-II UP) facility, and SG-II 5 PW facility, is operational and available for interested scientists studying inertial confinement fusion(ICF) and a broad range of high-energy-density physics. These facilities can provide important experimental capabilities by combining different pulse widths of nanosecond, picosecond, and femtosecond scales. In addition, the SG-II UP facility, consisting of a single petawatt system and an eight-beam nanosecond system, is introduced including several laser technologies that have been developed to ensure the performance of the facility. Recent developments of the SG-II 5 PW facility are also presented.Jianqiang Zhu Jian Zhu Xuechun Li Baoqiang Zhu Weixin Ma Xingqiang Lu Wei Fan Zhigang Liu Shenlei Zhou Guang Xu Guowen Zhang Xinglong Xie Lin Yang Jiangfeng Wang Xiaoping Ouyang Li Wang Dawei Li Pengqian Yang Quantang Fan Mingying Sun Chong Liu Dean Liu Yanli Zhang Hua Tao Meizhi Sun Ping Zhu Bingyan Wang Zhaoyang Jiao Lei Ren Daizhong Liu Xiang Jiao Hongbiao Huang Zunqi Lin 2018High Power Laser Science and Engineering2018,6,4:8
15Pressure sintering of W-15wt.%Cu alloys prepared by mechanical alloying as a subsequent densification treatment method显示文摘The sintered W-15wt.%Cu alloys fabricated by mechanical alloying were re-sintered under pressure to increase the density and improve the properties of these alloys. The pressure was applied vertically along the axis of the sintered sample. Properties such as density, hardness, and bending strength were measured. The microstructures of the sintered bod- ies were observed. The results showed that the subsequent pressure sintering could increase the density of the sintered W-15wt.%Cu alloys. Their hardness, bending strength, and some other physical properties were also improved by this sub- sequent densification treatment.LI Zhigang JIA Chengchang SUN Lan HE Yuntao FAN Shimin 2006Rare Metals2006,25,2:8
16Third generation high strength low alloy steels with improved toughness显示文摘On-line thermo mechanical controlled processing(TMCP) was conducted to develop the third generation high strength low alloy(HSLA) steel with high toughness economically.The ultra-low carbon content ensured a high level of upper shelf energy while ultrafine lath martensitic structure transformed from super-thin pancaked austenite during controlled rolling and cooling.The reduction of martensite block size decreased ductile-to-brittle transition temperature(DBTT) and compensated the strength loss due to carbon reduction.Consequently,the excellent balance of strength and toughness values was obtained as 950-1060 MPa for yield strength,180 J for Charpy V-notch impact absorbed energy at 30℃,which is much superior to that of traditional martensitic steel.Two mechanisms for the refinement of lath martensite block were proposed:One is the austenite grain refinement in the direction of thickness,and the other is the reduction in the fraction of sub-block boundaries with small misorientation and the increase in the fraction of block boundaries with large misorientation,possibly due to austenite hardening.SUN XinJun LI ZhaoDong YONG QiLong YANG ZhiGang DONG Han WENG YuQing 2012Science China(Technological Sciences)2012,55,7:7
17Evaluation of GNSS Signal-in-Space Continuity:A Weibull-Distribution-Based Method显示文摘Signal-in-space(SIS) continuity is an important performance index of Global navigation satellite system(GNSS). However, the studies on the continuity of GNSS SIS are limited both at home and abroad, and are mainly based on the exponential distribution method. We first employ this method to analyze SIS failures of GPS and BDS, finding that this method is not flexile when describing the characteristic of GNSS SIS failures and the fitting characteristic of this method is not well. Therefore, we propose a method based on Weibull distribution to evaluate the performance of GNSS SIS continuity. Our method is compared with the models of exponential distribution, normal distribution, and Gamma distribution regarding the fitting characteristics of the interruption time interval of GPS SIS, the critical parameter of continuity. Results show that the fitting characteristic of the Weibull-distributionbased method is the best and can be used in various forms to describe reliability problem. Then our method is used to evalute the SIS continuity of BDS and GLONASS and its effectiveness and rationality are validated again. The contributions of our study lie in the development of a practical method for evaluating GNSS SIS continuity and a reference for GNSS performance.LI Rui ZHENG Shuaiyong WANG Zhipeng TANG Yang SUN Si HUANG Zhigang 2018Chinese Journal of Electronics2018,27,3:6
18Possible mechanism underlying analgesic effect of Tuina in rats may involve piezo mechanosensitive channels within dorsal root ganglia axon显示文摘OBJECTIVE: To demonstrate the analgesic effect of Tuina mainly from mechanically sensitive ion channels in peripheral myelinated nerve fibers.METHODS: A total of 40 healthy and pathogen-free adult male Sprague-Dawley rats were used in the study [weight:(220.0 ± 1.4) g, Shanghai Slac Laboratory Animal Co., Ltd., Shanghai, China; license No. Shanghai ICP 05033115]. The rats were housed in cages with free access to water and food in a temperature-controlled room [(22 ± 1) ℃] and12-h/12-h light-dark cycle. Thirty-two rats were randomly divided into five groups: naive, sham, chronic compression of dorsal root ganglion(CCD), Tuina(7 d) and Tuina(21 d). CCD rat model was established via unilateral DRG compression by'L'liked steel bar. Chinese Tuina treatment was accepted once per day. Behavior monitoring of paw withdrawal threshold(PWT) and paw withdrawal latency(PWL) were tested. The expression of Piezo1 and Piezo2 in myelinated nerve fiber were analyzed by immunohistochemistry and Western-blotting.RESULTS: There was a high expression of Piezo2 and a low expression of Piezo1 in the naive and CCD groups. In contrast, the expression of Piezo2 was down regulated and Piezo1 was increased after a period of Tuina. There was significant difference(P ≤ 0.05) between the groups.CONCLUSION: Our findings suggest that Tuina therapy can increase the expression of Piezo2 and decrease the expression of Piezo1 in the test rats.The different changes in the expressions of Piezo1 and Piezo2 may play an important role in alleviating CCD-induced allodynia and hyperalgesia.Song Pengfei Lin Zhigang Zhu Qingguang Jiang Shichao Zhang Hao Cheng Yanbin Sun Wuquan Wu Zhiwei Zhou Xin Lv Zhizhen Fang Min 2018Journal of Traditional Chinese Medicine2018,38,6:6
19Holistic Service-Based Architecture for Space-Air-Ground Integrated Network for 5G-Advanced and Beyond显示文摘The Service-based Architecture(SBA) is one of the key innovations of 5G architecture that leverage modularized, self-contained and independent services to provide flexible and cloud-native 5G network. In this paper, SBA for Space-Air-Ground Integrated Network(SAGIN) is investigated to enable the 5G integration deployment. This paper proposes a novel Holistic Service-based Architecture(H-SBA)for SAGIN of 5G-Advanced and beyond, i.e., 6G. The H-SBA introduces the concept of end-to-end servicebased architecture design. The 'Network Function Service', introduced in 5G SBA, is extended from Control Plane to User Plane, from core network to access network. Based on H-SBA, the new generation of protocol design is proposed, which proposes to use IETF QUIC and SRv6 to substitute 5G HTTP/2.0 and GTP-U. Testing results show that new protocols can achieve low latency and high throughput, making them promising candidate for H-SBA.Xiaoyun Wang Tao Sun Xiaodong Duan Dan Wang Yongjing Li Ming Zhao Zhigang Tian 2022China Communications2022,19,1:6
20High salt diet accelerates the progression of murine lupus through dendritic cells via the p38 MAPK and STAT1 signaling pathways显示文摘The increased incidence of systemic lupus erythematosus(SLE)in recent decades might be related to changes in modern dietary habits.Since sodium chloride(NaCl)promotes pathogenic T cell responses,we hypothesize that excessive salt intake contributes to the increased incidence of autoimmune diseases,including SLE.Given the importance of dendritic cells(DCs)in the pathogenesis of SLE,we explored the influence of an excessive sodium chloride diet on DCs in a murine SLE model.We used an induced lupus model in which bone marrow-derived dendritic cells(BMDCs)were incubated with activated lymphocyte-derived DNA(ALD-DNA)and transferred into C57BL/6 recipient mice.We observed that a high-salt diet(HSD)markedly exacerbated lupus progression,which was accompanied by increased DC activation.NaCl treatment also stimulated the maturation,activation and antigenpresenting ability of DCs in vitro.Pretreatment of BMDCs with NaCl also exacerbated BMDC-ALD-DNA-induced lupus.These mice had increased production of autoantibodies and proinflammatory cytokines,more pronounced splenomegaly and lymphadenopathy,and enhanced pathological renal lesions.The p38 MAPK–STAT1 pathway played an important role in NaClinduced DC immune activities.Taken together,our results demonstrate that HSD intake promotes immune activation of DCs through the p38 MAPK–STAT1 signaling pathway and exacerbates the features of SLE.Thus,changes in diet may provide a novel strategy for the prevention or amelioration of lupus or other autoimmune diseases.Ze Xiu Xiao Xiaojiang Hu Ximei Zhang Zhigang Chen Julie Wang Ke Jin Feng Lin Cao Baoqing Sun Joseph A.Bellanti Nancy Olsen Song Guo Zheng 2020Signal Transduction and Targeted Therapy2020,5,1:6
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