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| 1 | Global Dynamic Molecular Profiling of Stomatal Lineage Cell Development by Single-Cell RNA Sequencing显示文摘The regulation of stomatal lineage cell development has been extensively investigated.However,a comprehensive characterization of this biological process based on single-cell transcriptome analysis has not yet been reported.In this study,we performed RNA sequencing on 12844 individual cells from the cotyledons of 5-day-old Arabidopsis seedlings.We identified 11 cell clusters corresponding mostly to cells at specific stomatal developmental stages using a series of marker genes.Comparative analysis of genes with the highest variable expression among these cell clusters revealed transcriptional networks that regulate development from meristemoid mother cells to guard mother cells.Examination of the developmental dynamics of marker genes via pseudo-time analysis revealed potential interactions between these genes.Collectively,our study opens the door for understanding how the identified novel marker genes participate in the regulation of stomatal lineage cell development. | Zhixin Liu Yaping Zhou Jinggong Guo Jiaoai Li Zixia Tian Zhinan Zhu Jiajing Wang Rui Wu Bo Zhang Yongjian Hu Yijing Sun Yan Shangguan Weiqiang Li Tao Li Yunhe Hu Chenxi Guo Jean-David Rochaix Yuchen Miao Xuwu Sun | 2020 | Molecular Plant2020，13，8： | 11 |
| 2 | Activated graphene with tailored pore structure parameters for long cycle-life lithium-sulfur batteries显示文摘 | Mingbo Zheng Songtao Zhang Shuangqiang Chen Zixia Lin Huan Pang Yan Yu | 2017 | Nano Research2017，10，12： | 4 |
| 3 | Design and analysis of multi-level physical-layer network coding for gaussian two-way relay channels显示文摘 | Chen Zhiyong Xia Bin Hu Zixia | 2014 | IEEE Transactions on Communications2014，62，6： | 1 |
| 4 | Amperometrie glucose biosensor based on self-assembly hydrophobin with high efficiency of enzyme utilization 显示文摘 | Zhao Zixia Qiao Mingqiang Yin Feng | 2007 | Biosensors and Bioelectronies2007，22，： | 1 |
| 5 | THD Analysis of High Speed Heavily loaded Journal Bearings Including Thermal Deformation, Mass Conserving Cavitation, and Turbulent Effects 显示文摘 | Chan Zhang Zixia Yi Zhiming Zhang | 2000 | ASME J Tribo12000，122，： | 1 |
| 6 | A Cognitive - Pragmatic Model for Transla- tion Studies Based on Relevance and Adaptation 显示文摘 | Zixia Chang | 2009 | Ca- nadian Social Science2009，，5： | 1 |
| 7 | Skilled doctors in tertiary hospitals are al- ready overworked in China显示文摘 | Yinhuan Hu Zixia Zhang | 2015 | Lancet Global Health2015，3，12： | 1 |
| 8 | Flooding-induced membrane damage, lipid oxidation and activated oxygen generation in corn leaves显示文摘 | Bin Yan Qiujie Dai Xiaozhong Liu Shaobai Huang Zixia Wang | 1996 | Plant and Soil1996，，2： | 1 |
| 9 | THD Analysis of High Speed Heavily Loaded Journal Bearings Including Thermal De-formation,and Turbulent Effects显示文摘 | Zhang Chao Yi Zixia Zhang Zhiming | | 0，，： | 1 |
| 10 | Oxygen defect-rich double-layer hierarchical porous Co3O4 arrays as high-efficient oxygen evolution catalyst for overall water splitting显示文摘Construction of oxygen evolution electrocatalysts with abundant oxygen defects and large specific surface areas can significantly improve the conversion efficiency of overall water splitting.Herein,we adopt a controlled method to prepare oxygen defect-rich double-layer hierarchical porous Co3O4 arrays on nickel foam(DL-Co3O4/NF)for water splitting.The unique array-like structure,crystallinity,porosity,and chemical states have been carefully investigated through SEM,TEM,XRD,BET,and XPS techniques.The designated DL-Co3O4/NF has oxygen defects of up to 67.7%and a large BET surface area(57.4 m2g-1).Electrochemical studies show that the catalyst only requires an overpotential of 256 mV to reach 20 mA cm-2,as well as a small Tafel slope of 60.8 mV dec-1,which is far better than all control catalysts.Besides,the catalyst also demonstrates excellent overall water splitting performance in a two-electrode system and good long-term stability,far superior to most previously reported catalysts.Electrocatalytic mechanisms indicate that abundant oxygen vacancies provide more active sites and good conductivity.At the same time,the unique porous arrays facilitate electrolyte transport and gas emissions,thereby synergistically improving OER catalytic performance. | Puxuan Yan Meilin Huang Benzhi Wang Zixia Wan Mancai Qian Hu Yan Tayirjan Taylor Isimjan Jianniao Tian Xiulin Yang | 2020 | Journal of Energy Chemistry2020，29，8： | 1 |
| 11 | The Erds-Jacobson-Lehel conjecture on potentially Pk-graphic sequences is true显示文摘 | LI Jiongsheng SONG Zixia LUO Rong | 1998 | Science in China Ser A1998，41，： | 1 |
| 12 | Design and analysis of multi-level physical-layer network coding for gaussian two-way relay channels显示文摘 | CHEN Zhiyong XIA Bin HU Zixia | 2014 | IEEE Transactions on Communications2014，62，6： | 1 |
| 13 | Comparison of Cloud Properties between Cloud Sat Retrievals and Airplane Measurements in Mixed-Phase Cloud Layers of Weak Convective and Stratus Clouds显示文摘Cloud microphysical properties including liquid and ice particle number concentration(NC),liquid water content(LWC),ice water content(IWC) and effective radius(RE) were retrieved from Cloud Sat data for a weakly convective and a widespread stratus cloud. Within the mixed-phase cloud layers,liquid-phase fractions needed to be assumed in the data retrieval process,and one existing linear(p1) and two exponential(p2and p3) functions,which estimate the liquid-phase fraction as a function of subfreezing temperature(from-20?C to 0?C),were tested. The retrieved NC,LWC,IWC and RE using p1 were on average larger than airplane measurements in the same cloud layer. Function p2 performed better than p1 or p3in retrieving the NCs of cloud droplets in the convective cloud,while function p1 performed better in the stratus cloud. Function p3 performed better in LWC estimation in both convective and stratus clouds. The REs of cloud droplets calculated using the retrieved cloud droplet NC and LWC were closer to the values of in situ observations than those retrieved directly using the p1 function. The retrieved NCs of ice particles in both convective and stratus clouds,on the assumption of liquid-phase fraction during the retrieval of liquid droplet NCs,were closer to those of airplane observations than on the assumption of function p1. | QIU Yujun Thomas CHOULARTON Jonathan CROSIER Zixia LIU | 2015 | Advances in Atmospheric Sciences2015，32，12： | 1 |
| 14 | Research on distribution centers location problem显示文摘 | Chen Zixia Wang Yeqing | 2008 | MultiMedia and Infor- mation Technology2008，，3： | 1 |
| 15 | An extremal problem on the potentially Pk-graphic sequence显示文摘 | LI Jiongsheng SONG Zixia | 2000 | Discrete Math2000，212，： | 1 |
| 16 | The smallest degree sum that yields potentially Pk-graphic sequences显示文摘 | LI Jiongsheng SONG Zixia | 1998 | J Graph Theory1998，29，： | 1 |
| 17 | PARP-1 inhibitors enhance the chemosensitivity of leukemia cells by attenuating NF-κB pathway activity and DNA damage response induced by Idarubicin显示文摘Idarubicin(IDA),an anthracycline antineoplastic drug,is commonly used in the treatment of acute myeloid leukemia(AML)with reasonable response rates and clinical benefits.However,some patients still relapse,or do not respond,and suffer high fatality rates.Recent studies have shown that overexpression of PARP-1 may represent an important risk factor in AML patients.The aim of the present study was to determine the underlying molecular mechanisms by which the PARP-1 inhibitor Olaparib enhances the chemosensitivity of the leukemia cell line K562 and THP1 to IDA.Our data demonstrated that PARP-1 is upregulated in AML patients as well as in K562 and THP1 cells,and that the suppression of PARP-1 activity by Olaparib enhances the inhibitory effect of IDA.A mechanistic study revealed that Olaparib decreases the expressions of p-ATM,p-IκBα,XIAP and p65,and upregulates Bax,cleaved-Caspase-3 andγ-H2AX.Olaparib can enhance the induction of DNA damage by IDA,probably mediated by the inhibition of the ATM-related DNA damage response.Moreover,we also found that the nuclear translocation of p65 and the nuclear export of NEMO are inhibited when IDA and Olaparib are combined.Our results suggest that Olaparib attenuates the activity of the NF-κB pathway and decreases the DNA damage response induced by IDA.Therefore,we conclude that Olaparib is a potentially valuable chemosensitizer for leukemia patients. | Bo Ke Anna Li Huan Fu Chunfang Kong Tingting Liu Qingqing Zhu Yue Zhang Zixia Zhang Chen Chen Chenghao Jin | 2022 | Acta Biochimica et Biophysica Sinica2022，54，1： | 1 |
| 18 | Flooding-induced membrane damage, lipid oxidation and activated oxygen generation in corn leaves显示文摘 | Bin Yan Qiujie Dai Xiaozhong Liu Shaobai Huang Zixia Wang | 1996 | Plant and Soil1996，，2： | 1 |
| 19 | The Erd?s-Jacobson-Lehel conjecture on potentiallyP k-graphic sequence is true显示文摘 | Jiongsheng Li Zixia Song Rong Luo | 1998 | Science in China Series A: Mathematics1998，，5： | 1 |
| 20 | Yishen Huoxue decoction(益肾活血方) attenuates unilateral ureteric obstruction-induced renal fibrosis and hypoxia-induced reactive oxygen species generation via adenosine monophosphate-activated protein kinase/peroxisome proliferator-activated receptor coa显示文摘OBJECTIVE:To investigate the effeicacy of Yishen Huoxue decoction(YSHX)on renal fibrosis induced by unilateral ureteric obstruction(UUO),and on reactive oxygen species(ROS)homeostasis in human umbilical vein endothelial cells(HUVECs).METHODS:Forty male mice were randomly divided into six groups,sham group,UUO group,UUO+resveratrol(RSV)(15 mg/kg)group,UUO+YSHX20 mg/kg group(UUO+YSHX-L),UUO+YSHX 40 mg/kg group(UUO+YSHX-M),UUO+YSHX 80 mg/kg group(UUO+YSHX-H).Western blotting was used to measure protein expression levels.Reverse transcription-quantitative polymerase chain reaction was used to measure the m RNA expression.Immunohistochemistry was used to examine the histopathological changes of kidney tissue sample.Cell apoptosis was measured by Annexin V/PI staining.Cell viability was measured using CCK-8/WST-8 assay.RESULTS:YSHX treatment reducedα-SMA and Col-4 expressions,and increased CD31 and VE-cadherin expressions in UUO model mice.In vitro,YSHX increased cell viability and decreased apoptosis of HUVECs under hypoxic conditions.YSHX inhibited ROS generation by activating adenosine monophosphate-activated protein kinase(AMPK)/peroxisome proliferator-activated receptor coactivator-1α(PGC-1α)/silent mating-type information regulation2 homolog 3(Sirt3)signaling.CONCLUSION:YSHX treatment reduced 109 KJ UUO-induced renal injury and fibrosis.Furthermore,YSHX treatment attenuated hypoxia-induced oxidative stress by regulating AMPK/PGC-1α/Sirt3 signaling. | ZHONG Jian FANG Guiyu WANG Zixia CHEN Ping LU Dengyong SHI Xiaodong | 2021 | Journal of Traditional Chinese Medicine2021，41，6： | 0 |
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