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| 1 | The roles of MAPKs in disease显示文摘印射响应许多 ligands 和房间刺激涉及大量的细胞的小径和功能的家族 ases transduce 信号。MAPK 的异常或不恰当的功能现在在从癌症到煽动性的疾病到肥胖和糖尿病的疾病被识别了。在许多房间类型, MAPK ERK1/2 被连接到细胞增殖。因为在地岬和 B-Raf 的变化,能激活 ERK1/2 串联,在许多人的肿瘤被发现, ERK1/2 被认为在一些癌症起一个作用。发信号的反常 ERK1/2 也在 polycystic 肾疾病被发现了,并且象 cardio-facio-cutaneous 症候群那样的严肃的发展混乱在 ERK1/2 串联的部件从变化产生。ERK1/2 在区分得好的房间是必要的并且在神经原并且在上皮的极性的维护被连接了到长期的 potentiation。另外, ERK1/2 为在胰腺的贝它房间的胰岛素基因抄写是重要的,它响应传播葡萄糖的增加生产胰岛素在有机体允许有效葡萄糖利用和存储。导致或镇压的营养素和荷尔蒙胰岛素分泌物以在贝它房间上反映能分泌的需求的一种方式激活或禁止 ERK1/2。在这和另外的规章的小径的骚乱可以导致对某些人的混乱的病原学的 ERK1/2 的贡献。 | Michael C Lawrence Arif Jivan Chunli Shao Lingling Duan Daryl Goad Elma Zaganjor Jihan Osborne Kathleen McGlynn Steve Stippec Svetlana Earnest Wei Chen Melanie H Cobb | 2008 | Cell Research2008，18，4： | 64 |
| 2 | Effects of dietary supplementation of probiotic,Clostridium butyricum,on growth performance,immune response,intestinal barrier function,and digestive enzyme activity in broiler chickens challenged with Escherichia coli K88显示文摘Background:Colibacillosis caused by enterotoxigenic Escherichia coli(E.coli) results in economic losses in the poultry industry.Antibiotics are usually used to control colibacillosis,however,E.coli has varying degrees of resistance to different antibiotics.Therefore the use of probiotics is becoming accepted as an alternative to antibiotics.In this study,we evaluated the effects of Clostridium butyricum(C.butyricum) on growth performance,immune response,intestinal barrier function,and digestive enzyme activity in broiler chickens challenged with Escherichia coli(E.coif) K88.Methods:The chickens were randomly divided into four treatment groups for 28 days.Negative control treatment(NC) consisted of birds fed a basal diet without E.coli K88 challenge and positive control treatment(PC) consisted of birds fed a basal diet and challenged with E.coli K88.C.butyricum probiotic treatment(CB) consisted of birds fed a diet containing 2×10~7 cfu C butyricum/kg of diet and challenged with E.coli K88.Colistin sulfate antibiotic treatment(CS)consisted of birds fed a diet containing 20 mg colistin sulfate/kg of diet and challenged with E.coli K88.Results:The body weight(BW) and average day gain(ADG) in the broilers of CB group were higher(P< 0.05) than the broilers in the PC group overall except the ADG in the 14-21 d post-challenge.The birds in CB treatment had higher(P < 0.05) concentration of tumor necrosis factor-α(TNF-α) at 3 and 7 d post-challenge,and higher(P < 0.05)concentration of interleukin-4(IL-4) at 14 d post-challenge than those in the PC treatment group.The concentration of serum endotoxin in CB birds was lower(P<0.05) at 21 d post-challenge,and the concentrations of serum diamine oxidase in CB birds were lower(P < 0.05) at 14 and 21 d post-challenge than in PC birds.Birds in CB treatment group had higher(P< 0.05) jejunum villi height than those in PC,NC,or CS treatment at 7,14,and 21 d post-challenge.In comparison to PC birds,the CB birds had lower(P < 0.05) jejunum crypt depth during the whole experiment.The birds in CB or CS treatment group had higher(P < 0.05) activities of amylase and protease at 3,7,and 14 d post-challenge,and higher(P< 0.05) activity of lipase at 3,7 d post-challenge than PC birds.Conclusions:In all,these results indicate that dietary supplementation with C.butyricum promotes immune response,improves intestinal barrier function,and digestive enzyme activities in broiler chickens challenged with E.coli K88.There is no significant difference between the C.butyricum probiotic treatment and the colistin sulfate antibiotic treatment.Therefore,the C.butyricum probiotic may be an alternative to antibiotic for broiler chickens. | Ling Zhang Lingling Zhang Xiu'an Zhan Xinfu Zeng Lin Zhou Guangtian Cao An'guo Chen Caimei Yang | 2016 | Journal of Animal Science and Biotechnology2016，7，1： | 43 |
| 3 | Helicity dependent directional surface plasmon polariton excitation using a metasurface with interfacial phase discontinuity显示文摘Surface plasmon polaritons(SPPs)have been widely exploited in various scientific communities,ranging from physics,chemistry to biology,due to the strong confinement of light to the metal surface.For many applications,it is important that the free space photon can be coupled to SPPs in a controllable manner.In this Letter,we apply the concept of interfacial phase discontinuity for circularly polarizations on a metasurface to the design of a novel type of polarization-dependent SPP unidirectional excitation at normal incidence.Selective unidirectional excitation of SPPs along opposite directions is experimentally demonstrated at optical frequencies by simply switching the helicity of the incident light.This approach,in conjunction with dynamic polarization modulation techniques,opens gateway towards integrated plasmonic circuits with electrically reconfigurable functionalities. | Lingling Huang Xianzhong Chen Benfeng Bai Qiaofeng Tan Guofan Jin Thomas Zentgraf Shuang Zhang | 2013 | Light(Science & Applications)2013，2，1： | 31 |
| 4 | Pollution characteristics of organic and elemental carbon in PM_(2.5) in Xiamen,China显示文摘Xiamen,located on the southeastern coastal line of China,is undergoing rapid urbanization and industrialization,so its air quality has a trend of degradation.However,studies on level,temporal and spatial changes of fine particles (PM 2.5) and their carbonaceous fractions are scarce.In this article,abundance,sources,seasonal and spatial variations,distribution of organic carbon (OC) and elemental carbon (EC) in PM 2.5,were studied at suburban,urban and industrial sites in Xiamen during four season-representative months in 2009-2010.PM 2.5 samples were collected with middle volume sampler and were analyzed for OC and EC with thermal optical transmittance (TOT) method.Results showed that the annual average PM 2.5 concentrations were 63.88-74.80 μg/m 3 at three sites.While OC and EC concentrations were in the range of 15.81-19.73 μg/m 3 and 2.74-3.49 μg/m 3,respectively,and clearly presented the summerminima and winter maxima in this study.The carbonaceous aerosol accounted for 42.8%-47.3% of the mass of PM 2.5.The annual average of secondary organic carbon (SOC) concentrations in Xiamen were 9.23-11.36 μg/m 3,accounting for approximately 56% of OC.Strong correlations between OC and EC was found in spring (R 2=0.50) and autumn (R 2=0.73),suggesting that there were similar emission and transport processes for carbonaceous aerosols in these two seasons,while weak correlations were found in summer (R 2=0.33) and winter (R 2=0.41).The OC/EC ratios in PM 2.5 varied from 2.1 to 8.7 with an annual average of 5.7,indicating that vehicle exhaust,coal smoke and biomass burning were main source apportionments of carbonaceous fractions in Xiamen. | Fuwang Zhang Jinping Zhao Jinsheng Chen Ya Xu Lingling Xu | 2011 | Journal of Environmental Sciences2011，23，8： | 27 |
| 5 | Effect of maternal age on the outcomes of in vitro fertilization and embryo transfer(IVF-ET)显示文摘This is a retrospective,observational study to evaluate the effect of maternal age on the outcomes of in vitro fertilization and embryo transfer(IVF-ET).11830 IVF-ET cycles from 10268 women were included.Four groups of different maternal age periods were compared.The groups were 21 30 years old group(4549 cycles),31-35 years old group(4424 cycles),36-40 years old group(2429 cycles),and over 40 years old group(428 cycles).The mean starting dose of Gn and mean total dose of Gn in each cycle were significantly higher(P<0.01),while the mean retrieved oocyte number was significantly lower(P<0.01) in groups of higher maternal age period than those in each of the lower groups.The biochemical pregnancy rate and the clinical pregnancy rate were significantly lower(P<0.01),while the miscarriage rate was significantly higher(P<0.01) in groups of higher maternal age period than those in the lower groups.No difference was found in two-pronuclear zygotes(2PN) rate and good quality embryo rate among different groups.Birth defect rate was also comparable in the born babies in different groups.In the group with patients' age over 40 years old,the pregnancy rate was 26.87%,the clinical pregnancy rate was 19.39%,while the miscarriage rate after clinical pregnancy was 36.14%.To draw the conclusion,patients with higher maternal age had worse IVF outcomes.In women of fertile age,patients between 20 and 30 years old have the best IVF outcomes.Patients over 40 years old have poor IVF outcome and high miscarriage rate,which suggested the necessity of preimplantation genetic screening(PGS). | YAN JunHao WU KeLiang TANG Rong DING LingLing CHEN Zi-Jiang | 2012 | Science China(Life Sciences)2012，55，8： | 23 |
| 6 | Chemical compositions of PM_(2.5) aerosol during haze periods in the mountainous city of Yong'an, China显示文摘Haze phenomena were found to have an increasing tendency in recent years in Yong'an, a mountainous industrial city located in the center part of Fujian Province, China. Atmospheric fine particles (PM2.5) in the urban area during haze periods in three seasons (spring, autumn and winter) from 2007 to 2008 were collected, and the mass concentrations and chemical compositions (seventeen elements, water soluble inorganic ions (WSIIs) and carbonaceous species) of PM2.5 were determined. PM2.5 mass concentrations did not show a distinct difference among the three seasons. The carbonaceous species organic carbon (OC) and elemental carbon (EC) constituted up to 19.2%-30.4% of the PM2.5 mass during sampling periods, while WSIIs made up 25.3%-52.5% of the PM2.5 mass. The major ions in PM2.5 were SO42-, NO3- and NH4+, while the major elements were Si, K, Pb, Zn, Ca and Al. The experimental results (from data based on three haze periods with a 10-day sampling length for each period) showed that the crustal element species was the most abundant component of PM2.5 in spring, and the secondary ions species (SO42-, NO3-, NH4+, etc.) was the most abundant component in PM2.5 in autumn and winter. This indicated that dust was the primary pollution source for PM2.5 in spring and combustion and traffic emissions could be the main pollution sources for PM2.5 in autumn and winter. Generally, coal combustion and traffic emissions were considered to be the most prominent pollution sources for this city on haze days. | LiqianYin Zhenchuan Niu Xiaoqiu Chen Jinsheng Chen Lingling Xu Fuwang Zhang | 2012 | Journal of Environmental Sciences2012，24，7： | 19 |
| 7 | Chemical characteristics of PM_(2.5) during haze episodes in the urban of Fuzhou,China显示文摘Atmospheric fine particles(PM_(2.5)) were collected in this study with middle volume samplers in Fuzhou,China,during both normal days and haze days in summer(September 2007) and winter(January 2008).The concentrations,distributions,and sources of polycyclic aromatic hydrocarbons(PAHs),organic carbon(OC),elemental carbon(EC),and water soluble inorganic ions(WSIIs) were determinated.The results showed that the concentrations of PM2.5,PAHs,OC,EC,and WSIIs were in the orders of haze > normal and winter > summer.The dominant PAHs of PM2.5 in Fuzhou were Fluo,Pyr,Chr,BbF,BkF,BaP,BghiP,and IcdP,which represented about 80.0%of the total PAHs during different sampling periods.The BaPeq concentrations of ∑PAHs were 0.78,0.99,1.22,and 2.43 ng/m3 in summer normal,summer haze,winter normal,and winter haze,respectively.Secondary pollutants(SO_4^(2-),NO_3^-,NH_4^+.and OC) were the major chemical compositions of PM2.5,accounting for 69.0%,55.1%,63.4%,and 64.9%of PM2.5 mass in summer normal,summer haze,winter normal,and winter haze,respectively.Correspondingly,secondary organic carbon(SOC) in Fuzhou accounted for 20.1%,48.6%,24.5%,and 50.5%of OC.The average values of nitrogen oxidation ratio(NOR) and sulfur oxidation ratio(SOR) were higher in haze days(0.08 and 0.27) than in normal days(0.05 and 0.22).Higher OC/EC ratios were also found in haze days(5.0) than in normal days(3.3).Correlation analysis demonstrated that visibility had positive correlations with wind speed,and negative correlations with relative humidity and major air pollutants.Overall,the enrichments of PM_(2.5),OC,EC,SO_4^(2-),and NO_3^- promoted haze formation.Furthermore,the diagnostic ratios of IcdP/(IcdP + BghiP),IcdP/BghiP,OC/EC,and NO_3^-/SO_4^(2-) indicated that vehicle exhaust and coal consumption were the main sources of pollutants in Fuzhou. | Fuwang Zhang Lingling Xu Jinsheng Chen Xiaoqiu Chen Zhenchuan Niu Tong Lei Chunming Li Jinping Zhao | 2013 | Particuology2013，11，3： | 19 |
| 8 | COVID-19 Outbreak Caused by Contaminated Packaging of Imported Cold-Chain Products—Liaoning Province,China,July 2020显示文摘Summary What is known about this topic?Few major outbreaks of coronavirus disease 2019(COVID-19)have occurred in China after major nonpharmaceutical interventions and vaccines have been deployed and implemented.However,sporadic outbreaks that had high possibility to be linked to cold chain products were reported in several cities of China..What is added by this report?In July 2020,a COVID-19 outbreak occurred in Dalian,China.The investigations of this outbreak strongly suggested that the infection source was from COVID-19 virus-contaminated packaging of frozen seafood during inbound unloading personnel contact.What are the implications for public health practice?Virus contaminated paper surfaces could maintain infectivity for at least 17–24 days at-25℃.Exposure to COVID-19 virus-contaminated surfaces is a potential route for introducing the virus to a susceptible population.Countries with no domestic transmission of COVID-19 should consider introducing prevention strategies for both inbound travellers and imported goods.Several measures to prevent the introduction of the virus via cold-chain goods can be implemented. | Huilai Ma1 Jianqun Zhang Ji Wang Ying Qin Cao Chen Yang Song Liang Wang Jun Meng Lingling Mao Fengqin Li Ning Li Jian Cai Yong Zhang Dayan Wang Yunting Xia Hong Wang Shaofeng Jiang Xiang Zhao Peihua Niu Wenjie Tan Tao Ma Yecheng Yao Naiying Mao Zhen Zhu Tianjiao Ji Qian Yang Baoying Huang Li Zhao Jianxing Yu Li Bai Shuangli Zhu Dongyan Wang Yan Zhang Yingwei Sun Mingchun Luan Yanhai Wang Haibo Sun Shihong Yang Zhijian Bo Xiang Ren Zhongjie Li George Fu Gao Wei Yao Wenqing Yao Zijian Feng Wenbo Xu | 2021 | China CDC weekly2021，3，21： | 16 |
| 9 | Attribute-Based Access Control for Multi-Authority Systems with Constant Size Ciphertext in Cloud Computing显示文摘In most existing CP-ABE schemes, there is only one authority in the system and all the public keys and private keys are issued by this authority, which incurs ciphertext size and computation costs in the encryption and decryption operations that depend at least linearly on the number of attributes involved in the access policy. We propose an efficient multi-authority CP-ABE scheme in which the authorities need not interact to generate public information during the system initialization phase. Our scheme has constant ciphertext length and a constant number of pairing computations. Our scheme can be proven CPA-secure in random oracle model under the decision q-BDHE assumption. When user's attributes revocation occurs, the scheme transfers most re-encryption work to the cloud service provider, reducing the data owner's computational cost on the premise of security. Finally the analysis and simulation result show that the schemes proposed in this thesis ensure the privacy and secure access of sensitive data stored in the cloud server, and be able to cope with the dynamic changes of users' access privileges in large-scale systems. Besides, the multi-authority ABE eliminates the key escrow problem, achieves the length of ciphertext optimization and enhances the effi ciency of the encryption and decryption operations. | CHEN Yanli SONG Lingling YANG Geng | 2016 | China Communications2016，13，2： | 15 |
| 10 | Two Comparable Earthquakes Produced Greatly Different Coseismic Landslides:The 2015 Gorkha,Nepal and 2008 Wenchuan,China Events显示文摘The 2015 Gorkha Earthquake in Nepal and the 2008 Wenchuan Earthquake in China occurred at the south and southeast margins of the Tibetan Plateau, respectively. Both earthquakes had similar magnitudes of Mw 7.8 and 7.9, caused catastrophic loss of life and damage to property, and generated tens of thousands of landslides. Comparisons of pre- and post-quake satellite images supported by field investigations show that the Gorkha Earthquake triggered at least 2 064 large landslides(defined as covering an area ≥10 000 m^2) over a ~35 600 km^2 region with a volume of(444–584)×10~6(average 509×10~6) m^3 and total area of 44.78×10~6 m^2. In contrast, the Wenchuan Earthquake triggered 25 580 large landslides over a region of ~44 000 km^2 with a volume of(7 128–9 479)×10~6(average 8 219×10~6) m^3 and a total area of about 670.65×10~6 m^2. Several controlling factors including topographic relief, slope steepness, and regional peak ground acceleration(PGA) were investigated to try to explain the great differences between the number, volume and area of the coseismic landslides associated with the two similar earthquakes. We found that the differences primarily arose from an unexpected factor, the dip angle of the seismogenic fault. This discovery should aid understanding the failure mechanisms of quake-triggered landslides, and suggests that more factors should be taken into consideration in estimating coseismic landslide volumes from earthquake magnitudes. | Chong Xu Xiwei Xu Yingying Tian Lingling Shen Qi Yao Xueqiang Huang Junxue Ma Xi Chen Siyuan Ma | 2016 | Journal of Earth Science2016，27，6： | 14 |
| 11 | Rice Functional Genomics Research: Past Decade and Future显示文摘瑞斯(Oryza sativa ) 是为世界范围的超过 35 亿个人的主要主食食物庄稼。在米饭理解复杂农学的特点的规章的机制为全球食物安全是批评的。瑞斯也是为单子叶植物的 genomics 研究的模型植物。由于功能的 genomic 技术的快速的发展,控制重要农学的特点的超过 2000 基因被克隆,并且他们的分子的生物机制也是部分描绘了。这里,我们简短在米饭考察进展功能的 genomics 研究在过去的 10 年期间包括功能的 genomics 平台的一篇摘要,基因 ? 并且调整重要农学的特点的分子的规章的网络,并且 ? 为基因鉴定的最新发达的工具。在功能的 genomics 研究做的这些成就将极大地便于发展 ? 绿超级米饭。我们也讨论未来挑战和米饭的前景功能的 genomics 研究。 | Yan Li Jinghua Xiaot Lingling Chen Xuehui Huang Zhukuan Cheng Bin Han Qifa Zhang Changyin Wu | 2018 | Molecular Plant2018，11，3： | 14 |
| 12 | Gene expression signatures for phlegm-dampness constitution of Chinese Medicine显示文摘Dear Editor,The term'individualized medicine'was first used in Biochemistry Individuality in 1956 by Williams(Williams et al.,1956).With the emergence of the post-genome era in the21st century,individualized precision medicine has attracted increasing attention.In traditional Chinese medicine(TCM),there is also concept of individualized medicine,which is known as the Chinese constitutional theory,proposed in the1970s(Wang,2012).According to this theory,the | Lingru Li Juan Feng Haiqiang Yao Lan Xie Yu Chen Lingling Yang Shujuan Hou Shipeng Zhao Ranran Sun Yanling Wu Tongtong Bai Yingshuai Li Ruoxi Yu Ji Wang Qi Wang | 2017 | Science China(Life Sciences)2017，60，1： | 13 |
| 13 | Recent development of a refined multiple air pollutant emission inventory of vehicles in the Central Plains of China显示文摘Central Plains region of China,represented by Henan Province,is facing serious air pollution problems.Vehicular exhaust emissions had adverse impacts on the atmospheric environment.The first comprehensive and novel vehicle emission inventory for Henan Province using vehicle kilometers traveled,localized emission factors,and activity data at city-level was developed.Furthermore,3 km×3 km gridded emission and temporal variations were determined by using localized information.Results show that the total emissions of sulfur dioxide(SO2),nitrogen oxides(NOx),carbon monoxide(CO),particular matter with aerodynamic diameter<10μm(PM10),aerodynamic diameter<2.5μm(PM2.5),volatile organic compounds(VOCs),VOCs-evaporation and ammonia in 2015 were 9.1,533.4,1190.7,23.7,21.6,150.8,31.5 and 10.4 Gg,respectively,and the emission intensities of the above pollutants were 0.05,2.7,6.0,0.1,0.1,0.8,0.2 and 0.05 g/km,respectively.Vehicles meeting the Primary China 1,China 3 and China 4 contributed 89.1%,82.7%,75.3%,75.5%,75.5%,68.2%,68.4%and 82.3%for SO2,NOx,CO,PM10,PM2.5,VOCs,VOCs-evaporation and ammonia emissions,respectively.Zhengzhou,Zhoukou,Nanyang,Luoyang,Shangqiu and Xinyang showed relatively higher emissions and contributed more than 50%of each pollutant.The spatial distribution indicated obvious characteristics of the road network,and high-level emission was concentrated in the downtown areas.Additionally,the ozone formation potential(OFP)based on the estimated speciated VOC emissions was 569.6 Gg in Henan Province.Aliphatic and aromatic hydrocarbons were the main species of VOCs,whereas olefins contributed the largest proportion of OFP,with 42.2%. | Xingke Gu Shasha Yin Xuan Lu Huan Zhang Lingling Wang Ling Bai Chen Wang Ruiqin Zhang Minghao Yuan | 2019 | Journal of Environmental Sciences2019，31，10： | 11 |
| 14 | Cryptotanshinone suppresses key onco-proliferative and drugresistant pathways of chronic myeloid leukemia by targeting STAT5 and STAT3 phosphorylation显示文摘C-Myc and signal transducer and activator of transcription(STAT) family proteins have been proposed to be important downstream genes of BCR-ABL, which characterizes most cases of chronic myeloid leukemia(CML). Here, we report a c-Myc pathway-targeted screening of seven natural anticancer compounds, in which we identified cryptotanshinone as a highly promising agent for CML therapy. Cryptotanshinone depletes c-Myc in CML by repressing the phosphorylation of STAT5.Decreased viability of K562 cells correlated with p-STAT5 suppression. Unexpectedly, imatinib activates rather than inhibits the phosphorylation of STAT3 in K562 cells. We demonstrated that cryptotanshinone, as a dual inhibitor of p-STAT5 and p-STAT3,can effectively block IL-6-mediated STAT3 activation and reverse BCR-ABL kinase-independent drug resistance. Moreover, we showed that the epigenetic rebalance between decreased BCR-ABL/STAT5/c-Myc and enhanced STAT3/multi-drug resistance(MDR) pathways is characteristic of the cancer stem cell-like property of K562/ADR. Simultaneously suppressing these two pathways using cryptotanshinone proves to be critical for the malignant network redress and MDR reversal of K562/ADR. These studies reveal the dual functions of cryptotanshinone that suppress key oncogenic proliferation and drug-resistant pathways in CML cells by targeting p-STAT5 and p-STAT3, providing a new strategy for CML therapy that takes advantage of natural products. | Bowen Dong Zirui Liang Zhirong Chen Bin Li Lingling Zheng Jianhua Yang Hui Zhou Lianghu Qu | 2018 | Science China(Life Sciences)2018，61，9： | 10 |
| 15 | Glycine attenuates myocardial ischemia-reperfusion injury by inhibiting myocardial apoptosis in rats显示文摘Glycine is a well-documented cytoprotective agent.However,whether it has a protective effect against myocar-dial ischemia-reperfusion injury in vivo is still unknown.By using an open-chest anesthetized rat model,we found that glycine reduced the infarct size by 21% in ischemia-reperfusion injury rats compared with that in the vehicle-treated MI/R rats.The left ventricular ejection fraction and fractional shortening were increased by 19.11% and 30.98%,respectively,in glycine-treated rats.The plasma creatine kinase levels in ischemia-reperfusion injury rats decreased following glycine treatment.Importantly,administration of glycine significantly inhibited apoptosis in post-ischemia-reperfusion myocardium,which was accompanied by suppression of phosphorylated p38 mitogen-activated protein kinase and c-Jun NH2-terminal kinase,as well as the Fas ligand.These results suggest that gly-cine attenuates myocardial ischemia-reperfusion injury in vivo by inhibiting cardiomyocytes apoptosis. | Xiaozheng Zhong Xiaoyu Li Lingling Qiana Yiming Xu Yan Lu Jing Zhang Nan Li Xudong Zhu Jingjing Ben Qing Yang Qi Chen | 2012 | The Journal of Biomedical Research2012，26，5： | 10 |
| 16 | Phase-transfer interface promoted corrosion from PtNi10 nanoctahedra to Pt4Ni nanoframes显示文摘向 PtNi 的腐蚀的一条新奇二阶段的途径 < 潜水艇 class= “ a-plus-plus ” > 10 nanoctahedra 被开发了。在这策略,在油可溶的 PtNi 的 Ni 的活跃部件 < 潜水艇 class= “ a-plus-plus ” > 居住在上面的甲苯阶段,受不了蚀刻并且是的 10 nanoctahedra 然后由 ethylenediaminetetraacetate (EDTA ) 与协作转了进一个更低的水的阶段。由于 EDTA 支持的阶段转移接口的存在,腐蚀反应在温和条件下面以加速的率继续了。明确地,八面的磅的结果的产品 < 潜水艇 class= “ a-plus-plus ” > 4 Ni nanoframes 成功地第一次被制作,并且 PtNi < 潜水艇 class= “ a-plus-plus ” > 4 当 EDTA-2Na 的剂量被减少时,多孔的 octahedra 能被获得。在这个二阶段的系统的系统的研究以后,合作腐蚀机制被建议说明八面的磅的形成<潜水艇class=“ a-plus-plus ”> 4 Ni nanoframes ,从许多种类包含贡献(即, O <潜水艇class=“ a-plus-plus ”> 2 , H <潜水艇class=“ a-plus-plus ”> 2 O , H <啜class=“ a-plus-plus ”>+, OAm ,和 EDTA <潜水艇class=“ a-plus-plus ”> 4 )。由于磅的迷人的三维的几何学<潜水艇class=“ a-plus-plus ”> 4 Ni nanoframes 和 PtNi <潜水艇class=“ a-plus-plus ”> 4 多孔的 octahedra ,两个在太古的 PtNi 上侵蚀的 nanocrystals 显示出优异活动<潜水艇class=“ a-plus-plus ”>为在硝基苯的碱的媒介和加氢的乙醇 electrooxidation 的 10 nanoctahedra 。 | Yu Wang Yueguang Chen Caiyun Nan Lingling Li Dingsheng Wang Qing Peng Yadong Li | 2015 | Nano Research2015，8，1： | 10 |
| 17 | Lentiviral-mediated gene transfer into human adipose-derived stem cells:role of NELL1 versus BMP2 in osteogenesis and adipogenesis in vitro显示文摘(NELL1 ) 象 NEL 一样分子 1 是与 craniosynostosis 联系的一个有势力 osteogenic 因素。侵入人体气管粘膜的病菌,大多数通常为基因治疗使用了病毒的向量,有可以限制成骨的几劣势。以前的研究证明了 lentiviruses 能为骨头新生为基因治疗用作理想的向量。在这研究,编码人的 NELL1 和骨头的二 lentiviral 向量(LvNELL1 和 LvBMP2 ) 分别地,形态基因的 protein-2 (BMP2 ) 被构造。在 vitro 的人的脂肪质导出干细胞(hADSCs ) 的增长,成骨,和 adipogenesis 上的 LvNELL1 感染的效果被估计并且与 LvBMP2 的相比。结果显示出感染 LvNELL1 的那 hADSCs 能高效地并且稳定地 overexpress 目标基因。3-(4,5-dimethylthiazol-2-yl )-2,5-diphenyltetrazolium 溴化物试金结果表明了那 LvBMP2,然而并非 LvNELL1,提高了 hADSCs 的增长。对碱的磷酸酶活动和细胞的矿化作用的评价显示 LvNELL1 感染支持了 hADSCs 的 osteogenic 区别,并且效果与 LvBMP2 的是可比较的。实时聚合酶链反应(PCR ) 在 hADSCs 揭示了那 LvNELL1 感染 upregulated OSX 表情然而并非 RUNX2 表示。另外,分析显示出的 adipogenic 标记(类脂化合物微滴, peroxisome 激活 proliferator 受体,和脂蛋白脂肪分解酵素) LvNELL1 能戏剧性地禁止 hADSCs,而是 LvBMP2 的 adipogenic 区别,这没有如此的效果。一起拿,这些调查结果建议在 hADSCs 的调停 lentiviral 的 NELL1 基因转移可以是一条新奇、有希望的途径完成有效、精确的骨头新生。 | Yajing Liu Caiyun Chen Huixia He Dongsheng Wang LingLing E Zhongyu Liu Hongchen Liu | 2012 | Acta Biochimica et Biophysica Sinica2012，44，10： | 10 |
| 18 | Toxicological effects involved in risk assessment of rare earth lanthanum on roots of Vicia faba L.seedlings显示文摘Combined chemical analyses and biological measurements were utilized to investigate potential toxicological effects and possible mechanisms involved in risk assessment of rare earth elements (REEs) on Vicia faba L.seedlings,which were hydroponically cultivated and exposed to various concentrations of lanthanum (La) for 15 days.The results showed that La contents in both the solution and roots increased with the increase of extraneous La,contributing to hormetic dose responses of superoxide dismutase (SOD),catalase (CAT),guaiacol peroxidase (GPX),ascorbate peroxidase (APX) and endoprotease (EP) isozymes activities,and HSP 70 production enhanced at low doses but suppressed at higher doses of La.These physiological responses constituted antioxidant and detoxification systems against La-induced oxidative stress.The elevated La levels also contributed to oxidatively modified proteins,which were most responsible for subsequent cell death and growth retardation of the roots.By combination of hormetic and traditional threshold dose levels,the threshold dose range was deduced to be 108-195 μg La/g dry weight in the roots,corresponding to 0.90-3.12 mg/L of soluble La in the culture solution.It suggests that persistent applications of REEs may lead to potential ecological risk in the environment. | Chengrun Wang Mei He Wen Shi Jessie Wong Tao Cheng Xiaorong Wang Lingling Hu Fenfen Chen | 2011 | Journal of Environmental Sciences2011，23，10： | 9 |
| 19 | 中国卫生人力资源:数量、质量和分布显示文摘在本文中,我们从数量、质量和分布的角度对中国现有的卫生人力资源进行了分析。与绝大多数国家不同,2005年中国拥有的医生总数大于护士总数——注册的执业医师和执业助理医师总数达190多万,注册的护士总数为140多万。城市地区的医生密度是农村地区的2倍多,而城市地区护士的密度是农村地区的3倍多。中国大多数医生(67.2%)和护士(97.5%)所接受的教育仅为大专或中专水平。自1998年以来,中国的医学卫生教育事业有了很大的发展,医学院校不断扩招又导致了卫生人员供过于求的局面。 | Sudhir Anand Victoria Y Fan Junhua Zhang Lingling Zhang Yang Ke Zhe Dang Lincoln C Chen | 2009 | 世界临床医学2009，3，1： | 9 |
| 20 | Efficient elimination of multidrug-resistant bacteria using copper sulfide nanozymes anchored to graphene oxide nanosheets显示文摘Antibacterial nanomaterials have attracted growing interest for bacterial infection therapy.However,most nanomaterials eliminate bacteria either physically or chemically,which hampers their efficacy when dealing with multidrug-resistant bacteria.To overcome this,we integrated copper sulfide(CuS)nanoparticles with active graphene oxide nanosheets(GO NSs)to synthesize a superior nanocomposite(CuS/GO NC)that acts both physically and chemically on the bacteria.CuS/GO NC was produced using a facile hydrothermal method,whereby the CuS nanoparticles grew and were uniformly dispersed on the GO NSs in situ.We found that the CuS/GO NC possesses a unique needle-like morphology that physically damages the bacterial cell membrane.CuS/GO NC also exhibits high oxidase-and peroxidase-like activity,ensuring efficient generation of the reactive oxygen species•OH from H2O2,which kills bacteria chemically.These features endow the CuS/GO NC with excellent antibacterial capabilities to kill multidrug-resistant bacteria such as methicillin-resistant Staphylococcus aureus(MRSA)with only a single dose.Additionally,it was found that the CuS/GO NC accelerated the healing of infected wounds in vivo owing to its good biocompatibility as well as facilitation of cell migration and collagen secretion.This study provides a new strategy to combine the physical and chemical antibacterial modes of nanomaterials to develop more effective therapies to combat multidrug-resistant bacterial infections. | Wanshun Wang Binglin Li Huili Yang Zefeng Lin Lingling Chen Zhan Li Jiayuan Ge Tao Zhang Hong Xia Lihua Li Yao Lu | 2020 | Nano Research2020，13，8： | 8 |
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