|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Treatment of spinal tuberculosis with ultrashort-course chemotherapy in conjunction with partial excision of pathologic vertebrae显示文摘 | Zili Wang Zhaohui Ge Weidong Jin Yongdong Qiao Huiqiang Ding Haoning Zhao Zhikai Lin Jun Chen Weiyu Yang | 2007 | The Spine Journal2007，，6： | 3 |
| 2 | Inhibition of ASCT2 induces hepatic stellate cell senescence with modified proinflammatory secretome through an IL-1α/NF-κB feedback pathway to inhibit liver fibrosis显示文摘Senescence of activated hepatic stellate cells(aHSCs) is a stable growth arrest that is implicated in liver fibrosis regression.Senescent cells often accompanied by a multi-faceted senescence-associated secretory phenotype(SASP).But little is known about how alanine-serine-cysteine transporter type-2(ASCT2),a high affinity glutamine transporter,affects HSC senescence and SASP during liver fibrosis.Here,we identified ASCT2 is mainly elevated in aHSCs and positively correlated with liver fibrosis in human and mouse fibrotic livers.We first discovered ASCT2 inhibition induced HSCs to senescence in vitro and in vivo.The proinflammatory SASP were restricted by ASCT2 inhibition at senescence initiation to prevent paracrine migration.Mechanically,ASCT2 was a direct target of glutaminolysisdependent proinflammatory SASP,interfering IL-1α/NF-κB feedback loop via interacting with precursor IL-1α at Lys82.From a translational perspective,atractylenolide Ⅲ is identified as ASCT2 inhibitor through directly bound to Asn230 of ASCT2.The presence of -OH group in atractylenolide Ⅲ is suggested to be favorable for the inhibition of ASCT2.Importantly,atractylenolide Ⅲ could be utilized to treat liver fibrosis mice.Taken together,ASCT2 controlled HSC senescence while modifying the proinflammatory SASP.Targeting ASCT2 by atractylenolide Ⅲ could be a therapeutic candidate for liver fibrosis. | Feixia Wang Zhanghao Li Li Chen Ting Yang Baoyu Liang Zili Zhang Jiangjuan Shao Xuefen Xu Guoping Yin Shijun Wang Hai Ding Feng Zhang Shizhong Zheng | 2022 | Acta Pharmaceutica Sinica B2022，12，9： | 2 |
| 3 | Blending LLDPE and ground rubber tires显示文摘 | Qin Jun Ding Hua Yu Zili | 2008 | Polymer-Plastics Technology and Engineering2008，47，2： | 1 |
| 4 | Evaluation of the effect of vacuum on mold filling in the magnesium EPC process显示文摘 | Zili Liu Jingyu Hu Wenjiang Ding | 2002 | Journal of Materials Processing Technology2002，120，： | 1 |
| 5 | Effect of processing parameters on mold filling in magnesium alloy EPC process显示文摘 | LIU ZILI HU JINGYU DING WENJIANG | 2001 | AFS Trans2001，101，： | 1 |
| 6 | Effect of Processing Parameters on Mold Filling in Magnesium Alloy EPC Process显示文摘 | Liu Zili Hu Jingyu Ding Wenjiang | 2001 | AFS Trans2001，101，： | 1 |
| 7 | Effect of processing parameters on mold filling in magnesium alloy EPC process显示文摘 | HU JINGYU DING WENJIANG | 2001 | AFS Trans2001，101，： | 1 |
| 8 | Highly-efficient Stereo-cultivation Model in Kiwifruit Orchards Interplanting Konjak显示文摘The kiwifruit orchards with plants growing for over two years were chosen for interplanting of konjak, which takes advantages of complementation of the two plants in terms of habits, reducing water and soil erosions effectively, and decreasing water evaporation, and konjak diseases. Furthermore, the interplanting doubles planting benefits and constitutes a highly-efficient planting model. | Jinping WU Zili DING Anquan LIU Chaozhu YANG Jiang Zhengjun Zhengming QIU | 2015 | Agricultural Science & Technology2015，16，6： | 1 |
| 9 | A fuzzy control and neural network based rotor speed controller for maximum power point tracking in permanent magnet synchronous wind power generation system显示文摘When the wind speed changes significantly in a permanent magnet synchronous wind power generation system,the maximum power point cannot be easily determined in a timely manner.This study proposes a maximum power reference signal search method based on fuzzy control,which is an improvement to the climbing search method.A neural network-based parameter regulator is proposed to address external wind speed fluctuations,where the parameters of a proportional-integral controller is adjusted to accurately monitor the maximum power point under different wind speed conditions.Finally,the effectiveness of this method is verified via Simulink simulation. | Min Ding Zili Tao Bo Hu Meng Ye Yingxiong Ou Ryuichi Yokoyama | 2023 | Global Energy Interconnection2023，6，5： | 0 |
| 10 | Current Situation of Introduction and Use of African Crop Germplasm Resources and Recommendations显示文摘Africa is the origin center of many crops. It is rich in original ecological resources,especially special resources which are excellent materials for breeding research. With acceleration of commercial seeds in agriculture of African countries,some original ecological resources are disappearing. Through experience of introduction of African varieties in recent years,it analyzed current situation of introduction and use of African crop germplasm resources. Finally,it came up with recommendations for rescuing and taking full advantage of excellent African resources,solving difficult problem restricting crop breeding,enriching China's crop germplasm bank,and improving China's and African crop breeding level and innovation ability. | Zili DING Minghua YAO Chunhai JIAO | 2015 | Asian Agricultural Research2015，7，4： | 0 |
| 11 | Chondroitinase ABC treatment of injured spinal cord in rats Evaluation of long-term outcomes显示文摘Chondroitin sulfate proteoglycans (CSPGs) which are produced by mature oligodendrocytes and reactive astrocytes can be upregulated after spinal cord injury and contribute to regenerative failure. Chondroitinase ABC (ChABC) digests glycosaminoglycan chains on CSPGs and can thereby overcome CSPG-mediated inhibition. However, many current studies have used an incomplete spinal cord injury model, and examined results after 8-12 weeks of ChABC treatment. In this study, a complete rat spinal cord transection injury model was used to study the long-term effects of ChABC treatment by subarachnoid catheter. Pathology of spinal cord regeneration was compared with control 24 weeks following ChABC treatment using immunohistochemistry and axon tracing techniques. At 24 weeks after injury, neurofilament 200 expression was significantly greater in the ChABC treatment group compared with the transection group. In the ChABC treatment group, axonal growth was demonstrated by a large number of biotinylated dextran amine positive axons caudal to, or past, the epicenter of injury. Biotinylated dextran amine-labeled fibers were found in the proximal end of the spinal cord in the transection alone group. These results confirm that ChABC can promote axon growth, neural regeneration, and repair after spinal cord injury in rats long after the initial injury. | Haifeng Yuan Yongli Ding Yueming Song Lihong Hu Zili Wang Hao Liu Limin Liu Quan Gong Tao Li Qingquan Kong | 2010 | Neural Regeneration Research2010，5，16： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员