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| 1 | Genotypic Characterization of Methicillin-resistant Staphylococcus aureus Isolated from Pigs and Retail Foods in China显示文摘Objective To investigate the genotypic diversity of Methicillin-resistant Staphylococcus aureus(MRSA) isolated from pigs and retail foods from different geographical areas in China and further to study the routes and rates of transmission of this pathogen from animals to food. Methods Seventy-one MRSA isolates were obtained from pigs and retail foods and then characterized by multi-locus sequencing typing(MLST), spa typing, multiple-locus variable number of tandem repeat analysis(MLVA), pulsed-field gel electrophoresis(PFGE), and antimicrobial susceptibility testing. Results All isolated MRSA exhibited multi-drug resistance(MDR). Greater diversity was found in food-associated MRSA(7 STs, 8 spa types, and 10 MLVA patterns) compared to pig-associated MRSA(3 STs, 1 spa type, and 6 MLVA patterns). PFGE patterns were more diverse for pig-associated MRSA than those of food-associated isolates(40 vs. 11 pulse types). Among the pig-associated isolates, CC9-ST9-t899-MC2236 was the most prevalent clone(96.4%), and CC9-ST9-t437-MC621(20.0%) was the predominant clone among the food-associated isolates. The CC9-ST9 isolates showed significantly higher antimicrobial resistance than other clones. Interestingly, CC398-ST398-t034 clone was identified from both pig-and food-associated isolates. Of note, some community-and hospital-associated MRSA strains(t030, t172, t1244, and t4549) were also identified as food-associated isolates. Conclusion CC9-ST9-t899-MC2236-MDR was the most predominant clone in pigs, but significant genetic diversity was observed in food-associated MRSA. Our results demonstrate the great need for improved surveillance of MRSA in livestock and food and effective prevention strategies to limit MDR-MRSA infections in China. | WANG Wei LIU Feng ZULQARNAIN Baloch ZHANG Cun Shan MA Ke PENG Zi Xin YAN Shao Fei HU Yu Jie GAN Xin DONG Yin Ping BAI Yao LI Feng Qin YAN Xiao Mei MA Ai Guo XU Jin | 2017 | Biomedical and Environmental Sciences2017，30，8： | 13 |
| 2 | Association between Plasma Metal Levels and Diabetes Risk: a Case-control Study in China显示文摘Objective Many metals, some of which have been classified as environmental endocrine disruptors, are used extensively in everyday consumer products and are ubiquitous in our living environment. In the present study, we aimed to explore the associations between the prevalence risk of type 2 diabetes and plasma levels of 20 trace elements as well as those of heavy metals in a Han Chinese population. Methods We conducted a case-control study to investigate the associations between plasma concentrations of 20 metals and diabetes in Jiangsu province. A total of 122 newly diagnosed cases of type 2 diabetes and 429 matched controls were recruited from community physical examinations in Suzhou City of Jiangsu Province. Plasma metal levels were measured by inductively-coupled plasma mass spectrometry. Results After adjusting for confounders, plasma vanadium, chromium, manganese, copper, zinc, arsenic, selenium, strontium, palladium, cadmium, cesium, and barium were associated with diabetes risk(P < 0.05). The adjusted OR increased with increasing concentration of vanadium, manganese, copper, zinc, and cesium. Conclusion Many metals, including manganese, copper, zinc, arsenic, selenium, and cadmium in plasma, are associated with the morbidity of diabetes. Monitoring of environmental metal levels and further studies are urgently needed. | LI Xiu Ting YU Peng Fei GAO Yan GUO Wen Hui WANG Jun LIU Xin GU Ai Hua JI Gui Xiang DONG Qiu WANG Bo Shen CAO Ying ZHU Bao Li XIAO Hang | 2017 | Biomedical and Environmental Sciences2017，30，7： | 8 |
| 3 | Hijacking antibody-induced CTLA-4 lysosomal degradation for safer and more effective cancer immunotherapy显示文摘It remains unclear why the clinically used anti-CTLA-4 antibodies, popularly called checkpoint inhibitors, have severe immunotherapy-related adverse effects (irAEs) and yet suboptimal cancer immunotherapeutic effects (CITE). Here we report that while irAE-prone Ipilimumab and TremeIgG1 rapidly direct cell surface CTLA-4 for lysosomal degradation, the non-irAE-prone antibodies we generated, HL12 or HL32, dissociate from CTLA-4 after endocytosis and allow CTLA-4 recycling to cell surface by the LRBA-dependent mechanism. Disrupting CTLA-4 recycling results in robust CTLA-4 downregulation by all anti-CTLA-4 antibodies and confers toxicity to a non-irAE-prone anti-CTLA-4 mAb. Conversely, increasing the pH sensitivity of TremeIgG1 by introducing designed tyrosine-to-histidine mutations prevents antibody-triggered lysosomal CTLA-4 downregulation and dramatically attenuates irAE. Surprisingly, by avoiding CTLA-4 downregulation and due to their increased bioavailability, pH-sensitive anti-CTLA-4 antibodies are more effective in intratumor regulatory T-cell depletion and rejection of large established tumors. Our data establish a new paradigm for cancer research that allows for abrogating irAE while increasing CITE of anti-CTLA-4 antibodies. | Yan Zhang Xuexiang Du Mingyue Liu Fei Tang Peng Zhang Chunxia Ai James K. Fields Eric J. Sundberg Olga S. Latinovic Martin Devenport Pan Zheng Yang Liu | 2019 | Cell Research2019，29，8： | 6 |
| 4 | Towards a global One Health index: a potential assessment tool for One Health performance显示文摘Background:A One Health approach has been increasingly mainstreamed by the international community, as it provides for holistic thinking in recognizing the close links and inter-dependence of the health of humans, animals and the environment. However, the dearth of real-world evidence has hampered application of a One Health approach in shaping policies and practice. This study proposes the development of a potential evaluation tool for One Health performance, in order to contribute to the scientific measurement of One Health approach and the identification of gaps where One Health capacity building is most urgently needed.Methods:We describe five steps towards a global One Health index (GOHI), including (i) framework formulation;(ii) indicator selection;(iii) database building;(iv) weight determination;and (v) GOHI scores calculation. A cell-like framework for GOHI is proposed, which comprises an external drivers index (EDI), an intrinsic drivers index (IDI) and a core drivers index (CDI). We construct the indicator scheme for GOHI based on this framework after multiple rounds of panel discussions with our expert advisory committee. A fuzzy analytical hierarchy process is adopted to determine the weights for each of the indicators.Results:The weighted indicator scheme of GOHI comprises three first-level indicators, 13 second-level indicators, and 57 third-level indicators. According to the pilot analysis based on the data from more than 200 countries/territories the GOHI scores overall are far from ideal (the highest score of 65.0 out of a maximum score of 100), and we found considerable variations among different countries/territories (31.8–65.0). The results from the pilot analysis are consistent with the results from a literature review, which suggests that a GOHI as a potential tool for the assessment of One Health performance might be feasible.Conclusions:GOHI—subject to rigorous validation—would represent the world’s first evaluation tool that constructs the conceptual framework from a holistic perspective of One Health. Future application of GOHI might promote a common understanding of a strong One Health approach and provide reference for promoting effective measures to strengthen One Health capacity building. With further adaptations under various scenarios, GOHI, along with its technical protocols and databases, will be updated regularly to address current technical limitations, and capture new knowledge. | Xiao-Xi Zhang Jing-Shu Liu Le-Fei Han Shang Xia Shi-Zhu Li Odel YLi Kokouvi Kassegne Min Li Kun Yin Qin-Qin Hu Le-Shan Xiu Yong-Zhang Zhu Liang-Yu Huang Xiang-Cheng Wang Yi Zhang Han-Qing Zhao Jing-Xian Yin Tian-Ge Jiang Qin Li Si-Wei Fei Si-Yu Gu Fu-Min Chen Nan Zhou Zi-Le Cheng Yi Xie Hui-Min Li Jin Chen Zhao-Yu Guo Jia-Xin Feng Lin Ai Jing-Bo Xue Qian Ye Liz Grant Jun-Xia Song Geoff Simm Jürg Utzinger Xiao-Kui Guo Xiao-Nong Zhou | 2022 | Infectious Diseases of Poverty2022，11，3： | 3 |
| 5 | Optimal Waist Circumference Cut-off values for Identifying Metabolic Risk Factors in Middle-aged and Elderly Subjects in Shandong Province of China显示文摘Objective To study the optimal waist circumference(WC) cut-off values for identifying metabolic risk factors in middle-aged and elderly subjects in Shandong Province of China. Methods A total of 2 873 men and 5 559 women were included in this cross-sectional study. Metabolic syndrome(MetS) was diagnosed according to the definition of Chinese Diabetes Society in 2004. The relation between WC and MetS was analyzed by multivariate logistic regression analysis. The optimal WC cut-off values were identified using the area under the ROC curve and the different diagnostic criteria for central obesity were compared. Results The WC was the risk factor for MetS independent of BMI, blood glucose, blood lipid, and blood pressure. The optimal WC cut-off value was 83.8 cm and 91.1 cm for identifying MetS in women and men, respectively. Compared with 80 cm and 85 cm for women and men, 85 cm and 90 cm had a higher Youden index for identifying all metabolic risk factors and MetS in women and men. Conclusion The appropriate WC cut-off value is 85 cm and 90 cm for identifying central obesity and MetS in women and men in Shandong Province of China. | HOU Xin Guo WANG Chuan MA Ze Qiang YANG Wei Fang WANG Ji Xiang LI Cheng Qiao WANG Yu Lian LIU Shu Min Hu Xiu Ping ZHANG Xiu Ping JIANG Mei WANG Wei Qing NING Guang ZHENG Hui Zhen MA Ai Xia SUN Yu SONG Jun LIN Peng LIANG Kai LIU Fu Qiang LI Wen Juan XIAO Juan GONG Lei WANG Mei Jian LIU Ji Dong YAN Fei YANG Jun Peng WANG Ling Shu TIAN Meng ZHAO Ru Xing JIANG Ling CHEN Li | 2014 | Biomedical and Environmental Sciences2014，27，5： | 3 |
| 6 | MRI findings in injured articular cartilage of the knee correlated with surgical findings显示文摘在那里的背景是对快 noninvasive 的强壮的需要能可靠地给软骨的地位的有效估计的诊断技术,从这研究的损害 cartilage.The 目标的各种各样的等级区别未经触动的软骨是估计膝软骨损害的发生并且比较二尺寸的旋转回响( 2D SE )和快旋转回响( FSE )(常规 MRI )的精确性,三维的宠坏的坡度回响( 3D SPGR ),采用稳定的州的 acquisit | LI Xiao-ming PENG Wen-jia WU Hua Kacher Daniel XIA Li-ming AI Fei LI Feng XIONG Wei | 2009 | Chinese Medical Journal2009，，21： | 3 |
| 7 | Preparation of magnetic anion exchange resin and their adsorption kinetic behavior of reactive blue显示文摘磁性的阴离子交换树脂(MD-1 ) 从磁性的 copolymeric 树脂(glycidyl methacrylate-co-divinylbenzene ) 的 quaternization 被准备。为比较,没有 quaternization 和无磁性的树脂(D-1 ) 的磁性的树脂 MD-0 也为吸附过程被综合。吸附主要被贡献,这被发现在第四级的铵组和反应蓝 RXHC 之间的化学相互作用。由于更小的尺寸, MD-1 比 D-1 有更快的吸附和解吸附作用动力学。结合了容易的分离的优点,磁性的阴离子交换树脂被认为比在反应染料的移动的普通阴离子交换树脂优异。 | Chen Dong Shuang Feng Yang Fei Pan Qing Zhou Wei Ben Yang Ai Min Li | 2011 | Chinese Chemical Letters2011，22，9： | 3 |
| 8 | Triple-transforming gel prepared byβ-cyclodextrin,diphenylamine and lithium chloride in N,N-dimethylacetamide显示文摘这份报纸第一次描述一个三倍转变的胶化系统(gelsolgel ) ,它是一 thermo 应答并且多部件 organogel 由 -cyclodextrin 准备了(-CD), 二苯胺(DPA ) 和在 N 的锂氯化物(LiCl ) ,在一个合适的比例的 N-dimethylacetamide (DMAC ) 基于超分子的相互作用。在三倍转变的胶化系统,胶化(胶化 A )能被-CD, DPA 和 LiCl 在房间温度在 DMAC 形成基于激动人心,然后,胶化能基于加热转变成一个清楚的解决方案,然后另外的胶化(胶化 B )能在相对高的温度被形成( Tgel ,由加热的冻结温度)。在三倍转变的胶化系统的二个胶化状态有不同微观结构。这个胶化系统被 OM, SEM,红外和流变学描绘。 | Yuan Yuan Li Wen Jing Zhao Hua Cheng Zhang Tao Sun Wei An Fei Fei Xin Ai You Hao | 2010 | Chinese Chemical Letters2010，21，10： | 3 |
| 9 | Evaluating the Quality of Case-control Studies involving the Association between Tobacco Exposure and Diseases in a Chinese Population based on the Newcastle-Ottawa Scale and Post-hoc Power显示文摘According to the 2017 Global Burden of Disease Study,smoking is among the four leading risk factors contributing to deaths and disability-adjusted life years(DALYs)in China.In the past 20 years,there has been a substantial increase in the number of studies focusing on the association between tobacco exposure and disease. | SHI Yu Lin ZHAO Jian AI Fei Ling WANG Yu Tong HU Kui Ru WANG Xue Wei YANG Wen Yi WANG Jing Xin AI Li Mei WAN Xia | 2022 | Biomedical and Environmental Sciences2022，35，9： | 2 |
| 10 | Vanadium-based metal-organic frameworks and their derivatives for electrochemical energy conversion and storage显示文摘With the excessive consumption of nonrenewable resources,the exploration of effective and durable materials is highly sought after in the field of sustainable energy conversion and storage system.In this aspect,metalorganic frameworks(MOFs)are a new class of crystalline porous organicinorganic hybrid materials.MOFs have recently been gaining traction in energy-related fields.Owing to the coordination flexibility and multiple accessible oxidation states of vanadium ions or clusters,vanadium-MOFs(V-MOFs)possess unique structural characteristics and satisfactory electrochemical properties.Furthermore,V-MOFs-derived materials also exhibit superior electrical conductivity and stability when used as electrocatalysts and electrode materials.This review summarizes the research progress of V-MOFs(inclusive of pristine V-MOFs,V/M-MOFs,and POVbased MOFs)and their derivatives(vanadium oxides,carbon-coated vanadium oxide,vanadium phosphate,vanadate,and other vanadium doped nanomaterials)in electrochemical energy conversion(water splitting,oxygen reduction reaction)and energy storage(supercapacitor,rechargeable battery).Future possibilities and challenges for V-MOFs and their derivatives in terms of design and synthesis are discussed.Lastly,their applications in energy-related fields are also highlighted. | Jing Zhu Xiaoyu Chen Ai Qin Thang Fei‐Long Li Dong Chen Hongbo Geng Xianhong Rui Qingyu Yan | 2022 | SmartMat2022，3，3： | 2 |
| 11 | Environmental Monitoring of A Laboratory for New Coronavirus Nucleic Acid Testing显示文摘The coronavirus disease 2019(COVID-19) is an infection of the respiratory tract which first broke out in Wuhan, China, in December 2019. The etiologic agent of this disease was identified as a betacoronavirus related to severe acute respiratory syndrome coronavirus(SARS-CoV). Thus, the International Committee on Virus Classification named the new coronavirus severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)[1]. | NING Pei Yong YU Ai Ping WANG Yuan GUO Li Ru SHAN Dan KONG Mei YU Ling Qi LYU Li Kun ZOU Ming SU Xu FEI Chun Nan ZHOU Yu Hui WANG Bai Qi | 2020 | Biomedical and Environmental Sciences2020，33，10： | 2 |
| 12 | Hydrochloric acid enhanced radiofrequency ablation for treatment of large hepatocellular carcinoma in the caudate lobe:Report of three cases显示文摘BACKGROUND To report on the use of percutaneous hydrochloric acid(HCl) enhanced radiofrequency ablation(HRFA) for the treatment of large(maximum diameter ≥5 cm) hepatocellular carcinoma(HCC) in the caudate lobe.CASE SUMMARY Between August 2013 and June 2016, three patients with a large HCC(maximum diameter: 5.0, 5.7, and 8.1 cm) in the caudate lobe were treated by transarterial chemoembolization followed by computer tomography(CT) guided RFA using a monopolar perfusion RF electrode, which was enhanced by local infusion of 10%HCl at 0.2 mL/min(total volume, 3 to 12 mL). The output power of HRFA reached 100 W, and the average ablation time was 39 min(range, 15 to 60 min).Two patients each underwent one session of HRFA and one patient two sessions.After treatment, CT/magnetic resonance imaging showed that all the three lesions were completely ablated. There was no major complication. Two patients had asymptomatic bile duct dilatation. One patient died of tongue cancer 24 mo after ablation. The remaining two patients were alive and no area of enhancement is detected in the caudate lobe at 28 and 60 mo after ablation, respectively.CONCLUSION Percutaneous CT-guided HRFA is safe and efficacious in treating large HCC in the caudate lobe. | Han-Xia Deng Jin-Hua Huang Wan Yee Lau Fei Ai Min-Shan Chen Zhi-Mei Huang Tian-Qi Zhang Meng-Xuan Zuo | 2019 | World Journal of Clinical Cases2019，7，4： | 2 |
| 13 | Morphologies of solid-liquid interface and surface steps during rapid growth of BaB_2O_4 single crystals显示文摘The evolution of solid-liquid interface during BBO single crystal growth was stud- ied by the differential interference microscopy. And the step morphology on (0001) surface of the as-grown crystal was observed by the atomic force microscopy as well. It was found that the transition from a flat solid-liquid interface to a skeletal shape will occur in case of rapid growth. However, AFM images of surface steps revealed morphology differences correlated with crystallographic directions. The steps advancing along <1010 > direction form the step flow, whereas those steps propagating along <0110 > direction shape into step segments. Measurements of step heights by AFM indicated that it is the high anisotropy of the dimension of growth unit and step bunching due to the enlargement of concentration difference along the surface that results in the anisotropy of step morphologies. | PAN XiuHong, AI Fei, JIN WeiQing, LIU Yan & ZHANG Ying Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China | 2007 | Science China(Physics,Mechanics & Astronomy)2007，50，4： | 2 |
| 14 | Two new furostanol saponins from the seeds of Allium cepa L.显示文摘从瞀或蒜之类 cepa L 的种子的 n-BuOH 摘录的 Phytochemical 分析。导致了四 furostanol saponins,其二是新混合物,命名 ceparoside A (1a ) 和 ceparoside B (2a ) 的隔离。新混合物的化学结构通过 NMR 的联合被阐明, MS 光谱数据和化学分析。 | Ling Yuan Teng Fei Ji Ai Guo Wang Jian Bo Yang Ya Lun Su | 2008 | Chinese Chemical Letters2008，19，4： | 2 |
| 15 | 显示文摘 | Fei B Chen C Peng S et ai | 2004 | Polymer Inter-national2004，53，12： | 1 |
| 16 | Clinical evaluation of single-shot and readout-segmented diffusion weighted imaging in stroke patients at 3T显示文摘 | Morelli J Porter D Ai Fei | | 0，，3： | 1 |
| 17 | A Novel Millimeter-Wave Channel Measurement Platform for 6G Intelligent Railway Scenarios显示文摘This paper presented a novel millimeterwave channel measurement platform for the 6G intelligent railway.This platform used phased array antenna with 64 elements and can support instant bandwidth up to 1 GHz.Combined with improved multi-tone sounding signals,the platform can enhance dynamic measurement capability in high-speed railway scenarios.We performed calibration works about frequency flatness,frequency offset and proved platform reliability with channel emulator based closed-loop verification.We also carried out field trials in high-speed railway carriage scenarios.Based on measurement results,we extracted channel characteristic parameters of path loss,power delay profile and delay spread to further verify the field measurement performance of the platform. | Dan Fei Chen Chen Peng Zheng Dongsheng Zhang Jingya Yang Haoran Chen Bo Ai | 2022 | China Communications2022，19，11： | 1 |
| 18 | Effects of tsaoko (Fructus tsaoko) cultivating on tree diversity and canopy structure in the habitats of eastern hoolock gibbon (Hoolock leuconedys)显示文摘In this study, the quadrat method was used to study the effects of tsaoko(Fructus tsaoko) plantation on tree diversity and canopy structure of two natural habitats of eastern hoolock gibbon(Hoolock leuconedys): Nankang(characterized by extensive tsaoko plantation) and Banchang(relatively well reserved and without tsaoko plantation). Totally, 102 tree species from 25 families and 16 woody liana species from 10 families were recorded in Nankang, whereas 108 tree species from 30 families and 17 woody liana species from 12 families were recorded in Banchang. Although the tree species between two habitats is different, both habitats are characterized by enriched food resources for eastern hoolock gibbons, sharing similar dominant plant families. Due to tsaoko plantation, tree density proportion and diversity of forest layerⅠ(>20 m) in Nankang were both significantly decreased, but the tree density of layerⅡ(10-20 m) increased. Likewise, in conjunction with these behavioral observations, we also address potential impacts of tsaoko plantation on the behavior of eastern hoolock gibbon. | Sheng-Dong YUAN Han-Lan FEI Shao-Han ZHU Liang-Wei CUI Huai-Sen AI Peng-Fei FAN | 2014 | Zoological Research2014，35，3： | 1 |
| 19 | The Retrospective Diagnostic Potential of Gene Xpert MTB/RIF for the Analysis of Formalin-Fixed Paraffin-Embedded Tissue from Extrapulmonary Tuberculosis Patients显示文摘Tuberculosis(TB)is a chronic disease caused by infection with Mycobacterium tuberculosis.Laboratory confirmation of this infection is challenging due to the paucibacillary nature of extrapulmonary tuberculosis(EPTB). | JIA Qing Jun ZENG Mei Chun CHENG Qing Lin HUANG Yin Yan WU Yi Fei LI Qing Chun WANG Le AI Li Yun FANG Zi Jian CHENG Shi SHU Li Ping | 2023 | Biomedical and Environmental Sciences2023，36，3： | 1 |
| 20 | Efficient separation of phenols from coal tar with aqueous solution of amines by liquid-liquid extraction显示文摘In this paper,a method of extracting phenols from coal tar by amines aqueous solution was proposed.The effects of various amines on the extraction properties of phenols in coal tar were researched from the views of molecular structure.The parameters such as molar ratio,concentration,extraction time and temperature for the extraction of coal tar by the monoethanolamine and ethylenediamine aqueous solution were examined.The results show that the organic amine with more amino groups,hydroxyl structure and strong electronegativity exhibited better extraction performance.Under the optimal conditions,the extraction yields of phenols in coal tar by the monoethanolamine or ethylenediamine aqueous solution are above 80%,and the recovery yields of amines reach 99%.Furthermore,the probable geometries of complexes formed by the combination of phenols and organic amines were calculated by density function theory.In addition,several thermodynamic models were evaluated through comparing the relative deviation of simulation results by ASPEN PLUS to the experimental ones,which provide feasibility thermodynamic models for the simulation of extraction process.The present work affords a mild,efficient and green approach for the extraction of phenols from coal tar by an aqueous solution of amines in industry application. | Yonglin Li He'an Luo Qiuhong Ai Kuiyi You Fei Zhao Wenlong Xiao | 2021 | Chinese Journal of Chemical Engineering2021，34，7： | 1 |
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