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| 1 | Paracrine and endocrine actions of bone——the functions of secretory proteins from osteoblasts, osteocytes, and osteoclasts显示文摘The skeleton is a dynamic organ that is constantly remodeled. Proteins secreted from bone cells, namely osteoblasts, osteocytes,and osteoclasts exert regulation on osteoblastogenesis, osteclastogenesis, and angiogenesis in a paracrine manner. Osteoblasts secrete a range of different molecules including RANKL/OPG, M-CSF, SEMA3A, WNT5A, and WNT16 that regulate osteoclastogenesis. Osteoblasts also produce VEGFA that stimulates osteoblastogenesis and angiogenesis. Osteocytes produce sclerostin(SOST) that inhibits osteoblast differentiation and promotes osteoclast differentiation. Osteoclasts secrete factors including BMP6, CTHRC1, EFNB2, S1P, WNT10B, SEMA4D, and CT-1 that act on osteoblasts and osteocytes, and thereby influencea A osteogenesis. Osteoclast precursors produce the angiogenic factor PDGF-BB to promote the formation of Type H vessels, which then stimulate osteoblastogenesis. Besides, the evidences over the past decades show that at least three hormones or 'osteokines'from bone cells have endocrine functions. FGF23 is produced by osteoblasts and osteocytes and can regulate phosphate metabolism. Osteocalcin(OCN) secreted by osteoblasts regulates systemic glucose and energy metabolism, reproduction, and cognition. Lipocalin-2(LCN2) is secreted by osteoblasts and can influence energy metabolism by suppressing appetite in the brain.We review the recent progresses in the paracrine and endocrine functions of the secretory proteins of osteoblasts, osteocytes, and osteoclasts, revealing connections of the skeleton with other tissues and providing added insights into the pathogenesis of degenerative diseases affecting multiple organs and the drug discovery process. | Yujiao Han Xiuling You Wenhui Xing Zhong Zhang Weiguo Zou | 2018 | Bone Research2018，6，2： | 52 |
| 2 | IL-17 response mediates acute lung injury induced by the 2009 Pandemic Influenza A (HIN1) Virus显示文摘 | Chenggang Li Penghui Yang Yang Sun Taisheng Li Chen Wang Zhong Wang Zhen Zou Yiwu Yan Wei Wang Chen Wang Zhongwei Chen Li Xing Chong Tang Xiangwu Ju Feng Guo Jiejie Deng Yan Zhao Peng Yang Jun Tang Huanling Wang Zhongpeng Zhao Zhinan Yin Bin Cao Xiliang Wang Chengyu Jiang | 2012 | Cell Research2012，22，3： | 22 |
| 3 | Comparison of Body Mass Index with Body Fat Percentage in the Evaluation of Obesity in Chinese显示文摘Objective To evaluate the present Chinese body mass index(BMI) criteria with body fat percentage(BF%) in determining obesity in Chinese population.Methods A total of 4 907 subjects(age:20-90 yrs) were enrolled in the baseline survey of a longitudinal epidemiological study,and 2 638 of them were reevaluated in 5.5 years later.The Chinese BMI and WHO BF%were used to define obesity,respectively.Results The diagnostic agreement between the Chinese BMI and WHO BF%definitions for obesity was poor for both men(kappa:0.210,95%CI:0.179-0.241) and women(kappa:0.327, 95%CI:0.296-0.358).However,BMI had a good correlation with BF%both in men(r:0.785,P<0,01) and women(r:0.864, P<0.01).The age and sex-adjusted relative risks(RR) for incidence of type 2 diabetes(T2DM) were significantly higher in subjects with intermediate BF%(BF%:20.1%-25%for men,30.1%-35%for women)(RR:2.35,95%CI:1.23-4.48) and high BF%(BF%>25%for men and>35%for women)(RR:2.89,95%CI:1.43-5.81),or in subjects with high BMI(BMI≥28 kg/m^2)(RR:2.46,95%CI:1.31-4.63) when compared to those with low BF%(BF%≤20%for men and≤30%for women) or low BMI(BMI<24 kg/m^2) respectively.No difference in risk could be found in those with intermediate BMI(BMI:24-27.9 kg/m^2)(RR:1.44,95%CI:0.86-2.40),as compared to those with low BMI(BMI<24 kg/m^2),whose BF%ranged widely from 7.8 to 50.3%.Conclusion BMI was correlated with BF%.Both BMI and BF%were associated with high risk for T2DM. However,BMI had its limitations in the interpretation of subjects with BMI between 24 and 27.9 kg/m^2. | CHEN WANG Xu-HONG HOU MING-LIANG ZHANG Yu-QIAN BAO Yu-HUA ZOU WEN-HONG ZHONG KUN-SAN XIANG WEI-PING JIA | 2010 | Biomedical and Environmental Sciences2010，23，3： | 17 |
| 4 | Generation of RAG 1- and 2-deficient rabbits by embryo microinjection of TALENs显示文摘 | Jun Song Juan Zhong Xiaogang Guo Yongqiang Chen Qingjian zou Jiao Huang Xiaoping Li Quanjun Zhang Zhiwu Jiang Chengcheng Tang Huaqiang Yang Tao Liu Peng Li Duanqing Pei Liangxue Lai | 2013 | Cell Research2013，23，8： | 15 |
| 5 | Serum calcium,albumin,globulin and matrix metalloproteinase-9 levels in acute cerebral infarction patients显示文摘BACKGROUND Hemorrhagic transformation(HT)is a common complication in patients with cerebral infarction.However,its pathogenesis is poorly understood.The knowledge of factors that may increase risk for HT may help in improving the safety of thrombolytic therapy.AIM To investigate the predictive value of serum calcium,albumin,globulin and matrix metalloproteinase-9(MMP-9)levels for HT after intravenous thrombolysis(IVT)in patients with acute cerebral infarction.METHODS Five hundred patients with acute cerebral infarction who received IVT with alteplase within 4.5 h after the onset of disease between January 2018 and January 2021 at our hospital were selected as the study subjects.They were divided into groups based on computed tomography scan results of the brain made within 36 h after thrombolysis.Forty patients with HT were enrolled in an observation group and 460 patients without HT were enrolled in a control group.Serum calcium,albumin,globulin and MMP-9 levels were compared between the two groups.Regression analysis was used to discuss the relationship between these indices and HT.RESULTS The previous history of hypertension,diabetes,atrial fibrillation,cerebrovascular diseases,smoking and alcohol intake were not associated with HT after IVT in patients with acute cerebral infarction(all P>0.05).The National Institutes of Health stroke scale(NHISS)score was associated with HT after IVT in patients with acute cerebral infarction(P<0.05).The serum calcium and albumin levels were lower in the observation group than in the control group(all P<0.05).The levels of globulin and MMP-9 were significantly higher in the observation group than in the control group(all P<0.05).Logistic regression analysis showed that NHISS score,serum calcium,albumin,globulins and MMP-9 were independent factors influencing the occurrence of HT following IVT in patients with cerebral infarction(P<0.05).CONCLUSION Serum calcium,albumin,globulin and MMP-9 levels are risk factors for HT after IVT in patients with acute cerebral infarction.Moreover,NHISS score can be used as a predictor of post-thrombolytic HT. | Ting-Ting Zhong Gang Wang Xiao-Qin Wang Wei-Dan Kong Xiao-Yu Li Qian Xue Yu-An Zou | 2021 | World Journal of Clinical Cases2021，9，30： | 15 |
| 6 | Biphasic effects of sodium danshensu on vesse function in isolated rat aorta显示文摘 | Ning ZHANG Hao ZOU Lei JIN Jian WANG Mei-fang ZHONG Peng HUANG Bing-qing GU Shi-long MAO Chuan ZHANG Hong CHEN | 2010 | Acta Pharmacologica Sinica2010，31，4： | 13 |
| 7 | Piglets cloned from induced pluripotent stem cells显示文摘 | Nana Fan Jijun Chen Zhouchun Shang Hongwei Dou Guangzhen Ji Qingjian Zou Lu Wu Lixiazi He Fang Wang Kai Liu Na Liu Jianyong Han Qi Zhou Dengke Pan Dongshan Yang Bentian Zhao Zhen Ouyang Zhaoming Liu Yu Zhao Lin Lin Chongming Zhong Quanlei Wang Shouqi Wang Ying Xu Jing Luan Yu Liang Zhenzhen Yang Jing Li Chunxia Lu Gabor Vajta Ziyi Li Hongsheng Ouyang Huayan Wang Yong Wang Yang Yang Zhonghua Liu Hong Wei Zhidong Luan Miguel A Esteban Hongkui Deng Huanming Yang Duanqing Pei Ning Li Gang Pei Lin Liu Yutao Du Lei Xiao Liangxue Lai | 2013 | Cell Research2013，23，1： | 12 |
| 8 | Full-color quantum dots active matrix display fabricated by ink-jet printing显示文摘Making full-color active matrix display based on quantum dot light emitting diodes(AM-QLEDs) via ink-jet printing is attractive in display industry due to QLEDs' wide color gamut and their potential manufacturing advantages of large screen size and low cost. The challenges for realizing AM-QLED display are how to achieve high quality films through ink-jet printing, multi-color patterning, electroluminescence(EL) color purity, and high efficiency. Herein, a 2-inch diagonal full-color AM-QLEDs display with pixel density of 120 pixels per inch(PPI) fabricated by ink-jet printing technique is presented. Driven by a metal oxide TFT(MOTFT) back-panel, the display exhibits a maximum brightness of 400 cd m.2, and a color gamut of 109%(NTSC 1931). The red, green, and blue(RGB) monochrome QLEDs passive matrix panels fabricated by ink-jet printing technique have a current efficiency(CE) of 2.5, 13.9, and 0.30 cd A.1, respectively. To the best of our knowledge, the efficiencies are the highest among passive matrix QLEDs panels made by ink-jet printing technique. The ink-jet printed QDs films show good thickness uniformity due to high viscosity and low volatility of the printable inks, and no cross-contamination between adjacent pixels resulting from the hydrophobic pixel defining layer. | Congbiao Jiang Lan Mu Jianhua Zou Zhiwei He Zhenji Zhong Lei Wang Miao Xu Jian Wang Junbiao Peng Yong Cao | 2017 | Science China Chemistry2017，60，10： | 10 |
| 9 | Liquid-FEP-based U-tube triboelectric nanogenerator for harvesting water-wave energy显示文摘收获周围的机械精力是为认识到自我动力的电子学的一种关键技术。与稳定性和耐久性的优点, liquid-solid-based 摩擦电 nanogenerator (TENG ) 最近引起了许多注意。然而, TENG 表演和相关工作原则上的液体性质的影响仍然是不清楚的。我们此处基于液体固体模式装配了 U 试管 TENG 并且使用了 11 液体在 TENG 输出性能上学习液体性质的效果。结果证实影响产量的关键因素是极性,绝缘的常数,和与氟化的乙烯丙烯(FEP ) 的亲密关系。在 11 液体之中,纯以水为基的U试管 TENG 与开电路的电压展出了最好的产量( V 81.7 V 和电线走火电流的 oc )(我 为摇晃的模式( 0.5 Hz )的 0.26 A 的 sc ),它能推进增加到 93.0 V 和 0.48 A ,分别地为水平变模式( 1.25 Hz )。U 试管 TENG 能与比 92% 高的精确性为一个水的答案作为一个自我动力的集中传感器(部件集中或 metalion 集中) 被利用。最后,升级的像三明治的 water-FEP U 试管 TENG 被使用收获水波浪精力,显示出有 V 350 V 的 oc ,我 1.75 A 的 sc ,和 2.04 W/m 3 的力量密度。我们成功地照亮了 60 LEDs 并且动力一温度湿度米。给它的高输出性能, water-FEP U 试管 TENG 是为为自我动力的电子学收获水波浪精力的一条很有希望的途径。 | Lun Pan Jiyu Wang Peihong Wang Ruijie Gao Yi-Cheng Wang Xiangwen Zhang Ji-Jun zou Zhong Lin Wang | 2018 | Nano Research2018，11，8： | 10 |
| 10 | Olivine-norite rock detected by the lunar rover Yutu-2 likely crystallized from the SPA-impact melt pool显示文摘Chang’E-4 landed in the South Pole-Aitken(SPA)basin,providing a unique chance to probe the composition of the lunar interior.Its landing site is located on ejecta strips in Von Karm´an crater that´possibly originate from the neighboring Finsen crater.A surface rock and the lunar regolith at 10 sites along the rover Yutu-2 track were measured by the onboard Visible and Near-Infrared Imaging Spectrometer in the first three lunar days of mission operations.In situ spectra of the regolith have peak band positions at 1 and 2μm,similar to the spectral data of Finsen ejecta from the Moon Mineralogy Mapper,which confirms that the regolith’s composition of the landing area is mostly similar to that of Finsen ejecta.The rock spectrum shows similar band peak positions,but stronger absorptions,suggesting relatively fresh exposure.The rock may consist of 38.1±5.4%low-Ca pyroxene,13.9±5.1%olivine and 48.0±3.1%plagioclase,referred to as olivine-norite.The plagioclase-abundant and olivine-poor modal composition of the rock is inconsistent with the origin of the mantle,but representative of the lunar lower crust.Alternatively,the rock crystallized from the impact-derived melt pool formed by the SPA-impact event via mixing the lunar crust and mantle materials.This scenario is consistent with fast-cooling thermal conditions of a shallow melt pool,indicated by the fine to medium-sized texture(<3 mm)of the rock and the SPA-impact melting model[Icarus 2012;220:730–43]. | Honglei Lin Zhiping He Wei Yang Yangting Lin Rui Xu Chi Zhang Meng-Hua Zhu Rui Chang Jinhai Zhang Chunlai Li Hongyu Lin Yang Liu Sheng Gou Yong Wei Sen Hu Changbin Xue Jianfeng Yang Jie Zhong Xiaohui Fu Weixing Wan Yongliao Zou | 2020 | National Science Review2020，7，5： | 9 |
| 11 | Types and Causes of Debris Flow Damage to Drainage Channels in the Wenchuan Earthquake Area显示文摘Debris flows are among the most common geological disasters in China,and have been particularly frequent in Sichuan Province since the Wenchuan earthquake on 12 May 2008.The construction of debris flow drainage channels is a countermeasure used to distribute debris flow fans,and these channels play a critical role in the mitigation and prevention of damage resulting from debris flows.Under field conditions,the useful life of drainage channels can be greatly shortened as a result of strong abrasions to the drainage structure caused by the debris flow.Field investigations have shown that the types of damage to drainage channels include(a) erosion caused by hyper-concentrated silt flow,(b) impact fractures and foundation scour at the groundsills of the drainage channel,(c) destruction of the drainage channel outlet,and(d) destruction of the drainage channel caused by debris flow abrasion.In addition,based on the destruction of the drainage channel during the debris flow drainage process,a new type of drainage channel with energy dissipation components was proposed and applied in a steep,narrow gully for debris flow mitigation.Moreover,design and engineering repair recommendations for drainage channels are provided as a reference for repairing the damage to the channel.The results can provide an important reference for the effective repair and optimal design of drainage channels. | CHEN Jian-gang CHEN Xiao-qing WANG Tao ZOU Yu-hua ZHONG Wei | 2014 | Journal of Mountain Science2014，11，6： | 8 |
| 12 | Prospective randomized comparison of transumbilical two-port laparoscopic and conventional laparoscopic varicocele ligation显示文摘我们证实了一个新奇方法为精索静脉曲张把 transumbilical 称为二港口的 laparoscopic 精索静脉曲张结扎(TTLVL ) ,它仍然被需要评估。在这研究,有等级 II-III 的左自发的征兆的精索静脉曲张的 90 个病人随机根据分级系统的 Dubin 被分到 TTLVL (n = 45 ) 并且常规 laparoscopic 精索静脉曲张结扎(CLVL )(n = 45 ) 。人口统计, intraoperative,手术后,并且后续数据在二个组之间被记录并且比较。在二个组的所有过程没有 intraoperative 复杂并发症和没有变换成功地被完成打开外科。没有重要差别在起作用的时间被发现,恢复在二个组之间的阴囊的疼痛的移动,肠恢复,手术后的医院停留,和手术后的分辨率(P >0.05 ) 。然而,为 TTLVL 组的手术后的吝啬的视觉模拟疼痛规模分数都与 CLVL 相比手术后地是在 24 h, 48 h, 72 h,和 7 天的更少(P = 0.001, 0.010, 0.006,和 0.027,分别地) 。在手术后的月内的吝啬的耐心的疤评价问询表分数 3 为 CLVL 组与 32.1 相比为 TTLVL 组是 29.7 (P <0.001 ) 。没有阴囊的萎缩,在后续时期期间在两个组观察。学习证明 TTLVL 是为精索静脉曲张的治疗的 CLVL 的一种安全、可行、有效的最低限度地侵略的外科的选择。与 CLVL 相比, TTLVL 可以减少手术后伤害并且改善化妆结果。 | Guo-Xi Zhang Jan Yang Da-Zhi Long Min Liu Xiao-Feng Zou Yuan-Hu Yuan Ri-Hai Xiao Yi-Jun Xue Xin Zhong Quan-Liang Liu Fo-Lin Liu Bo Jiang Rui-Quan Xu Kun-Lin Xie | 2017 | Asian Journal of Andrology2017，19，1： | 8 |
| 13 | Flexible devices:from materials, architectures to applications显示文摘Flexible devices, such as flexible electronic devices and flexible energy storage devices, have attracted a significant amount of attention in recent years for their potential applications in modern human lives. The development of flexible devices is moving forward rapidly, as the innovation of methods and manufacturing processes has greatly encouraged the research of flexible devices. This review focuses on advanced materials, architecture designs and abundant applications of flexible devices, and discusses the problems and challenges in current situations of flexible devices. We summarize the discovery of novel materials and the design of new architectures for improving the performance of flexible devices. Finally, we introduce the applications of flexible devices as key components in real life. | Mingzhi Zou Yue Ma Xin Yuan Yi Hu Jie Liu Zhong Jin | 2018 | Journal of Semiconductors2018，39，1： | 7 |
| 14 | Unsaturated-sulfur-rich MoS2 nanosheets decorated on free-standing SWNT film: Synthesis, characterization and electrocatalytic application显示文摘此处,我们报导一条自底向上的 solvothermal 线路综合为氢进化反应的灵活、高度有效的瞬间 2@SWNT electrocatalyst (她的) 。描述表明包含 sulfurrich 地点的像分支的瞬间 2 nanosheets 在一致地在自立的围单人赛的碳 nanotube (SWNT ) 上驱散的 situ 电影,能暴露更不饱和的硫原子,与活跃地点允许优秀电的接触。展出的灵活催化剂优秀她有低过电位的表演(~ 在 10 妈 / 厘米 2) 和小 Tafel 斜坡(41 mV/dec ) 的 150 mV。为了推进,解释改进表演,本地电子结构被 X 光检查吸收调查近边的结构(XANES ) 分析,证明不饱和的硫原子并且在瞬间 2 和 SWNT 之间的强壮的电子联合的存在。这研究提供一条在原处合成的线路在催化剂微观结构,电子结构,和性质之中创造新多功能的灵活 hybridized 催化剂和有用卓见进关系。 | Daobin Liu Weiyu Xu Qin Liu Qun He Yasir A. Haleem Changda Wang Ting Xiang Chongwen Zou Wangsheng Chu Jun Zhong Zhiqiang Niu Li Song | 2016 | Nano Research2016，9，7： | 7 |
| 15 | Paleoceanographic Indicators for Early Cambrian Black Shales from the Yangtze Platform, South China: Evidence from Biomarkers and Carbon Isotopes显示文摘The lower Cambrian Niutitang Formation, a widespread black shale deposition, is of geological interest because of its polymetallic beds, Cambrian explosion, depositional ages, dramatic environmental changes and so on. Previous study focused mainly on inorganic geochemistry and few studies have investigated the organic fractions of upper Neoproterozoic-lower Cambrian strata in South China. Here we report a study of biomarkers plus organic carbon isotopes for black shales from Ganziping, Hunan Province (China). All the saturated hydrocarbon fractions have a unimodal distribution of n-alkanes, a high content of short-chain alkanes and maximize at C 19 or C 20 (C 23 for sample Gzh00-1). The C 27 /C 29 sterane ratio ranges from 0.77 to 1.20 and 4-methylsteranes are in low abundance. These parameters indicate that algae and bacteria are the important primary producers. Furthermore, biomarker maturity proxies show the samples to be higher maturity. The low Pr/Ph values (<0.7) suggest that the samples were deposited under anoxic conditions and, likely, under stratified water columns. In addition, 25-norhopanes and gammacerane are present as diagnostic indicators of normal marine salinity and dysoxic to anoxic conditions. During the Early Tommotian, known to coincide with a transgression event, small shelly fossils increased in abundance and diversity. Moreover, positive δ 13 C org excursions close to 1.4‰ occur at the base of the Tommotian stage. In summary, the Early Cambrian black shales were deposited under dramatic paleoenvironmental changes, including oceanic anoxia, higher primary productivity and sea-level rise. | CHEN Lan ZHONG Hong HU Ruizhong XIAO Jiafei TSAI Louis Loung-Yie LIN Andrew Tien-Shun ZOU Yanrong | 2012 | Acta Geologica Sinica(English Edition)2012，86，5： | 6 |
| 16 | Broadband perovskite quantum dot spectrometer beyond human visual resolution显示文摘The quantum dot spectrometer,fabricated by integrating different quantum dots with an image sensor to reconstruct the target spectrum from spectral-coupled measurements,is an emerging and promising hyperspectrometry technology with high resolution and a compact size.The spectral resolution and spectral range of quantum dot spectrometers have been limited by the spectral variety of the available quantum dots and the robustness of algorithmic reconstruction.Moreover,the spectrometer integration of quantum dots also suffers from inherent photoluminescence emission and poor batch-to-batch repeatability.In this work,we developed nonemissive in situ fabricated MA_(3)Bi_(2)X_(9) and Cs_(2)SnX_(6)(MA=CH_(3)NH_(3);X=Cl,Br,I)perovskite-quantum-dot-embedded films(PQDFs)with precisely tunable transmittance spectra for quantum dot spectrometer applications.The resulting PQDFs contain in situ fabricated perovskite nanocrystals with homogenous dispersion in a polymeric matrix,giving them advantageous features such as high transmittance efficiency and good batch-to-batch repeatability.By integrating a filter array of 361 kinds of PQDFs with a silicon-based photodetector array,we successfully demonstrated the construction of a perovskite quantum dot spectrometer combined with a compressive-sensing-based total-variation optimization algorithm.A spectral resolution of ~1.6 nm was achieved in the broadband of 250-1000 nm.The performance of the perovskite quantum dot spectrometer is well beyond that of human eyes in terms of both the spectral range and spectral resolution.This advancement will not only pave the way for using quantum dot spectrometers for practical applications but also significantly impact the development of artificial intelligence products,clinical treatment equipment,scientific instruments,etc. | Xiaoxiu Zhu Liheng Bian Hao Fu Lingxue Wang Bingsuo Zou Qionghai Dai Jun Zhang Haizheng Zhong | 2020 | Light(Science & Applications)2020，9，1： | 5 |
| 17 | Temperature dependence of pyro-phototronic effect on self-powered ZnO/perovskite heterostructured photodetectors显示文摘自我动力的 ZnO/perovskite heterostructured 紫外(紫外) 光电探测器(PD ) 最近作为的一个有希望的解决方案基于 pyro-phototronic 效果被报导了精力有效, ultrafast 反应,和高效的紫外 PD。在这研究,自我动力的 ZnO/perovskite heterostructured PD 的察觉到相片的表演上的 pyro-phototronic 效果的温度依赖被调查。到紫外光的这些 PD 的当前的回答被 174.1% 在 77 K 提高, 28.7% 在低温度在由于改进 pyro-phototronic 的 300 K 完成。pyro-phototronic 效果的基础被在紫外照明之上分析 chargetransfer 过程和 PD 的当前的反应的时间常数彻底地学习。这个工作在 ZnO/perovskite heterostructure 上关于 pyrophototronic 效果介绍深入的理解并且为 ultrafast 相片察觉到, optothermal 察觉,和 biocompatible optoelectronic 探针为相应光电子的设计和发展提供指导。 | Wenbo Peng Ruomeng Yu Xingfu Wang Zhaona Wang Haiyang Zou Yongning He Zhong Lin Wang | 2016 | Nano Research2016，9，12： | 5 |
| 18 | The pathologic relevance of metabolic criteria in patients with biopsy-proven nonalcoholic fatty liver disease and metabolic dysfunction associated fatty liver disease:A multicenter cross-sectional study in China显示文摘Background:This study aimed to assess the association between metabolic syndrome(Met S)and severity of nonalcoholic fatty liver disease(NAFLD),and to discuss the pathological relevance of the diagnostic criteria in metabolic(dysfunction)associated fatty liver disease(MAFLD).Methods:This was a multicenter,cross-sectional study.Patients with NAFLD confirmed by liver biopsy were enrolled between July 2016 and December 2018 from 14 centers across the mainland of China.Anthropometric and metabolic parameters were collected to assess the pathological relevance.Results:Of 246 enrolled patients with NAFLD,150(61.0%)had the comorbidity of Met S.With the increase of metabolic components,the proportions of nonalcoholic steatohepatitis(NASH)and significant fibrosis were notably increased.The comorbid three metabolic components significantly increased the proportion of NASH,and further increase of metabolic components did not increase the proportion of NASH.However,the increase of metabolic components was parallel to the increase of the proportion of liver fibrosis.Among the 246 patients,239(97.2%)met the diagnostic criteria of MAFLD.Although non-MAFLD patients had less NASH,they present with similar proportion of significant fibrosis and cirrhosis.In the diagnostic criteria of MAFLD,BMI≥23 kg/m2 was related to NASH(Mantel-Haenszel Common Estimate OR:2.975;95%CI:1.037–8.538;P=0.043),and T2 DM was related to significant fibrosis(Mantel-Haenszel Common Estimate OR:2.531;95%CI:1.388–4.613;P=0.002).The homeostasis model assessment of insulin resistance(HOMA-IR)≥2.5 was the most significant factor for NASH(OR:4.100;95%CI:1.772–9.487;P=0.001)and significant factor for liver fibrosis(OR:2.947;95%CI:1.398–6.210;P=0.004)after the adjustments of the BMI and diabetes.Conclusions:Metabolic dysregulations are important risk factors in NAFLD progression.The insulin resistance status may play a predominant role in the progression in MAFLD patients. | Rui-Xu Yang Zheng-Sheng Zou Bi-Hui Zhong Hong Deng Fang-Ping He Jun-Ping Shi Cai-Yan Zhao Yu-Qiang Mi Yong-Jian Zhou Fu-Sheng Di Rui-Dan Zheng Qin Du Jia Shang Branko Popovic Jin Jun Chen Jian-Gao Fan | 2021 | Hepatobiliary & Pancreatic Diseases International2021，20，5： | 5 |
| 19 | Oxide dispersion strengthened stainless steel 316L with superior strength and ductility by selective laser melting显示文摘Dense oxide dispersion strengthened(ODS) 316 L steels with different amount of Y2O3 additions were succe s s fully fabricated by selective laser melting(SLM) even though part of the added Y2O3 got lost during the process.The microstructure was characterized in details and the mechanical properties were tested at room temperature,250℃ and 400℃,respectively.The effect of the scanning speed on agglomeration of nanoparticles during SLM process was discussed.Superior properties,e.g.,yield strength of 574 MPa and elongation of 91%,were achieved at room temperature in SLM ODS 316 L with additional 1% of Y2 O3.At elevated temperature s,the strength kept high but the elongations dropped dra matically.It was observed that nano-voids nucleated throughout the whole gauge section at the sites where nanoinclusions located.The growth and coalescence of these voids were suppre s sed by the formation of an element segregation network before necking,which relieved local stress concentration and thus delayed necking.This unusual necking behavior was studied and compared to the previous theory.It appeared that the strong convection presented in the melt pool can evenly redistribute the short-time milled coarse Y2O3 precursor powder during SLM process.These findings can not only solve the problems encountered during the fabrication of ODS components but also replenish the strengthening mechanism of SLM 316 L thus pave a way for further improving of mechanical properties. | Yuan Zhong Leifeng Liu Ji Zou Xiaodong Li Daqing Cui Zhijian Shen | 2020 | Journal of Materials Science & Technology2020，42，7： | 5 |
| 20 | Imaging energetic electron spectrometer onboard a Chinese navigation satellite in the inclined GEO orbit显示文摘The energetic electron measurement is one of the most important issues to understand dynamics in space physics and the applications for space weather. In this study, the principle and functional components of the imaging energetic electron spectrometer(IES) onboard a Chinese navigation satellite in the inclined GEO orbit(IGSO) was introduced. The IES instrument is developed by the team in Peking University(BeiDa), thus it is named as BD-IES. Based on the pin-hole technique, the instrument can measure 50–600 keV electrons incident from 9 directions over a range of 180° in polar angle. With pulse height analysis(PHA), the spectrum can be determined for each direction. The energy and angular calibrations were performed, which show the good energy and angular characteristics of BD-IES. Monte Carlo simulations show that the anti-proton design of BDIES can effectively decrease the proton contamination on the electron measurements in the inclined GEO orbit. The primary results of BD-IES verify the successful design of this instrument. | ZOU Hong YE YuGuang ZONG QiuGang CHEN HongFei ZOU JiQing CHEN Jiang SHI WeiHong YU XiangQian ZHONG WeiYing WANG YongFu ZHOU XuZhi HAO YiXin CHEN XingRan JIA XiangHong XU Feng SHAO SiPei WANG Bo HAO XiaoYun ZHANG XiaoXin | 2018 | Science China(Technological Sciences)2018，61，12： | 5 |
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