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| 1 | Biodegradation Kinetics for Pre-treatment of Klebsiella pneumoniae Waste with Autothermal Thermophilic Aerobic Digestion显示文摘Biodegradation parameters and kinetic characteristics for pre-treating waste strains of Klebsiella pneu-moniae were studied in laboratory scale with an insulated reactor by an innovative technique,autothermal thermo-philic aerobic digestion(ATAD) . Based on an Arrhenius-type equation,an empirical model was developed to corre-late the removal of total suspended solid(TSS) with the initial TSS concentration,influent reaction temperature,aeration rate and stirring rate. The reaction temperatures of the ATAD system could be raised from the ambient temperatures of 25 °C to a maximum temperature of 65 °C. The exponentials for the initial TSS concentration,aeration rate and stirring rate were 1.579,-0.8175 and-0.6549,respectively,and the apparent activation energy was 6.8774 kJ·mol-1. The correlation coefficient for the pre-exponential factor was 0.9223. The TSS removal effi-ciency predicted by the model was validated with an actual test,showing a maximum relative deviation of 10.79%. The new model has a good practicability. | LIU Jingming SUN Dongdong LIU Hui NIE Yingbin ZHU Zhirong | 2010 | Chinese Journal of Chemical Engineering2010，18，6： | 2 |
| 2 | Atomistic dynamics of disconnection-mediated grain boundary plasticity:A case study of gold nanocrystals显示文摘Grain boundary(GB)mediated deformation is a vital contributor to the plasticity of polycrystalline materials,where the disconnection model has become a widely recognized approach to depict the GB dynamics.However,experimental understanding of the atomistic disconnection dynamics remains scarce.In this case study of gold nanocrystals,atomistic disconnection dynamics governing the shear-coupled migration of flat GBs have been systematically investigated via in situ transmission electron microscopy nanomechanical testing supported by molecular dynamics simulations.Specifically,the site-dependent nucleation,shear-driven propagation,and diverse interactions associated with distinct GB disconnections are systematically elucidated and quantitatively compared.Moreover,the disconnection-mediated GB plasticity proves to prevail among different tilt and mixed GBs in gold.Eventually,a conceptual map of disconnection-mediated GB dynamics is established,which would furnish a unified understanding of GB plasticity in metallic materials. | Qi Zhu Haofei Zhou Yingbin Chen Guang Cao Chuang Deng Ze Zhang Jiangwei Wang | 2022 | Journal of Materials Science & Technology2022，，30： | 1 |
| 3 | Coordinated grain boundary deformation governed nanograin annihilation in shear cycling显示文摘Grain growth and shrinkage are essential to the thermal and mechanical stability of nanocrystalline metals,which are assumed to be governed by the coordinated deformation between neighboring grain boundaries(GBs)in the nanosized grains.However,the dynamics of such coordination has rarely been reported,especially in experiments.In this work,we systematically investigate the atomistic mechanism of coordinated GB deformation during grain shrinkage in an Au nanocrystal film through combined stateof-the-art in situ shear testing and atomistic simulations.We demonstrate that an embedded nanograin experiences shrinkage and eventually annihilation during a typical shear loading cycle.The continuous grain shrinkage is accommodated by the coordinated evolution of the surrounding GB network via dislocation-mediated migration,while the final grain annihilation proceeds through the sequential dislocation-annihilation-induced grain rotation and merging of opposite GBs.Both experiments and simulations show that stress distribution and GB structure play important roles in the coordinated deformation of different GBs and control the grain shrinkage/annihilation under shear loading.Our findings establish a mechanistic relation between coordinated GB deformation and grain shrinkage,which reveals a general deformation phenomenon in nanocrystalline metals and enriches our understanding on the atomistic origin of structural stability in nanocrystalline metals under mechanical loading. | Yingbin Chen Qishan Huang Qi Zhu Kexing Song Yanjun Zhou Haofei Zhou Jiangwei Wang | 2021 | Journal of Materials Science & Technology2021，，27： | 1 |
| 4 | A Novel mRNA Signature Related to Immunity to Predict Survival and Immunotherapy Response in Hepatocellular Carcinoma显示文摘Background and Aims:Hepatocellular carcinoma(HCC)is the most common primary liver cancer and the incidence and mortality rates are increasing.Given the limited treatments of HCC and promising application of immunotherapy for cancer,we aimed to identify an immune-related prognostic signature that can predict overall survival(OS)rates and immunotherapy response in HCC.Methods:The initial signature development was conducted using a training dataset from the Cancer Genome Atlas followed by independent internal and external validations from that resource and the Gene Expression Omnibus.A signature based nomogram was generated using multivariate Cox regression analysis.The associations of signature score with tumor immune phenotype and response to immunotherapy were analyzed using single-sample gene set enrichment analysis and tumor immune dysfunction and exclusion algorithm.A cohort from Zhongshan Hospital was employed to verify the pre dictive robustness of the signature regarding prognostic risk and immunotherapy response.Results:The prognostic signature,IGS_(HCC),consisting of 22 immune-related genes,had independent prognostic ability,with training and validation cohorts.Also,IGS_(HCC)stratified HCC patients with different outcomes in subgroups.The prognostic accuracy of IGS_(HCC)was better than three reported prognostic signatures.The IGS_(HCC)-based nomogram had high accuracy and significant clinical benefits in predicting 3-and 5-year OS.IGS_(HCC)reflected distinct immunosuppressive phenotypes in low-and high-score groups.Patients with low IGS_(HCC)scores were more likely than those with high scores to benefit from immunotherapy.Conclusions:IGS_(HCC)predicted HCC prognosis and response to immunotherapy,and contributed to individualized clinical management. | Chenhao Zhou Jialei Weng Yuan Gao Chunxiao Liu Xiaoqiang Zhu Qiang Zhou Chia-Wei Li Jialei Sun Manar Atyah Yong Yi Qinghai Ye Yi Shi Qiongzhu Dong Yingbin Liu Mien-Chie Hung Ning Ren | 2022 | Journal of Clinical and Translational Hepatology2022，10，5： | 1 |
| 5 | Role of soil total nitrogen in aroma synthesis of traditional regional aromatic rice in China显示文摘 | Shuying Yang Yingbin Zou Yizeng Liang Bing Xia Shaokun Liu Md Ibrahim Diqin Li Yanqing Li Lin Chen Yan Zeng Liang Liu Ying Chen Ping Li Jiawen Zhu | 2011 | Field Crops Research2011，，： | 1 |
| 6 | Propagation of stochastic Gaussian-Schell model array beams in turbulent atmosphere显示文摘 | Zhu Yingbin Zhao Daomu Du Xinyue | 2008 | Opt Ex press2008，16，18： | 1 |
| 7 | Microstructure design to improve the efficiency of thermal barrier coatings显示文摘The insulation effect of ceramic coating in a turbine blade is of great importance for the service of engine in the field of aviation industry. Fabricating microstructure in the thermal barrier coatings(TBCs) is considered to be able to enhance the thermal insulation effect. In this study, the traditional three-layer structure, containing ceramic top coat, bonding coat and substrate, is firstly simplified into a double-layer structure, where only ceramic layer and substrate are left, for analyzing the thermal insulation. Afterwards, the thermal insulation effect of the designed microstructure in the bonding coat of the three-layer structure is further studied. Column-like microstructures, filled with hollow ceramic microspheres in the interspace, are designed to improve the thermal insulation effect. The size parameters of the designed microstructure were optimized. The existence of the designed microstructure can significantly prolong the efficiency of thermal barrier coatings. The insulation temperature between the heating surface and lower surface of the substrate can exceed 300℃ and the thermal balance time has a big improvement of 240 s, more than 50%, than the traditional TBCs structure. Compared with the TBCs structure without microstructure, the designed microstructure can significantly improve the insulation temperature of more than 110℃. | Yanyan Yin Rui Qi Hongye Zhang Shangbin Xi Yingbin Zhu Zhanwei Liu | 2018 | Theoretical & Applied Mechanics Letters2018，8，1： | 0 |
| 8 | Development of A Neonatal Mouse Model for Coxsackievirus B1 Antiviral Evaluation显示文摘Coxsackievirus B1(CVB1) is a leading causative agent of severe infectious diseases in humans and has been reported to be associated with outbreaks of aseptic meningitis, myocarditis, and the development of chronic diseases such as type 1 diabetes mellitus(T1DM). There is no approved vaccine or effective antiviral therapy to treat CBV1 infection. And animal models to assess the effects of antiviral agents and vaccine remain limited. In this study, we established a neonatal mouse model of CVB1 using a clinically isolated strain to characterize the pathological manifestations of virus infection and to promote the development of vaccines and antiviral drugs against CVB1. One-day-old BALB/c mice were susceptible to CVB1 infection by intraperitoneal injection. Mice challenged with CVB1 at a low dose [10 median tissue culture infective dose(TCID_(50))] exhibited a series of clinical symptoms, such as inactivity, emaciation, limb weakness, hair thinning,hunching and even death. Pathological examination and tissue viral load analysis showed that positive signals of CVB1 were detected in the heart, spinal cord, limb muscle and kidney without pathological damage. Particularly, CVB1 had a strong tropism towards the pancreas, causing severe cellular necrosis with inflammatory infiltration, and was spread by viraemia. Notably, the monoclonal antibody(mAb) 6H5 and antisera elicited from CVB1-vaccinated mice effectively protected the mice from CVB1 infection in the mouse model. In summary, the established neonatal mouse model is an effective tool for evaluating the efficacy of CVB1 antiviral reagents and vaccines. | Zhichao Yin Yuanyuan Wu Rui Zhu Longfa Xu Yu Lin Hongwei Yang Wenkun Fu Qiongzi Huang Dongqing Zhang Jue Wang Wei Wang Yingbin Wang Tong Cheng Ningshao Xia | 2021 | Virologica Sinica2021，36，6： | 0 |
| 9 | Whole-exome mutational landscape of neuroendocrine carcinomas of the gallbladder显示文摘Neuroendocrine carcinoma(NEC)of the gallbladder(GB-NEC)is a rare but extremely malignant subtype of gallbladder cancer(GBC).The genetic and molecular signatures of GB-NEC are poorly understood;thus,molecular targeting is currently unavailable.Inthe present study,we applied whole-exome sequencing(WES)technology to detect gene mutations and predicted somatic singlenucleotide variants(SNVs)in 15 cases of GB-NEC and 22 cases of general GBC.in 15 GB-NECs,the C>T mutation was predominantamong the 6 types of SNVs.TP53 showed the highest mutation frequency(73%,11/15).Compared with neuroendocrine carcinomasof other organs,signifcantly mutated genes(SMGs)in GB-NECs were more similar to those in pulmonary large-cell euroendocrinecarcinomas(LCNECs),with drver roles for TP53 and RB1.Iin the COSMIC database of cancer-related genes,211 genes were mutated.Strikingly,RB1(4/15,27%)and NAB2(3/15,20%)mutations were found specifically in GB-NECs;in contrast,mutations in 29 genes,including ERB82 and ERBB3,were identified exclusively in GBC.Mutations in RB1 and NAB2 were significanty related to downregulation of the RB1 and NAB2 proteins,respectively,according to immunohistochemical(IHC)data(p values=0.0453 and0.0303).Clinically actionable genes indicated 23 mutated genes,including ALK,BRCA1,and BRCA2.Iin addition,potential somaticSNVs predicted by ISowN and SomVarlUS constituted 6 primary coSMIC mutation signatures(1,3,30,6,7,and 13)in GB-NEC.Genes carrying somatic SNVs were enriched mainly in oncogenic signaling pathways involving the Notch,WNT,Hippo,and RTK-RASpathways.In summary,we have systematically identified the mutation landscape of GB-NEC,and these findings may providemechanistic insights into the specifc pathogenesis of this deadly disease. | Fatao Liu Yongsheng Li Dongjian Ying Shimei Qiu Yong He Maoian Li Yun Liu Yijian Zhang Qin Zhu Yunping Hu Liguo Liu Guoqiang Li Weihua Pan Wei Jin Jiasheng Mu Yang Cao Yingbin Liu | 2021 | Signal Transduction and Targeted Therapy2021，6，3： | 0 |
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