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| 1 | Evidence chain-based causality identification in herb-induced liver injury: exemplification of a well-known liver-restorative herb Polygonum multiflorum显示文摘草药的药最近在美国作为导致药的肝损害(DILI ) 的第二个很普通的原因被认出了。然而,识别一些植物的 DILI 诱发性的可靠方法例如 Heshouwu (蓼 multiflorum 的弄干的根) ,留下缺乏。在这研究,有肝机能障碍和 Heshouwu DILI 的 147 个报导文学的案例的 12 307 个住院病人的一个总数被屏蔽。一个一般算法仅仅显示了那 22.5%(9/40 ) 并且(45/147 ) 分别地, 30.6% 所有住院和文学案例报告表明 Heshouwu 的 DILI 诱发性的高概率。由对比,(19/20 )95% 生药学,植物化学,和 metabolomic 有希望地调查的所有情况测试展出高度可能的诱发性,包括不正确地以前被归因的一个病人和从由 pharmacognostic 证据的 Heshouwu 诱发性被排除的一个案例。污染也是的毒素(重金属,杀虫剂,和 mycotoxins ) 从 Heshouwu DILI 诱发性排除了。为 Heshouwu DILI 诊断地址安全的这些屏蔽方法的客观性担心考虑包含芪的草药的药和饮食的补充。 | Jiabo Wang Zhijie Ma Ming Niu Yun Zhu Qingsheng Liang Yanling Zhao Jingyuan Song Zhaofang Bai Yaming Zhang Ping Zhang Na Li Yakun Meng Qi Li Lushan Qin Guangju Teng Junling Cao Baosen Li Shilin Chen Yonggang Li Zhengsheng Zou Honghao Zhou Xiaohe Xiao | 2015 | Frontiers of Medicine2015，9，4： | 47 |
| 2 | Effect of particle inertia on temperature statistics in particle-laden homogeneous isotropic turbulence显示文摘The fluid temperature statistics along particle trajectories is crucial to under- stand the mechanisms of turbulent non-isothermal or reactive fluid-particle flow, especially for the Lagrangian model of non-isothermal particle-laden turbulent flow. In the present study, direct numerical simulations were utilized to generate temperature field statistics in particle-laden incompressible stationary homogeneous isotropic turbulent flows, which is focused on the effect of particle response time on the Lagrangian statistics of the particle and the fluid temperature seen by particles. It shows that, for the particles with τp/τk < 1, the ratio of the fluid intensity seen by particle to fluid temperature intensities deceased as τp/τk increased; while for larger particles (τp/τk > 1), the trend is inversed. For small parti- cles (τp/τk<5), the Lagrangian autocorrelation coefficient of the particle temperature RpT decreases as the particle inertia (τp/τk) increases. The trend is reversed for larger particles. The autocorrelation of fluid temperature along the particle path, RpfT, decreased as the particle inertia increased. And as the particle inertia increased, the autocorrelation coeffi- cient of the fluid temperature seen by particle decreased more rapidly than that of the particle temperature. The mean temperature gradient contributes to the correlation be- tween the particles velocity component and temperature fluctuations in the direction of the gradient. For the particles with τp/τk<1, the magnitude of the correlation coefficient in- creases as the particle inertia increases, while this value is independent of the particle time constant for larger particles. | HE Zhu LIU Zhaohui CHEN Sheng LIU Yaming ZHENG Chuguang | 2006 | Science China(Technological Sciences)2006，49，2： | 8 |
| 3 | New insights into hepatitis B virus biology and implications for novel antiviral strategies显示文摘Hepatitis B virus(HBV), a small DNA virus with a unique replication mode, can cause chronic hepatitis(CHB), which is characterized by the persistence of the viral covalently closed circular DNA that serves as the template for HBV replication and the production of large amounts of secreted HBV surface antigen(HBs Ag) that is present in excess of the levels of infectious virus. Despite the success of currently approved antiviral treatments for CHB patients, including interferon and nucleotide analogs, which suppress HBV replication and reduce the risk of CHB-related liver diseases, these therapies fail to eradicate the virus in most of the patients. With the development of the cell and animal models for HBV study, a beter understanding of the HBV life cycle has been achieved and a series of novel antiviral strategies that target diferent stages of HBV replication have been designed to overcome the viral factors that contribute to HBV persistence. Such basic HBV research advancements and therapeutic developments are the subject of this review. | Jieliang Chen Min Wu Kuancheng Liu Wen Zhang Yaming Li Xiaohui Zhou Lu Bai Zhenghong Yuan | 2015 | National Science Review2015，2，3： | 6 |
| 4 | Experimental investigation of ash deposits on convection heating surfaces of a circulating fluidized bed municipal solid waste incinerator显示文摘Incineration of municipal solid waste(MSW) is a waste treatment method which can be sustainable in terms of waste volume reduction, as well as a source of renewable energy.During MSW combustion, increased formation of deposits on convection heating exchanger surfaces can pose severe operational problems, such as fouling, slagging and corrosion.These problems can cause lower heat transfer efficiency from the hot flue gas to the working fluid inside the tubes. A study was performed where experiments were carried out to examine the ash deposition characteristics in a full-scale MSW circulating fluidized bed(CFB) incinerator, using a newly designed deposit probe that was fitted with six thermocouples and four removable half rings. The influence of probe exposure time and probe surface temperature(500, 560, and 700℃) on ash deposit formation rate was investigated. The results indicate that the deposition mass and collection efficiency achieve a minimum at the probe surface temperature of 560℃. Ash particles are deposited on both the windward and leeward sides of the probe by impacting and thermophoretic/condensation behavior. The major inorganic elements present in the ash deposits are Ca,Al and Si. Compared to ash deposits formed on the leeward side of the probe,windward-side ash deposits contain relatively higher Ca and S concentrations, but lower levels of Al and Si. Among all cases at different surface temperatures, the differences in elemental composition of the ash deposits from the leeward side are insignificant.However, as the surface temperature increases, the concentrations of Al, Si, K and Na in the windward-side ash deposits increase, but the Ca concentration is reduced. Finally,governing mechanisms are proposed on the basis of the experimental data, such as deposit morphology, elemental composition and thermodynamic calculations. | Zhi Tang Xiaoping Chen Daoyin Liu Yaming Zhuang Minghua Ye Hongchan Sheng Shaojuan Xu | 2016 | Journal of Environmental Sciences2016，28，10： | 6 |
| 5 | Single-cell RNA sequencing reveals Nestin+active neural stem cells outside the central canal after spinal cord injury显示文摘Neural stem cells(NSCs)in the spinal cord hold great potential for repair after spinal cord injury(SCI).The ependyma in the central canal(CC)region has been considered as the NSCs source in the spinal cord.However,the ependyma function as NSCs after SCI is still under debate.We used Nestin as a marker to isolate potential NSCs and their immediate progeny,and characterized the cells before and after SCI by single-cell RNA-sequencing(scRNA-seq).We identified two subgroups of NSCs:the subgroup located within the CC cannot prime to active NSCs after SCI,while the subgroup located outside the CC were activated and exhibited the active NSCs properties after SCI.We demonstrated the comprehensive dynamic transcriptome of NSCs from quiescent to active NSCs after SCI.This study reveals that Nestin+cells outside CC were NSCs that activated upon SCI and may thus serve as endogenous NSCs for regenerative treatment of SCI in the future. | Muya Shu Xiaoyu Xue Hu Nie Xianming Wu Minghan Sun Lianyong Qiao Xing Li Bai Xu Zhifeng Xiao Yannan Zhao Yongheng Fan Bing Chen Jixiang Zhang Ya Shi Yaming Yang Falong Lu Jianwu Dai | 2022 | Science China(Life Sciences)2022，65，2： | 2 |
| 6 | National Alveolar Echinococcosis Distribution--China, 2012−2016显示文摘What is already known about this topic?Both alveolar echinococcosis(AE)and cystic echinococcosis are endemic in China,among which alveolar echinococcosis has a very high mortality rate.What is added by this report?The survey results showed the prevalence and scope of AE in China and identified high-risk groups including children,monks,herdsmen and illiterate people.At the same time,all the cases found in the survey(more than 90%of the patients did not go to the hospital for diagnosis and treatment before survey)were promptly diagnosed and treated.What are the implications for public health practice?This study provides information for the development of a plan for AE prevention and control and for the implementation of interventions targeted to high-risk populations. | Canjun Zheng Chuizhao Xue Shuai Han Zhongjie Li Hu Wang Liying Wang Ying Wang Qian Wang Yu Feng Yanyan Hou Xiao Ma Junying Ma Xiumin Han Gongsang Quzhen Xiaofeng Jiang Weidong Guo Xianglin Wu Yaming Yang Lei Cao Fanka Li Weiqi Chen Xinliu Yan Shicheng Yu Meihua Fu Qing Yu Ning Xiao Jiangping Cao Jun Yan Weiping Wu Xiao-nong Zhou | 2020 | China CDC weekly2020，2，1： | 2 |
| 7 | Lineage tracing reveals the origin of Nestin-positive cells are heterogeneous and rarely from ependymal cells after spinal cord injury显示文摘Nestin is expressed extensively in neural stem/progenitor cells during neural development, but its expression is mainly restricted to the ependymal cells in the adult spinal cord. After spinal cord injury(SCI), Nestin expression is reactivated and Nestinpositive(Nestin;) cells aggregate at the injury site. However, the derivation of Nestin;cells is not clearly defined. Here, we found that Nestin expression was substantially increased in the lesion edge and lesion core after SCI. Using a tamoxifen inducible CreER(T2)-loxP system, we verified that ependymal cells contribute few Nestin;cells either to the lesion core or the lesion edge after SCI. In the lesion edge, GFAP+astrocytes were the main cell type that expressed Nestin;they then formed an astrocyte scar.In the lesion core, Nestin;cells expressed αSMA or Desmin, indicating that they might be derived from pericytes. Our results reveal that Nestin;cells in the lesion core and edge came from various cell types and rarely from ependymal cells after complete transected SCI, which may provide new insights into SCI repair. | Xiaoyu Xue Muya Shu Zhifeng Xiao Yannan Zhao Xing Li Haipeng Zhang Yongheng Fan Xianming Wu Bing Chen Bai Xu Yaming Yang Weiyuan Liu Sumei Liu Jianwu Dai | 2022 | Science China(Life Sciences)2022，65，4： | 2 |
| 8 | CircRNA.0007127 triggers apoptosis through the miR-513a-5p/CASP8 axis in K-562 cells显示文摘Background:Circular RNAs(circR NAs)are covalently closed single-stranded RNAs with multiple biological functions.CircRNA.0007127 is derived from the carbon catabolite repression 4-negative on TATA-less(CCR4-NOT)complex subunit2(CNOT2),which was found to regulate tumor cell apoptosis through caspase pathway.Methods:Potential circR NA.0007127 target microRNAs(miRNAs)were analyzed by miRanda,TargetScan,and RNAhybrid software,and the miRNAs with binding sites for apoptosis-related genes were screened.The roles of circR NA.0007127 and its downstream target,microR NA(miR)-513a-5p,were validated by quantitative real-time polymerase chain reaction(qPCR),flow cytometry,mitochondrial membrane potential,immunofluorescence,western blot,and caspase-8(CASP8)protein activity in vitro in HO-induced K-562 cells.The circRNA.0007127-miR-513a-5p and CASP8-miR-513a-5p interactions were verified by luciferase reporter assays.Results:Silencing circRNA.0007127 decreased cell apoptosis by inhibiting CASP8 pathway activation in K-562 cells.Compared with the control group,the expression of CASP8 was reduced by 50%and the 43-kD fragment of CASP8 protein was significantly reduced(P≤0.05).The luciferase reporting assay showed that circRNA.0007127 combined with miR-513a-5p or CASP8,with extremely significant differences(P≤0.001).The overexpression of miR-513a-5p inhibited the gene expression level of CASP8in a human myeloid leukemia cell model(75%change)and the level of a 43-kD fragment of CASP8 protein(P small-interfering RNA(siRNA)and the miR-≤0.01).The rescue experiment showed that cotransfection with circRNA.0007127513a-5p inhibitor increased CASP8 gene expression and the apoptosis rate,suggesting that the miR-513a-5p inhibitor is a circRNA.0007127siRNA antagonist.Conclusions:CircRNA.0007127 regulates K-562 cell apoptosis through the miR-513a-5p/CASP8 axis,which can serve as a novel powerful molecular target for K-562 cells. | Xiajing LI Yiyu ZHANG Ning WANG Zhaohu YUAN Xiaojie CHEN Qicong CHEN Hui DENG Xinxin TONG Honglin CHEN Yuyou DUAN Yaming WEI | 2022 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2022，23，9： | 1 |
| 9 | Cleaning using nanobubbles: Defouling by electrochemical generation of bubbles显示文摘 | Zhihua Wu Hongbing Chen Yaming Dong Huiling Mao Jielin Sun Shenfu Chen Vincent S.J. Craig Jun Hu | 2008 | Journal of Colloid And Interface Science2008，，1： | 1 |
| 10 | Copper deficiency in yaks on pasture in western China显示文摘 | Shen Xiaoyun Du Guozhen Chen Yaming | 2006 | The Canadian Veterinary Journal2006，47，： | 1 |
| 11 | Ultrafine Fe-modulated Ni nanoparticles embedded within nitrogen-doped carbon from Zr-MOFs-confined conversion for efficient oxygen evolution reaction显示文摘Improvement of the low-cost transition metal electrocatalyst used in sluggish oxygen evolution reaction is a significant but challenging problem. In this study, ultrafine Fe-modulated Ni nanoparticles embedded in a porous Ni-doped carbon matrix were produced by the pyrolysis of zirconium metal–organic–frameworks, in which 2,2′-bipyridine-5,5′-dicarboxylate operating as a ligand can coordinate with Ni^(2+) and Fe^(3+). This strategy allows formation of Fe-modulated Ni nanoparticles with a uniform dimension of about 2 nm which can be ascribed to the spatial blocking effect of ZrO_(2). This unique catalyst displays an efficient oxygen evolution reaction electrocatalytic activity with a low overpotential of 372 mV at 10 mA·cm^(–2) and a small Tafel slope of 84.4 mV·dec^(–1) in alkaline media. More importantly, it shows superior durability and structural stability after 43 h in a chronoamperometry test. Meanwhile, it shows excellent cycling stability during 4000 cyclic voltammetry cycles. This research offers a new insight into the construction of uniform nanoscale transition metals and their alloys as highly efficient and durable electrocatalysts. | Lingtao Kong Zhouxun Li Hui Zhang Mengmeng Zhang Jiaxing Zhu Mingli Deng Zhenxia Chen Yun Ling Yaming Zhou | 2022 | Frontiers of Chemical Science and Engineering2022，16，7： | 1 |
| 12 | A Lifting Method for Fokker-Planck Equations with Drift-Admitting Jumps显示文摘We develop in this paper a lifting method for Fokker-Planck equations with drift-admitting jumps,such that high-order finite difference schemes.can be constructed directly based on grids with pure solution points.To illustrate the idea,we present as an example the construction of a fifth-order finite difference scheme.The validity of the scheme is demonstrated by conducting numerical experiments for the cases with drift admitting one jump and two jumps,respectively.Additionally,by introducing a splitting technique,we show that the lifting method can be extended to high dimensions.In particular,a two-dimensional case is studied in details to show the effectiveness of the extension. | Ningbo Guol Yaming Chen Xiaogang Deng | 2022 | Communications in Mathematical Research2022，38，3： | 1 |
| 13 | Optimal exercise intensity and volume to impact rats with Traditional Chinese Medicine phlegm-dampness constitution显示文摘Objective:We aim to investigate the effects of different exercise intensities and volumes on Phlegm-dampness constitution(PDC).Methods:The rats were fed with high-fat food and lived in 75%–85%humidity for 6 weeks to establish the model of PDC.Then PDC rats were screened and intervened by varying exercise intensities for 8 weeks.Weight,constitution scores,blood and liver tissues were collected to detect the concentration of serum total cholesterol(Tch),triglyceride(TG),low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C),homocysteine(Hcy),blood glucose(GLU),alanine transaminase(ALT)and percentage of lipid droplet area in liver tissue(PLDA).Results:The weight,Tch,TG,HDL-C,LDL-C,Hcy,GLU,and ALT of rats in moderate-intensity exercise group returned to normal.The rats with high-intensity or low-intensity exercise did not recover as well as moderate-intensity.Conclusion:Different exercise intensities and volumes have different effects on PDC,moderate-intensity exercise over an 8-week intervention is most appropriate. | Zhangmeng Xu Yong Chen Duoduo Yu Donghong Feng Chenjian Tang Tao Li Jing Zhou Yaming Yu | 2021 | Sports Medicine and Health Science2021，3，1： | 1 |
| 14 | NSC606985, a novel camptothecin analog, induces apoptosis and growth arrest in prostate tumor cells显示文摘 | Chen Tan Li-Qun Cai Wendy Wu Yaming Qiao Julianne Imperato-McGinley Guo-Qiang Chen Yuan-Shan Zhu | 2009 | Cancer Chemotherapy and Pharmacology2009，，2： | 1 |
| 15 | Positron emission tomography detector performance with different crystal pitches显示文摘Aims:In this work,we evaluated the performance of three pitches positron emission tomography(PET)detectors for building a high-resolution small-animal PET imaging experimental platform.Methods:The evaluation of PET detectors includes twodimensional crystal identification,energy resolution,and crystal look-up table.The nuclear instrumentation module and PXI data acquisition(DAQ)system were both used to obtain flood images.The energy spectrum of the Na-22 source was measured.PET detectors of 2.0 and 1.6 mm pitches used in our present experiment were composed of lutetium yttrium oxyorthosilicate(LYSO)crystals directly coupled to position-sensitive photomultiplier tubes(PSPMTs).The 1.3-mm pitch detector comprises a LYSO crystal,a tapered light-guide,and a PSPMT.The crystal sizes of the detectors were a 10×10 array of 2.0×2.0×10 mm^(3) crystals,a 10×10 array of 1.6×1.6×10 mm^(3) crystals,and an 18×18 array of 1.3×1.3×10 mm^(3) crystals,respectively.Due to the lower sampling frequency of the DAQ system,a spline interpolation algorithm was introduced in the signal waveform to reconstruct the peak values.Results:The experimental results indicated that all three PET detector crystals could be clearly identified.A detailed analysis demonstrated that the key characteristic full width at half maximum(FWHM)values of the crystals profile could reach 0.46±0.03,0.32±0.03,and 0.21±0.02 mm,while the crystal average energy resolutions were 16.8%±1.76%,20.1%±2.24%,and 31.5%±3.76%,which correspond to pitches of 2.0-,1.6-,and 1.3-mm,respectively.Conclusions:The PET detector modules of LYSO crystal arrays could be potentially used in the small-animal PET imaging applications and are promising to achieve submillimeter PET images. | LinGe Tong YaMing Fan Ming Dong Liang Zhao ZhongXing Li YingGuo Li TianQuan Wang YongZhi Yin XiMeng Chen | 2017 | Radiation Detection Technology and Methods2017，1，2： | 1 |
| 16 | Enhanced removal efficiency of bromate from aqueous solutions by nanoscale zero-valent iron immobilized on activated carbon显示文摘 | Chunhua Xu Xiaohong Wang Sheng Lin Liujia Zhu Yaming Chen | 2015 | Desalination and Water Treatment2015，，9： | 1 |
| 17 | High-fidelity structured illumination microscopy by point-spread-function engineering显示文摘Structured illumination microscopy(SIM)has become a widely used tool for insight into biomedical challenges due to its rapid,long-term,and super-resolution(SR)imaging.However,artifacts that often appear in SIM images have long brought into question its fidelity,and might cause misinterpretation of biological structures.We present HiFi-SIM,a high-fidelity SIM reconstruction algorithm,by engineering the effective point spread function(PSF)into an ideal form.HiFi-SIM can effectively reduce commonly seen artifacts without loss of fine structures and improve the axial sectioning for samples with strong background.In particular,HiFi-SIM is not sensitive to the commonly used PSF and reconstruction parameters;hence,it lowers the requirements for dedicated PSF calibration and complicated parameter adjustment,thus promoting SIM as a daily imaging tool. | Gang Wen Simin Li Unbo Wang Xiaohu Chen Zhenglong Sun Yong Liang Xin Jin Yifan Xing Yaming jiu Yuguo Tang Hui Li | 2021 | Light(Science & Applications)2021，10，5： | 1 |
| 18 | A Lifting Method for Krause's Consensus Model显示文摘In this work,we aim to show how to solve the continuous-time and continuous-space Krause model by using high-order finite difference(FD)schemes.Since the considered model admits solutions withδ-singularities,the FD method cannot be applied directly.To deal with the annoyingδ-singulariti-es,we propose to lift the solution space by introducing a spltting method,such that theδ-singularities in one spatial direction become step functions with dis-continuities.Thus the traditional shock-capturing FD schemes can be applied directly.In particular,we focus on the two dimensional case and apply a fifth-order weighted nonlinear compact scheme(WCNS)to ilustrate the validity of the proposed method.Some technical details for implementation are also presented.Numerical results show that the proposed method can captureδ-singularities well,and the obtained number of delta peaks agrees with the the-oretical prediction in the literature. | Ningbo Guo Yaming Chen Xiaogang Deng | 2022 | Communications in Mathematical Research2022，38，1： | 1 |
| 19 | An ultrapotent pan-β-coronavirus lineage B(β-CoV-B)neutralizing antibody locks the receptor-binding domain in closed conformation by targeting its conserved epitope显示文摘New threats posed by the emerging circulating variants of SARS-CoV-2 highlight the need to find conserved neutralizing epitopes for therapeutic antibodies and efficient vaccine design.Here,we identified a receptorbinding domain(RBD)-binding antibody,XG014,which potently neutralizesβ-coronavirus lineage B(β-CoV-B),including SARS-CoV-2,its circulating variants,SARSCoV and bat SARSr-CoV WIV1.Interestingly,antibody family members competing with XG014 binding show reduced levels of cross-reactivity and induce antibodydependent SARS-CoV-2 spike(S)protein-mediated cellcell fusion,suggesting a unique mode of recognition by XG014.Structural analyses reveal that XG014 recognizes a conserved epitope outside the ACE2 binding site and completely locks RBD in the non-functional“down”conformation,while its family member XG005 directly competes with ACE2 binding and position the RBD“up”.Single administration of XG014 is effective in protection against and therapy of SARS-CoV-2 infection in vivo.Our findings suggest the potential to develop XG014 as pan-β-CoV-B therapeutics and the importance of the XG014 conserved antigenic epitope for designing broadly protective vaccines againstβ-CoV-B and newly emerging SARS-CoV-2 variants of concern. | Zezhong Liu Wei Xu Zhenguo Chen Wangjun Fu Wuqiang Zhan Yidan Gao Jie Zhou Yunjiao Zhou Jianbo Wu Qian Wang Xiang Zhang Aihua Hao Wei Wu Qianqian Zhang Yaming Li Kaiyue Fan Ruihong Chen Qiaochu Jiang Christian TMayer Till Schoofs Youhua Xie Shibo Jiang Yumei Wen Zhenghong Yuan Kang Wang Lu Lu Lei Sun Qiao Wang | 2022 | Protein & Cell2022，13，9： | 1 |
| 20 | Synergic effect of 3′-azido-3′-deoxythymidine and arsenic trioxide in suppressing hepatoma cells显示文摘 | Che Chen Yingmei Zhang Yong Wang Dejun Huang Yaming Xi Yongmei Qi | 2011 | Anti-Cancer Drugs2011，，5： | 1 |
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