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| 1 | Reconfigurable intelligent surfaces for smart wireless environments:channel estimation,system design and applications in 6G networks显示文摘Reconfigurable intelligent surface(RIS),one of the key enablers for the sixth-generation(6G)mobile communication networks,is considered by designers to smartly reconfigure the wireless propagation environment in a controllable and programmable manner.Specifically,an RIS consists of a large number of low-cost and passive reflective elements(REs)without radio frequency chains.The system gain of RIS wireless systems can be achieved by adjusting the phase shifts and amplitudes of the REs so that the desired signals can be added constructively at the receiver.However,an RIS typically has limited signal processing capability and cannot perform active transmitting/receiving in general,which leads to new challenges in the physical layer design of RIS wireless systems.In this paper,we provide an overview of the RIS-aided wireless systems,including the reflection principle,channel estimation,and system design.In particular,two types of emerging RIS systems are considered:RIS-aided wireless communications(RAWC)and RISbased information transmission(RBIT),where the RIS plays the role of the reflector and the transmitter,respectively.We also envision the potential applications of RIS in 6G networks. | Ying-Chang LIANG Jie CHEN Ruizhe LONG Zhen-Qing HE Xianqi LIN Chenlu HUANG Shilin LIU Xuemin(Sherman)SHEN Marco DI RENZO | 2021 | Science China(Information Sciences)2021，64，10： | 12 |
| 2 | The design,mechanism and biomedical application of self-healing hydrogels显示文摘Hydrogels are promising materials with outstanding characteristics such as tunable and reversible physical/chemical properties,stimuli-responsiveness,biomimetic,and biocompatibility.However,the structural and functional integrity of the hydrogels can be compromised by external mechanical forces or chemical erosion when used,especially in sophisticated in vivo environment.To address this problem,self-healing hydrogels which possess the intrinsic ability of self-repair have been developed to adapt to destructive factors.In this review,we focused on the current advances made in self-healing hydrogels.First,the testing methods for self-healing hydrogels were summarized.Then,we looked into the designing strategies of self-healing hydrogels and illustrated the self-healing mechanism.What's more,the biomedical application of self-healing hydrogels in vivo was discussed. | Qiwen Li Chenlu Liu Junru Wen Yongzhi Wu Yue Shan Jinfeng Liao | 2017 | Chinese Chemical Letters2017，28，9： | 11 |
| 3 | Synthesis of ordered mesoporous carbonaceous materials and their highly efficient capture of uranium from solutions显示文摘An extremely effortless method was applied for successful synthesis of mesoporous carbonaceous materials(MCMs) using well-ordered mesoporous silica as template. Various characterizations(scanning electron microscopy(SEM), transmission electron microscopy(TEM), X-ray diffraction(XRD), Fourier transform infrared spectroscopy(FT-IR), Raman, X-ray photoelectron spectroscopy(XPS), Brunner-Emmet-Teller(BET) and Zeta potential) confirmed that MCMs had large surface area, uniform pore size distribution, and abundant oxygen-containing functional groups. The batch techniques were employed to study U(VI) adsorption on MCMs under a wide range of experiment conditions. The adsorption kinetics of U(VI) onto MCMs were well-fitted by pseudo-second-order kinetic model, indicating a chemisorption process. The excellent adsorption capacity of MCMs calculated from the Langmuir model was 293.95 mg g^(-1) at pH 4.0. The FT-IR and XPS analyses further evidenced that the binding of U(VI) onto MCMs was ascribed to the plentiful adsorption sites(–OH and –COOH groups) in the internal mesoporous structure, which could efficiently trap guest U(VI) ions. The results presented herein revealed that MCMs were ideal adsorbents in the efficient elimination of uranium or other lanthanides/actinides from aqueous solutions, which would play an important role in environmental pollution management application. | Chenlu Zhang Xing Li Zhongshan Chen Tao Wen Shuyi Huang Tasawar Hayat Ahmed Alsaedi Xiangke Wang | 2018 | Science China Chemistry2018，61，3： | 8 |
| 4 | Interactive effects of understory removal and fertilization on soil respiration in subtropical Eucalyptus plantations显示文摘Aims It has been well recognized that understory vegetation plays an important role in driving forest ecosystem processes and functioning.In subtropical plantation forests,understory removal and fertiliza-tion have been widely applied;however,our understanding on how understory removal affects soil respiration and how the process is regulated by fertilization is limited.Here,we conducted an under-story removal experiment combined with fertilization to evaluate the effects of the two forest management practices and their inter-actions on soil respiration in subtropical forest in southern China.Methods The study was conducted in a split-plot design with fertilization as the whole-plot factor,understory removal as the subplot factor and block as the random factor in subtropical Eucalyptus plantations.In total,there were four treatments:control with unfertilized and intact understory(CK),understory removal but without fertilization(UR),with fertilization but without understory removal(FT)and with fertilization+understory removal(FT+UR).Eucalyptus above-and belowground biomass increment,fine root biomass,soil tempera-ture,soil moisture and soil respiration were measured in the present study.understory respiration(Ru)was quantified in different ways:Ru=RCK−Ru or Ru=RFT−R(FT+u);fertilization increased soil respiration(RFI)was also quantified in different ways:RFI=RFT−RCK or RFI=R(FT+u)−Ru.Important Findingsover a 2-year experiment,our data indicate that understory removal significantly decreased soil respiration,while fertilization increased soil respiration.understory removal decreased soil respiration by 28.8%under fertilization,but only 15.2%without fertilization.Fertilization significantly increased soil respiration by 23.6%with the presence of understory vegetation,and only increased by 3.7%when understory was removed,indicating that fertilization increased soil respiration mainly by increasing the contribution of the understory.our study advances our understanding of the interactive effects of understory management and fertilization on soil respiration in subtropical plantations. | Songze Wan Chenlu Zhang Yuanqi Chen Jie Zhao Xiaolin Zhu Jianping Wu Lixia Zhou Yongbiao Lin Zhanfeng Liu Shenglei Fu | 2015 | Journal of Plant Ecology2015，8，3： | 6 |
| 5 | Toward emerging gallium oxide semiconductors:A roadmap显示文摘Owing to the advantages of ultra-wide bandgap and rich material systems,gallium oxide(Ga_(2)O_(3))has emerged as a highly viable semiconductor material for new researches.This article mainly focuses on the growth processes,material characteristics,and applications of Ga_(2)O_(3).Compared with single crystals and the epitaxial growth of other wide-bandgap semiconductors,large-size and high-quality��-Ga_(2)O_(3) single crystals can be efficiently grown with a low cost,making them highly competitive.Thanks to the availability of high-quality single crystals,epi-taxial films,and rich material systems,high-performance semiconductor devices based on Ga_(2)O_(3) go through a booming development in recent years.The defects and interfaces of Ga_(2)O_(3) are comprehensively analyzed owing to their significant influence on practical applications.In this study,the two most common applications of Ga_(2)O_(3) materials are introduced.The high breakdown electric field,high working temperature,and excellent Baliga’s figure-of-merit of Ga_(2)O_(3) represent an inspiring prospect for power electronic devices.In addition,the excellent absorption in deep-ultraviolet band provides new ideas for optoelectronic detectors and ensures the dramatic progress.Finally,the summary,challenges,and prospects of the Ga_(2)O_(3) materials and devices are presented and discussed. | Yuan Yuan Weibing Hao Wenxiang Mu Zhengpeng Wang Xuanhu Chen Qi Liu Guangwei Xu Chenlu Wang Hong Zhou Yanni Zou Xiaolong Zhao Zhitai Jia Jiandong Ye Jincheng Zhang Shibing Long Xutang Tao Rong Zhang Yue Hao | 2021 | Fundamental Research2021，1，6： | 5 |
| 6 | Temperature-induced Lifshitz transition in topological insulator candidate HfTe_5显示文摘The ongoing discoveries and studies of novel topological quantum materials have become an emergent and important field of condensed matter physics.Recently,HfTe_5 ignited renewed interest as a candidate of a novel topological material.The single-layer HfTe_5 is predicted to be a two-dimensional large band gap topological insulator and can be stacked into a bulk that may host a temperature-driven topological phase transition.Historically,HfTe_5 attracted considerable interest for its anomalous transport properties characterized by a peculiar resistivity peak accompanied by a sign reversal carrier type.The origin of the transport anomaly remains under a hot debate.Here we report the first high-resolution laser-based angle-resolved photoemission measurements on the temperature-dependent electronic structure in HfTe_5.Our results indicated that a temperature-induced Lifshitz transition occurs in HfTe_5,which provides a natural understanding on the origin of the transport anomaly in HfTe_5.In addition,our observations suggest that HfTe_5 is a weak topological insulator that is located at the phase boundary between weak and strong topological insulators at very low temperature. | Yan Zhang Chenlu Wang Guodong Liu Aiji Liang Lingxiao Zhao Jianwei Huang Qiang Gao Bing Shen Jing Liu Cheng Hu Wenjuan Zhao Genfu Chen Xiaowen Jia Li Yu Lin Zhao Shaolong He Fengfeng Zhang Shenjin Zhang Feng Yang Zhimin Wang Qinjun Peng Zuyan Xu Chuangtian Chen Xingjiang Zhou | 2017 | Science Bulletin2017，62，13： | 4 |
| 7 | Cytosolic delivery of the immunological adjuvant PolyⅠ:C and cytotoxic drug crystals via a carrier-free strategy significantly amplifies immune response显示文摘Co-delivery of chemotherapeutics and immunostimulant or chemoimmunotherapy is an emerging strategy in cancer therapy.The precise control of the targeting and release of agents is critical in this methodology.This article proposes the asynchronous release of the chemotherapeutic agents and immunostimulants to realize the synergistic effect between chemotherapy and immunotherapy.To obtain a proof-of-concept,a co-delivery system was prepared via a drug-delivering-drug(DDD)strategy for cytosolic co-delivery of Poly I:C,a synthetic ds RNA analog to activate RIG-I signaling,and PTX,a commonly used chemotherapeutics,in which pure PTX nanorods were sequentially coated with Poly I:C and mannuronic acid via stimulating the RIG-I signaling axis.The co-delivery system with a diameter of 200 nm enables profound immunogenicity of cancer cells,exhibiting increased secretion of cytokines and chemokines,pronounced immune response in vivo,and significant inhibition of tumor growth.Also,we found that intracellularly sustained release of cytotoxic agents could elicit the immunogenicity of cancer cells.Overall,the intracellular asynchronous release of chemotherapeutics and immunomodulators is a promising strategy to promote the immunogenicity of cancer cells and augment the antitumor immune response. | Xiaoqing Du Yuqi Hou Jia Huang Yan Pang Chenlu Ruan Wei Wu Chenjie Xu Hongwei Zhang Lifang Yin Wei He | 2021 | Acta Pharmaceutica Sinica B2021，11，10： | 3 |
| 8 | High CO_(2) absorption capacity of metal-based ionic liquids: A molecular dynamics study显示文摘The absorption of CO_(2)is of importance in carbon capture,utilization,and storage technology for greenhouse gas control.In the present work,we clarified the mechanism of how metal-based ionic liquids (MBILs),Bmim[XCl_(n)]_(m)(X is the metal atom),enhance the CO_(2)absorption capacity of ILs via performing molecular dynamics simulations.The sparse hydrogen bond interaction network constructed by CO_(2)and MBILs was identified through the radial distribution function and interaction energy of CO_(2)-ion pairs,which increase the absorption capacity of CO_(2)in MBILs.Then,the dynamical properties including residence time and self-diffusion coefficient confirmed that MBILs could also promote the diffusion process of CO_(2)in ILs.That's to say,the MBILs can enhance the CO_(2)absorption capacity and the diffusive ability simultaneously.Based on the analysis of structural,energetic and dynamical properties,the CO_(2)absorption capacity of MBILs increases in the order Cl^-→[ZnCl_(4)]^(2-)→[CuCl_(4)]^(2-)→[CrCl_(4)]^-→[FeCl_(4)]^-,revealing the fact that the short metal–Cl bond length and small anion volume could facilitate the performance of CO_(2)absorbing process.These findings show that the metal–Cl bond length and effective volume of the anion can be the effective factors to regulate the CO_(2)absorption process,which can also shed light on the rational molecular design of MBILs for CO_(2)capture and other key chemical engineering processes,such as IL-based gas sensors,nano-electrical devices and so on. | Biwen Li Chenlu Wang Yaqin Zhang Yanlei Wang | 2021 | Green Energy & Environment2021，6，2： | 3 |
| 9 | Prediction of radiosensitivity in primary central nervous system germ cell tumors using dynamic contrast-enhanced magnetic resonance imaging显示文摘Objective: To evaluate the feasibility of dynamic contrast-enhanced magnetic resonance imaging(DCEMRI) for predicting tumor response to radiotherapy in patients with suspected primary central nervous system(CNS) germ cell tumors(GCTs).Methods: DCE-MRI parameters of 35 patients with suspected primary CNS GCTs were obtained prior to diagnostic radiation, using the Tofts and Kermode model. Radiosensitivity was determined in tumors diagnosed 2 weeks after radiation by observing changes in tumor size and markers as a response to MRI. Taking radiosensitivity as the gold standard, the cut-off value of DCE-MRI parameters was measured by receiver operating characteristic(ROC) curve. Diagnostic accuracy of DCE-MRI parameters for predicting radiosensitivity was evaluated by ROC curve.Results: A significant elevation in transfer constant(Ktrans) and extravascular extracellular space(Ve)(P=0.000), as well as a significant reduction in rate constant(Kep)(P=0.000) was observed in tumors. Ktrans, relative Ktrans, and relative Kep of the responsive group were significantly higher than non-responsive groups. No significant difference was found in Kep, Ve, and relative Ve between the two groups. Relative Ktrans showed the best diagnostic value in predicting radiosensitivity with a sensitivity of 100%, specificity of 91.7%, positive predictive value(PPV) of 95.8%, and negative predictive value(NPV) of 100%.Conclusions: Relative Ktrans appeared promising in predicting tumor response to radiation therapy(RT). It is implied that DCE-MRI pre-treatment is a requisite step in diagnostic procedures and a novel and reliable approach to guide clinical choice of RT. | Chenlu Feng Peiyi Gao Xiaoguang Qiu Tianyi Qian Yan Lin Jian Zhou Binbin Sui | 2015 | Chinese Journal of Cancer Research2015，27，3： | 3 |
| 10 | Graphene oxide-silver/cotton fiber fabric with anti-bacterial and anti-UV properties for wearable gas sensors显示文摘Wearable gas sensors can improve early warning provision for workers in special worksites and can also be used as flexible electronic platforms.Here,the flexible multifunctional gas sensor was prepared by grafting graphene oxide(GO)-Ag onto cotton fabric after swelling.The maximum bacterial inhibition rate of GO-150/cotton fabric was 95.6%for E.coli and 87.6%for S.aureus,while retaining the original high moisture permeability of cotton fabric.So GO/cotton fabric can resist the multiplication of bacteria.At the same time,GO can greatly improve the UV protection performance of cotton fabric used in garments.With increase of the GO concentration,the UV protection ability of composite fabric is enhanced.Finally,GO-Ag/cotton fabric sensors had stable NH3 gassensitive properties and good washing stability.In conclusion,these cotton fabric sensors with antibacterial properties,UV resistance and highly sensitive gas-sensitive properties have potential applications in wearable early warning devices and textile products. | Xia HE Qingchun LIU Ying ZHOU Zhan CHEN Chenlu ZHU Wanhui JIN | 2021 | Frontiers of Materials Science2021，15，3： | 2 |
| 11 | Considerable impacts of litter inputs on soil nematode community composition in a young Acacia crassicapa plantation显示文摘Aboveground litter inputs and root exudates provide basal resources for soil communities,however,their relative contributions to soil food web are still not well understood.Here,we conducted a field manipulative experiment to differentiate the effects of litter inputs and living root on nematode community composition of surface and subsoils in a young Acacia crassicapa plantation in southern China.Our results showed that both litter addition and root presence significantly enhanced soil nematode abundance by 17.3%and 35.3%,respectively.Litter addition altered nematode trophic group composition,decreased fungivore to bacterivore ratio,and enhanced maturity index and structure index,which led to a bacterial-based energy channel and a more complex food web structure.However,root presence had a limited impact on the nematode community composition and ecological indices.Despite nematodes surface assembly,soil depth did not affect nematode trophic group composition or ecological index.Our findings highlight the importance of litter inputs in shaping soil nematode community structure and regulating soil energy channel. | CANCAN ZHAO YIN LI CHENLU ZHANG Yuan Miao Mengzhou Liu Wanlin Zhuang Yuanhu Shao Weixin Zhang Shenglei Fu | 2021 | Soil Ecology Letters2021，3，2： | 2 |
| 12 | HSP70 alleviates sepsis-induced cardiomyopathy by attenuating mitochondrial dysfunction-initiated NLRP3 inflammasome-mediated pyroptosis in cardiomyocytes显示文摘Background:Sepsis-induced cardiomyopathy(SIC)is an identified serious complication of sepsis that is associated with adverse outcomes and high mortality.Heat shock proteins(HSPs)have been implicated in suppressing septic inflammation.The aim of this study was to investigate whether HSP70 can attenuate cellular mitochondrial dysfunction,exuberated inflammation and inflammasome-mediated pyroptosis for SIC intervention.Methods:Mice with cecal ligation plus perforation(CLP)and lipopolysaccharide(LPS)-treated H9C2 cardiomyocytes were used as models of SIC.The mouse survival rate,gross profile,cardiac function,pathological changes and mitochondrial function were observed by photography,echocardiography,hematoxylin-eosin staining and transmission electron microscopy.In addition,cell proliferation and the levels of cardiac troponin I(cTnI),interleukin-1β(IL-1β)and tumor necrosis factor-α(TNF-α)were determined by Cell Counting Kit-8,crystal violet staining and enzyme-linked immunosorbent assay.Moreover,mitochondrial membrane potential was assessed by immunofluorescence staining,and dynamin-related protein 1 and pyroptosis-related molecules[nucleotide-binding domain,leucine-rich-repeat containing family pyrin domain-containing 3(NLRP3),caspase-1,gasdermin-D(GSDMD),gasdermin-D N-terminal(GSDMD-N)]were measured by western blotting,immunoprecipitation and immunoblotting.Finally,hsp70.1 knockout mice with CLP were used to verify the effects of HSP70 on SIC and the underlying mechanism.Results:Models of SIC were successfully established,as reduced consciousness and activity with liparotrichia in CLP mice were observed,and the survival rate and cardiac ejection fraction(EF)were decreased;conversely,the levels of cTnI,TNF-αand IL-1βand myocardial tissue damage were increased in CLP mice.In addition,LPS stimulation resulted in a reduction in cell viability,mitochondrial destabilization and activation of NLRP3-mediated pyroptosis molecules in vitro.HSP70 treatment improved myocardial tissue damage,survival rate and cardiac dysfunction caused by CLP.Additionally,HSP70 intervention reversed LPS-induced mitochondrial destabiliza-tion,inhibited activation of the NLRP3 inflammasome,caspase-1,GSDMD and GSDMD-N,and decreased pyroptosis.Finally,knockout of hsp70.1 mice with CLP aggravated cardiac dysfunction and upregulated NLRP3 inflammasome activity,and exogenous HSP70 significantly rescued these changes.It was further confirmed that HSP70 plays a protective role in SIC by attenuating mitochondrial dysfunction and inactivating pyroptotic molecules.Conclusions:Our study demonstrated that mitochondrial destabilization and NLRP3 inflammasome activation-mediated pyroptosis are attributed to SIC.Interestingly,HSP70 ameliorates sepsis-induced myocardial dysfunction by improving mitochondrial dysfunction and inhibiting the acti-vation of NLRP3 inflammasome-mediated pyroptosis,and such a result may provide approaches for novel therapies for SIC. | Chenlu Song Yiqiu Zhang Qing Pei Li Zheng Meiyu Wang Youzhen Shi Shan Wu Wei Ni Xiujun Fu Yinbo Peng Wen Zhang Min Yao | 2022 | Burns & Trauma2022，10，1： | 2 |
| 13 | Oxidation of nitric oxide in a two-stage chemical scrubber using DC corona discharge 显示文摘 | Yang Chenlu Chen Luke | 2000 | Journal of Hazardous Materials2000，80，： | 2 |
| 14 | Visualizing DC morphology and T cell motility to characterize DC-T cell encounters in mouse lymph nodes under mTOR inhibition显示文摘Mammalian target of rapamycin(mTOR),a serine/threonine kinase orchestrating cellular metabolism,is a crucial immune system regulator.However,it remains unclear how mTOR regulates dendritic cell(DC) function in vivo,especially DC-T cell encounters,a critical step for initiating adaptive immune responses.We dynamically visualized DC-T contacts in mouse lymph node using confocal microscopy and established an encounter model to characterize the effect of mTOR inhibition on DC-T cell encounters using DC morphology.Quantitative data showed mTOR inhibition via rapamycin altered DC shape,with an increased form factor(30.17%) and decreased cellular surface area(20.36%) and perimeter(22.43%),which were associated with Cdc42 protein downregulation(52.71%).Additionally,DCs adopted a similar morphological change with Cdc42 inhibition via ZCL278 as that observed with mTOR inhibition.These morphologically altered DCs displayed low encounter rates with T cells.Time-lapse imaging data of T cell motility supported the simulated result of the encounter model,where antigen-specific T cells appeared to reduce arrest in the lymph nodes of rapamycin-pretreated mice relative to the untreated group.Therefore,mTOR inhibition altered DC morphology in vivo and decreased the DC-T cell encounter rate,as well as Cdc42 inhibition.By establishing an encounter model,our study provides an intuitive approach for the early prediction of DC function through morphological quantification of form factor and area. | Qiaoya Lin Zheng Liu Meijie Luo Hao Zheng Sha Qiao Chenlu Han Deqiang Deng Zhan Fan Yafang Lu Zhihong Zhang Qingming Luo | 2019 | Science China(Life Sciences)2019，62，9： | 2 |
| 15 | Coupled Tamm plasmon polaritons induced narrow bandpass filter with ultra-wide stopband显示文摘Narrow bandpass filters(NBPFs)play important roles in optics,such as quantum communication,spectrometer,and wavelength division multiplexing.However,the stopband and restraint ability of traditional NBPFs is limited.In this article,a coupled Tamm plasmon polaritons(TPPs)induced transmission theory has been proposed to design high-efficiency NBPFs with ultra-wide deep stopbands.An NBPF at 1.55 μm has been experimentally demonstrated with full width at half maximum(FWHM)of 10 nm and stopband ranging from 0.2 to 25 μm which is 62 times wider than that of traditional ones.Furthermore,the restraint depth of the stopband reaches 0.03%,which is only 1/20 of a traditional filter with the same FWHM.Its advantage in restraining ambient light over traditional ones has also been demonstrated with an InGaAs infrared detector.It provides a very powerful way to capture specific narrowband optical signals from ultra-wide strong ambient light,especially useful for daytime quantum communications. | Qingquan Liu Xinchao Zhao Chenlu Li Xinglei Zhou Yu Chen Shaowei Wang Wei Lu | 2022 | Nano Research2022，15，5： | 2 |
| 16 | Daily power demand prediction for buildings at a large scale using a hybrid of physics-based model and generative adversarial network显示文摘Power demand prediction for buildings at a large scale is required for power grid operation.The bottom-up prediction method using physics-based models is popular,but has some limitations such as a heavy workload on model creation and long computing time.Top-down methods based on data driven models are fast,but less accurate.Considering the similarity of power demand patterns of single buildings and the superiority of generative adversarial network(GAN),this paper proposes a new method(E-GAN),which combines a physics-based model(EnergyPlus)and a data-driven model(GAN),to predict the daily power demand for buildings at a large scale.The new E-GAN method selects a small number of typical buildings and utilizes EnergyPlus models to predict their power demands.Utilizing the prediction for those typical buildings,the GAN then is adopted to forecast the power demands of a large number of buildings.To verify the proposed method,the E-GAN is used to predict 24-hour power demands for a set of residential buildings.The results show that(1)4.3%of physics-based models in each building category are required to ensure the prediction accuracy;(2)compared with the physics-based model,the E-GAN can predict power demand accurately with only 5%error(measured by mean absolute percentage error,MAPE)while using only approximately 9%of the computing time;and(3)compared with data-driven models(e.g.,support vector regression,extreme learning machine,and polynomial regression model),E-GAN demonstrates at least 60%reduction in prediction error measured by MAPE. | Chenlu Tian Yunyang Ye Yingli Lou Wangda Zuo Guiqing Zhang Chengdong Li | 2022 | Building Simulation2022，15，9： | 2 |
| 17 | Metro-Wordle:An Interactive Visualization for Urban Text Distributions Based on Wordle显示文摘With the development of cities and the explosion of infonnation,vast amounts of geo-tagged textural data about Points of Interests(POIs)have been generated.Extracting useful information and discovering text spatial distributions from the data are challenging and meaningful.Also,the huge numbers of POIs in modem cities make it important to have efficient approaches to retrieve and choose a destination.This paper provides a visual design combing metro map and wordles to meet the needs.In this visualization,metro lines serve as the divider lines splitting the city into several subareas and the boundaries to constrain wordles within each subarea.The wordles are generated from keywords extracted from the text about POIs(including reviews,descriptions,etc.)and embedded into the subareas based on their geographical locations.By generating intuitive results and providing an interactive visualization to support exploring text distribution patterns,our strategy can guide the users to explore urban spatial characteristics and retrieve a location efficiently.Finally,we implement a visual analysis of the restaurants data in Shanghai,China as a case study to evaluate our strategy. | Chenlu Li Xiaoju Dong Xiaoru Yuan | 2018 | Visual Informatics2018，2，1： | 2 |
| 18 | Coupling magnetic particles with flocculants to enhance demulsification and separation of waste cutting emulsion for engineering applications显示文摘Magnetic particles were coupled with a flocculant to enhance the demulsification and separation of waste cutting emulsions.The optimal magnetic particle size and critical magnetic field conditions were investigated to achieve large-scale engineering application of magnetic demulsification separation for waste cutting emulsion treatment.The micro-scale magnetic particles were found to show comparable effects to nano-scale magnetic particles on enhancing the demulsification and separation of cutting emulsions,which are beneficial for broadening the selectivity of low-cost magnetic particles.The critical magnetic separation region was determined to be an area 40 mm from the magnetic field source.Compared to the flocculant demulsification,the magnetic demulsification separation exhibited a significant advantage in accelerating flocs-water separation by decreasing the separation time of flocs from 180-240 min to less than 15 min,compressing the flocs by reducing the floc volume ratio from 60%-90%to lower than 20%,and showing excellent adaptability to the variable properties of waste cutting emulsions.Coupled with the design of the magnetic disk separator,continuous demulsification separation of the waste cutting emulsion was achieved at 1.0 t/hr for at least 10 hr to obtain clear effluent with 81%chemical oxygen demand removal and 89%turbidity reduction.This study demonstrates the feasibility of applying magnetic demulsification separation to large-scale continuous treatment of waste emulsion.Moreover,it addresses the flocs-water separation problems that occur in practical flocculant demulsification engineering applications. | Yongjiao Xiong Baoqiang Wu Xiangfeng Huang Chenlu Li Bin Lu Jia Liu Lijun Lu Shiyang Li Kaiming Peng | 2021 | Journal of Environmental Sciences2021，33，7： | 2 |
| 19 | Versatility of the pedicled peroneal artery perforator flaps for softtissue coverage of the lower leg and foot defects显示文摘 | Ting- chenLu Cheng- HungLin Chih- HungLin | 2011 | J plast Reconstructive & Aesthetic Surgery2011，64，7： | 1 |
| 20 | Toripalimab in advanced biliary tract cancer显示文摘Gemcitabine combined with platinum/fluorouracil drugs is the standard firstline treatment for advanced biliary tract cancers(BTCs).We explored the safety and efficacy of toripalimab plus gemcitabine and S-1(GS)as the first-line treatment for advanced BTCs.At a one-sided significance level of 0.025,a total of 50 patients could provide 80%power to show the efficacy at targeted progression-free survival(PFS)rate at 6 months of 70%versus 40%for the combined treatment.This single-arm,phase II study enrolled 50 patients with advanced BTCs who previously received no systemic treatment.The regimen was as follows:toripalimab(240 mg,i.v.,d1),gemcitabine(1,000 mg/m2,i.v.,d1 and d8),and S-1(40–60 mg bid p.o.,d1–14,Q21d).The primary endpoint was progression-free survival.The secondary endpoints included overall survival(OS),objective response rate(ORR),duration of response(DOR),and safety.The associations between response with PDL1 expression,tumor mutational burden(TMB),and genetic variations were explored.Patients were enrolled from January 2019 to August 2020,with a median follow-up time of 24.0 months(IQR:4.3–31.0 months). | Wei Li Yueqi Wang Yiyi Yu Qian Li Yan Wang Chenlu Zhang Xiaojing Xu Xi Guo Yu Dong Yuehong Cui Qing Hao Lujia Huang Houbao Liu Tianshu Liu | 2022 | The Innovation2022，3，4： | 1 |
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