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| 1 | Geochemistry of Platinum Group and Rare Earth Elements of the Polymetallic Layer in the Lower Cambrian,Weng'an,Guizhou Province显示文摘在华南的 Yangtze 站台上,在 Weng'an 的更低的寒武纪的 Niutitang 形成的黑页岩包含多卷的 polymetallic 硫化物存款。踪迹,稀土元素,和铂组元素(PGE ) 的全面 geochemical 调查被承担了以便讨论它有 tectono-depositional 背景的矿石开始和关联。忍受矿石的层充实铝(瞬间) ,镍(Ni ) ,钒(V) ,铅(Pb ) ,锶(Sr ) ,钡(Ba ) ,铀(U) ,砷(作为) ,并且在丰富的稀土元素元素(REE ) 。高铀 / 钍(U/Th ) 比率(U/Th>1 ) 显示那个矿化作用被热水的过程主要影响。δU 价值超过 1.9 是沉积状况,显示出减少。REE 模式在轻稀土元素元素(LREE ) 显示出高丰富(重稀土元素元素(HREE )(LREE/HREE=5 17 ) ,稍微否定的铕(Eu ) 和铈(Ce ) 异例(δEu=0.81 0.93 ) ,并且积极 Ce 异例(δCe=0.76 1.12 ) 。PGE 丰富被 PGE 类型分发模式描绘,充实铂(磅) ,钯(Pd ) ,钌(Ru ) 和锇(O ) 。Pt/Pd 比率是 0.8,它接近海水和 ultramafic 岩石的比率。这些, geochemical 展示的所有建议矿化作用被热水的活动在前触发在 Rodinian 超级大陆的分散的上下文的紧张的背景。 | FU Yong WU Chaodong GUAN Ping QU Wenjun CHEN Jiafu | 2009 | Acta Geologica Sinica(English Edition)2009，83，3： | 10 |
| 2 | CMHX008,a PPAR γ partial agonist,enhances insulin sensitivity with minor influences on bone loss显示文摘Traditional thiazolidinediones(TZDs),such as rosiglitazone,are peroxisome proliferator-activated receptor g(PPARg)potent agonists that can be used to treat type 2 diabetes but carry unwanted effects,including increased risk for fracture.The present work aimed to compare the insulin-sensitizing efficacies and bone-loss side effects of CMHX008,a novel TZDs-like PPARg partial agonist,with those of rosiglitazone.A TR-FRET PPARg competitive binding assay was used to compare the binding affinity between CMHX008 and rosiglitazone.Mice were administered vehicle,CMHX008 or rosiglitazone for 16 weeks.Mesenchymal stem cells(MSCs)were used to examine differences in differentiation into osteoblasts after compounds treatment.TR-FRET showed lower affinity to PPARg by CMHX008 compared with rosiglitazone.Mice treated with CMHX008 showed insulin sensitization similar to that of mice treated with rosiglitazone,which was related to the significant inhibition of PPARg Ser273 phosphorylation and improved insulin sensitivity by facilitating the phosphorylation of insulin receptor and Akt in adipose tissues.Micro-CT and histomorphometric analyses demonstrated that the degree of trabecular bone loss after treatment with CMHX008 was weaker than that observed with rosiglitazone,as evidenced by consistent changes in BV/TV,Tb.N,Tb.Th,Tb.Sp,and the mineral apposition rate.MSCs treated with CMHX008 showed higher ALP activity and mRNA levels of bone formation markers than did cells treated with rosiglitazone in the osteoblast differentiation test.Thus,CMHX008 showed insulin-sensitizing effects similar to those of rosiglitazone with a lower risk of bone loss,suggesting that PPARg sparing eliminates the skeletal side effects of TZDs while maintaining their insulin-sensitizing properties. | Yi Hou Xuemei Cao Xiangnan Hu Xinyu Li Xiaoqin Shi Hongying Wang Chuan Peng Jiayu Li Jibin Li Qifu Li Chaodong Wu Xiaoqiu Xiao | 2018 | Genes & Diseases2018，5，3： | 6 |
| 3 | Metformin and metabolic diseases: a focus on hepatic aspects显示文摘Metformin 广泛地为类型 2 糖尿病(T2D ) 的处理被用作首要的反糖尿病的药。作为首先指向肝的药, metformin 压制肝的葡萄糖生产(HGP ) ,用作 metformin 由改进 T2D 的多糖症的主要机制。生物化学地, metformin 压制 gluconeogenesis 并且刺激 glycolysis。Metformin 也禁止 glycogenolysis,它是极其贡献提高的 HGP 的一条小径。当在多糖症上产生有益的效果时, metformin 也改进胰岛素抵抗并且与 T2D 在病人改正 dyslipidemia。metformin 的这些有益的效果含有为在管理非酒精的脂肪肝的 metformin 的一个角色疾病。是从人和动物研究由结果支持了, metformin 改进肝的脂肪变性并且压制肝发炎。机械学地,肝的方面上的 metformin 的有益的效果通过腺苷被调停激活 monophosphate 的蛋白质 kinase (AMPK ) 依赖者和 AMPK 独立的小径。另外, metformin 通常是安全的并且可以也与另外的长期的肝疾病有益于病人。 | Juan Zheng Shih-Lung Woo Xiang Hu Rachel Botchlett Lulu Chen Yuqing Huo Chaodong Wu | 2015 | Frontiers of Medicine2015，9，2： | 6 |
| 4 | Sedimentary filling and sequence structure dominated by T-R cycles of the Nenjiang Formation in the Songliao Basin显示文摘The Nenjiang Formation in the Songliao Basin is a symmetrical sequence of progradation-retrogradation,and is formed in the transgression cycle and regression cycle(T-R cycles)of the base level of deposition.We analyzed the drilling,well logging,core data,and seismic profiles of basin level,and by using the sequence stratigraphy,identified one secondary sequence boundary,two third-order sequence boundaries,and eight fourth-order sequence boundaries in the Nenjiang Formation.These eleven sequence boundaries can be divided into structural unconformity,depositional unconformity,flooding surface,and forced regression surface.Therefore the Nenjiang Formation can be subdivided into one secondary sequence,three third-order sequences,and ten fourth-order sequences.We have restored the sedimentary filling evolution within the stratigraphic framework of fourth-order sequences in the Nenjiang Formation.The sedimentary period of the first member of the Nenjiang Formation was corresponded to the global transgression period,which is also the development period of transgression cycle(T cycle),when the lake basin had the largest scope and deepest sedimentary water,the SB07(the maximum flooding surface)was formed on the top of strata during this period;covering above the SB07,there developed a set of condensation layer-oil shale,which is distributed in the whole basin and is the important source bed and regional cover.Therefore,a retrogradation sequence was formed in the T cycle of the first member of the Nenjiang Formation,characterized by the retrograding delta at a low angle.The delta has a giant front,a small plain,and many underwater distributary channels.Meanwhile,large gravity flow channels and sublacustrine fans are developed in the front of the delta.During the depositional period of the second member of the Nenjiang Formation,the R cycle began to develop due to the compression of the pacific tectonic domain;the source direction rotated 90°along with the eastern uplifting of the basin,and formed a series of east-west prograded and forced retrogradations.The prograding delta at high angel was developed in the interior of the sequence;the delta had a small front,a giant plain,and fewer underwater distributary channels,with the collapse at the foreslope,forming a series of slump fans.The slump fans can be divided into three types:discrete type,superimposed type,and fluid type.We built a whole'triad model'of the slump fan.Pointed out that the sequence of forced retrogradation formed by R cycle is a good structural mark of basin optimization,and rejected the viewpoint of'transgression'in the Nenjiang Formation of the Songliao Basin. | ZHANG ChenChen ZHANG Shun WEI Wei WU ChaoDong LIANG JiangPing NIU Wen DU JinXia FU XiuLi CUI KunNing WANG Chao WANG Hui | 2014 | Science China Earth Sciences2014，57，2： | 5 |
| 5 | Hippocampal overexpression of TREM2 ameliorates high fat diet induced cognitive impairment and modulates phenotypic polarization of the microglia显示文摘Type 2 diabetes mellitus(T2DM)and Alzheimer's disease(AD)share several common pathophysiological features.Rare variants of triggering receptor expressed on myeloid cells 2(TREM2)increase the risk of developing AD,suggesting the involvement of TREM2 and innate immunity in AD development.It is still unknown whether TREM2 is related to cognitive impairment in T2DM.Here,we investigated the effects of the hippocampal overexpression of TREM2 on cognitive in long-term high-fat diet(HFD)-fed mice.Male C57BL/6J mice were maintained on HFD for 50 weeks.TREM2 was overexpressed in the hippocampus 36 weeks after HFD feeding using adeno-associated virus vector(AAV)-mediated gene delivery.The results showed that the HFD feeding induced rapid and persistent weight gain,glucose intolerance and significant impairments in learning and memory.Compared with AAV-con,AAV-TREM2 significantly ameliorated cognitive impairment without altering body weight and glucose homeostasis in HFD mice.The overexpression of TREM2 upregulated the synaptic proteins spinophilin,PSD95 and synaptophysin,suggesting the improvement in synaptic transmission.Dendritic complexity and spine density in the CA1 region were rescued after TREM2 overexpression.Furthermore,TREM2 markedly increased the number of iba-1/Arg-1-positive microglia in the hippocampus,suppressed neuroinflammation and microglial activation.In sum,hippocampal TREM2 plays an important role in improving HFD-induced cognitive dysfunction and promoting microglial polarization towards the M2 anti-inflammatory phenotype.Our study also suggests that TREM2 might be a novel target for the intervention of obesity/diabetes-associated cognitive decline. | Min Wu Maolin Liao Rongfeng Huang Chunxiu Chen Tian Tian Hongying Wang Jiayu Li Jibin Li Yuxiang Sun Chaodong Wu Qifu Li Xiaoqiu Xiao | 2022 | Genes & Diseases2022，9，2： | 4 |
| 6 | Glycolysis in the control of blood glucose homeostasis显示文摘Glycolysis,a simple pathway of glucose metabolism,critically regulates insulin secretion and metabolic functions of various cells.Depending on cell types,rates of glycolysis are determined at various steps of glycolysis that are subjected to the control of key metabolic and regulatory enzyme(S),which include glucokinase,6-phosphofructo-I-kinase,and 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase.These enzymes are regulated by both nutritional and hormonal signals at the levels of transcription,translation,and post-translational modifications.In hepatocytes,glycolysis is involved in the control of hepatic glucose production.The latter,when excessive,contributes to hyperglycemia in diabetes.In pancreatic β cells,glycolysis couples glucose-stimulated insulin secretion.Absolute or relatively low levels of circulating insulin causes hyperglycemia.In adipocytes,glycolysis generates metabolites for lipogenesis and channels fatty acids from excessive oxidation to triglyceride synthesis,thereby reducing oxidative stress.With increased proinflammatory status,adipocytes produce pro-hyperglycemic factors and bring about hyperglycemia and insulin resistance.In hypotha lamic neurons,glycolysis conveys nutrient sensing that is related to feeding control.Dysregulation of glycolysis occurs in conditions of insulin deficiency or resistance,and is attributable to inappropriate amount and/or activities of metabolic and regulatory enzymes of glycolysis.Targeting key metabolic and regulatory enzymes to enhance glycolysis may offer viable approaches for treatment of diabetes. | Xin Guo Honggui Li Hang Xu Shihlung Woo Hui Dong Fuer Lu Alex J.Lange Chaodong Wu | 2012 | Acta Pharmaceutica Sinica B2012，2，4： | 3 |
| 7 | Reclassification of Oligodon ningshaanensis Yuan, 1983(Ophidia:Colubridae) into a New Genus, Stichophanes gen. nov. with Description on Its Malacophagous Behavior显示文摘The complete mitochondrial cytb gene and the partial nuclear c-mos gene of Oligodon ningshaanensis Yuan, 1983 were sequenced and used for reconstructing the phylogenetic relationship of this taxon amongst alethinophidian snakes. Its strong affinity to the New World subfamily Dipsadinae and the Old World species Thermophis baileyi was inferred. Hemipenial morphology found by authors conflicts with the original description and its similarity with those of the dipsadid snakes is in accordance with our molecular results. Feeding tests show that O. ningshaanensis is a malacophagous predator, which is another matchless character for this species. This behavior is described and compared with other known slug- and snail-feeding snakes. The discovery of the particular position of our subject indicates that erecting a new genus is necessary accommodate this unique species. | Xiaohe WANG Kevin MESSENGER Ermi ZHAO Chaodong ZHU | 2014 | Asian Herpetological Research2014，5，3： | 3 |
| 8 | An Estimation Method for Multi-channel EEG Data Based on Canonical Correlation Analysis显示文摘Electroencephalogram(EEG) signal is often contaminated by electronic noise as well as movement artifacts. This paper presented an algorithm based on Canonical correlation analysis(CCA) to estimate multichannel EEG data. Different from previous studies, in which CCA was mainly used to detect the invariant features specific to each brain state, in this paper, the canonical variates computed by CCA were used to reconstruct the multi-channel EEG data. Firstly, two data sets, EEG signals and the reference signals based on prior knowledge were constructed. Next, canonical variates were computed by pro jecting the two data sets onto basis vectors. Finally,a least squares solution was used to estimate the multichannel EEG data. The experiment results suggested that the algorithm is capable of reconstructing the actual specific components with high quality. We also hint future possible application of the algorithm in the estimation of functional connectivity patterns at the end of the paper. | YAN Zheng WAN Xiaojiao LING Chaodong | 2015 | Chinese Journal of Electronics2015，24，3： | 2 |
| 9 | Hepatitis B virus subgenotyping: History, effects of recombination, misclassifications, and corrections显示文摘 | Weifeng Shi Zhong Zhang Cheng Ling Weimin Zheng Chaodong Zhu Michael J. Carr Desmond G. Higgins | 2013 | Infection Genetics and Evolution2013，，： | 2 |
| 10 | Parkin dosage mutations in patients with early-onset sporadic and familial Parkinson’s disease in Chinese: An independent pathogenic role显示文摘 | Chaodong Wang Huili Ma Xiuli Feng Shu Xie Piu Chan | 2010 | Brain Research2010，，： | 2 |
| 11 | Pyrite morphology and episodic euxinia of the Ediacaran Doushantuo Formation in South China显示文摘The Ediacaran Doushantuo Formation with well-preserved fossil record in South China provides a rare window for our understanding of biological evolution,global carbon cycle,and oceanic redox states.Prominent negativeδ^(13)C anomalies(i.e.,the Shuram excursion)in Ediacaran successions worldwide fundamentally challenge the traditional models of isotopic mass balance.Additionally,conflicting opinions of both oxic and anoxic conditions have been proposed for the deep waters during this period.Here,we present a detailed study of pyrite morphology and carbonate carbon isotope data documented from drill core samples at Songtao County,northeastern Guizhou.Framboid aggregates are the dominant pyrite form in black shale and they can transfer to euhedral crystals through continuous growth of the constituent microcrystals.A positive correlation between microcrystal sizes(d)and framboid diameters(D)is observed,while the different D/d ratios of framboids in argillaceous dolostone and black shale reflect different substrate availability.Electron microprobe analyses reveal no consistent compositional patterns between framboidal and euhedral pyrites.Framboid size distributions of the investigated drill core,in combination with previously published redox data from the intra-shelf Jiulongwan section,shelf margin Zhongling section,and lower slope Wuhe section,suggest that three episodes of marine euxinia have been established throughout the deposition of the Doushantuo Formation.The time lag between the uppermost euxinic interval and the Shuram excursion may arise from the depression of sulfate reduction maintained by other oxidants. | YE YunTao WU ChaoDong ZHAI LiNa AN ZhengZe | 2017 | Science China Earth Sciences2017，60，1： | 2 |
| 12 | Referential significance of sulfur isotopes and separation of S species in black shales of Southwest China显示文摘The states of S species in black shales are very complex, such as organic sulfur, pyrite sulfur and sulphate sulfur. The mineral microtexture, sulfur content and sulfur isotope can indicate the formation conditions and diagenetic processes of the black shales. The S species are separated perfectly and the relation between the content, mineral microtexture and | Chaodong Wu Fangang Zeng Jiajin Lei Rui Zhao | 1999 | Chinese Science Bulletin1999，44，17： | 2 |
| 13 | 亚热带丘陵区稻田周边氨气干沉降研究显示文摘农业源在氨(NH3)排放清单中占比较大,但农业排放的NH3是否全部进入大气亟待评估。本文选择亚热带丘陵区双季稻田为研究对象,研究了农田排放NH3的去向和沉降过程。结果表明,稻田(0.6 ha)下风向100 m范围较高的NH3浓度主要出现在施用基肥和追肥后15 d内。随着距稻田距离的增加,下风向大气中NH3浓度呈指数下降。稻田下风向100 m范围内NH3沉降量约占挥发量的80%,表明近源沉降是亚热带丘陵区稻田排放NH3的重要汇机制。该机制大幅减少了农业排放NH3进入大气的总量,应该在清单编制过程中予以考虑,以期客观评价农业排放对大气污染的潜在影响。 | YI Yuchen SHEN Jianlin YANG Chaodong WANG Juan LI Yong WU Jinshui | 2020 | Atmospheric and Oceanic Science Letters2020，13，3： | 2 |
| 14 | Positioning taxonomic research for the future显示文摘Why do taxonomists matter? The work of taxonomists is often understated if not completely misunderstood. Without taxonomists, organisms cannot be accurately identified, neither can these organisms be given universally accepted names, and reliably positioned in the phylogenetic tree of life. Thanks to the work of taxonomists over the last 269 years since Carl Linnaeus established the binomial system, we can now measure the health and wealth of our biodiversity in a refined, science-based inventory prescribed by stringent nomenclatural rules. | Deyuan Hong Wenying Zhuang Min Zhu Keping Ma Xiaoquan Wang Dawei Huang Yalin Zhang Guodong Ren Wenjun Bu Wanzhi Cai Dong Ren Ding Yang Aiping Liang Fengyan Bai Runzhi Zhang Fumin Lei Shuqiang Li Hongzhi Kong Lei Cai Yucheng Dai Chaodong Zhu Qisen Yang Jun Chen Zhongli Sha Jianping Jiang Jing Che Donghui Wu Jiatang Li Qiang Wang Xinli Wei Ming Bai Xingyue Liu Xuexin Chen Gexia Qiao | 2022 | Zoological Systematics2022，47，3： | 2 |
| 15 | Effects of Microbial Inoculums on Soil Enzyme Activity and Microbial Diversity in a Reclaimed Mining Area显示文摘Through a pot experiment,effects of various microbial inoculums on soil microbial diversity and enzyme activity in a typical reclaimed mining area in Shanxi Province were discussed based on quantitative analysis of PLFA,soil urease,phosphatase and sucrase activity. The results showed that the application of microbial inoculums increased microorganism quantity in rhizosphere of rape by 2. 3%-66. 4%,and quantities of bacteria,gram-positive bacteria,gram-negative bacteria,fungi and actinomycetes in the treatments with microbial inoculums were significantly higher than the contrast( P <0. 05),while there was no obvious change in protist quantity. In comparison with the contrast,the application of various microbial inoculums also improved soil urease,sucrase and phosphatase activity by 4. 2%-61. 4%,18. 0%-32. 5% and 64. 2%-199. 0% respectively. It indicated that the application of microbial inoculums can improve soil microbial diversity and enzyme activity,so it is an effective way to speed up ecological restoration of soil. | Gao Chunhua Chang Bo Li Jianhua Zhang Qiang Lu Chaodong Jin Dongsheng | 2014 | Meteorological and Environmental Research2014，5，6： | 2 |
| 16 | A new method for measuring solvent diffusivity in heavy oil by dynamic pendant drop shape analysis (DPDSA) 显示文摘 | Chaodong Yang Yongan Gu | 2006 | SPE842022006，，： | 1 |
| 17 | Eeigenvalue problem of elliptic equations with Hardy potential 显示文摘 | XIE Chaodong SHEN Yaotian YAO Yangxin | 2009 | Acta Mathematica Scientia2009，29，： | 1 |
| 18 | Age and Provenance of Loess deposits on the Northern Flank of Tianshan Mountain显示文摘分发,光学地刺激的光标明日期和 granulometric 性质建议 Tian 掸人的北胁腹上的黄土应该被划分成二种类型。象披风一样并且是的说出类型 A,位于上风斜坡并且对大约 54.5 ± 5 .73 Ka 过时。其它,叫的类型 B,平平地躺在河或低山的平台上并且以前渗透了 30.8 ± 2 .05 Ka。这里,我们学习起源和黄土的二种类型的年龄,并且黄土形成的一个模型被建议。灰尘从季风从蒙古定位到 Tian 掸人的北方的 Gobi 沙漠被乘火车,由高山妨碍了并且扔了在上上风山的斜坡。河和流动然后把风神的黄土搬运了到低平台和山麓冲积平原。 | YUAN Qingdong ZHANG Zhicheng WU Chaodong GUO Zhaojie | 2009 | Acta Geologica Sinica(English Edition)2009，83，3： | 1 |
| 19 | Dynamic Analysis and Optimal Design of a Novel Small 2-D planar Ultrasonic Motor显示文摘 | Chaodong Li Shi Xu Runfeng Liu | 2006 | IEEE Ultrasonics Sympoisum2006，，： | 1 |
| 20 | Research and applications of linear ultrasonic motors 显示文摘 | Li Chaodong Zhao Chunsheng | 1997 | Journal of Southeast University1997，27，5： | 1 |
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