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| 1 | Carbon dioxide insufflation during colonoscopy in deeply sedated patients显示文摘AIM:To compare the impact of carbon dioxide(CO2) and air insufflation on patient tolerance/safety in deeply sedated patients undergoing colonoscopy.METHODS:Patients referred for colonoscopy were randomized to receive either CO2 or air insufflation during the procedure.Both the colonoscopist and patient were blinded to the type of gas used.During the procedure,insertion and withdrawal times,caecal intubationrates,total sedation given and capnography readings were recorded.The level of sedation and magnitude of patient discomfort during the procedure was assessed by a nurse using a visual analogue scale(VAS)(0-3).Patients then graded their level of discomfort and abdominal bloating using a similar VAS.Complications during and after the procedure were recorded.RESULTS:A total of 142 patients were randomized with 72 in the air arm and 70 in the CO2 arm.Mean age between the two study groups were similar.Insertion time to the caecum was quicker in the CO2 group at 7.3 min vs 9.9 min with air(P = 0.0083).The average withdrawal times were not significantly different between the two groups.Caecal intubation rates were 94.4% and 100% in the air and CO2 groups respectively(P = 0.012).The level of discomfort assessed by the nurse was 0.69(air) and 0.39(CO2)(P = 0.0155) and by the patient 0.82(air) and 0.46(CO2)(P = 0.0228).The level of abdominal bloating was 0.97(air) and 0.36(CO2)(P = 0.001).Capnography readings trended to be higher in the CO2 group at the commencement,caecal intubation,and conclusion of the procedure,even though this was not significantly different when compared to readings obtained during air insufflation.There were no complications in both arms.CONCLUSION:CO2 insufflation during colonoscopy is more efficacious than air,allowing quicker and better cecal intubation rates.Abdominal discomfort and bloating were significantly less with CO2 insufflation. | Rajvinder Singh Eu Nice Neo Nazree Nordeen Ganesananthan Shanmuganathan Angelie Ashby Sharon Drummond Garry Nind Elizabeth Murphy Andrew Luck Graeme Tucker William Tam | 2012 | World Journal of Gastroenterology2012，18，25： | 3 |
| 2 | CD133 expression is not restricted to stem cells, and both CD133^sup +^ and CD133^sup -^ metastatic colon cancer cells initiate tumors显示文摘 | Shmelkov Sergey V Butler Jason M Hooper Andrea T Hormigo Adilia Kushner Jared Milde Till Clair Ryan St Baljevic Muhamed White Ian Jin David K Chadburn Amy Murphy Andrew J Valenzuela David M Gale Nicholas W Thurston Gavin Yancopoulos George | 2008 | Journal of Clinical Investigation2008，，： | 2 |
| 3 | Multicenter experience using simeprevir and sofosbuvir with or without ribavirin to treat hepatitis C genotype 1 after liver transplant显示文摘 | Surakit Pungpapong Bashar Aqel Michael Leise K. Tuesday Werner Jennifer L. Murphy Tanisha M. Henry Kristen Ryland Amy E. Chervenak Kymberly D. Watt Hugo E. Vargas Andrew P. Keaveny | 2015 | Hepatology2015，，6： | 2 |
| 4 | RORγ-Expressing Th17 Cells Induce Murine Chronic Intestinal Inflammation via Redundant Effects of IL-17A and IL-17F显示文摘 | Moritz Leppkes Christoph Becker Ivaylo I. Ivanov Sebastian Hirth Stefan Wirtz Clemens Neufert Sandrine Pouly Andrew J. Murphy David M. Valenzuela George D. Yancopoulos Burkhard Becher Dan R. Littman Markus F. Neurath | 2009 | Gastroenterology2009，，1： | 2 |
| 5 | Expression of the Chemokine Receptors CCR4, CCR5, and CXCR3 by Human Tissue-Infiltrating Lymphocytes显示文摘 | Eric J. Kunkel Judie Boisvert Kristine Murphy Mark A. Vierra Mark C. Genovese Andrew J. Wardlaw Harry B. Greenberg Martin R. Hodge Lijun Wu Eugene C. Butcher James J. Campbell | 2002 | The American Journal of Pathology2002，，1： | 2 |
| 6 | TIMI Risk Score for ST-Elevation Myocardial Infarction: A Convenient, Bedside, Clinical Score for Risk Assessment at Presentation: An Intravenous nPA for Treatment of Infarcting Myocardium Early II Trial Substudy显示文摘 | David A. Morrow Elliott M. Antman Andrew Charlesworth Richard Cairns Sabina A. Murphy James A. de Lemos Robert P. Giugliano Carolyn H. McCabe Eugene Braunwald | 2000 | Circulation: Journal of the American Heart Association2000，，17： | 2 |
| 7 | Interleukin-22 but Not Interleukin-17 Provides Protection to Hepatocytes during Acute Liver Inflammation显示文摘 | Lauren A. Zenewicz George D. Yancopoulos David M. Valenzuela Andrew J. Murphy Margaret Karow Richard A. Flavell | 2007 | Immunity2007，，4： | 2 |
| 8 | Designing a Core IT Artefact for Knowledge Manage- ment Systems using Participatory Action Research in a Govern- ment and a non-government Organisation显示文摘 | Tom Butler Joseph Feller Andrew Pope Bill Emerson Ciaran Murphy | 2008 | Journal of Strate- gic Information Systems2008，，17： | 1 |
| 9 | The Toxicology of Perfluorooctanoate显示文摘 | Gerald L. Kennedy John L. Butenhoff Geary W. Olsen John C. O’Connor Andrew M. Seacat Roger G. Perkins Lisa B. Biegel Sandra R. Murphy David G. Farrar | 2004 | Critical Reviews in Toxicology2004，，4： | 1 |
| 10 | Grounding the virtual: The material effects of electronic grocery shopping显示文摘 | Andrew J. Murphy | 2007 | Geoforum2007，，5： | 1 |
| 11 | Deficiency of ATP-Binding Cassette Transporters A1 and G1 in Macrophages Increases Inflammation and Accelerates Atherosclerosis in Mice显示文摘 | Marit Westerterp Andrew J. Murphy Mi Wang Tamara A. Pagler Yuliya Vengrenyuk Mojdeh S. Kappus Darren J. Gorman Prabhakara R. Nagareddy Xuewei Zhu Sandra Abramowicz John S. Parks Carrie Welch Edward A. Fisher Nan Wang Laurent Yvan-Charvet Alan R. Tall | 2013 | Circulation Research2013，，11： | 1 |
| 12 | Misdiagnosis of the vege?tative state: retrospective study in a rehabilitation unit显示文摘 | Andrews K Murphy L Munday R | 1996 | BMJ1996，313，： | 1 |
| 13 | A Mitochondria-Targeted Macrocyclic Mn(II) Superoxide Dismutase Mimetic显示文摘 | Geoffrey F. Kelso Andrej Maroz Helena M. Cochemé Angela Logan Tracy A. Prime Alexander V. Peskin Christine C. Winterbourn Andrew M. James Meredith F. Ross Sally Brooker Carolyn M. Porteous Robert F. Anderson Michael P. Murphy Robin A.J. Smith | 2012 | Chemistry & Biology2012，，10： | 1 |
| 14 | Open Versus Laparoscopic Pyloromyotomy for Pyloric Stenosis: A Prospective, Randomized Trial显示文摘 | Shawn D. St. Peter George W. Holcomb Casey M. Calkins J Patrick Murphy Walter S. Andrews Ronald J. Sharp Charles L. Snyder Daniel J. Ostlie | 2006 | Annals of Surgery2006，，3： | 1 |
| 15 | A Fenton-like Reaction to Neutralize For maldehyde wasterwater 显示文摘 | Murphy W J Boegliv M | 1989 | Environ sci Techno1989，23，2： | 1 |
| 16 | Transected dorsal column axons within the guinea pig spinal cord regene-rate in the presence of an applied electric field显示文摘 | Richard BB Andrew RB Murphy DJ | 1986 | J Comp Neurol1986，250，： | 1 |
| 17 | Activation of metallothionein gene expression by hypoxia involves metal response elements and metal transcription factor- l显示文摘 | Murphy B J Andrews G K Bittel D | 1999 | Cancer Research1999，59，6： | 1 |
| 18 | Geographies of food: ’Afters’显示文摘 | Cook Ian Hobson Kersty Hallett Lucius Guthman Julie Murphy Andrew Hulme Alison Sheller Mimi Crewe Louise Nally David Roe Emma Mather Charles Kingsbury Paul Slocum Rachel Imai Shoko Duruz Jean Philo Chris Buller Henry Goodman Mike Hayes-C | 2011 | Progress in Human Geography2011，，1： | 1 |
| 19 | Crawley Reduced aggression in mice lacking the serotonin transporter显示文摘 | ANDREW HOLMES DENNIS L MURPHY JACQUELINE N | 2002 | Psychopharmacology2002，16，1： | 1 |
| 20 | SIRT4 Inhibits Glutamate Dehydrogenase and Opposes the Effects of Calorie Restriction in Pancreatic β Cells显示文摘 | Marcia C. Haigis Raul Mostoslavsky Kevin M. Haigis Kamau Fahie Danos C. Christodoulou Andrew J. Murphy David M. Valenzuela George D. Yancopoulos Margaret Karow Gil Blander Cynthia Wolberger Tomas A. Prolla Richard Weindruch Frederick W. Alt Leonard Guaren | 2006 | Cell2006，，5： | 1 |
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