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| 1 | Herbal decoctosome is a novel form of medicine显示文摘Traditionally, herbal medicine is consumed by drinking decoctions produced by boiling herbs with water. The functional components of the decoction are heat stable. Small RNAs(sRNAs) were reported as a new class of functional components in decoctions. However, the mechanisms by which sRNAs survive heat treatment of the decoction and enter cells are unclear.Previous studies showed that plant-derived exosome-like nanoparticles(ELNs), which we call botanosomes, could deliver therapeutic reagents in vivo. Here, we report that heat-stable decoctosomes(ELNs) from decoctions have more therapeutic effects than the decoctions in vitro and demonstrate therapeutic efficacy in vivo. Furthermore, sRNAs, such as HJT-sRNA-m7 and PGY-sRNA-6, in the decoctosome exhibit potent anti-fibrosis and anti-inflammatory effects, respectively. Decoctosome is comprised of lipids, chemical compounds, proteins, and s RNAs. A medical decoctosome mimic is called bencaosome. A single lipid sphinganine(d22:0) identified in the decoctosome was mixed and heated with the synthesized sRNAs to form the simplest bencaosome. This simple bencaosome structure was identified by critical micelle concentration(cmc) assay that sRNAs coassembled with sphinganine(d22:0) to form the lipid layers of vesicles. The heating process facilitates co-assembly of sRNAs and sphinganine(d22:0) until a steady state is reached. The artificially produced sphinganine-HJT-sRNA-m7 and sphinganinePGY-sRNA-6 bencaosomes could ameliorate bleomycin-induced lung fibrosis and poly(I:C)-induced lung inflammation, respectively, following oral administration in mice. Our study not only demonstrates that the herbal decoctosome may represent a combinatory remedy in precision medicine but also provides an effective oral delivery route for nucleic acid therapy. | Xiaoyun Li Zhu Liang Jianchao Du Zhiqing Wang Song Mei Zhiqing Li Yan Zhao DANDan Zhao Yiming Ma Jun Ye Jiantao Xu Yu Zhao Jiahui Chang Yuhao Qin Lanlan Yu Chenxuan Wang Chengyu Jiang | 2019 | Science China(Life Sciences)2019，62，3： | 26 |
| 2 | Comparison of simple discectomy and instrumented posterior lumbar interbody fusion for treatment of lumbar disc herniation combined with Modic endplate changes显示文摘 | Cao Peng Chen Zhe Zheng Yuehuan Wang Yuren Jiang Leisheng Yang Yaoqi Zhuang Chengyu Liang Yu Zheng Tao Gong Yaocheng Zhang Xingkai Wu Wenjian Qiu Shijing | 2014 | Chinese Medical Journal2014，，15： | 15 |
| 3 | Strengthening effect of Cu-rich phase precipitation in 18Cr9Ni3CuNbN austenitic heat-resisting steel显示文摘The Cu-containing austenitic heat-resistant steel 18Cr9Ni3CuNbN, which is being used as superheater and reheater tube material for modern ultra-super-critical (USC) power plants all over the world, has been investigated at 650 ℃ long time aging till 10 000 h. SEM, TEM and 3DAP (three dimensional atom probe) have been used to follow microstructural changes with mechanical property variations. Experimental results show that Cu-rich phase and MX precipitate in the grains as well as M 23 C 6 precipitates at grain boundaries are the main precipitation strengthening phases in this steel. Among them Cu-rich phase is the most important strengthening phase. Homogeneous distribution of very fine nano-size Cu-rich phase has been formed at very early stage of 650 ℃ aging (less than 1 h). Cu atoms gradually concentrate to Cu-rich particles and the other elements (such as Fe, Cr, Ni etc) diffuse away from Curich particles to γ-matrix with the increasing of aging time at 650 ? C. The growth rate of Cu-rich phase at 650 ℃ long time aging is very slow and the average diameters of Cu-rich phase have been determined by TEM method. Cu-rich phase keeps in about 30 nm till 650 ℃ aging for 10 000 h. It shows that nano-size Cu-rich phase precipitation strengthening can be kept for long time aging at 650 ℃ because of its excellent stability at high temperatures. According to structure stability study and mechanical properties determination results the Cu-rich phase precipitation sequence and its strengthening mechanism model have been suggested and discussed. | Chengyu CHI Hongyao YU Jianxin DONG Xishan XIE Zhengqiang CUI Xiaofang CHEN Fusheng LIN | 2011 | Acta Metallurgica Sinica(English Letters)2011，24，2： | 6 |
| 4 | Human RBCs blood group conversion from A to O using a novel α-N-acetylgalactosaminidase of high specific activity显示文摘α-N-acetylgalactosaminidase (αNAGA) can convert group A human red blood cells (RBCs) to group O. One novel αNAGA gene was cloned by PCR from Elizabethkingia meningosepticum isolated from a domestic clinical sample. Pure recombinant αNAGA was obtained by genetic engineering and protein purification with a calculated molecule of 49.6 kD. αNAGA was selective for terminal α-N-acetylgalacto-samine residue with a high specific activity. αNAGA could completely remove A antigens of 1 U (about 100 mL) group A1 or A2 RBCs in 1 h at pH 6.8 and 25℃ with a consumption of 1.5 or 0.4 mg recombinant enzyme. Enzyme-converted group A RBCs did not agglutinate after being mixed with monoclonal anti-A or sera of groups A,B,AB and O. Other blood group antigens except ABO had no change. FCM analy-sis showed that A antigens and A1 antigens disappeared while H antigens increased. It indicated that αNAGA successfully converted human blood group A RBCs to universally transfusable group O RBCs without the risk of ABO-incompatible transfusion reactions. This αNAGA was suitable for producing universal RBCs to increase clinical transfusion safety,improve the RBCs supply,and to decrease transfusion cost and support transfusion service in case of emergency. | YU ChengYu XU Hua WANG LiSheng ZHANG JianGeng ZHANG YangPei | 2008 | Chinese Science Bulletin2008，53，13： | 5 |
| 5 | Lacrimal sac diverticulum presenting as a lower eyelid mass with a secreting fistula显示文摘 | Zhang Chengyue Wu Qian Yu Jifeng Cui Yanhui Cao Wenhong Fan Yunwei Yu Gang | 2014 | Chinese Medical Journal2014，，18： | 4 |
| 6 | Preparation and luminescence properties of orange-red Ba3Y4O9:Sm3+phosphors显示文摘A novel orange-red emitting Ba_3 Y_4 O_9:Sm^(3+) phosphors were prepared by a high temperature solidstate reaction in air. X-ray diffraction(XRD), photoluminescence spectra, fluorescence decay and temperature-dependent emission spectra were utilized to characterize the structure and luminescence properties. The results show that the excitation spectrum includes a series of linear peaks at350, 367, 382, 410, 424, 445, 470 and 495 nm, respectively. Under 410 nm excitation, the emission peaks were located at 574 nm(~4 G_(5/2)-~6 H_(5/2)), 608 nm(~4 G_(5/2)-~6 H_(7/2)),659 nm(~4 G_(5/2)-~6 H_(9/2)) and722 nm(~4 G_(5/2)-~6 H_(11/2)), respectively. The concentration quenching occurs when x equals 0.08 for Ba_3 Y_(4-x)O_9:xSm^(3+) phosphor and its mechanism is ascribed to the dipole-dipole interaction. The chromaticity coordinates of Ba_3 Y_(3.92)O_9:0.08 Sm^(3+) phosphor are in the orange-red region. The temperature-dependent study shows that this phosphor has excellent luminescence thermal-stability.And the luminescence intensity of Ba_3 Y_(3.92)O_9:0.08 Sm^(3+) phosphor at 473 K only declines by about25.75% of its initial intensity. The experimental data indicate that Ba_3 Y_4 O_9:Sm^(3+) phosphor may be promising as an orange-red emitting phosphor for white light emitting diodes. | Jiayu Li Ran Pang Zhan Yu Liyan Liu Haiyan Wu Huimin Li Lihong Jiang Su Zhang Jing Feng Chengyu Li | 2018 | Journal of Rare Earths2018，36，7： | 3 |
| 7 | MacroH2A1.1 cooperates with EZH2 to promote adipogenesis by regulating Wnt signaling显示文摘白 adipocytes 玩在许多生理的过程的重要角色包括精力存储,内分泌的发信号,并且煽动性的回答。理解 adipocyte 形成(adipogenesis ) 的分子的机制对肥胖和它的相关疾病提供卓见进治疗学的途径。许多 transcriptional 因素和 epigenetic 酶被知道调整 adipogenesis;然而, histone 变体是否在这个过程起一个作用,是未知的。这里,我们发现了那 macroH2A1.1 (mH2A1.1 ) , histone H2A 的变体,在在 3T3-L1 房间并且在肥胖的鼠标的白脂肪质的织物的 adipocyte 区别期间是 upregulated。mH2A1.1 的脱离激活表明小径的 Wnt/-catenin,当 mH2A1.1 的 overexpression 出现在效果对面时。我们进一步发现 mH2A1.1 调整了由与 EZH2 合作表明小径的 Wnt/-catenin, histone H3K27 methyltransferase,因此在 Wnt 基因的倡导者上导致了 H3K27me2 和 H3K27me3 的累积。在宏域的变化, mH2A1.1 G224E , 和 mH2A1.1 G314E , 不仅损害了 adipogenesis,而且在 Wnt 基因的倡导者上损害了 mH2A1.1 的有约束力的能力到 EZH2 和 H3K27me2 和 H3K27me3 的丰富。一起,我们的学习在 adipogenesis 和肥胖揭示 mH2A1.1 的一个新奇规章的角色,它在白胖开发提供新卓见。 | Danyang Wan Chengyu Liu Yu Sun Wenjun Wang Kun Huang Ling Zheng | 2017 | Journal of Molecular Cell Biology2017，9，4： | 3 |
| 8 | Erratum to:Herbal decoctosome is a novel form of medicine显示文摘Following the published article,we noticed an error duplication in Figure 5G“control”and“PGY-6”that was introduced during the revised process,with an attempt to replace it with higher-resolution images.Here we provide the original data in the first submitted manuscript(Figure 5G). | Xiaoyun Li Zhu Liang Jianchao Du Zhiqing Wang Song Mei Zhiqing Li Yan Zhao Dandan Zhao Yiming Ma Jun Ye Jiantao Xu Yu Zhao Jiahui Chang Yuhao Qin Lanlan Yu Chenxuan Wang Chengyu Jiang | 2020 | Science China(Life Sciences)2020，63，9： | 2 |
| 9 | A one-for-all strategy of polyimide coating layer for resolving the comprehensive issues of phosphorus anode显示文摘Phosphorus is a promising anode with high capacity (2596 mAh g^(-1)and 6075~6924 mAh cm^(-3)),low lithium-ion diffusion barrier (0.08 e V),and appropriate lithiation potential (~0.7 V vs Li+/Li).However,it faces the problems of huge volume expansion (~300%),low electronic conductivity (10^(-14)~10^(2)S cm^(-1)),soluble intermediates (lithium polyphosphides,Li_(x)Ps),degradation in air,and low thermal stability.In this work,phosphorus/carbon nanotube composites were coated with a polyimide layer,which plays the roles of a buffer layer to relieve the volume expansion of phosphorus,an obstruct layer to confine LixPs,an inert layer to prevent the degradation of phosphorus in air,a heat resistant layer to improve the thermal stability of the anode.The resulting composites (P/CNT@PI) display high capacity retention of798.1 m Ah g^(-1)after 150 cycles at 1 A g^(-1),achieving 17 times as much as the control sample (P/CNT). | Muyao Han Shaojie Zhang Yu Cao Chengyu Han Xu Li Yiming Zhang Zhanxu Yang Jie Sun | 2022 | Journal of Energy Chemistry2022，31，7： | 2 |
| 10 | Identification of prognostic biomarkers in hepatitis B virus-related hepatocellular carcinoma and stratification by integrative multi-omics analysis显示文摘 | Ruoyu Miao Haitao Luo Huandi Zhou Guangbing Li Dechao Bu Xiaobo Yang Xue Zhao Haohai Zhang Song Liu Ying Zhong Zhen Zou Yan Zhao Kuntao Yu Lian He Xinting Sang Shouxian Zhong Jiefu Huang Yan Wu Rebecca A. Miksad Simon C. Robson Chengyu Jiang Yi Zhao Haita | 2014 | Journal of Hepatology2014，，： | 2 |
| 11 | PULSED Nd-YAG LASER WELDING OF AN AI-SiC_p METAL MATRIX COMPOSITE显示文摘A study is presented of the laser welding behaviour of an SiC particulate re-inforced Al-alloy comPOsite using a pulsed Nd-YAG laser. The influences of laser weldingparameters of laser intensity, pulse duration and the beamjs focus position on the depth ofweld penetration as well as the size of weld bead width were investigated. A typical mi-crostructure of a weld section reveals that the three distinct zones are present. Cracks andporosity were fOund to be two major defects in laser welded metal matrix composites(MMC). These investigations have led to an optimum welding condition proposed forlaser welding of SiC partiulate reinforced aluminium alloy comPosites with minimum de-fects. | Xu Jiukua Jiang Chengyu(Mechanical Engineering Institute, Nanjing University of Aeronauticsand Astronautics, Nanjing, 210016, China)Yu Damin Liu Weicheng(Department of Manufacturing Engineering, Hong Kong Polytechnic University) | 1997 | Chinese Journal of Aeronautics1997，10，1： | 2 |
| 12 | Carbon Dots-in-Zeolite via In-Situ Solvent-Free Thermal Crystallization:Achieving High-Efficiency and Ultralong Afterglow Dual Emission显示文摘Organic afterglow materials are highly desirable for optoelectronic applications,but they usually suffer from complex preparation process,low quantum efficiency,and short lifetime due to the ultrafast deactivation of the highly active excited states involved.Here,we succeeded in achieving solventfree thermal syntheses of high-efficiency afterglow CDs@zeolite composite materials by simply grinding the solid raw materials of zeolite and precursor CDs at room temperature,followed by thermal crystallization.This method afforded maximum embedding of CDs into growing zeolite crystals,as well as strong host–guest interaction to surpass the nonradiative transition of CDs,thus producing composite materials with ultralong dual emission of thermally activated delayed fluorescence and room temperature phosphorescence with a record high lifetime of 1.7 and 2.1 s,respectively,and the quantum yield of 90.7%.Furthermore,in a preliminary experiment,we applied the composite materials in alternatingcurrent light-emitting diode supplementary lighting,which exhibited a promising potential in optoelectronic applications. | Hongyue Zhang Kaikai Liu Jiancong Liu Bolun Wang Chengyu Li Wei Song Jiyang Li Ling Huang Jihong Yu | 2020 | CCS Chemistry2020，2，3： | 1 |
| 13 | Investigation of a plasma delivery system for optical figuring process显示文摘Plasma figuring process enables the correction of metre-scale optical surfaces,which has advantages such as rapid convergence to ultra-precision accuracy level,no subsurface damage,ease of upscale thanks to the conditions of operation at atmospheric.Such attributes make plasma figuring a highly competitive technology.To maintain a stable discharge of plasma for long period,a robust Plasma Delivery System(PDS)is required for large optics manufacturing.A dedicated PDS,mainly based on an L-type radio frequency(RF)network and an inductively coupled plasma(ICP)torch,had been previously proposed and designed.This study addresses the requirement for improving the robustness and securing the performance of the plasma etching.Due to the complexity of interactions of PDS parameters,single variable optimization is conducted for adjusting the impedance of the plasma torch.The PDS optimization is analysed based on ignition power demand,test repeatability and reflected power values.The results show that reflected power values are controllable within 10 W,when the RF power is supplied from 200 W up to 800 W.Finally,plasma processing is carried out on fused silica glass,using the optimum parameters of the PDS. | Nan YU Renaud JOURDAIN Marco CASTELLI Adam BENNETT Jiang GUO Chengyu MA Fengzhou FANG | 2021 | Chinese Journal of Aeronautics2021，34，4： | 1 |
| 14 | Characteristics of the sea ice reflectance spectrum polluted by oil spills based on field experiments in the Bohai Sea显示文摘Oil spilled on the sea ice surface in the Bohai Sea of China is studied through the field measurements of the reflectance of a simulated sea ice-oil film mixed pixel. The reflection characteristics of sea ice and oil film are also analyzed. It is found that the mixed pixel of sea ice and oil film is a linear mixed pixel. The means of extracting sea ice pixels containing oil film is presented using a double-band ratio oil-film sea-ice index(DROSI) and a normalized difference oil-film sea-ice index(NDOSI) through the analysis of the reflectance curves of the sea iceoil film pixel for different ratios of oil film. The area proportion of the oil film in the sea ice-oil film pixel can be accurately estimated by the average reflectance of the band of 1 610–1 630 nm, and the volume of the spilled oil can be further estimated. The method of the sea ice-oil film pixel extraction and the models to estimate the proportion of oil film area in the sea ice-oil film pixel can be applied to the oil spill monitoring of the ice-covered area in the Bohai Sea using multispectral or hyperspectral remote sensing images in the shortwave infrared band(1 500–1 780 nm). | CHAO Jinlong LIU Chengyu LI Ying LIN Xia YAN Yu | 2017 | Acta Oceanologica Sinica2017，36，1： | 1 |
| 15 | Preparation of long-lastlng phosphorescence (LLP) glass-ceramic materials 显示文摘 | Li Chengyu Wang Shubin Yu Yingning | 2004 | Journal of Rare Earths2004，22，1： | 1 |
| 16 | Oral administration of the herbal oligonucleotide XKC-sRNA-h3 prevents angiotensinⅡ-induced hypertension in mice显示文摘Hypertension has become a growing public health concern worldwide.In fact,hypertension is commonly associated with increased morbidity and mortality.Currently,oligonucleotide drugs have proven to be promising therapeutic agents for various diseases.In the present study,we aimed to demonstrate that a herbal small RNA(s RNA),XKC-sRNA-h3(B55710460,F221.I000082.B11),exhibits potent antihypertensive effects by targeting angiotensin-converting enzyme(ACE)in mice.When compared with captopril,oral administration of the sphingosine(d18:1)-XKC-s RNA-h3 bencaosome more effectively prevented angiotensin II-induced hypertensive cardiac damage and alleviated kidney injury in mice.Such findings indicated that XKC-sRNA-h3 may be a novel orally available ACE inhibitor type oligonucleotide drug for hypertension. | Kegong Tang Xiaona Wang Yu Zhao Xiaobei Li Zhenyu Jiang Song Mei Mingrui Chen Yiming Ma Xinyi Du Xiangyu Qiao Na Sun Jiaqi Liu Chengyu Jiang | 2023 | Science China(Life Sciences)2023，66，10： | 1 |
| 17 | Consumption of salted meat and its interactions with alcohol drinking and tobacco smoking on esophageal squamous‐cell carcinoma显示文摘 | Sihao Lin Xiaorong Wang Chengyu Huang Xudong Liu Jin Zhao Ignatius T.S. Yu David C. Christiani | 2015 | Int. J. Cancer2015，，3： | 1 |
| 18 | Engineered extracellular vesicles for delivery of siRNA promoting targeted repair of traumatic spinal cord injury显示文摘Spinal cord injury(SCI)is a severe disease of the nervous system that causes irreparable damage and loss of function,for which no effective treatments are available to date.Engineered extracellular vesicles(EVs)carrying therapeutic molecules hold promise as an alternative SCI therapy depending on the specific functionalized EVs and the appropriate engineering strategy.In this study,we demonstrated the design of a drug delivery system of peptide CAQK-modified,siRNA-loaded EVs(C-EVs-siRNA)for SCI-targeted therapy.The peptide CAQK was anchored through a chemical modification to the membranes of EVs isolated from induced neural stem cells(iNSCs).CCL2-siRNA was then loaded into the EVs through electroporation.The modified EVs still maintained the basic properties of EVs and showed favorable targeting and therapeutic effects in vitro and in vivo.C-EVs-siRNA specifically delivered siRNA to the SCI region and was taken up by target cells.C-EVs-siRNA used the inherent anti-inflammatory and neuroreparative functions of iNSCs-derived EVs in synergy with the loaded siRNA,thus enhancing the therapeutic effect against SCI.The combination of targeted modified EVs and siRNA effectively regulated the microenvironmental disturbance after SCI,promoted the transformation of microglia/macrophages from M1 to M2 and limited the negative effects of the inflammatory response and neuronal injury on functional recovery in mice after SCI.Thus,engineered EVs are a potentially feasible and efficacious treatment for SCI,and may also be used to develop targeted treatments for other diseases. | Yuluo Rong Zhuanghui Wang Pengyu Tang Jiaxing Wang Chengyue Ji Jie Chang Yufeng Zhu Wu Ye Jianling Bai Wei Liu Guoyong Yin Lipeng Yu Xuhui Zhou Weihua Cai | 2023 | Bioactive Materials2023，，5： | 1 |
| 19 | Experimental study of water force acting on spur dike显示文摘 | Yu Tao Wang pingyi Yang Chengyu | 2011 | Advances in Civil Engineering2011，3，： | 1 |
| 20 | Experi- mental study of water force acting on spur dike显示文摘 | Yu Tao Wang Pingyi Yang Chengyu | 2011 | Advances in Civil Engineering2011，，3： | 1 |
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